Message 152: From wais@quake.think.com Sun Mar 6 15:44:09 1994 Date: Sun, 6 Mar 94 12:41:21 PST From: wais@quake.think.com (SWAIS Telnet User) Apparently-To: sergey@water.bu.edu LOCUS HUMHBB 73326 bp ds-DNA PRI 26-AUG-1993 DEFINITION Human beta globin region on chromosome 11. ACCESSION J00179 J00093 J00094 J00096 J00158 J00159 J00160 J00161 J00162 J00163 J00164 J00165 J00166 J00167 J00168 J00169 J00170 J00171 J00172 J00173 J00174 J00175 J00177 J00178 K01239 K01890 K02544 M18047 M19067 M24868 M24886 X00423 X00424 X00672 KEYWORDS Alu repeat; HPFH; KpnI repetitive sequence; RNA polymerase III; allelic variation; alternate cap site; beta-1 pseudogene; beta-globin; delta-globin; epsilon-globin; gamma-globin; gene duplication; globin; polymorphism; promoter mutation; pseudogene; repetitive sequence; thalassemia. SOURCE Human mRNA, cDNA and DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. 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Chem. 252, 5019-5031 (1977) STANDARD full automatic REFERENCE 9 (bases 62205 to 63628) AUTHORS Cohen-Solal,M.M., Forget,B.G., Prensky,W., Marotta,C.A. and Weissman,S.M. TITLE Human beta-globin messenger RNA: II. Nucleotide sequences derived from 125-I-labeled globin messenger RNA JOURNAL J. Biol. Chem. 252, 5032-5039 (1977) STANDARD full automatic REFERENCE 10 (bases 54808 to 54899; 62427 to 62649; 63500 to 63733) AUTHORS Marotta,C.A., Wilson,J.T., Forget,B.G. and Weissman,S.M. TITLE Human beta-globin messenger RNA. III. Nucleotide sequences derived from complementary DNA JOURNAL J. Biol. Chem. 252, 5040-5053 (1977) STANDARD full automatic REFERENCE 11 (bases 62155 to 62207) AUTHORS Chang,J.C., Temple,G.F., Poon,R., Neumann,K.H. and Kan,Y.W. TITLE The nucleotide sequences of the untranslated 5' regions of human alpha- and beta-globin mRNAs JOURNAL Proc. Natl. Acad. Sci. 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TITLE Insertion of synthetic copies of human globin genes into bacterial plasmids JOURNAL Nucleic Acids Res. 5, 563-581 (1978) STANDARD full automatic REFERENCE 15 (bases 34496 to 34581; 39432 to 39517) AUTHORS Chang,J.C., Poon,R., Neumann,K.H. and Kan,Y.W. TITLE The nucleotide sequence of the 5' untranslated region of human gamma-globin mRNA JOURNAL Nucleic Acids Res. 5, 3515-3522 (1978) STANDARD full automatic REFERENCE 16 (bases 40857 to 41003) AUTHORS Poon,R., Wai,K.Y. and Boyer,H.W. TITLE Sequence of the 3' noncoding and adjacent regions of human gamma-globin mRNA JOURNAL Nucleic Acids Res. 5, 4625-4630 (1978) STANDARD full automatic REFERENCE 17 (bases 35844 to 35925; 40760 to 40841) AUTHORS Smithies,O., Blechl,A.E., Denniston-Thompson,K., Newell,N., Richards,J.E., Slightom,J.L., Tucker,P.W. and Blattner,F.R. TITLE Cloning human fetal gamma globin and mouse alpha-type globin DNA: Characterization and partial sequencing JOURNAL Science 202, 1284-1289 (1978) STANDARD full automatic REFERENCE 18 (bases 34496 to 34554; 62155 to 62210; 63626 to 63760) AUTHORS Kan,Y.W., Chang,C.S. and Poon,R. TITLE Nucleotide sequences of the untranslated 5' and 3' regions of human alpha-, beta-, and gamma-globin mRNAS JOURNAL (in) Stamatoyannopoulos,G. and Newhouse,A.W. (Eds.); CELLULAR AND MOLECULAR REGULATION OF HEMOGLOBIN SWITCHING: 0-0, Grune and Stratton, New York (1979) STANDARD full automatic REFERENCE 19 (sites) AUTHORS Chang,J.C. and Kan,Y.W. TITLE Beta-0 thalassemia, a nonsense mutation in man JOURNAL Proc. Natl. Acad. Sci. U.S.A. 76, 2886-2889 (1979) STANDARD full automatic REFERENCE 20 (bases 19864 to 19983) AUTHORS Proudfoot,N.J. and Baralle,F.E. TITLE Molecular cloning of human epsilon-globin gene JOURNAL Proc. Natl. Acad. Sci. 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TITLE Human fetal G-gamma and A-gamma globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes JOURNAL Cell 21, 627-638 (1980) STANDARD full automatic REFERENCE 25 (bases 54636 to 56620) AUTHORS Spritz,R.A., DeRiel,J.K., Forget,B.G. and Weissman,S.M. TITLE Complete nucleotide sequence of the human delta-globin gene JOURNAL Cell 21, 639-646 (1980) STANDARD full automatic REFERENCE 26 (bases 62052 to 64101) AUTHORS Lawn,R.M., Efstratiadis,A., O'Connell,C. and Maniatis,T. TITLE The nucleotide sequence of the human beta-globin gene JOURNAL Cell 21, 647-651 (1980) STANDARD full automatic REFERENCE 27 (sites) AUTHORS Efstratiadis,A., Posakony,J.W., Maniatis,T., Lawn,R.M., O'Connell,C., Spritz,R.A., DeRiel,J.K., Forget,B.G., Weissman,S.M., Slightom,J.L., Blechl,A.E., Smithies,O., Baralle,F.E., Shoulders,C.C. and Proudfoot,N.J. TITLE The structure and evolution of the human beta-globin gene family JOURNAL Cell 21, 653-668 (1980) STANDARD full automatic REFERENCE 28 (bases 17841 to 20001) AUTHORS Baralle,F.E., Shoulders,C.C., Goodbourn,S., Jeffreys,A. and Proudfoot,N.J. TITLE The 5' flanking region of human epsilon-globin gene JOURNAL Nucleic Acids Res. 8, 4393-4404 (1980) STANDARD full automatic REFERENCE 29 (bases 32371 to 43746) AUTHORS Shen,S.-H.H., Slightom,J.L. and Smithies,O. TITLE A history of the human fetal globin gene duplication JOURNAL Cell 26, 191-203 (1981) STANDARD full automatic REFERENCE 30 (sites) AUTHORS Busslinger,M., Moschonas,N. and Flavell,R.A. TITLE +beta thalassemia: Aberrant splicing results from a single point mutation in an intron JOURNAL Cell 27, 289-298 (1981) STANDARD full automatic REFERENCE 31 (bases 32371 to 33236; 51996 to 52490) AUTHORS Duncan,C.H., Jagadeeswaran,P., Wang,R.R. and Weissman,S.M. TITLE Structural analysis of templates and RNA polymerase III transcripts of Alu family sequences interspersed among the human beta-like globin genes JOURNAL Gene 13, 185-196 (1981) STANDARD full automatic REFERENCE 32 (sites) AUTHORS Orkin,S.H. and Goff,S.C. TITLE Nonsense and frameshift mutations in beta-0-thalassemia detected in cloned beta-globin genes JOURNAL J. Biol. Chem. 256, 9782-9784 (1981) STANDARD full automatic REFERENCE 33 (bases 62472 to 62631) AUTHORS Orkin,S.H., Goff,S.C. and Nathan,D.G. TITLE Heterogeneity of DNA deletion in gamma-delta-beta-thalassemia JOURNAL J. Clin. Invest. 67, 878-884 (1981) STANDARD full automatic REFERENCE 34 (sites) AUTHORS Trecartin,R.F., Liebhaber,S.A., Chang,J.C., Lee,K.Y., Kan,Y.W., Furbetta,M., Angius,A. and Cao,A. TITLE Beta-0 thalassemia in Sardinia is caused by a nonsense mutation JOURNAL J. Clin. Invest. 68, 1012-1017 (1981) STANDARD full automatic REFERENCE 35 (sites) AUTHORS Westaway,D. and Williamson,R. TITLE An intron nucleotide sequence variant in a cloned beta-plus-thalassemia globin gene JOURNAL Nucleic Acids Res. 9, 1777-1787 (1981) STANDARD full automatic REFERENCE 36 (sites) AUTHORS Moschonas,N., de Boer,E., Grosveld,F.G., Dahl,H.-H.M., Wright,S., Shewmaker,C.K. and Flavell,R.A. TITLE Structure and expression of a cloned beta-0 thalassemic globin gene JOURNAL Nucleic Acids Res. 9, 4391-4401 (1981) STANDARD full automatic REFERENCE 37 (bases 60507 to 60966) AUTHORS Spritz,R.A. TITLE Duplication/deletion polymorphism 5'- to the human beta globin gene JOURNAL Nucleic Acids Res. 9, 5037-5047 (1981) STANDARD full automatic REFERENCE 38 (bases 59363 to 59611) AUTHORS Miesfeld,R., Krystal,M. and Arnheim,N. TITLE A member of a new repeated sequence family which is conserved throughout eukaryotic evolution is found between the human delta and beta globin genes JOURNAL Nucleic Acids Res. 9, 5931-5947 (1981) STANDARD full automatic REFERENCE 39 (bases 16595 to 17840) AUTHORS Di Segni,G., Carrara,G., Tocchini-Valentini,G.R., Shoulders,C.C. and Baralle,F.E. TITLE Selective in vitro transcription of one of the two Alu family repeats present in the 5' flanking region of the human epsilon-globin gene JOURNAL Nucleic Acids Res. 9, 6709-6722 (1981) STANDARD full automatic REFERENCE 40 (sites) AUTHORS Adams,J.G.III., Steinberg,M.H., Newman,M.V., Morrison,W.T., Benz,E.J.Jr.. and Iyer,R. TITLE Beta-thalassemia present in cis to a new beta-chain structural variant, Hb Vicksburg [beta75(e19)leu->0] JOURNAL Proc. Natl. Acad. Sci. 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TITLE A gene deletion ending at the midpoint of a repetitive DNA sequence in one form of hereditary persistence of fetal haemoglobin JOURNAL Nature 296, 469-470 (1982) STANDARD full automatic REFERENCE 48 (sites) AUTHORS Orkin,S.H., Kazazian,H.H.Jr.., Antonarakis,S.E., Goff,S.C., Boehm,C.D., Sexton,J.P., Waber,P.G. and Giardina,P.J. TITLE Linkage of beta-thalassemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster JOURNAL Nature 296, 627-631 (1982) STANDARD full automatic REFERENCE 49 (sites) AUTHORS Ottolenghi,S. and Giglioni,B. TITLE The deletion in a type of delta-0-beta-0-thalassemia begins in an inverted AluI repeat JOURNAL Nature 300, 770-771 (1982) STANDARD full automatic REFERENCE 50 (bases 62669 to 62733) AUTHORS Spence,S.E., Pergolizzi,R.G., Donovan-Peluso,M., Kosche,K.A., Dobkin,C.S. and Bank,A. 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TITLE Multiple origins of transcription in the 4.5 kb upstream of the epsilon-globin gene JOURNAL Cell 35, 187-197 (1983) STANDARD full automatic REFERENCE 61 (sites) AUTHORS Vanin,E.F., Henthorn,P.S., Kioussis,D., Grosveld,F. and Smithies,O. TITLE Unexpected relationships between four large deletions in the human beta-globin gene cluster JOURNAL Cell 35, 701-709 (1983) STANDARD full automatic REFERENCE 62 (bases 50762 to 67222) AUTHORS Poncz,M., Schwartz,E., Ballantine,M. and Surrey,S. TITLE Nucleotide sequence analysis of the delta-beta-globin gene region in humans JOURNAL J. Biol. Chem. 258, 11599-11609 (1983) STANDARD full automatic REFERENCE 63 (bases 62068 to 62068; 62297 to 62297; 62301 to 62301) AUTHORS Treisman,R., Orkin,S.H. and Maniatis,T. TITLE Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes JOURNAL Nature 302, 591-596 (1983) STANDARD full automatic REFERENCE 64 (bases 62208 to 62262) AUTHORS Chang,J.C., Alberti,A. and Kan,Y.W. 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TITLE A point mutation in the alpha-gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin JOURNAL Nature 313, 325-326 (1985) STANDARD full automatic REFERENCE 83 (bases 67089 to 73326) AUTHORS Hattori,M., Hidaka,S. and Sakaki,Y. TITLE Sequence analysis of a KpnI family member near the 3'end of human beta-globin gene JOURNAL Nucleic Acids Res. 13, 7813-7827 (1985) STANDARD full automatic REFERENCE 84 (sites) AUTHORS van Santen,V.L. and Spritz,R.A. TITLE mRNA precursor splicing in vivo: Sequence requirements determined by deletion analysis of an intervening sequence JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 2885-2889 (1985) STANDARD full automatic REFERENCE 85 (sites) AUTHORS Tuan,D., Solomon,W., Li,Q. and London,I.M. TITLE The 'beta-like-globin' gene domain in human erythroid cells JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 6384-6388 (1985) STANDARD full automatic REFERENCE 86 (sites) AUTHORS Chabot,B., Black,D.L., LeMaster,D.M. and Steitz,J.A. TITLE The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein JOURNAL Science 230, 1344-1349 (1985) STANDARD full automatic REFERENCE 87 (bases 21372 to 21378) AUTHORS Collins,F.S. JOURNAL Unpublished (1986) STANDARD full automatic REFERENCE 88 (bases 58817 to 58976; 63054 to 63313) AUTHORS Popovich,B.W., Rosenblatt,D.S., Kendall,A.G. and Nishioka,Y. TITLE Molecular characterization of an atypical beta-thalassemia caused by a large deletion in the 5' beta-globin gene region JOURNAL Am. J. Hum. Genet. 39, 797-810 (1986) STANDARD full automatic REFERENCE 89 (bases 54892 to 54910) AUTHORS Lapoumeroulie,C., Pagnier,J., Bank,A., Labie,D. and Krishnmoorthy,R. TITLE Beta thalassemia due to a novel mutation in IVS 1 sequence donor site consensus sequence creating a restriction site JOURNAL Biochem. Biophys. Res. Commun. 139, 709-713 (1986) STANDARD full automatic REFERENCE 90 (bases 62391 to 62437) AUTHORS Metherall,J.E., Collins,F.S., Pan,J., Weissman,S.M. and Forget,B.G. TITLE Beta-0 thalassemia caused by a base substitution that creates an alternative splice acceptor site in an intron JOURNAL EMBO J. 5, 2551-2557 (1986) STANDARD full automatic REFERENCE 91 (bases 37658 to 37695; 40180 to 40217) AUTHORS Tate,V.E., Hill,A.V., Bowden,D.K., Sadler,J.R., Weatherall,D.J. and Clegg,J.B. TITLE A silent deletion in the beta-globin gene cluster JOURNAL Nucleic Acids Res. 14, 4743-4750 (1986) STANDARD full automatic REFERENCE 92 (sites) AUTHORS Prchal,J.T., Cashman,D.P. and Kan,Y.W. TITLE Hemoglobin Long Island is caused by a single mutation (adenine to cytosine) resulting in a failure to cleave amino-terminal methionine JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83, 24-27 (1986) STANDARD full automatic REFERENCE 93 (bases 59607 to 59736; 72229 to 72358) AUTHORS Gilman,J.G. and Abraham,J. TITLE DNA sequence analysis of the Dutch beta-0-thalassemia deletion JOURNAL Biomed. Biochim. Acta 46, 131-135 (1987) STANDARD full automatic REFERENCE 94 (bases 43741 to 50739) AUTHORS Miyamoto,M.M., Slightom,J.L. and Goodman,M. TITLE Phylogenetic relations of humans and African apes from DNA sequences in the pseudo-eta-globin region JOURNAL Science 238, 369-373 (1987) STANDARD full automatic REFERENCE 95 (sites) AUTHORS Fei,Y.J., Stoming,T.A., Efremov,G.D., Efremov,D.G., Battacharia,R., Gonzalez-Redondo,J.M., Altay,C., Gurgey,A. and Huisman,T.H. TITLE Beta-thalassemia due to a T->A mutation within the ATA box JOURNAL Biochem. Biophys. Res. Commun. 153, 741-747 (1988) STANDARD full automatic REFERENCE 96 (bases 55056 to 55070) AUTHORS Atweh,G.F., Brickner,H.E., Zhu,X.-X., Kazazian,H.H.Jr.. and Forget,B.G. TITLE New amber mutation in a beta-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo JOURNAL J. Clin. Invest. 82, 557-561 (1988) STANDARD full automatic REFERENCE 97 (sites) AUTHORS Engelke,D.R., Hoener,P.A. and Collins,F.S. TITLE Direct sequencing of enzymatically amplified human genomic DNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85, 544-548 (1988) STANDARD full automatic REFERENCE 98 (sites) AUTHORS Guidal,C., Lapoumeroulie,C., Krishnamoorthy,R. and Elion,J. TITLE Sequence correction and reassignment of the TaqI polymorphic site in the human inter-gamma-globin gene region, an African-specific marker JOURNAL Unpublished (1993) STANDARD full automatic COMMENT [1] cRNA fragments. [2] mRNA. [5] sites; polyadenylation signal and site for the beta gene. [4] cDNA from normal and thalassemic mRNAs. [6] cDNA. [9] mRNA and cDNA fragments. [10] mRNA. [7] cDNA. [13] see comment below for 35872 to 35964 - may be 40788 to 40880. [19] sites; amber mutation at codon 17 of the beta chain. [22] sites; gene order for the beta-like globin cluster. [27] sites; consensus sequences in the promoter regions. [40] sites; mutation associated with Hb Vicksburg. [41] beta thalassemia DNA. [42] sites; mutation associated with beta-0 thalassemia. [35] sites; mutation associated with beta-plus thalassemia. [36] sites; mutation associated with beta-0 thalassemia. [37] six alleles over this span. [32] sites; mutations associated with beta-0 thalassemia. [34] sites; mutation associated with beta-0 thalassemia. [52] sites; alternative cap sites for mRNA. [53] sites; mutation associated with beta-plus thalassemia. [56] sites; deletion mutation associated with beta-0 thalassemia;. [48] sites; mutations associated with beta thalassemias. [49] sites; deletion mutation; for sequence, see separate entry. [62] DNA from Kurdish Jew with thalassemia. [58] sites; promoter region for beta gene. [59] sites; termini for RNA polymerase III transcripts. [60] sites; alternative cap sites for mRNA. [61] sites; deletion mutations associated with thalassemias;. [65] for the R allele;. [73] sites; beta and gamma gene cap sites. [71] sites; mutation associated with beta thalassemia. [66] sites; Miyada Hb lesion; for sequence, see separate entry. [75] sites; hsRTVL-H element; for sequence, see separate entry. [67] sites; mutations associated with thalassemia. [68] sites; mutation associated with thalassemia. [69] sites; mutation associated with thalassemia. [76] see comment; review. [74] sites; mutations in the A-gamma gene. [81] sites; mutation in promoter region leading to HPFH;. [82] sites; mutation in promoter region leading to HPFH. [85] sites; DNAse I hypersensitivity sites in the region. [78] sites; cryptic branch points in beta IVS1. [79] sites; 3' segments of beta and G-gamma cDNAs. [84] sites; mutational analysis of G-gamma IVS-2. [86] sites; small nuclear ribonucleoprotein binding site to mRNA. [92] sites; hemoglobin Long Island mutation. [94] revises [72]. [95] sites; mutations resulting in beta-thalassemia. [97] sites; sickle cell anemia mutation site. [30] sites; thalassemia mutations. [43] sites; thalassemia mutations. [44] sites; thalassemia mutation. [Ann. N.Y. Acad. Sci. 344, 113-119 (1980)] sites; thalassemia mutation. [90] beta-0 thalassemia mutations. This 73 kb sequence, which includes all of the known beta genes in the cluster on chromosome 11, was compiled from the following sources primarily: bases references ------ ------------ 1 to 10409 [80] 10410 to 13774 [55] 13775 to 16594 [80] 16595 to 21399 [23], [28], [39] 21400 to 32370 [63; see acknowledgments therein; bases 31906-32038 sequenced on one strand only] 32371 to 43746 [29] 43747 to 50733 [94] 50734 to 67222 [47], [62] 67223 to 73326 [83] Other sequence work is referenced and annotated below. Oliver Smithies provided the sequence in [80] via Arpanet and Francis Collins supplied a diskette with the sequence in [76]. Computer-readable sequence for [94] kindly provided by M.M.Miyamoto, 15-FEB-1988. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon -G-gamma -A-gamma -delta -beta-3' [22] Additionally, the pseudogene beta-1 is located between the A-gamma and delta genes [72]. A region 5' to the epsilon gene was thought to be another pseudogene; however [55] shows this not to be so. These embryonic, fetal and adult beta-like genes have the same overall exonic structure, leading to the conclusion that they are derived from one ancestral gene. In particular, they have many consensus sequences and repetitive sequences in common which have been analyzed by [27] and [76]. Epsilon gene ------------ The epsilon globin gene (hbe below) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin; see separate entry) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The promoter region sequences 'ccaat', 'ata' and 'cttccg' found at 19421, 19476 and 19513 are characteristic of all human beta-like genes, as well as of some other mammalian genes, and are thought to influence initiation of transcription and translation [27],[76]. However, at least nine alternative cap sites which do not possess these conserved sequences have been found upstream from the so-called canonical cap sites at 19504 and 19506 [52],[60]. The Alu family sequences found at 16910-17176 and 17945-18208 are typical of the 5' flanking regions of the beta-like globin genes [23],[39]. The first of these bipolar repeats has been shown to be active as a template for RNA polymerase III [39]. G-gamma and A-gamma genes ------------------------- The gamma globin genes (hbgg and hbga below) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions (HPFH or 'hereditary persistence of fetal hemoglobin'), gamma chain production continues into adulthood. The mapping of deletions in these pathologies is therefore of special interest with regard to developmental control mechanisms. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product and alanine is found in the A-gamma product. The former is predominant at birth. Because of the sequence identity of the two genes over large stretches, it was not always possible in the early work to know which sequence was being investigated [13],[15],[17]. Moreover, because allelic variation has been reported for each of these non-allelic genes, further sequence work is required to determine the consensus sequence for each. Thus far the sequences of two A-gamma alleles have been reported ([24]; see separate entry which annotates the allelic variation). The second introns for the hbgg and hbga genes shown below contain 886 and 866 bases respectively, while their alleles on the opposing chromosome have 904 and 876 bases for the corresponding introns. [24] and [29] present an analysis of this phenomenon and conclude that intergenic exchange can occur in human germ line cells with significant frequency. Given the above-mentioned uncertainties with regard to polymorphism and material, differences, where annotated, are treated as variations rather than as conflicts. The promoter region sequences 'ccaat', 'ata' and 'cttctg' found at bases 34408, 34466 and 34503 in the hbgg gene, and bases 39344, 39402 and 39439 in the hbga gene, are characteristic of all beta-like genes, as well as of some other mammalian genes, and are thought to influence transcription and translation [27],[76]. The gamma genes each manifest duplicate 'ccaat' boxes at positions 34381 (hbgg) and 39317 (hbga). Alternative cap sites are active in vitro upstream from the canonical cap sites at 34496 and 39432: at bases 34416, 34426, 34436 and 34446 for hbgg, and at bases 39352, 39362, 39372 and 39382 for hbga [73]. Alternative cap sites have also been reported for epsilon and beta mRNAs when there is no duplication of the 'ccaat' sequence. [81] and [82] show that the distal 'ccaat' box for the hbga gene (for the B allele -- see separate sequence) has some vital function: a g -> a mutation at base 39315 is apparently responsible for one form of Greek HPFH. The Alu family sequences found at bases 32408-32741 (approx.) and 37343-37580 (approx.) are typical of the beta-like globin Alu's [27],[76],[31],[29]. A study of the hbgg repeat has revealed RNA transcription by polymerase III [31]( also reported for Alu regions in the 5' flanks of the epsilon and beta genes). Pseudo-beta-1 ------------- Human, gorilla and chimpanzee beta-like pseudogenes were sequenced and compared (see separate entries for the other primate sequences) by [72] and revised by [94]. The pseudogene structure was deduced through comparison with the A-gamma globin gene. Base substitutions in the initiation codon and in codons downstream, that create internal termination signals in exons 2 and 3, make this sequence a pseudogene. Delta and beta genes -------------------- The delta and beta genes (denoted hbd and hbb below) are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. The sequence given below has been reconstructed from the sequences reported by [47] and [62]: the mutation at base 62161 is apparently sufficient to distinguish the Kurdish Jew thalassemic sequence from a normal (consensus) beta globin DNA; [62] has resolved all sequence differences to date with exception of the differences reported herein as variations. The promoter region sequences 'ccaat', 'ata' and 'cttctg' found at bases 54690, 54727 and 54765 in the delta gene, and at bases 62079, 62124 and 62162 in the beta gene, are characteristic of all beta-like genes, as well as of some other mammalian genes, and are thought to influence transcription and translation [27],[76]. However, alternative cap sites have been found for these genes as well as other beta-like genes [58],[73]. [95] describes the mutation (substitution of 'a' for 't' at position 62125, thereby destroying the promoter) found in an Hb Lepore-beta+ -thalassemia patient, who was homozygous for this mutation. The father who had the simple beta-thalassemia trait was found to be heterozygous. A form of thalassemia exists, where 19 bp are added after the first exon, starting at position 62408 and ending at a stop codon at position 62424-62426 [30],[43],[57]. This aberrant splicing is caused by a mutation of 'g' to 'a' in the first intron of beta-hemoglobin at position 62406. The substitution of a 'g' for a 't' at position 62412 also causes premature splicing and results in an abnormal and abbreviated beta hemoglobin [90]. Another form of beta-thalassemia is produced by the substitution of an 'a' for a 'g' at position 62650. This causes a readthrough at the exon/intron boundary of exon 2/intron 2 [44]. The Alu family sequences found at bases 50933, 51994, 65531 and 66794 are again typical of the beta-like globin Alu's. These sequences are of considerable interest in relation to regulation, recombination and transcription by RNA polymerase III. There are non-Alu repetitive elements in the gene cluster that have been partially characterized: the EC-1 repeat [38] and a retrovirus-like element in the 3' flank about 300 kb downstream of this sequence [75] (see separate entry); there are numerous repeats in the 5' flank which will be included in a future update [80]. Reference [83] has characterized a novel KpnI family sequence in the 3' flank of the cluster. Potential polyadenylation signals were identified for the following genes: hbe positions 21073-21078 hbgg positions 36061-36066 hbga positions 40977-40982 hbd positions 56383-56388 hbb positions 63736-63741. NCBI gi: 183807 FEATURES Location/Qualifiers exon <19559..19650 /number=1 /gene="HBE1" /map="11p15.5" /note="epsilon-globin" exon <34549..34640 /number=1 /gene="HBG2" /map="11p15.5" /note="G-gamma globin" exon <39485..39576 /number=1 /gene="HBG1" /map="11p15.5" /note="A-gamma globin" exon <54808..54899 /number=1 /gene="HBD" /map="11p15.5" /note="delta-globin" exon <62205..62296 /number=1 /gene="HBB" /map="11p15.5" /note="beta-globin" exon <62205..62296 /number=1 /note="beta-globin thalassemia, [30],[43]" exon <45728..45818 /number=1 /note="pseudo-hbp, [72]" CDS join(45728..45818,45940..46163,47015..47142) /pseudo /codon_start=1 /note="pseudo-hbp" repeat_region 10597..10611 /note="Alu flank repeat 5' copy" repeat_region 10612..10924 /note="Alu family repeat" repeat_region 10925..10939 /note="Alu flank repeat 3' copy" repeat_region complement(16910..17176) /note="Alu family repeat [28],[39]" variation 17864..17866 /note="cag in clone lambda-epsilon; g in ph 1.8 [28]" repeat_region 17945..18208 /note="Alu family repeat [28],[39]" prim_transcript 19289..21098 /note="hbe mRNA (alt.) [23],[52],[60]" prim_transcript 19504..21098 /note="hbe mRNA (alt.) [23],[52],[60]" prim_transcript 19506..21098 /note="hbe mRNA (alt.) [23],[52],[60]" intron 19651..19772 /note="hbe intron 1 [23]" exon 19773..19995 /number=2 intron 19996..20850 /note="hbe intron 2 [23]" exon 20851..>20979 /number=3 /note="epsilon-globin" variation 21001 /note="g in [76]; c in [23]" old_sequence replace(21372..21378,"") /citation=[76] unsure 31906..32038 /note="sequenced on one strand only [76]" repeat_region 32408..32424 /note="Alu flank repeat 5' copy [31]" repeat_region 32425..32729 /note="Alu family repeat [31]" variation 32626 /note="g in [29]; a in [31]" repeat_region 32730..32746 /note="Alu flank repeat 3' copy [31]" variation 32761..32762 /note="ag in [29]; ga in [31]" variation 33204 /note="a in [29]; g in [31]" variation 33216 /note="a in [29]; g in [31]" mutation 34294 /note="c in wt; g in persons with elevated gamma chain [77]" mutation 34300 /note="c in wt; t in persons with elevated gamma chain [77]" mutation 34339 /note="c in wt; t in high G-gamma SS; beta thalassemia; and in low Hb F G-gamma-beta+-HPHF and HPFH [77]" mutation 34379 /note="g in wt; a in persons with elevated gamma chain [77]" prim_transcript 34496..36087 /note="hbgg mRNA [15],[24],[27]" intron 34641..34762 /note="hbgg intron 1 [24]" exon 34763..34985 /number=2 intron 34986..35871 /note="hbgg intron 2 [24]" exon 35872..>36000 /number=3 /note="G-gamma globin" conflict replace(37504,"t") /citation=[98] /citation=[29] mutation 37675..40197 /note="g-25 kb-c in wt; gc in silent deletion [91]" variation replace(37993,"t") /citation=[98] /citation=[29] /note="t in all Benin-type sickle cell (beta-S) chromosomes and some African beta-A chromosomes; t abolishes a TaqI site" mutation 39315 /note="g in wt (b allele, see separate sequence); a in HPFH [81],[82]" prim_transcript 39432..41003 /note="hbga mRNA [5],[15],[24],[27]" variation 39456 /note="a in [29]; g in [15]" intron 39577..39698 /note="hbga intron 1 [24]" exon 39699..39921 /number=2 intron 39922..40787 /note="hbga intron 2 [17],[24]" exon 40788..>40916 /number=3 /note="A-gamma globin" variation 43800..43802 /note="gat in [94]; gt in [76]" variation 43848..43850 /note="ttg in [94]; tg in [76]" variation 43861 /note="t in [94]; c in [76]" variation 44140 /note="t in [94]; c in [76]" variation 45087..45095 /note="aaaaaaaaa in [94]; aa in [76]" variation 45245..45246 /note="ca in [94]; ctca in [76]" variation 45298 /note="t in [94]; c in [76]" variation 45315 /note="c in [94]; t in [76]" variation 45317 /note="t in [94]; c in [76]" variation 45327..45329 /note="cat in [94]; ct in [76]" variation 45335..45337 /note="tta in [94]; ta in [76]" variation 45339..45341 /note="tag in [94]; tg in [76]" mRNA 45675..47388 /note="pseudo-hbp mRNA [72]" intron 45819..45941 /note="pseudo-hbp intron 1 (no splice consensus at 45941 [17],[24],[72]; putative" exon 45940..46163 /pseudo /number=2 /note="pseudo-hbp, [72]" intron 46164..47014 /note="pseudo-hbp intron 2 (no splice consensus at 46164 [72]; putative" exon 47015..>47142 /number=3 /note="pseudo-hbp, [72]" repeat_region complement(50907..50912) /note="Alu flank repeat 3' copy [47],[62]" repeat_region complement(50933..51216) /note="Alu family repeat [47],[62]" repeat_region complement(51217..51222) /note="Alu flank repeat 5' copy [47],[62]" repeat_region 51984..51993 /note="Alu flank repeat 5' copy [62]" repeat_region 51994..52277 /note="Alu family repeat [31],[62]" repeat_region 52304..52313 /note="Alu flank repeat 3' copy [62]" prim_transcript 54758..56407 /note="hbd mRNA [25]" intron 54900..55027 /note="hbd intron 1 [25]" mutation 54904 /note="g in wt; a in beta thalassemia [89]" exon 55028..55250 /number=2 mutation 55065 /note="g in wt; t in beta-thalassemia Glu->stop" intron 55251..56148 /note="hbd intron 2 [25]" variation 55541 /note="ct in [54],[62],[76]; tc in [25]" variation 55589..55590 /note="ct in [62],[76]; c in [25]; cc in [54]" exon 56149..>56277 /number=3 /note="delta-globin" mutation 58873..63111 /note="a-4239 bp-c in wt; ac in atypical beta-thalassemia [88]" mutation 59681..72304 /note="t-12622 bp-t in wt; tt in Dutch beta-0- thalassemia [93]" variation 60763..60768 /note="tatttt in [62],[76]; t in [37]" variation 60850 /note="a in [37],[62],[76]; g in [51]" variation 60860 /note="c in [62],[76]; ca in [37],[51]" variation 61166 /note="c in [51],[62],[76]; g in [51]" variation 61312 /note="c in [62],[76]; t in [51]" variation 61326 /note="t in [62],[76]; tt in [51]" allele 61604 /note="t in wt; c in Albanian allele (produces RsaI site) [70]" allele 61626..61627 /note="tt in wt; tatat in Albanian allele [70]" variation 61681 /note="a in [62],[76]; g in [51]" variation 61771 /note="gc in [62],[76]; g in [51]" variation 61791 /note="g in [62]; a in [76]" variation 61815 /note="t in [54],[62],[76]; c in [51]" variation 61842 /note="g in [62],[76]; c in [51]" variation 61940 /note="g in [51],[62],[76]; c in [41]" variation 61950 /note="a in [51],[62],[76]; t in [41]" mutation 62068 /note="c in wt; g in beta-thalassemia [63]" mutation 62125 /note="t in normal promoter; a in thalassemia patient (Hb Lepore-beta+ -thal)" mutation 62127 /note="a in [26],[41],[51]; c in [62],[76],[J. Biol. C" prim_transcript 62155..63760 /note="hbb mRNA [5],[11],[10],[7],[26]" variation 62174 /note="c in [62],[76]; t in [48]" variation 62213 /note="c in [26],[62],[76]; t in [48]" mutation 62223..62225 /note="gag in wt; gg in beta-thalassemia [64]" mutation 62224 /note="a in normal hbb; t in sickle cell anemia 78]" mutation 62256 /note="a in wt; t in thalassemia [Ann. N.Y. Acad. Sci. 344, 113-119 (1980)]" intron 62297..62426 /note="hbb intron 1 [10],[26],[54]" mutation 62297 /note="g in wt; a in thalassemia [63]" intron 62297..62407 /gene="HBB thalassemia" mutation 62301 /note="g in wt; c in thalassemia [63]" mutation 62302 /note="t in wt; c in thalassemia [63]" mutation 62406 /note="g in wt; a in thalassemia [30],[43],[57],[90]" exon 62408..>62426 /number=2 /note="beta-globin thalassemia, [30],[43]" mutation 62412 /note="t in wt; g in thalassemia [90]" exon 62427..62649 /number=2 mutation 62448 /note="g in wt; a in a form of thalassemia [30]" intron 62650..63499 /note="hbb intron 2 [10],[12],[26]" mutation 62650 /note="g in wt; a in a form of thalassemia [44]" variation 62665 /note="c in [26],[48],[62],[76]; g in [48]" variation 62723 /note="g in [26],[62],[76]; t in [48]" variation 62730 /note="c in [26],[62],[76]; t in [48]" variation 63315 /note="t in [26],[48],[62],[76]; c in [48]" mutation 63394 /note="c in wt; g thalassemia [63] (causes an extra exon)" exon 63500..>63628 /number=3 /note="beta-globin" variation 63848..63849 /note="ta in [62],[76]; t in [26]" mutation 63936..63937 /note="ct in wt; cct in a form of thalassemia [45]" variation 63936 /note="c in [62],[76]; cc in [26]" mutation 63975..63976 /note="tt in wt; aa in a form of thalassemia [45]" variation 63975..63976 /note="aa in [37],[62],[76]; tt in [26]" variation 63992 /note="g in [37],[62],[76]; c in [26]" repeat_region 65508..65520 /note="Alu flank repeat 5' copy [62],[76]" repeat_region 65531..65785 /note="Alu family repeat [62],[76]" repeat_region 65786..65798 /note="Alu flank repeat 3' copy [62],[76]" repeat_region 66783..66793 /note="Alu flank repeat 5' copy [62],[76]" repeat_region 66794..67060 /note="Alu family repeat [62],[76]" repeat_region 67087..67097 /note="Alu flank repeat 3' copy [62],[76]" repeat_region 67089..73213 /note="KpnI family repeat [83]" source 1..73326 /organism="Homo sapiens" CDS join(19559..19650,19773..19995,20851..20979) /note="epsilon-globin;; NCBI gi: 183808." /codon_start=1 /translation="MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFD SFGNLSSPSAILGNPKVKAHGKKVLTSFGDAIKNMDNLKPAFAKLSELHCDKLHVDPE NFKLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAIALAHKYH" CDS join(34549..34640,34763..34985,35872..36000) /note="G-gamma globin;; NCBI gi: 183809." /codon_start=1 /translation="MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFD SFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPE NFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTGVASALSSRYH" CDS join(39485..39576,39699..39921,40788..40916) /note="A-gamma globin;; NCBI gi: 183810." /codon_start=1 /translation="MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFD SFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPE NFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVASALSSRYH" CDS join(54808..54899,55028..55250,56149..56277) /note="delta-globin;; NCBI gi: 183811." /codon_start=1 /translation="MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFE SFGDLSSPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDPE NFRLLGNVLVCVLARNFGKEFTPQMQAAYQKVVAGVANALAHKYH" CDS join(62205..62296,62427..62649,63500..63628) /note="beta-globin;; NCBI gi: 183812." /codon_start=1 /translation="MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFE SFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPE NFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH" CDS join(62205..62296,62408..62426) /note="beta-globin thalassemia;; NCBI gi: 183813." /codon_start=1 /translation="MVHLTPEEKSAVTALWGKVNVDEVGGEALGSLFSHP" BASE COUNT 22072 a 14169 c 14789 g 22293 t 3 others ORIGIN 1 bp upstream of EcoRI site; chromosome 11p15 [J. Biol. Chem. 260 1 gaattctaat ctccctctca accctacagt cacccatttg gtatattaaa gatgtgttgt 61 ctactgtcta gtatccctca agtagtgtca ggaattagtc atttaaatag tctgcaagcc 121 aggagtggtg gctcatgtct gtaattccag cactggagag gtagaagtgg gaggactgct 181 tgagctcaag agtttgatat tatcctggac aacatagcaa gacctcgtct ctacttaaaa 241 aaaaaaaaat tagccaggca tgtgatgtac acctgtagtc ccagctactc aggaggccga 301 aatgggagga tcccttgagc tcaggaggtc aaggctgcag tgagacatga tcttgccact 361 gcactccagc ctggacagca gagtgaaacc ttgcctcacg aaacagaata caaaaacaaa 421 caaacaaaaa actgctccgc aatgcgcttc cttgatgctc taccacatag gtctgggtac 481 tttgtacaca ttatctcatt gctgttcgta attgttagat taattttgta atattgatat 541 tattcctaga aagctgaggc ctcaagatga taacttttat tttctggact tgtaatagct 601 ttctcttgta ttcaccatgt tgtaactttc ttagagtagt aacaatataa agttattgtg 661 agtttttgca aacacagcaa acacaacgac ccatatagac attgatgtga aattgtctat 721 tgtcaattta tgggaaaaca agtatgtact ttttctacta agccattgaa acaggaataa 781 cagaacaaga ttgaaagaat acattttccg aaattacttg agtattatac aaagacaagc 841 acgtggacct gggaggaggg ttattgtcca tgactggtgt gtggagacaa atgcaggttt 901 ataatagatg ggatggcatc tagcgcaatg actttgccat cacttttaga gagctcttgg 961 ggaccccagt acacaagagg ggacgcaggg tatatgtaga catctcattc tttttcttag 1021 tgtgagaata agaatagcca tgacctgagt ttatagacaa tgagcccttt tctctctccc 1081 actcagcagc tatgagatgg cttgccctgc ctctctacta ggctgactca ctccaaggcc 1141 cagcaatggg cagggctctg tcagggcttt gatagcacta tctgcagagc cagggccgag 1201 aaggggtgga ctccagagac tctccctccc attcccgagc agggtttgct tatttatgca 1261 tttaaatgat atatttattt taaaagaaat aacaggagac tgcccagccc tggctgtgac 1321 atggaaacta tgtagaatat tttgggttcc attttttttt ccttctttca gttagaggaa 1381 aaggggctca ctgcacatac actagacaga aagtcaggag ctttgaatcc aagcctgatc 1441 atttccatgt catactgaga aagtccccac ccttctctga gcctcagttt ctctttttat 1501 aagtaggagt ctggagtaaa tgatttccaa tggctctcat ttcaatacaa aatttccgtt 1561 tattaaatgc atgagcttct gttactccaa gactgagaag gaaattgaac ctgagactca 1621 ttgactggca agatgtcccc agaggctctc attcagcaat aaaattctca ccttcaccca 1681 ggcccactga gtgtcagatt tgcatgcact agttcacgtg tgtaaaaagg aggatgcttc 1741 tttcctttgt attctcacat acctttagga aagaacttag cacccttccc acacagccat 1801 cccaataact catttcagtg actcaaccct tgactttata aaagtcttgg gcagtataga 1861 gcagagatta agagtacaga tgctggagcc agaccacctg agtgattagt gactcagttt 1921 ctcttagtaa ttgtatgact cagtttcttc atctgtaaaa tggagggttt tttaattagt 1981 ttgtttttga gaaagggtct cactctgtca cccaaatggg agtgtagtgg caaaatctcg 2041 gctcactgca acttgcactt cccaggctca agcggtcctc ccacctcaac atcctgagta 2101 gctggaacca caggtacaca ccaccatacc tcgctaattt tttgtatttt tggtagagat 2161 ggggtttcac atgttacaca ggatggtctc agactccgga gctcaagcaa tctgcccacc 2221 tcagccttcc aaagtgctgg gattataagc atgattacag gagttttaac aggctcataa 2281 gattgttctg cagcccgagt gagttaatac atgcaaagag tttaaagcag tgacttataa 2341 atgctaacta ctctagaaat gtttgctagt attttttgtt taactgcaat cattcttgct 2401 gcaggtgaaa actagtgttc tgtactttat gcccattcat ctttaactgt aataataaaa 2461 ataactgaca tttattgaag gctatcagag actgtaatta gtgctttgca taattaatca 2521 tatttaatac tcttggattc tttcaggtag atactattat tatccccatt ttactacagt 2581 taaaaaaact acctctcaac ttgctcaagc atacactctc acacacacaa acataaacta 2641 ctagcaaata gtagaattga gatttggtcc taattatgtc tttgctcact atccaataaa 2701 tatttattga catgtacttc ttggcagtct gtatgctgga tgctggggat acaaagatgt 2761 ttaaatttaa gctccagtct ctgcttccaa aggcctccca ggccaagtta tccattcaga 2821 aagcattttt tactctttgc attccactgt ttttcctaag tgactaaaaa attacacttt 2881 attcgtctgt gtcctgctct gggatgatag tctgactttc ctaacctgag cctaacatcc 2941 ctgacatcag gaaagactac accatgtgga gaaggggtgg tggttttgat tgctgctgtc 3001 ttcagttaga tggttaactt tgtgaagttg aaaactgtgg ctctctggtt gactgttaga 3061 gttctggcac ttgtcactat gcctattatt taacaaatgc atgaatgctt cagaatatgg 3121 gaatattatc ttctggaata gggaatcaag ttatattatg taacccagga ttagaagatt 3181 cttctgtgtg taagaatttc ataaacatta agctgtctag caaaagcaag ggcttggaaa 3241 atctgtgagc tcctcaccat atagaaagct tttaacccat cattgaataa atccctatag 3301 gggatttcta ccctgagcaa aaggctggtc ttgattaatt cccaaactca tatagctctg 3361 agaaagtcta tgctgttaac gttttcttgt ctgctacccc atcatatgca caacaataaa 3421 tgcaggccta ggcatgactg aaggctctct cataattctt ggttgcatga atcagattat 3481 caacagaaat gttgagacaa actatgggga agcagggtat gaaagagctc tgaatgaaat 3541 ggaaaccgca atgcttcctg cccattcagg gctccagcat gtagaaatct ggggctttgt 3601 gaagactggc ttaaaatcag aagccccatt ggataagagt agggaagaac ctagagccta 3661 cgctgagcag gtttccttca tgtgacaggg agcctcctgc cccgaacttc cagggatcct 3721 ctcttaagtg tttcctgctg gaatctcctc acttctatct ggaaatggtt tctccacagt 3781 ccagcccctg gctagttgaa agagttaccc atgcagaggc cctcctagca tccagagact 3841 agtgcttaga ttcctacttt cagcgttgga caacctggat ccacttgccc agtgttcttc 3901 cttagttcct accttcgacc ttgatcctcc tttatcttcc tgaaccctgc tgagatgatc 3961 tatgtgggga gaatggcttc tttgagaaac atcttcttcg ttagtggcct gcccctcatt 4021 cccactttaa tatccagaat cactataaga agaatataat aagaggaata actcttatta 4081 taggtaaggg aaaattaaga ggcatacgtg atgggatgag taagagagga gagggaagga 4141 ttaatggatg ataaaatcta ctactatttg ttgagacctt ttatagtcta atcaattttg 4201 ctattgtttt ccatcctcac gctaactcca taaaaaaaca ctattattat ctttattttg 4261 ccatgacaag actgagctca gaagagtcaa gcatttgcct aaggtcggac atgtcagagg 4321 cagtgccaga cctatgtgag actctgcagc tactgctcat gggccctgtg ctgcactgat 4381 gaggaggatc agatggatgg ggcaatgaag caaaggaatc attctgtgga taaaggagac 4441 agccatgaag aagtctatga ctgtaaattt gggagcagga gtctctaagg acttggattt 4501 caaggaattt tgactcagca aacacaagac cctcacggtg actttgcgag ctggtgtgcc 4561 agatgtgtct atcagaggtt ccagggaggg tggggtgggg tcagggctgg ccaccagcta 4621 tcagggccca gatgggttat aggctggcag gctcagatag gtggttaggt caggttggtg 4681 gtgctgggtg gagtccatga ctcccaggag ccaggagaga tagaccatga gtagagggca 4741 gacatgggaa aggtggggga ggcacagcat agcagcattt ttcattctac tactacatgg 4801 gactgctccc ctataccccc agctaggggc aagtgccttg actcctatgt tttcaggatc 4861 atcatctata aagtaagagt aataattgtg tctatctcat agggttatta tgaggatcaa 4921 aggagatgca cactctctgg accagtggcc taacagttca ggacagagct atgggcttcc 4981 tatgtatggg tcagtggtct caatgtagca ggcaagttcc agaagatagc atcaaccact 5041 gttagagata tactgccagt ctcagagcct gatgttaatt tagcaatggg ctgggaccct 5101 cctccagtag aaccttctaa ccagctgctg cagtcaaagt cgaatgcagc tggttagact 5161 ttttttaatg aaagcttagc tttcattaaa gattaagctc ctaagcaggg cacagatgaa 5221 attgtctaac agcaactttg ccatctaaaa aaatctgact tcactggaaa catggaagcc 5281 caaggttctg aacatgagaa atttttagga atctgcacag gagttgagag ggaaacaaga 5341 tggtgaaggg actagaaacc acatgagaga cacgaggaaa tagtgtagat ttaggctgga 5401 ggtaaatgaa agagaagtgg gaattaatac ttactgaaat ctttctatat gtcaggtgcc 5461 attttatgat atttaataat ctcattacat atggtaattc tgtgagatat gtattattga 5521 acatactata attaatacta atgataagta acacctcttg agtacttagt atatgctaga 5581 atcaaattta agtttatcat atgaggccgg gcacggtggc tcatatatgg gattacatgc 5641 ctgtaatccc agcactttgg gaggccaagg caattggatc acctgaggtc aggagttcca 5701 gaccagcctg gccaacatgg tgaaacccct tctctactaa aaaatacaaa aaatcagcca 5761 ggtgtggtgg cacgcgtcta taatcccagc tactcaggag gctgaggcag gagaatcact 5821 tgaacccagg aggtggaggt tgcagtgagc taagattgca ccactgcact ccagcctagg 5881 cgacagagtg agactccatc tcaaaaaaaa aaaaagaagt ttattatatg aattaactta 5941 gttttactca caccaatact cagaagtaga ttattacctc atttattgat gaggagccca 6001 atgtacttgt agtgtagatc aacttattga aagcacaagc taataagtag acaattagta 6061 attagaagtc agatggtctg agctctccta ctgtctacat tacatgagct cttattaact 6121 ggggactcga aaatcaaaga catgaaataa tttgtccaag cttacagaac caccaagtag 6181 taaggctagg atgtagaccc agttctgcta cctctgaaga cagtgttttt tccacagcaa 6241 aacacaaact cagatattgt ggatgcgaga aattagaagt agatattcct gccctgtggc 6301 ccttgcttct tacttttact tcttggcgat tggaagttgt ggtccaagcc acagttgcag 6361 accatacttc ctcaaccata attgcatttc ttcaggaaag tttgagggag aaaaaggtaa 6421 agaaaaattt agaaacaact tcagaataaa gagattttct cttgggttac agagattgtc 6481 atatgacaaa ttataagcag acacttgaga aaactgaagg cccatgcctg cccaaattac 6541 cctttgaccc cttggtcaag ctgcaacttt ggttaaaggg agtgtttatg tgttatagtg 6601 ttcatttact cttctggtct aacccattgg ctccgtcttc atcctgcagt gacctcagtg 6661 cctcagaaac atacatatgt ttgtctagtt taagtttgtg tgaaattcta actagcgtca 6721 agaactgagg gccctaaact atgctaggaa tagtgctgtg gtgctgtgat aggtacacaa 6781 gaaatgagaa gaaactgcag attctctgca tctccctttg ccgggtctga caacaaagtt 6841 tccccaaatt ttaccaatgc aagccatttc tccatatgct aactacttta aaatcatttg 6901 gggcttcaca ttgtctttct catctgtaaa aagaatggaa gaactcattc ctacagaact 6961 ccctatgtct tccctgatgg gctagagttc ctctttctca aaaattagcc attattgtat 7021 ttccttctaa gccaaagctc agaggtcttg tattgcccag tgacatgcac actggtcaaa 7081 agtaggctaa gtagaagggt actttcacag gaacagagag caaaagaggt gggtgaatga 7141 gagggtaagt gagaaaagac aaatgagaag ttacaacatg atggcttgtt gtctaaatat 7201 ctcctaggga attattgtga gaggtctgaa tagtgttgta aaataagctg aatctgctgc 7261 ctaacattaa cagtcaagaa atacctccga ataactgtac ctccaattat tctttaaggt 7321 agcatgcaac tgtaatagtt gcatgtatat atttatcata atactgtaac agaaaacact 7381 tactgaatat atactgtgtc cctagttctt tacacaataa actaatctca tcctcataat 7441 tctattagct aatacatatt atcatcctat atttcagaga cttcaagaag ttaagcaact 7501 tgctcaagat catctaagaa gtaggtggta tttctgggct catttggccc ctcctaatct 7561 ctcatggcaa catggctgcc taaagtgttg attgccttaa ttcatcaggg atgggctcat 7621 actcactgca gaccttaact ggcatcctct tttcttatgt gatctgcctg accctagtag 7681 aacttatgaa atttctgatg agaaaggaga gaggagaaag gcagagctga ctgtgatgag 7741 tgatgaaggt gccttctcat ctgggtacca gtggggcctc taagactaag tcactctgtc 7801 tcactgtgtc ttagccagtt ccttacagct tgccctgatg ggagatagag aatgggtatc 7861 ctccaacaaa aaaataaatt ttcatttctc aaggtccaac ttatgttttc ttaattttta 7921 aaaaaatctt gaccattctc cactctctaa aataatccac agtgagagaa acattctttt 7981 cccccatccc ataaatacct ctattaaata tggaaaatct gggcatggtg tctcacacct 8041 gtaatcccag cactttggga ggctgaggtg ggtggactgc ttggagctca ggagttcaag 8101 accatcttgg acaacatggt gataccctgc ctctacaaaa agtacaaaaa ttagcctggc 8161 atggtggtgt gcacctgtaa tcccagctat tagggtggct gaggcaggag aattgcttga 8221 acccgggagg cggaggttgc agtgagctga gatcgtgcca ctgcactcca gcctggggga 8281 cagagcacat tataattaac tgttattttt tacttggact cttgtgggga ataagataca 8341 tgttttattc ttatttatga ttcaagcact gaaaatagtg tttagcatcc agcaggtgct 8401 tcaaaaccat ttgctgaatg attactatac tttttacaag ctcagctccc tctatccctt 8461 ccagcatcct catctctgat taaataagct tcagtttttc cttagttcct gttacatttc 8521 tgtgtgtctc cattagtgac ctcccatagt ccaagcatga gcagttctgg ccaggcccct 8581 gtcggggtca gtgccccacc cccgccttct ggttctgtgt aaccttctaa gcaaaccttc 8641 tggctcaagc acagcaatgc tgagtcatga tgagtcatgc tgaggcttag ggtgtgtgcc 8701 cagatgttct cagcctagag tgatgactcc tatctgggtc cccagcagga tgcttacagg 8761 gcagatggca aaaaaaagga gaagctgacc acctgactaa aactccacct caaacggcat 8821 cataaagaaa atggatgcct gagacagaat gtgacatatt ctagaatata ttatttcctg 8881 aatatatata tatatatata tacacatata cgtatatata tatatatata tatatttgtt 8941 gttatcaatt gccatagaat gattagttat tgtgaatcaa atatttatct tgcaggtggc 9001 ctctatacct agaagcggca gaatcaggct ttattaatac atgtgtatag atttttagga 9061 tctatacaca tgtattaata tgaaacaagg atatggaaga ggaaggcatg aaaacaggaa 9121 aagaaaacaa accttgtttg ccattttaag gcacccctgg acagctaggt ggcaaaaggc 9181 ctgtgctgtt agaggacaca tgctcacata cggggtcaga tctgacttgg ggtgctactg 9241 ggaagctctc atcttaagga tacatctcag gccagtcttg gtgcattagg aagatgtagg 9301 caactctgat cctgagagga aagaaacatt cctccaggag agctaaaagg gttcacctgt 9361 gtgggtaact gtgaaggact acaagaggat gaaaaacaat gacagacaga cataatgctt 9421 gtgggagaaa aaacaggagg tcaaggggat agagaaggct tccagaagaa tggctttgaa 9481 gctggcttct gtaggagttc acagtggcaa agatgtttca gaaatgtgac atgacttaag 9541 gaactataca aaaaggaaca aatttaagga gaggcagata aattagttca acagacatgc 9601 aaggaatttt cagatgaatg ttatgtctcc actgagcttc ttgaggttag cagctgtgag 9661 ggttttgcag gcccaggacc cattacagga cctcacgtat acttgacact gttttttgta 9721 ttcatttgtg aatgaatgac ctcttgtcag tctactcggt ttcgctgtga atgaatgatg 9781 tcttgtcagc ctacttggtt tcgctaagag cacagagaga agatttagtg atgctatgta 9841 aaaacttcct ttttggttca agtgtatgtt tgtgatagaa atgaagacag gctacatgat 9901 gcatatctaa cataaacaca aacattaaga aaggaaatca acctgaagag tatttataca 9961 gataacaaaa tacagagagt gagttaaatg tgtaataact gtggcacagg ctggaatatg 10021 agccatttaa atcacaaatt aattagaaaa aaaacagtgg ggaaaaaatt ccatggatgg 10081 gtctagaaag actagcattg ttttaggttg agtggcagtg tttaaagggt gatatcagac 10141 taaacttgaa atatgtggct aaataactag aatactcttt attttttcgt atcatgaata 10201 gcagatatag cttgatggcc ccatgcttgg tttaacatcc ttgctgttcc tgacatgaaa 10261 tccttaattt ttgacaaagg ggctattcat tttcatttta tattgggcct agaaattatg 10321 tagatggtcc tgaggaaaag tttatagctt gtctatttct ctctctaaca tagttgtcag 10381 cacaatgcct aggctatagg aagtactcaa agcttgttaa attgaattct atccttctta 10441 ttcaattcta cacatggagg aaaaactcat cagggatgga ggcacgcctc taaggaaggc 10501 aggtgtggct ctgcagtgtg attgggtact tgcaggacga agggtggggt gggagtggct 10561 aaccttccat tcctagtgca gaggtcacag cctaaacatc aaattccttg aggtgcggtg 10621 gctcactcct gtaatcacag cagtttggga cgccaaggtg ggcagatcac ttgaggtcag 10681 gagttggaca ccagcccagc caacatagtg aaacctggtc tctgcttaaa aatataaaaa 10741 ttagctggac gtggtgacgg gagcctgtaa tccaactact tgggaggctg aggcaggaga 10801 atcgcttgaa ccggggaggt ggagtttgca ctgagcagag atcatgccat tgcactccag 10861 cctccagagc gagactctgt ctaaagaaaa acgaaaacaa acaaacaaac aaacaaacaa 10921 aacccatcaa attccctgac cgaacagaat tctgtctgat tgttctctga cttatctacc 10981 attttccctc cttaaagaaa ctgtggaact tccttcagct agaggggcct ggctcagaag 11041 cctctggtca gcatccaaga aatacttgat gtcactttgg ctaaaggtat gatgtgtaga 11101 caagctccag agatggtttc tcatttccat atccacccac ccagctttcc aattttaaag 11161 ccaattctga ggtagagact gtgatgaaca aacaccttga caaaattcaa cccaaagact 11221 cactttgcct agcttcaaaa tccttactct gacatatact cacagccaga aattagcatg 11281 cactagagtg tgcatgagtg caacacacac acacaccaat tccatattct ctgtcagaaa 11341 atcctgttgg tttttcgtga aaggatgttt tcagaggctg accccttgcc ttcacctcca 11401 atgctaccac tctggtctaa gtcactgtca ccaccaccta aattatagct gttgactcat 11461 aacaatcttc ctgcttctac cactgcccca ctacaatttc ttcccaatat actatccaaa 11521 ttagtctttt caaaatgtaa gtcatatatg gtcacctctt tgttcaaagt cttctgatag 11581 tttcctatat catttataat aaaaccaaat ccttacaatt ctctacaata gttgttcatg 11641 catatattat gtttattaca gatacgcata tatatagctc tcatataaat aaatatatat 11701 atttatgtgt atgtgtgtag agtgtttttt cttacaactc tatgatgtag gtattattag 11761 tgtcccaaat tttataattt aggacttcta tgatctcatc ttttattctc cccttcaccg 11821 aatctcatcc tacattggcc ttattgatat tccttgaaaa ttctaagcat cttacatctt 11881 tagggtattt acatttgcca ttccctatgc cctaaatatt taatcatagt ttcatataaa 11941 tgggttcctc atcatctatg ggtactctct caggtgttaa ctttatagtg aggactttcc 12001 tgccatacta cttaaagtag cgataccctt tcaccctgtc ctaatcacac tctggccttc 12061 atttcagttt tttttttttc tccatagcac ctaatctcat tggtatataa catgtttcat 12121 ttgcttattt aatgtcaagc tctttccact atcaagtcca tgaaaacagg aactttattc 12181 ctctattctg tttttgtgct gtattcttag caattttaca attttgaatg aaatgaatga 12241 gcagtcaaac acatatacaa ctataattaa aaggatgtat gctgacacat ccactgctat 12301 gcacacacaa agaaatcagt ggagtagagc tggaagcgct aagcctgcat agagctagtt 12361 agccctccgc aggcagagcc ttgatgggat tactgagttc tagaattgga ctcatttgtt 12421 ttgtaggctg agatttgctc ttgaaaactt gttctgacca aaataaaagg ctcaaaagat 12481 gaatatcgaa accagggtgt tttttacact ggaatttata actagagcac tcatgtttat 12541 gtaagcaatt aattgtttca tcagtcaggt aaaagtaaag aaaaactgtg ccaaggcagg 12601 tagcctaatg caatatgcca ctaaagtaaa cattattcca taggtgtcag atatggctta 12661 ttcatccatc ttcatgggaa ggatggcctt ggcctggaca tcagtgttat gtgaggttca 12721 aaacacctct aggctataag gcaacagagc tccttttttt tttttctgtg ctttcctggc 12781 tgtccaaatc tctaatgata agcatacttc tattcaatga gaatattctg taagattata 12841 gttaagaatt gtgggagcca ttccgtctct tatagttaaa tttgagcttc ttttatgatc 12901 actgtttttt taatatgctt taagttctgg ggtacatgtg ccatggtggt ttgctgcacc 12961 catcaacccg tcatctacat taggtatttc tcctaatgct atccttcccc tagcccccca 13021 cccccaacag gccccagtgt gtgatgttcc cctccctgtg tccatggatc actggttttt 13081 tttttttttt tttttttttt tttaaagtct cagttaaatt tttggaatgt aatttatttt 13141 cctggtatcc taggacctgc aagttatctg gtcactttag ccctcacgtt ttgatgataa 13201 tcacatattt gtaaacacaa cacacacaca cacacacaca cacatatata tatataaaac 13261 atatatatac ataaacacac ataacatatt tatcgggcat ttctgagcaa ctaactcatg 13321 caggactctc aaacactaac ctatagcctt ttctatgtat ctacttgtgt agaaaccaag 13381 cgtggggact gagaaggcaa tagcaggagc attctgactc tcactgcctt tggctaggtc 13441 cctccctcat cacagctcag catagtccga gctcttatct atatccacac acagtttctg 13501 acgctgccca gctatcacca tcccaagtct aaagaaaaaa ataatgggtt tgcccatctc 13561 tgttgattag aaaacaaaac aaaataaaat aagcccctaa gctcccagaa aacatgacta 13621 aaccagcaag aagaagaaaa tacaataggt atatgaggag actggtgaca ctagtgtctg 13681 aatgaggctt gagtacagaa aagaggctct agcagcatag tggtttagag gagatgtttc 13741 tttccttcac agatgcctta gcctcaataa gcttgcggtt gtggaagttt actttcagaa 13801 caaactcctg tggggctaga attattgatg gctaaaagaa gcccggggga gggaaaaatc 13861 attcagcatc ctcaccctta gtgacacaaa acagaggggg cctggttttc catatttcct 13921 catgatggat gatctcgtta atgaaggtgg tctgacgaga tcattgcttc ttccatttaa 13981 gccttgctca cttgccaatc ctcagtttta accttctcca gagaaataca cattttttat 14041 tcaggaaaca tactatgtta tagtttcaat actaaataat caaagtactg aagatagcat 14101 gcataggcaa gaaaaagtcc ttagctttat gttgctgttg tttcagaatt taaaaaagat 14161 caccaagtca aggacttctc agttctagca ctagaggtgg aatcttagca tataatcaga 14221 ggtttttcaa aatttctaga catgagattc aaagccctgc acttaaaata gtctcatttg 14281 aattaactct ttatataaat tgaaagcaca ttctgaacta cttcagagta ttgttttatt 14341 tctatgttct tagttcataa atacattagg caatgcaatt taattaaaaa aacccaagaa 14401 tttcttagaa ttttaatcat gaaaataaat gaaggcatct ttacttactc aaggtcccaa 14461 aaggtcaaag aaaccaggaa agtaaagcta tatttcagcg gaaaatggga tatttatgag 14521 ttttctaagt tgacagactc aagttttaac cttcagtgcc catgatgtag gaaagtgtgg 14581 cataactggc tgattctggc tttctactcc tttttcccat taaagatccc tcctgcttaa 14641 ttaacattca caagtaactc tggttgtact ttaggcacag tggctcccga ggtcagtcac 14701 acaataggat gtctgtgctc caagttgcca gagagagaga ttactcttga gaatgagcct 14761 cagccctggc tcaaactcac ctgcaaactt cgtgagagat gaggcagagg tacactacga 14821 aagcaacagt tagaagctaa atgatgagaa cacatggact catagaggga aacaacgcat 14881 actggggcct atcagagggt ggagggtgag agaaggagag gatcaggaaa aatcactaat 14941 ggatgctaag cgtaatacct gagtgatgag atcatctata caacaaaccc ccttgacatt 15001 catttatcta tgtaacaaac ctgcacatcc tgtacacgta cccctgaact taaaataaaa 15061 gttgaaaaca agaaagcaac agtttgaaca cttgttatgg tctattctct cattctttac 15121 aattacacta gaaaatagcc acaggctcct gcaaggcagc cacagaattt atgacttgtg 15181 atatccaagt cattcctgga taatgcaaaa tctaacacaa aatctagtag aatcatttgc 15241 ttacatctat ttttgttctg agaatataga tttagataca taatggaagc agaataattt 15301 aaaatctggc taatttagaa tcctaagcag ctcttttcct atcagtggtt tacaagcctt 15361 gtttatattt ttcctatttt aaaaataaaa ataaagtaag ttatttgtgg taaagaatat 15421 tcattaaagt atttatttct tagataatac catgaaaaac attcagtgaa gtgaagggcc 15481 tactttaccc aacaagaatc taatttatat aatttttcat actaatagca tctaagaaca 15541 gtacaatatt tgactcttca ggttaaacat atgtcataaa ttagccagaa agatttaaga 15601 aaatattgga tgtttccttg tttaaattag gcatcttaca gtttttagaa tcctgcatag 15661 aacttaagaa attacaaatg ctaaagcaaa cccaaacagg caggaattaa tcttcatcga 15721 atttgggtgt ttctttctaa aagtccttta tacttaaatg tcttaagaca tacatagatt 15781 ttattttact aattttaatt atacagacaa taaatgaata ttcttactga ttactttttc 15841 tgactgtcta atctttctga tctatcctgg atggccataa cacttatctc tctgaacttt 15901 gggcttttaa tataggaaag aaaagcaata atccattttt catggtatct catatgataa 15961 acaaataaaa tgcttaaaaa tgagcaggtg aagcaattta tcttgaacca acaagcatcg 16021 aagcaataat gagactgccc gcagcctacc tgacttctga gtcaggattt ataagccttg 16081 ttactgagac acaaacctgg gcctttcaat gctataacct ttcttgaagc tcctccctac 16141 cacctttagc cataaggaaa catggaatgg gtcagatccc tggatgcaag ccaggtctgg 16201 aaccataggc agtaaggaga gaagaaaatg tgggctctgc aactggctcc gagggagcag 16261 gagagaatca accccatact ctgaatctaa gagaagactg gtgtccatac tctgaatggg 16321 aagaatgatg ggattaccca tagggcttgt tttagggaga aacctgttct ccaaactctt 16381 ggccttgaga tacctggtcc ttattccttg gactttggca atgtctgacc ctcacattca 16441 agttctgagg aagggccact gccttcatac tgtggatctg tagcaaattc cccctgaaaa 16501 cccagagctg tatcttaatt gtttaaaaaa attatattat ctcaaggact gttcttctct 16561 gagtagccaa gctcagcttg gttcaagcta caagcagctg cgctgctttt tgtctagtca 16621 ttgttctttt atttcagtgg atcaaatacg ttctttccaa acctaggatc ttgtcttcct 16681 ggactatata ttttatccac gaagtcttaa tctggggtcc acagaacact agggggctgg 16741 tgaagtttat agaaaaaaaa tctgtatttt tacttacatg taactgaaat ttagcatttt 16801 cttctacttt gaatgcaaag gacaaactag aatgacatca tcagtaccta ttgcatagtt 16861 ataaagagaa accacagata ttttcatact acaccatagg tattgcagat ctttttgttt 16921 ttgtttttgt ttgagatgga gtttcgctct tattgcccag gctggagtgc agtggcatga 16981 tttcggctca ctgcaacctc cccttcctgc attcaagcaa ttctcctgcc ttggcctcca 17041 gagtagctgg ggattacagg cacctgccac catgccagtc taatttttgt atttttagta 17101 gagaatgggt ttcgccatgt tggccaggct ggtcttgaac tcctgacctc agatgatctg 17161 cccgccttgg cctcctgaag tgctgggatt ataggtgtga gccaccacgc ctggcccatt 17221 gcagatattt ttaattcaca tttatctgca tcactacttg gatcttaagg tagctgcaga 17281 cccaatccca gatctaatgc tttcataaag aagcaaatat aataaatact ataccacaaa 17341 tgtaatgttt gatgtctgat aatgatattt cagtgtaatt aaacttagca ctccatgtat 17401 attatttgat gcaataaaaa catatttttt tagcacttac agtctgccaa actggcctgt 17461 gacacaaaaa aagtttaggg gaattcccct agttttgtct gtgttagcca atggttagaa 17521 tatatgctca gaaagatacc attggttaat agctaaaaga aaatggagta gaaattcagt 17581 ggcctggaat aataacaatt tgggcagtca ttaagtcagg tgaagacttc tggaatcatg 17641 ggagaaaagc aagggagaca ttcttacttg ccacaagtgt tttttttttt tttttttttt 17701 atcacaaaca taagaaaata taataaataa caaagtcagg ttatagaaga gagaaacgct 17761 cttagtaaac ttggaatatg gaatccccaa aggcacttga cttgggagac aggagccata 17821 ctgctaagtg aaaaagacga agaacctcta gggcctgaac atacaggaaa ttgtaggaac 17881 agaaattcct agatctggtg gggcaagggg agccatagga gaaagaaatg gtagaaatgg 17941 atggagacgg aggcagaggt gggcagatca tgaggtcaag agatcgagac catcctggca 18001 aacatggtga aatcccgtct ctactaaaaa taaaaaaatt agctgggcat ggtggcatgc 18061 gcctgtagtc ccagctgctc gggaggctga ggcaggagaa tcgtttgaac ccaggaggcg 18121 aaggttgcag tgagctgaga tagtgccatt gcactccagt ctggcaacag agtgagactc 18181 cgtctcaaaa aaaaaaaaaa gaaagaaaga aaagaaaaag aaaaaagaaa aaataaatgg 18241 atgtagaaca agccagaagg aggaactggg ctggggcaat gagattatgg tgatgtaagg 18301 gacttttata gaattaacaa tgctggaatt tgtggaactc tgcttctatt attcccccaa 18361 tcattacttc tgtcacattg atagttaaat aatttctgtg aatttattcc ttgantccca 18421 aaatattgag gtaaataaca atggtattat aaaagggcag attaagtgat atagcataag 18481 caatattctt caggcacatg gatcgaattg aatacactgt aaatcccaac ttccagtttc 18541 agctctacca agtaaagagc tagcaagtca tcaaaatggg gacatacaga aaaaaaaaag 18601 gacactagag gaataatata ccctgactcc tagcctgatt aatatatcga ttcactttta 18661 ctctgtttgg tgacaaattc tggctttaaa taattttagg attttaggct tctcagctcc 18721 cttcccagtg agaagtataa gcaggacagc aggcaagcaa gaagagagcc caaggcaata 18781 ctcacaaagt agccagtgtc ccctgtggtc atagagaaat ggaaagagag aggantcccc 18841 ccttggagcc actgggtggt aatcctttcc gtccgttcct ctctagggaa tcaccccaag 18901 gtactgtact ttgggattaa ggctttagtc ccactgtgga ctacttgcta ttctgttcag 18961 tttctgaagg aactatgtac ggtttttgtc tccctagaga aactaaggta cagaagtttt 19021 gtttacaatg cactccttaa gagagctaga actgggtgaa gantcctggt ttaaccagcc 19081 ttaatttcct ttccctgggc cccggtttgg tcacgtcact gtcaccacct ttaaggcaaa 19141 tgttaaatgc gctttggctg aactttttcc tattttgaga tttgctcctt tatatgaggc 19201 tttcttggaa aaggagaatg ggagagatgg atatcatttt ggaagatgat gaagagggta 19261 aaaaagggta caaatggaaa tttgtgttgc agatagtatg aggagccaac aaaaaagagc 19321 ctcaggatcc agcacacatt atcacaaact tagtgtccat ccatcactgc tgaccctctc 19381 cggacctgac tccacccctg aggacacagg tcagccttga ccaatgactt ttaagtacca 19441 tggagaacag ggggccagaa cttcggcagt aaagaataaa aggccagaca gagaggcagc 19501 agcacatatc tgcttccgac acagctgcaa tcactagcaa gctctcaggc ctggcatcat 19561 ggtgcatttt actgctgagg agaaggctgc cgtcactagc ctgtggagca agatgaatgt 19621 ggaagaggct ggaggtgaag ccttgggcag gtaagcattg gttctcaatg catgggaatg 19681 aagggtgaat attaccctag caagttgatt gggaaagtcc tcaagatttt ttgcatctct 19741 aattttgtat ctgatatggt gtcatttcat agactcctcg ttgtttaccc ctggacccag 19801 agattttttg acagctttgg aaacctgtcg tctccctctg ccatcctggg caaccccaag 19861 gtcaaggccc atggcaagaa ggtgctgact tcctttggag atgctattaa aaacatggac 19921 aacctcaagc ccgcctttgc taagctgagt gagctgcact gtgacaagct gcatgtggat 19981 cctgagaact tcaaggtgag ttcaggtgct ggtgatgtga ttttttggct ttatattttg 20041 acattaattg aagctcataa tcttattgga aagaccaaca aagatctcag aaatcatggg 20101 tcgagcttga tgttagaaca gcagacttct agtgagcata accaaaactt acatgattca 20161 gaactagtga cagtaaagga ctactaacag cctgaattgg cttaactttt caggaaatct 20221 tgccagaact tgatgtgttt atcccagaga attgtattat agaattgtag acttgtgaaa 20281 gaagaatgaa atttggcttt tggtagatga aagtccattt caaggaaata gaaatgcctt 20341 attttatgtg ggtcatgata attgaggttt agaagagatt tttgcaaaaa aaataaaaga 20401 tttgctcaaa gaaaaataag acacattttc taaaatatgt taaatttccc atcagtattg 20461 tgaccaagtg aaggcttgtt tccgaatttg ttggggattt taaactcccg ctgagaactc 20521 ttgcagcact cacattctac atttacaaaa attagacaat tgcttaaaga aaaacaggga 20581 gagagggaac ccaataatac tggtaaaatg gggaaggggg tgagggtgta ggtaggtaga 20641 atgttgaatg tagggctcat agaataaaat tgaacctaag ctcatctgaa ttttttgggt 20701 gggcacaaac cttggaacag tttgaggtca gggttgtcta ggaatgtagg tataaagccg 20761 tttttgtttg tttgtttgtt ttttcatcaa gttgttttcg gaaacttcta ctcaacatgc 20821 ctgtgtgtta ttttgtcttt tgcctaacag ctcctgggta acgtgatggt gattattctg 20881 gctactcact ttggcaagga gttcacccct gaagtgcagg ctgcctggca gaagctggtg 20941 tctgctgtcg ccattgccct ggcccataag taccactgag ttctcttcca gtttgcaggt 21001 cttcctgtga ccctgacacc ctccttctgc acatggggac tgggcttggc cttgagagaa 21061 agccttctgt ttaataaagt acattttctt cagtaatcaa aaattgcaat tttatcttct 21121 ccatctttta ctcttgtgtt aaaaggaaaa agtgttcatg ggctgaggga tggagagaaa 21181 cataggaaga accaagagct tccttaagaa atgtatgggg gcttgtaaaa ttaatgtgga 21241 tgttatggga gaattcccaa gattcccaag gaggatgata tgatggagaa aaatctttat 21301 cggggtggga aaatggttaa ttaagtggca gagactccta ggcagttttt actgcaccgg 21361 ggaaagaagg agctgttgtg gtacctgaga aagcagattt gtggtacatg tcacttttca 21421 ttaaaaacaa aaacaaaaca aaacaaaact tcatagatat ccaagatata ggctgagaat 21481 tactatttta atttactctt atttacattt tgaagtagct agcttgtcac atgttttatg 21541 aaattgattt ggagataaga tgagtgtgta tcaacaatag cctgctcttt ccatgaagga 21601 ttccattatt tcatgggtta gctgaagcta agacacatga tatcattgtg cattatcttc 21661 tgatacaatg taacatgcac taaaataaag ttagagttag gacctgagtg ggaaagtttt 21721 tggagagtgt gatgaagact ttccgtggga gatagaatac taataaaggc ttaaattcta 21781 aaaccagcaa gctagggctt cgtgacttgc atgaaactgg ctctctggaa gtagaaggga 21841 gagtaagaca tacgtagagg actaggaaag accagatagt acagggcctg gctacaaaaa 21901 tacaagcttt tactatgcta ttgcaatact aaacgataag cattaggatg ttaagtgact 21961 caggaaataa gattttggga aaaagtaatc tgcttatgtg cacaaaatgg attcaagttt 22021 gcagataaaa taaaatatgg atgatgattc aaggggacag atacaatggt tcaaacccaa 22081 gaggagcagt gagtctgtgg aattttgaag gatggacaaa ggtggggtga gaaagacata 22141 gtattcgacc tgactgtggg agatgagaag gaagaaggag gtgataaatg actgaaagct 22201 cccagactgg tgaagataac aggaggaaac catgcacttg accctggtga ctctcatgtg 22261 tgaagggtag agggatatta acagatttac tttttaggaa gtgctagatt ggtcagggag 22321 ttttgacctt caggtcttgt gtctttcata tcaaggaacc tttgcatttt ccaagttaga 22381 gtgccatatt ttggcaaata taactttatt agtaatttta tagtgctctc acattgatca 22441 gactttttcc tgtgaattac ttttgaattt ggctgtatat atccagaata tgggagagag 22501 acaaataatt attgtagttg caggctatca acaatactgg tctctctgag ccttataacc 22561 tttcaatatg ccccataaac agagtaaaca gggattattc atggcactaa atattttcac 22621 ctaggtcagt caacaaatgg aggcaatgtg cattttttga tacatatttt tatatattta 22681 tggggcatgt gatacttaca tgcctagaac atgtgactga ttaagtctag atatttagga 22741 tatccattac tttgagcatt tatcatttct atgtattgag aaaatttcaa atcctcattt 22801 ctgaccattt tgaaatatat aataaatagt aattaactat agtcacccta ctcaaatatc 22861 aacattataa actaactaat ccttctttcc acttttttac caaccaacat ctcttaaatc 22921 ccctgccata cacatcacac atttttcagc tctgataact atcattctac tctcatacca 22981 ccatgagacc acttttttag ctccacagat gaataaaaac atgtgatatt tgactttctg 23041 tatctggctt attttattat ctatctcttt ggcataccaa gagtttgttt ttgttctgct 23101 tcagggcttt caattaacat aatgacctct ggttccatcc atgttgctac aaatgacaag 23161 atttcattct ttttcatggc aaaatagtac tgtgcaaaaa atacaatttt ttaatccgtt 23221 catctgttga tagacactta ggttgatccc aaaccttaac tattgtgaat aggtgcttca 23281 ataaacatga gtgtaatgtg tccattggat atactgattt cctttctttt ggataaataa 23341 ccactagtga gattgctgga ttgtatgata gttctgtttt tagtttattg agaaatcttc 23401 atactgtttt ccataatggt tgtactattt tacattccca ccaacagtgt gtaagaaaga 23461 gttccctttt ctccatatcc tcacaaggat ctgttatttt ttgtcttttt tgttaatagc 23521 attttaacta gagtaagtag atatctcatt gtagttttga tttgcatttc cctgatcatt 23581 agtgatgttg agattttttc atatgtttgt tggtcatttg tatatctttt tctgagattg 23641 tctgttcatg tccttatcct acttttattg ggattgttgt tattttcttg ataatcattg 23701 tgtcatttta gagcctggat attattcttt tgtcagatgt atagattgtg aagattttct 23761 cctctgtggg ttgtctgttt attctgcaga ctcttccttt tgccatgcaa aagctcttta 23821 gtttaattta gtcccagata ttttctttgt ttttatgtgt ttgcatttgt gttcttgtca 23881 tgaaatcctt tcctaagcca atgtgtagaa gggtttttcc gatgttattt tctagaattg 23941 ttacagtttc aggcttagat ttaagtcctt gatccatctt aagttgattt ttgtataagg 24001 tgagagatga agatccagtt tcattctcct acatgtagct tgccagctat cccgactcat 24061 ttgttgaata gggtgccctt tcccatttat gtttttgttt gctttgtcaa agatcagttc 24121 ggatgtaagt atttgagttt atttctgggt tctctattct gttccattgg tccgatgtgc 24181 ctatttgtac accagcatca tgctgtgttt ttggtgacta tggccttatt gtatagtttg 24241 aaatgaggta atgtaatgcc attcagattt gttctttttt ttagacttgc ttgtttattg 24301 ggctcttttt tggttccata agaattttag gattgttttt tctagttctg tgaaggctaa 24361 tggtggtatt tatgggaatt gcaatgcaat ttgtaggttg cttctggcat tatggccatt 24421 ttcacaatat tgattctacc catctatgag aatggcatgt gtttccattt gtttgtgtct 24481 tatatgatta ctatcagccg tgttttgtag ttttccttgt agatgtcttt cacctccttg 24541 gttaggtata tattcctaag tttttgtttt gttttgtttt gttttttgca gctattgtaa 24601 aaggggttga gttattgatt ttattctcat cttggtcatt gctggtatgt aagaaagcaa 24661 ctcattggtg tacgttaatt ttgtatccag aaactttgct gaattatttt atcagttcta 24721 gggggttttg gaggagtctt tagagttttc tacatacaca atcatatcat cagcaaacag 24781 tgacagtttg actttctctt taacaatttg gatgtgcttt acttgtttct cttgtctgat 24841 tgctcttgct aggacttcca gtaatatgtt aaagagaagt ggtgagagtg ggtatccttg 24901 tctcattcca gttttcagac agaatgcttt taactttttc ccattcaata taatgttggc 24961 tgtgtgttta ccatagctgg cttttattac attgaggtat gtcctttgta aaccgatttt 25021 gctgagtttt agtcataaag tgatgttgaa ttttgttgaa tgcagtttct gtggctattg 25081 agataatcac atgatttttg tttccaattc tctttatgtt gtgtatcaca cttattgact 25141 tgcgtatgtt aaaccatccg tgcatccctc gcatgaaacc acttgatcat gggttttgat 25201 atgccgtgtg ggatgctatt agctatattt tgtcaaggat gttggcatct atgttcatca 25261 gggatattga tctgtagtgt tttttttttt tggttatgtt ctttcccagt tttggtatta 25321 aggtgatact ggcttcatag aatgatttag ggaggattct ctctttctct atcttgtaga 25381 atactgtcaa taggattggt atcaattctt ctttgaatgt ctggtagaat tcgaacgtct 25441 cctttaggtt ttctagttta ttcatgtaaa ggtgttcata gtaaccttga ataatctttt 25501 gtatttctgt ggtatcagta atagtatctc ctgttttgtt tctaactgag tttatttgca 25561 cttctctcct cttttcttgg ttaatcttgc taatggtcta tcagttttat ttatcttttc 25621 aaagaaccag ctttttattt catttagctt ttgtattttt ttgcagttgt tttaatttca 25681 tttagttctc ctcttatctt agttattccc tttcttttgc tgggttttgg ttctgtttgt 25741 ttttgtttct ctagtttctt gtggtgtgac cttatattgt ctgtcctctt tcagactctt 25801 tgacatcgac atttagggct gtgaactttc cttttagcac catctttgct gtatcctaga 25861 ggttttgata ggtgtgtcac tattgtcggt cagttcaagt aattttgttg ttcttattat 25921 actttaagtt ctgggataca tgtgcagaat gtgcaggttt gttacatagg tatagatgtg 25981 ccatggtggt ttgctgctcc catcaacctg tcatctacat taggtatttc ttttaatgtt 26041 atccctctcc taaccccctc accccccgac aggccctggt gtgtgatgtt cccctccctg 26101 tgtccatgtg ttctcattgt tcaactccca cttatgagtg agaacgtgtg gtgtttggtt 26161 tctctgttcc tgtgttagtt tgctcagaat gatgtttcca ccttcaccat gtccctgcaa 26221 agacatgaac tcatcatttt atggctgcat atattccatg gtgtatatgt gccacatttt 26281 ctttatccat tatatcgctg atggccattt gggttggttc caagtctttg gtattgtgaa 26341 tagtgccgca ataaacatac gtgtgcacat gtctttatag tagaatgatt tctaattctt 26401 tgggtatata cccagtaatg ggattgctgg gtcaaacagt atttctggtt ctagatcctt 26461 gaggaattgc cacactgtct tccacaatgg ttgaactaat ttacacaccc atcaacagtg 26521 taaaattttt cctattcttc cacatcctct ccagcacctt ttgtttcctg actttttaat 26581 aattgccatt ctaactggca tgagatggta tctcattgtg gttttgattt gcatttctct 26641 aatgaccagt gatgatgagc ttcttttcat gtgtttcttg gccacataaa tgacttcttt 26701 agagaagcat ctgttcatat cctttgtcca ctttttgatg gggtcgttag gttttttctt 26761 gtaaatttgt tgaagttctt tgtagatttt ggatgttagc cctttgtcag atggatagat 26821 tggcaaaaat tttctcccat tctgtaggtt gcctgttcac tctgatgata gtcttttgct 26881 gtgcagaagc tctttagttt aattagatcc catatgtcaa ttttggcctt tgttgtcatt 26941 gcttttgatg tttagtcgtg gaattttgcc catgcctatg tcctgaatgg tattgcctag 27001 gttatcttct aggattttta tggttttagg ttgcacattt aagtctttaa tccaccttga 27061 gttaattttt gtataaggtg taaggaaggg gtacagtttc agttttatgc atattgctag 27121 ccagtttttc cagcaccatt tattaaatag ggaattcttt ctccattgct tttgtgatgt 27181 ttgtcaaaga tcagatggtc gtagatgtgt ggcattattt ctgaggcttc tgttctgttc 27241 cactggtcta tatatctgtt ttggtaccag taccatgctg tttttgttac tgtagccttg 27301 tagtatagct tgaagtcagg tagcatcatg cctccagctt tgttcttttt gtttaggatt 27361 gtcttggcta tatgggctct tttttgattc catatgacat ttaaagtagt tttttctaat 27421 tctttgaaaa aagtcagtgg tagcttgatg gggatagcat tgaatctata aattactttg 27481 ggcagtatgg ccattttaaa gatattgatt ctttctatct atgagcatgg aatgtttttc 27541 catttgtttg tgtcctctct tatttccttg agcagtgagt ggtttgtagc tctccttgaa 27601 gaggttcttc acatccctta taagttgtat ttctaggtat tttattttat tctctttgca 27661 gcaattgtga atgggagttc acccatgatt tggctctctg cttgtctatt attggtgtat 27721 aggaatgctt gtgatttttg cacactgatt ttgtatcttg agactttgct gaagctgttt 27781 atcagcttaa gattttgggc tgagatgaca gggtcttcta aatatacaat catgtcatct 27841 gcaaacagag acaatttgac ttcctctctt cctatttgaa tatgctttat ttctttctct 27901 tgcctgattg tcctggcgag aacttccaat actatgttga gtaagagtgg cgagagggca 27961 tccttgtctt gtgccggttt tcaaagcaaa tgatttttaa atttccgtct tgatttcatt 28021 gttgacccaa tgatcattca ggagcaggtt atttaatttc cctgtatttg catggttttg 28081 aaggttcctt ttgtagttga tttccaattt tattctactg tggtctgaga gagtgcttga 28141 tataatttca atttttaaaa atttattgag gcttgttttg tggcatatca tatggcctat 28201 cttggagaaa gttccatgtg ctgatgaata gaatgtgtat tctgcagttg ttgggtagaa 28261 tgtcctgtaa atatctgtta agtccatttg ttctttaaat ccattgtttc tttgtagact 28321 gtcttgatga cctgcctagt gcagtcagtg gagtattgaa gtcccccact attattatgt 28381 tgctgtctag tagtaattgt tttataaatt tgggatctcc agtattagat gcatatatat 28441 taagaattgt aatattctcc cattggacaa gggcttttat cattatatga tgtccctctt 28501 tgtctttttt aactgctgtt tctttaaagt ttgttttgtc tgacataaga atagctgctt 28561 tggctcgctt ttggtgtcca tttgtgtgga atgtcatttt ccaccccttt accttaagtt 28621 tatgtgagtc cttatgtgtt aggtgagtct cctgaaggcg gcagataact ggttggtgaa 28681 ttctattcat tctgcaattc tgtatctttt aagtggagca tttagtccat ttacattcaa 28741 catcagtatt gaggtgtgag gtgactattc cattcttcgt ggtatttgtt gcctgtgtat 28801 ctttttatct gtatttttgt tgtatatgtc ctatgggatt tatgctttaa agaggttctg 28861 ttttgatgtg cttccagggt ttatttcaag atttagagct ccttttatca ttcttgtagt 28921 gttggcttgg tagtgccgaa ttctctcagc atttgttttt ctgaaaaaca ctgtgtattt 28981 tcttcatttg tgaagcttag tttcactgga tataaaattc ttggctgata attgttttgt 29041 ttaagaaggc tgaagatagg gccatattca cttctagctt ttacggtttc tgctgagaaa 29101 tctgctgtta atctgatagg ttttctttca taggttacct ggtagtttca cctcacagct 29161 cttaagattc tctttgtctt tagataactt tggatactct gatgacaatg tacctaggca 29221 atgatatttt tgcaatgaat ttcccaggtg tttattgagc ttctttgtat ttggatatct 29281 aggtctctag caaggagggg gaagttttcc ttgattattt ccatggacaa gttttccaaa 29341 cttttagatt tctcttcttt ctcaggaatg ctgattattc ttaggtttga ttgtttaaca 29401 taatcccaga tttcttggag gctttgttca tattttctta ttcttttttc tttgtctttg 29461 ttggattggg taattcaaaa actttgtctt caagctctga atttcttctg cttggattct 29521 attgctgaga ctttctagag cattttgcat ttctataagt gcatccattc atccattgtt 29581 tcctgaagtt ttgaatgttt tttatttatg ctatctcttt aactgaagat ttctcccctc 29641 atttcttgta tcatattttt ggttttttta aaattggact tcaccttcct cggatgcctc 29701 cttgattagc ttaataactg accttctgaa ttatttttca ggtaaatcag ggatttcttc 29761 ttggtttgga tgcattgctg gtgagctagt atgatttttt ggggggtgtt aaagaacctt 29821 gtttttcata ttaccagagt tagttttctg gttccttctc acttgggtag gctctgtcag 29881 agggaaagtc taggcctcaa ggctgagact tttgtcccag caggtgttcc cttgatgtag 29941 cacagtcccc cttttcctag gacgtggggc ttcctgagag ccgaactgta gtgattgtta 30001 tctctcttct ggatctagcc acccatcagg tctaccagac tccaggctgg tactggggtt 30061 tgtctgcaca gagtcttgtg acgtgaacca tctgtgggtc tctcagccat agatacaacc 30121 acctgctcca atggaggtgg tagaggatga aatgaactct gtgagggtcc ttacttttgg 30181 ttgttcaatg cactatcttt ttgtgctggt tggcctcctg ccaggaggtg gcactttcta 30241 gaaagcatca gcagaggcag tcaggtggtg gtggctgggg gggctggggc actagaactc 30301 ccaagaatat atgccctttg tcttcagcta ctagggtgag taaggaagga ccatcaggtg 30361 ggggcaggac tagtcgtgtc tgagctcaga gtctccttgg gcaggtcttt ctgtggctac 30421 tgtgggagga tgggggtgta gtttccaggt caatggattt atgttcctag gacaattatg 30481 gctgcctctg ctgtgtcatg caggtcatca ggaaagtggg ggaaagcaag cagtcacgtg 30541 acttgcccag ctcccatgca actcaaaagg ttggtctcac ttccagcgtg caccctcccc 30601 cgcaacagct ccgaatctgt ttccatgcag tcagtgagca aggctgagaa cttgcccagg 30661 ctaccagctg cgaaaccaag tagggctgtc ctacttccct gccagtggag tctgcacacc 30721 aaattcatgt ccccccacca acccccccac tgcccagccc ctagatctgg ccaggtggag 30781 attttctttt tcctgtctct tttcccagtt cctctggcag ccctcccaaa tgacccctgt 30841 gaggcaaggc agaaatggct tcctagggga cccagagagc ccacagggct tttcccgctg 30901 cttcctctac ccctgtattt tgcttggccc tctaaattga ctcagctcca ggtaaggtca 30961 gaatcttctc ctgtggtcta gatcttcagg ttcccagtga ggatgtgtgt ttgggggtag 31021 acggtccccc ttttccactt ccacagtttg ggcactcaca atatttgggg tgtttcccgg 31081 gtcctacatg agcaatctgc ttctttcaga gggtgtgtgc gttctctcag ctttcttgaa 31141 tttatttctg caggtggttc tgcaaaaaaa attcctgatg ggagacttca catgctgctc 31201 tgtgcatccg agtgggagct gcaatgtact tctgctgcca cccatctgcc atcaccctct 31261 aatttgtcgg taatatgcat ttttaatcaa tctttttttc tctctctctc ttttcttctc 31321 ccccaaaact atactgccct ttgatatcaa ggaatcaagg ccgtgatgtt gaggggtggg 31381 cagtggatac actctttacc ccttagggag catatctaga tttagatatt gccaattcaa 31441 gataacttaa ttgaaagcaa attcataatg aatacacaca cacacacaca catctgcatg 31501 acaagatttt taatagttga aagaataact aataattgtc cacaggcaat aagggctttt 31561 taagcaaaac agttgtgata aaacaggtca ttcttagaat agtaatccag ccaatagtac 31621 aggttgctta gagattatga cattaccaga gttaaaattc aataatggct tctcactccc 31681 taccactgag gacaagttta tgtccttagg tttatgcttc cctgaaacaa taccacctgc 31741 tattctccac tttacatatc aacggcactg gttctttatc taactctctg gcacagcagg 31801 agtttgtttt cttctgcttc agagctttga atttactatt tcagcttcta aactttattt 31861 gcaatgcctt cccatggcag actccttctg tcattttgcc tctgttcgaa aactttttcc 31921 ttaatttcat tcttagttaa taatatctga aattattttg ttgtttaact taattattaa 31981 ttttatgtat gttctaccta gatataatct tctagaggat tgttttattc tctgacttat 32041 ttaacttaaa tgcccactac ctttaaaaat tatgacattt atttaacaga tatttgctga 32101 acaaatgttt gaaaatacat gggaaagaat gcttgaaaac acttgaaatt gcttgtgtaa 32161 agaaacagtt ttatcagtta ggatttaatc aatgtcagaa gcaatgatat aggaaaaatc 32221 gaggaataag acagttatgg ataaggagaa atcaacaaac tcttaaaaga tattgcctca 32281 aaagcataag aggaaataag ggtttataca tgacttttag aacactgcct gggtttttgg 32341 ataaatgggg aagttgttgg aaaacaggag ggatcctaga tattccttag tctgaggagg 32401 agcaattaag attcacttgt ttagaggctg ggagtggtgg ctcacgcctg taatcccaga 32461 attttgggag gccaaggcag gcagatcacc tgaggtcaag agttcaagac caacctggcc 32521 aacatggtga aatcccatct ctacaaaaat acaaaaatta gacaggcatg atggcaagtg 32581 cctgtaatcc cagctacttg ggaggctgag gaaggagaat tgcttgaacc tggaaggcag 32641 gagttgcagt gagccgagat cataccactg cactccagcc tgggtgacag aacaagactc 32701 tgtctcaaaa aaaaaaaaga gagattcaaa agattcactt gtttaggcct tagcgggctt 32761 agacaccagt ctctgacaca ttcttaaagg tcaggctcta caaatggaac ccaaccagac 32821 tctcagatat ggccaaagat ctatacacac ccatctcaca gatcccctat cttaaagaga 32881 ccctaatttg ggttcacctc agtctctata atctgtacca gcataccaat aaaaatcttt 32941 ctcacccatc cttagattga gagaagtcac ttattattat gtgagtaact ggaagatact 33001 gataagttga caaatctttt tctttccttt cttattcaac ttttatttta acttccaaag 33061 aacaagtgca atatgtgcag ctttgttgcg caggtcaaca tgtatctttc tggtctttta 33121 gccgcctaac actttgagca gatataagcc ttacacagga ttatgaagtc tgaaaggatt 33181 ccaccaatat tattataatt cctatcaacc tgataagtta ggggaaggta gagctctcct 33241 ccaataagcc agatttccag agtttctgac gtcataatct accaaggtca tggatcgagt 33301 tcagagaaaa aacaaaagca aaaccaaacc taccaaaaaa taaaaatccc aaagaaaaaa 33361 taaagaaaaa aacagcatga atacttcctg ccatgttaag tggccaatat gtcagaaaca 33421 gcactgagtt acagataaag atgtctaaac tacagtgaca tcccagctgt cacagtgtgt 33481 ggactattag tcaataaaac agtccctgcc tcttaagagt tgttttccat gcaaatacat 33541 gtcttatgtc ttagaataag attccctaag aagtgaacct agcatttata caagataatt 33601 aattctaatc catagtatct ggtaaagagc attctaccat catctttacc gagcatagaa 33661 gagctacacc aaaaccctgg gtcatcagcc agcacataca cttatccagt gataaataca 33721 catcatcggg tgcctacata catacctgaa tataaaaaaa atacttttgc tgagatgaaa 33781 caggcgtgat ttatttcaaa taggtacgga taagtagata ttgaagtaag gattcagtct 33841 tatattatat tacataacat taatctattc ctgcactgaa actgttgctt tataggattt 33901 ttcactacac taatgagaac ttaagagata atggcctaaa accacagaga gtatattcaa 33961 gaataagtat agcacttctt atttggaaac caatgcttac taaatgagac taagacgtgt 34021 cccatcaaaa atcctggacc tatgcctaaa acacatttca caatccctga acttttcaaa 34081 aattggtaca tgctttaact ttaaactaca ggcctcactg gagctacaga caagaaggtg 34141 aaaaacggct gacaaaagaa gtcctggtat cttctatggt gggagaagaa aactagctaa 34201 agggaagaat aaattagaga aaaattggaa tgactgaatc ggaacaaggc aaaggctata 34261 aaaaaaatta agcagcagta tcctcttggg ggccccttcc ccacactatc tcaatgcaaa 34321 tatctgtctg aaacggttcc tggctaaact ccacccatgg gttggccagc cttgccttga 34381 ccaatagcct tgacaaggca aacttgacca atagtcttag agtatccagt gaggccaggg 34441 gccggcggct ggctagggat gaagaataaa aggaagcacc cttcagcagt tccacacact 34501 cgcttctgga acgtctgagg ttatcaataa gctcctagtc cagacgccat gggtcatttc 34561 acagaggagg acaaggctac tatcacaagc ctgtggggca aggtgaatgt ggaagatgct 34621 ggaggagaaa ccctgggaag gtaggctctg gtgaccagga caagggaggg aaggaaggac 34681 cctgtgcctg gcaaaagtcc aggtcgcttc tcaggatttg tggcaccttc tgactgtcaa 34741 actgttcttg tcaatctcac aggctcctgg ttgtctaccc atggacccag aggttctttg 34801 acagctttgg caacctgtcc tctgcctctg ccatcatggg caaccccaaa gtcaaggcac 34861 atggcaagaa ggtgctgact tccttgggag atgccataaa gcacctggat gatctcaagg 34921 gcacctttgc ccagctgagt gaactgcact gtgacaagct gcatgtggat cctgagaact 34981 tcaaggtgag tccaggagat gtttcagcac tgttgccttt agtctcgagg caacttagac 35041 aactgagtat tgatctgagc acagcagggt gtgagctgtt tgaagatact ggggttggga 35101 gtgaagaaac tgcagaggac taactgggct gagacccagt ggcaatgttt tagggcctaa 35161 ggagtgcctc tgaaaatcta gatggacaac tttgactttg agaaaagaga ggtggaaatg 35221 aggaaaatga cttttcttta ttagatttcg gtagaaagaa ctttcacctt tcccctattt 35281 ttgttattcg ttttaaaaca tctatctgga ggcaggacaa gtatggtcgt taaaaagatg 35341 caggcagaag gcatatattg gctcagtcaa agtggggaac tttggtggcc aaacatacat 35401 tgctaaggct attcctatat cagctggaca catataaaat gctgctaatg cttcattaca 35461 aacttatatc ctttaattcc agatgggggc aaagtatgtc caggggtgag gaacaattga 35521 aacatttggg ctggagtaga ttttgaaagt cagctctgtg tgtgtgtgtg tgtgtgtgcg 35581 cgcgtgtgtt tgtgtgtgtg tgagagcgtg tgtttctttt aacgttttca gcctacagca 35641 tacagggttc atggtggcaa gaagataaca agatttaaat tatggccagt gactagtgct 35701 gcaagaagaa caactacctg catttaatgg gaaagcaaaa tctcaggctt tgagggaagt 35761 taacataggc ttgattctgg gtggaagctt ggtgtgtagt tatctggagg ccaggctgga 35821 gctctcagct cactatgggt tcatctttat tgtctccttt catctcaaca gctcctggga 35881 aatgtgctgg tgaccgtttt ggcaatccat ttcggcaaag aattcacccc tgaggtgcag 35941 gcttcctggc agaagatggt gactggagtg gccagtgccc tgtcctccag ataccactga 36001 gctcactgcc catgatgcag agctttcaag gataggcttt attctgcaag caatacaaat 36061 aataaatcta ttctgctaag agatcacaca tggttgtctt cagttctttt ttttatgtct 36121 ttttaaatat atgagccaca aagggtttta tgttgaggga tgtgtttatg tgtatttata 36181 catggctatg tgtgtttgtg tcatgtgcac actccacact tttttgttta cgttagatgt 36241 gggttttgat gagcaaataa aagaactagg caataaagaa acttatacat gggagcgtct 36301 gcaagtggga gtaaaaggtg caggagaaat ctggttggaa gaaagacctc tataggacag 36361 gactcctcag aaacagatgt tttggaagag atggggaaag gttcagtgaa gggggctgaa 36421 cccccttccc tggattgcag cacagcagcg aggaaggggc tcaacgaaga aaaagtgttc 36481 caagctttag gaagtcaagg tttaggcagg gatagccatt ctattttatt aggggcaata 36541 ctatttccaa cggcatctgg cttttctcag cccttgtgag gctctacggg gaggttgagg 36601 tgttagagat cagagcagga aacaggtttt tctttccacg gtaactacaa tgaagtgatc 36661 cttactttac taaggaactt tttcatttta agtgttgacg catgcctaaa gaggtgaaat 36721 taatcccata cccttaagtc tacagactgg tcacagcatt tcaaggagga gacctcattg 36781 taagcttcta gggaggtggg gacctaggtg aaggaaatga gccagcagaa gctcacaagt 36841 cagcatcagc gtgtcatgtc tcagcagcag aacagcacgg tcagatgaaa atatagtgtg 36901 aagaatttgt ataacattaa ttgagaaggc agattcactg gagttcttat ataattgaaa 36961 gttaatgcac gttaataagc aagagtttag tttaatgtga tggtgttatg aacttaacgc 37021 ttgtgtctcc agaaaattca catgctgaat ccccaactcc caattggctc catttgtggg 37081 ggaggctttg gaaaagtaat caggtttaga ggagctcatg agagcagatc cccatcatag 37141 aattattttc ctcatcagaa gcagagagat tagccatttc tcttccttct ggtgaggaca 37201 cagtgggaag tcagccacct gcaacccagg aagagagccc tgaccaggaa ccagcagaaa 37261 agtgagaaaa aatcctgttg ttgaagtcac ccagtctatg ctattttgtt atagcacctt 37321 gcactaagta aggcagatga agaaagagaa aaaaataagc ttcggtgttc agtggattag 37381 aaaccatgtt tatctcaggt ttacaaatct ccacttgtcc tctgtgtttc agaataaaat 37441 accaactcta ctactctcat ctgtaagatg caaatagtaa gcctgatccc ttctgtctaa 37501 cttcgaattc tattttttct tcaacgtact ttaggcttgt aatgtgttta tatacagtga 37561 aatgtcaagt tctttcttta tatttctttc tttctttttt ttcctcagcc tcagagtttt 37621 ccacatgccc ttcctacctt caggaacttc tttctccaaa cgtcttctgc ctggcctcca 37681 ttcaaatcat aaaggaccca cttcaaatgc catcactcac taccatttca caattcgcac 37741 tttctttctt tgtccttttt ttttttagta aaacaagttt ataaaaaatt gaaggaataa 37801 atgaatggct acttcatagg cagagtagac acaagggcta ctggttgccg atttttattg 37861 ttatttttca atagtatgct aaacaagggg tagattattt atgctgccca tttttagacc 37921 ataaaagata acttcctgat gttgccatgg catttttttt ccttttaatt ttatttcatt 37981 tcattttaat ttcgaaggta catgtgcagg atgtgcaggc ttgttacatg ggtaaatgtg 38041 tgtctttctg gccttttagc catctgtatc aatgagcaga tataagcttt acacaggatc 38101 atgaaggatg aaagaatttc accaatatta taataatttc aatcaacctg atagcttagg 38161 ggataaacta atttgaagat acagcttgcc tccgataagc cagaattcca gagcttctgg 38221 cattataatc tagcaaggtt agagatcatg gatcactttc agagaaaaac aaaaacaaac 38281 taaccaaaag caaaacagaa ccaaaaaacc tccataaata cttcctaccc agttaatggt 38341 ccaatatgtc agaaacagca ctgtgttaga aataaagctg tctaaagtac actaatattc 38401 gagttataat agtgtgtgga ctattagtca ataaaaacaa cccttgcctc tttagagttg 38461 ttttccatgt acacgcacat cttatgtctt agagtaagat tccctgagaa gtgaacctag 38521 catttataca agataattaa ttctaatcca cagtacctgc caaagaacat tctaccatca 38581 tctttactga gcatagaaga gctacgccaa aaccctgggt catcagccag cacacacact 38641 tatccagtgg taaatacaca tcatctggtg tatacataca tacctgaata tggaatcaaa 38701 tatttttcta agatgaaaca gtcatgattt atttcaaata ggtacggata agtagatatt 38761 gaggtaagca ttaggtctta tattatgtaa cactaatcta ttactgcgct gaaactgtgg 38821 tctttatgaa aattgttttc actacactat tgagaaatta agagataatg gcaaaagtca 38881 caaagagtat attcaaaaag aagtatagca ctttttcctt agaaaccact gctaactgaa 38941 agagactaag atttgtcccg tcaaaaatcc tggacctatg cctaaaacac atttcacaat 39001 ccctgaactt ttcaaaaatt ggtacatgct ttagctttaa actacaggcc tcactggagc 39061 tacagacaag aaggtaaaaa acggctgaca aaagaagtcc tggtatcctc tatgatggga 39121 gaaggaaact agctaaaggg aagaataaat tagagaaaaa ctggaatgac tgaatcggaa 39181 caaggcaaag gctataaaaa aaattaagca gcagtatcct cttgggggcc ccttccccac 39241 actatctcaa tgcaaatatc tgtctgaaac ggtccctggc taaactccac ccatgggttg 39301 gccagccttg ccttgaccaa tagccttgac aaggcaaact tgaccaatag tcttagagta 39361 tccagtgagg ccaggggccg gcggctggct agggatgaag aataaaagga agcacccttc 39421 agcagttcca cacactcgct tctggaacgt ctgagattat caataagctc ctagtccaga 39481 cgccatgggt catttcacag aggaggacaa ggctactatc acaagcctgt ggggcaaggt 39541 gaatgtggaa gatgctggag gagaaaccct gggaaggtag gctctggtga ccaggacaag 39601 ggagggaagg aaggaccctg tgcctggcaa aagtccaggt cgcttctcag gatttgtggc 39661 accttctgac tgtcaaactg ttcttgtcaa tctcacaggc tcctggttgt ctacccatgg 39721 acccagaggt tctttgacag ctttggcaac ctgtcctctg cctctgccat catgggcaac 39781 cccaaagtca aggcacatgg caagaaggtg ctgacttcct tgggagatgc cataaagcac 39841 ctggatgatc tcaagggcac ctttgcccag ctgagtgaac tgcactgtga caagctgcat 39901 gtggatcctg agaacttcaa ggtgagtcca ggagatgttt cagcactgtt gcctttagtc 39961 tcgaggcaac ttagacaact gagtattgat ctgagcacag cagggtgtga gctgtttgaa 40021 gatactgggg ttgggagtga agaaactgca gaggactaac tgggctgaga cccagtggca 40081 atgttttagg gcctaaggag tgcctctgaa aatctagatg gacaactttg actttgagaa 40141 aagagaggtg gaaatgagga aaatgacttt tctttattag atttcggtag aaagaacttt 40201 cacctttccc ctatttttgt tattcgtttt aaaacatcta tctggaggca ggacaagtat 40261 ggtcgttaaa aagatgcagg cagaaggcat atattggctc agtcaaagtg gggaactttg 40321 gtggccaaac atacattgct aaggctattc ctatatcagc tggacacata taaaatgctg 40381 ctaatgcttc attacaaact tatatccttt aattccagat gggggcaaag tatgtccagg 40441 ggtgaggaac aattgaaaca tttgggctgg agtagatttt gaaagtcagc tctgtgtgtg 40501 tgtgtgtgtg tgtgtgtgtc agcgtgtgtt tcttttaacg tcttcagcct acaacataca 40561 gggttcatgg tgggaagaag atagcaagat ttaaattatg gccagtgact agtgcttgaa 40621 ggggaacaac tacctgcatt taatgggaag gcaaaatctc aggctttgag ggaagttaac 40681 ataggcttga ttctgggtgg aagctgggtg tgtagttatc tggaggccag gctggagctc 40741 tcagctcact atgggttcat ctttattgtc tcctttcatc tcaacagctc ctgggaaatg 40801 tgctggtgac cgttttggca atccatttcg gcaaagaatt cacccctgag gtgcaggctt 40861 cctggcagaa gatggtgact gcagtggcca gtgccctgtc ctccagatac cactgagcct 40921 cttgcccatg attcagagct ttcaaggata ggctttattc tgcaagcaat acaaataata 40981 aatctattct gctgagagat cacacatgat tttcttcagc tctttttttt acatcttttt 41041 aaatatatga gccacaaagg gtttatattg agggaagtgt gtatgtgtat ttctgcatgc 41101 ctgtttgtgt ttgtggtgtg tgcatgctcc tcatttattt ttatatgaga tgtgcatttt 41161 gatgagcaaa taaaagcagt aaagacactt gtacacggga gttctgcaag tgggagtaaa 41221 tggtgttgga gaaatccggt gggaagaaag acctctatag gacaggactt ctcagaaaca 41281 gatgttttgg aagagatggg aaaaggttca gtgaagacct gggggctgga ttgattgcag 41341 ctgagtagca aggatggttc ttaatgaagg gaaagtgttc caagctttag gaattcaagg 41401 tttagtcagg tgtagcaatt ctattttatt aggaggaata ctatttctaa tggcacttag 41461 cttttcacag cccttgtgga tgcctaagaa agtgaaatta atcccatgcc ctcaagtgtg 41521 cagattggtc acagcatttc aagggagaga cctcattgta agactctggg ggaggtgggg 41581 acttaggtgt aagaaatgaa tcagcagagg ctcacaagtc agcatgagca tgttatgtct 41641 gagaaacaga ccagcactgt gagatcaaaa tgtagtggga agaatttgta caacattaat 41701 tggaaggttt acttaatgga atttttgtat agttggatgt tagtgcatct ctataagtaa 41761 gagtttaata tgatggtgtt acggacctgg tgtttgtgtc tcctcaaaat tcacatgctg 41821 aatccccaac tcccaactga ccttatctgt gggggaggct tttgaaaagt aattaggttt 41881 agctgagctc ataagagcag atccccatca taaaattatt ttccttatca gaagcagaga 41941 gacaagccat ttctctttcc tcccggtgag gacacagtga gaagtccgcc atctgcaatc 42001 caggaagaga accctgacca cgagtcagcc ttcagaaatg tgagaaaaaa ctctgttgtt 42061 gaagccaccc agtcttttgt attttgttat agcaccttac actgagtaag gcagatgaag 42121 aaggagaaaa aaataagctt gggttttgag tgaactacag accatgttat ctcaggtttg 42181 caaagctccc ctcgtcccct atgtttcagc ataaaatacc tactctacta ctctcatcta 42241 taagacccaa ataataagcc tgcgcccttc tctctaactt tgatttctcc tatttttact 42301 tcaacatgct ttactctagc cttgtaatgt ctttacatac agtgaaatgt aaagttcttt 42361 attctttttt tctttctttc ttttttctcc tcagcctcag aatttggcac atgcccttcc 42421 ttctttcagg aacttctcca acatctctgc ctggctccat catatcataa aggtcccact 42481 tcaaatgcag tcactaccgt ttcaggatat gcactttctt tcttttttgt tttttgtttt 42541 ttttaagtca aagcaaattt cttgagagag taaagaaata aacgaatgac tactgcatag 42601 gcagagcagc cccgagggcc gctggttgtt ccttttatgg ttatttcttg atgatatgtt 42661 aaacaagttt tggattattt atgccttctc tttttaggcc atatagggta actttctgac 42721 attgccatgg catgtttctt ttaatttaat ttactgttac cttaaattca ggggtacacg 42781 tacaggatat gcaggtttgt tttataggta aaagtgtgcc atggttttaa tgggtttttt 42841 ttttcttgta aagttgttta agtttcttgt ttactctgga tattggcctt tgtcagaaga 42901 atagattgga aaatcttttt cccattctgt agattgtctt tcgctctgat ggtagtttct 42961 tttgctgagc aggagctctt tagtttaatt agattccatt ggtcaatttt tgcttttgct 43021 gcaattgctt ttcacgcttt catcatgaaa tctgtgcccg tgtttatatc atgaatagta 43081 ttgccttgat ttttttctag gctttttata gtttggggtt tttcatttaa gtctctaatc 43141 catccggagt taattttgga taaggtataa ggaaggagtc cagtttcatt tttcagcata 43201 tggctagcca gttctccccc atcatttatt aaattgaaaa tcctttcccc attgcttgct 43261 tttgtcaggt ttctaaaaga cagatggttg taggtacaat atgcagtttc ttcaagtcat 43321 ataataccat ctgaaatctc ttattaattc atttctttta gtatgtatgc tggtctcctc 43381 tgctcactat agtgagggca ccattagcca gagaatctgt ctgtctagtt catgtaagat 43441 tctcagaatt aagaaaaatg gatggcatat gaatgaaact tcatggatga catatggaat 43501 ctaatgtgta tttgttgaat taatgcataa gatgcaacaa gggaaaggtt gacaactgca 43561 gtgataacct ggtattgatg atataagagt ctatagatca cagtagaagc aataatcatg 43621 gaaaacaatt ggaaatgggg aacagccaca aacaagaaag aatcaatact accaggaaag 43681 tgactgcagg tcacttttcc tggagcgggt gagagaaaag tggaagttgc agtaactgcc 43741 gaattcctgg ttggctgatg gaaagatggg gcaactgttc actggtacgc agggttttag 43801 atgtatgtac ctaaggatat gaggtatggc aatgaacaga aattcttttg ggaatgagtt 43861 ttagggccat taaaggacat gacctgaagt ttcctctgag gccagtcccc acaactcaat 43921 ataaatgtgt ttcctgcata tagtcaaagt tgccacttct ttttcttcat atcatcgatc 43981 tctgctctta aagataatct tggttttgcc tcaaactgtt tgtcactaca aactttcccc 44041 atgttcctaa gtaaaacagg taactgcctc tcaactatat caagtagact aaaatattgt 44101 gtctctaata tcagaaattc agctttaata tattgggttt aactctttga aatttagagt 44161 ctccttgaaa tacacatggg ggtgatttcc taaactttat ttcttgtaag gatttatctc 44221 aggggtaaca cacaaaccag catcctgaac ctctaagtat gaggacagta agccttaaga 44281 atataaaata aactgttctt ctctctgccg gtggaagtgt gccctgtcta ttcctgaaat 44341 tgcttgtttg agacgcatga gacgtgcagc acatgagaca cgtgcagcag cctgtggaat 44401 attgtcagtg aagaatgtct ttgcctgatt agatataaag acaagttaaa cacagcatta 44461 gactatagat caagcctgtg ccagacacaa atgacctaat gcccagcacg ggccacggaa 44521 tctcctatcc tcttgcttga acagagcagc acacttctcc cccaacacta ttagatgttc 44581 tggcataatt ttgtagatat gtaggatttg acatggacta ttgttcaatg attcagagga 44641 aatctccttt gttcagataa gtacactgac tactaaatgg attaaaaaac acagtaataa 44701 aacccagttt tccccttact tccctagttt gtttcttatt ctgctttctt ccaagttgat 44761 gctggataga ggtgtttatt tctattctaa aaagtgatga aattggccgg gcgcggtggc 44821 tcacacctgt aatcccagca ctttgggagg ctgaggtggg cggatcacga ggtcaggaga 44881 tcaagaccat cctggctaac atggtgaaac cccatctcta ctaaaaatac aaaaaattag 44941 ccagagacgg tggcgggtgc ctgtagtccc agctactcgg gaggctgagg caggagaatg 45001 gcgtgaacct gggaggcaga gctgcagtga gcagagatcg cgccactgca cactccagcc 45061 tgggtgacaa agcgagactc catctcaaaa aaaaaaaaaa aaaaaaaaag aaagaaagaa 45121 agaaaaaaaa agtgatgaaa ttgtgtattc aatgtagtct caagagaatt gaaaaccaag 45181 aaaggctgtg gcttcttcca cataaagcct ggatgaataa caggataaca cgttgttaca 45241 ttgtcacaac tcctgatcca ggaattgatg gctaagatat tcgtaattct tatccttttc 45301 agttgtaact tattcctatt tgtcagcatt caggttatta gcggctgctg gcgaagtcct 45361 tgagaaataa actgcacact ggatggtggg ggtagtgtag gaaaatggag gggaaggaag 45421 taaagtttca aattaagcct gaacagcaaa gttcccctga gaaggccacc tggattctat 45481 cagaaactcg aatgtccatc ttgcaaaact tccttgccca aaccccaccc ctggagtcac 45541 aacccaccct tgaccaatag attcatttca ctgagggagg caaagggctg gtcaatagat 45601 tcatttcact gggagaggca aagggctggg ggccagagag gagaagtaaa aagccacaca 45661 tgaagcagca atgcaggcat gcttctggct catctgtgat caccaggaaa ctcccagatc 45721 tgacactgta gtgcatttca ctgctgacaa gaaggctgct gccaccagcc tgtgaagcaa 45781 ggttaaggtg agaaggctgg aggtgagatt ctgggcaggt aggtactgga agccgggaca 45841 aggtgcagaa aggcagaaag tgtttctgaa agagggatta gcccgttgtc ttacatagtc 45901 tgactttgca cctgctctgt gattatgact atcccacagt ctcctggttg tctacccatg 45961 gacctagagg tactttgaaa gttttggata tctgggctct gactgtgcaa taatgggcaa 46021 ccccaaagtc aaggcacatg gcaagaaggt gctgatctcc ttcggaaaag ctgttatgct 46081 cacggatgac ctcaaaggca cctttgctac actgagtgac ctgcactgta acaagctgca 46141 cgtggaccct gagaacttcc tggtgagtag taagtacact cacgctttct tctttaccct 46201 tagatatttg cactatgggt acttttgaaa gcagaggtgg ctttctcttg tgttatgagt 46261 cagctatggg atatgatatt tcagcagtgg gattttgaga gttatgttgc tgtaaataac 46321 ataactaaaa tttggtagag caaggactat gaataatgga aggccactta ccatttgata 46381 gctctgaaaa acacatctta taaaaaattc tggccaaaat caaactgagt gttttggatg 46441 agggaacaga agttgagata gagaaaataa catctttcct ttggtcagcg aaattttcta 46501 taaaaattaa tagtcacttt tctgcatagt cctggaggtt agaaaaagat caactgaaca 46561 aagtagtggg aagctgttaa aagaggattg tttccctccg aatgatgatg gtatactttt 46621 gtacgcatgg tacaggattc tttgttatga gtgtttggga aaattgtatg tatgtatgta 46681 tgtatgtgat gactggggac ttatcctatc cattactgtt ccttgaagta ctattatcct 46741 actttttaaa aggacgaagt ctctaaaaaa aaaatgaaac aatcacaata tgttggggta 46801 gtgagttggc atagcaagta agagaaggat aggacacaat gggaggtgca gggctgccag 46861 tcatattgaa gctgatatct agcccataat ggtgagagtt gctcaaactc tggtcaaaaa 46921 ggatgtaagt gttatatcta tttactgcaa gtccagcttg aggccttcta ttcactatgt 46981 accattttct tttttatctt cactccctcc ccagctctta ggcaacgtga tattgattgt 47041 tttggcaacc cacttcagcg aggattttac cctacagata caggcttctt ggcagtaact 47101 aacaaatgct gtggttaatg ctgtagccca caagaccact gagttccctg tccactatgt 47161 ttgtacctat gtcccaaaat ctcatctcct ttagatgggg gaggttgggg agaagagcag 47221 tatcctgcct gctgattcag ttcctgcatg ataaaaatag aataaagaaa tatgctctct 47281 aagaaatatc attgtactct ttttctgtct ttatatttta ccctgattca gccaaaagga 47341 cgcactattt ctgatggaaa tgagaatgtt ggagaatggg agtttaagga cagagaagat 47401 actttcttgc aatcctgcaa gaaaagagag aactcgtggg tggatttagt ggggtagtta 47461 ctcctaggaa ggggaaatcg tctctagaat aagacaatgt ttttacagaa agggaggtca 47521 atggaggtac tctttggagg tgtaagagga ttgttggtag tgtgtagagg tatgttagga 47581 ctcaaattag aagttctgta taggctatta tttgtatgaa actcaggata tagctcattt 47641 ggtgactgca gttcacttct acttatttta aacaacatat tttttatgat ttataatgaa 47701 gtggggatgg ggcttcctag agaccaatca agggccaaac cttgaacttt ctcttaacgt 47761 cttcaatggt attaatagag aattatctct aaggcatgtg aactggctgt cttggttttc 47821 atctgtactt catctgctac ctctgtgacc tgaaacatat ttataattcc attaagctgt 47881 gcatatgata gatttatcat atgtattttc cttaaaggat ttttgtaaga actaattgaa 47941 ttgatacctg taaagtcttt atcacactac ccaataaata ataaatctct ttgttcagct 48001 ctctgtttct ataaatatgt acaagtttta ttgtttttag tggtagtgat tttattctct 48061 ttctatatat atacacacac atgtgtgcat tcataaatat atacaatttt tatgaataaa 48121 aaattattag caatcaatat tgaaaaccac tgatttttgt ttatgtgagc aaacagcaga 48181 ttaaaaggct gagatttagg aaacagcacg ttaagtcaag ttgatagagg agaatatgga 48241 catttaaaag aggcaggatg atataaaatt agggaaactg gatgcagaga ccagatgaag 48301 taagaaaaat agctatcgtt ttgagcaaaa atcactgaag tttcttgcat atgagagtga 48361 cataataaat agggaaacgt agaaaattga ttcacatgta tatatatata tagaactgat 48421 tagacaaagt ctaacttggg tatagtcaga ggagcttgct gtaattatat tgaggtgatg 48481 gataaagaac tgaagttgat ggaaacaatg aagttaagaa aaaaaatcga gtaagagacc 48541 attgtggcag tgattgcaca gaactggaaa acattgtgaa acagagagtc agagatgaca 48601 gctaaaatcc ctgtctgtga atgaaaagaa ggaaatttat tgacagaaca gcaaatgcct 48661 acaagccccc tgtttggatc tggcaatgaa cgtagccatt ctgtggcaat cacttcaaac 48721 tcctgtaccc aagaccctta ggaagtatgt agcaccctca aacctaaaac ctcaaagaaa 48781 gaggttttag aagatataat accctttctt ctccagtttc attaatccca aaacctcttt 48841 ctcaaagtat ttcctctatg tgtccacccc aaagagctca cctcaccata tctcttgagt 48901 gggagcacat agataggcgg tgctaccatc taacagcttc tgaaattcct ttgtcatatt 48961 tttgagtccc cactaataac ccacaaagca gaataaatac cagttgctca tgtacaataa 49021 tcactcaact gctgtcttgt agcatacatt aattaagcac attctttgaa taattactgt 49081 gtccaaacaa tcacacttta aaatctcaca cttgtgctat cccttgccct tctgaatgtc 49141 actctgtatt ttaaatgaag agatgagggt tgaatttcct gtgttactta ttgttcattt 49201 ctcgatgagg agttttcaca ttcaccttta ctggaaaaca cataagtaca catcttacag 49261 gaaaaatata ccaaactgac atgtagcatg aatgcttgtg catgtagtca tataaaatct 49321 tgtagcaatg taaacattct ctgatataca catacagatg tgtctatatg tctacacaat 49381 ttcttatgct ccatgaacaa acattccatg cacacataag aacacacact gttacagatg 49441 catacttgag tgcattgaca aaattacccc agtcaatcta gagaatttgg atttctgcat 49501 ttgactctgt tagctttgta catgctgttc atttactctg ggtgatgtct ttccctcatt 49561 ttgccttgtc tatcttgtac tcatacttta agtcctaact tatatgttat ctcaactaag 49621 aagctatttt tttttaattt taactgggct taaagccctg tctataaact ctgctacaat 49681 tatgggctct ttcttataat atttagtgtt tttcctacta atgtacttaa tctgctcatt 49741 gtatattcct accactaaat tttaacctct tttatggtag agacattgtc ttgtaaactc 49801 ttatttccct agtatttgga gatgaaaaaa aagattaaat tatccaaaat tagatctctc 49861 ttttctacat tatgagtatt acactatcca tagggaagtt tgtttgagac ctaaactgag 49921 gaacctttgg ttctaaaatg actatgtgat atcttagtat ttataggtca tgaggttcct 49981 tcctctgcct ctgctatagt ttgattagtc agcaagcatg tgtcatgcat ttattcacat 50041 cagaatttca tacactaata agacatagta tcagaagtca gtttattagt tatatcagtt 50101 agggtccatc aaggaaagga caaaccatta tcagttactc aacctagaat taaatacagc 50161 tcttaatagt taattatcct tgtattggaa gagctaaaat atcaaataaa ggacagtgca 50221 gaaatctaga tgttagtaac atcagaaaac ctcttccgcc attaggccta gaagggcaga 50281 aggagaaaat gtttatacca ccagagtcca gaaccagagc ccataaccag aggtccactg 50341 gattcagtga gctagtgggt gctccttgga gagagccaga actgtctaat gggggcatca 50401 aagtatcagc cataaaaaac cataaaaaag actgtctgct gtaggagatc cgttcagaga 50461 gagagagaga ccagaaataa tcttgcttat gctttccctc agccagtgtt taccattgca 50521 gaatgtacat gcgactgaaa gggtgaggaa acctgggaaa tgtcagttcc tcaaatacag 50581 agaacactga gggaaggatg agaaataaat gtgaaagcag acatgaatgg taattgacag 50641 aaggaaacta ggatgtgtcc agtaaatgaa taattacagt gtgcagtgat tattgcaatg 50701 attaatgtat tgataagata atatgaaaac acagaattca aacagcagtg aactgagatt 50761 agaattgtgg agagcactgg catttaagaa tgtcacactt agaatgtgtc tctaggcatt 50821 gttctgtgca tatatcatct caatattcat tatctgaaaa ttatgaatta ggtacaaagc 50881 tcaaataatt tattttttca ggttagcaag aacttttttt tttttttttt ctgagatgga 50941 gcattgctat ggttgcccag gctggagtgc aatggcatga tccaggctca ctgcaacatc 51001 tgcctcccag gttcaagcga ttctcctgcc tcagcctccc aagtagctgg cattacaggc 51061 atgtgccacc accatgcctg gctaattttc tatttttagt agataggggg tttcaccatg 51121 ttggtcaggc tgatctcgaa ctcctaacat caggtgatcc accctcctcg gcctctgaat 51181 gtactgggat cacaggcgtg agccaccaca cccagccaag aatgtgaatt ttgtagaagg 51241 atataaccca tatttctctg accctagagt ccttagtata cctcccatac catgtggctc 51301 atcctcctta catacatttc ccatctttca ccctaccttt tcctttttgt ttcagctttt 51361 cactgtgtgt caaaatctag aaccttatct cctacctgct ctgaaaccaa cagcaagttg 51421 acttccattc taacccacat tggcattaca ctaattaaaa tcgatactga gttctaaaat 51481 catctgggat tttggggact atgtcttact tcatacttcc ttgagatttc acattaaatg 51541 ttggtgttca ttaaaggtcc ttcatttaac tttgtattca tcacactctt ggattcacag 51601 ttatatctaa actcttatat atagcctgta taatcccaat tcccaagtct gatttctaac 51661 ctctgacctc caacctcagt gccaaaccca tatatcaaac aatgtactgg gcttatttat 51721 atagatgtcc tataggcacc tcagactcag catgggtatt tcacttgtta tactaaaact 51781 gtttctcttc cagtgttttc cattttagtc attagatagc tacttgccca ttcaccaagg 51841 tcacagatta aaatcatttc cctacctcta atcaacagtt caattctgct tcaatttgtc 51901 cctatctatt aatcaccact cttactgccc agtcaggtcc tcattgtttc ctgaacaaga 51961 gtagatgcta ttctttccac tttaagacct tatcctggct ggatgcggtg gctcaggctt 52021 gtaaacccag cactttggga ggccgaggca ggcagatcac ttgaggtcag gagttcaaga 52081 ccagcctgac caacatggtg aaaccccatc tctactaaaa atacaaaatc agccgggcgt 52141 gtggtgcatg cctgcagtcc cagctattca ggtggctgag gcaggagaat tgcttgaacc 52201 caggaggcgg aggttgcggt gagcctagat tgcaccattg cactctagct tgggcaatag 52261 ggatgaaact ccatctcaga agagaaaaga aaaaaagacc ttattctgtt acacaaatcc 52321 tctcaatgca atccatatag aataaacatg taaccagatc tcccaatgtg taaaatcatt 52381 tcaggtagaa cagaattaaa gtgaaaagcc aagtctttgg aattaacaga caaagttcaa 52441 ataacagtcc tcatggcctt aagaatttac ctaacatttt ttttagaatc aattttctta 52501 tatatgaatt ggaaacataa ttcctccctc acaaacacat tctaagattt taaggagata 52561 ttgatgaagt acatcatctg tcatttttaa cagttagtgg tagtgattca cacagcacat 52621 tatgatctgt tcttgtatgt tctgttccat tctgtattct tgacctggtt gtattctttc 52681 tgagctccag atccacatat ctaagtacat ctttttgcat tttacaagag tgcatacaat 52741 acaatgtatc caagactgta tttctgattt tatcgtacca ctaaactcac aaatgtggcc 52801 ctattcttgt gttcacgact gacatcaccg tcatggtcca agtctgataa tagaaatggc 52861 attgtcactt tcttccctac tgcaacagaa gcccagctat ttgtctccca ttttctctac 52921 ttctaaaata catttcttca ctaagtgaga ataatctttt aaagacacaa atcaaaccat 52981 gccaccacct ttcttgaatt attcaatatc tttcgttggc ttccaggtta cagaaaaata 53041 acttgtaaca aagtttaaag gtcattcatg gctcctctct accctatttt ataacatttc 53101 cccttgtgat cagaatctca ggcacatcat ccatctttct atatacaaat aaagtcatat 53161 agtttgaact cacctctggt tacttttaat caaccaaatg ctgtaaaatg catttgtatc 53221 gctacgtgtt aagcagtagt tgattctttt catttcttgt taatattcta ttctttgact 53281 ataccgtaat ttatcaattc tactgttggt aagcatttaa gtggctaccg gtttgaggtt 53341 tttatgatta ttgctgtcat aagcatttct atacatgtct ttggatacac acatgcatgt 53401 gtttctgaat atctaaaaat gtaattgcta ggtaatagac ttatcaagca tccagcattt 53461 gtggatacta ttaaaggttt tccaaagggg ttatactatt gtacagtgtc accaacagag 53521 tttgagtttc tattgatcca tatcaccacc aaaatttgaa ctgtcagtct tatctcttct 53581 cttgtctctt ttttcctctt ttttttcctt cccttcccct ctcttcgttt cttttctctc 53641 ctcttctctt ctttcctctc ttcccttccc tttctctttc tcttccctat cccttctcct 53701 ctcctctccc ctcctttttt ctcctctcct ctccattatt tatttttcct tcttctcctc 53761 catcccttcc atcctctctc ttcccctctt ccttccttcc tttctccatt tcttcctcct 53821 ctttccctca atccttcctt ttggatatgc tcatgggtgt gtatttgtct gccattgtgg 53881 cattatttga attcagaaaa gagtgaaaaa ctactgggat cttcattctg ggtctaattc 53941 cacatttttt tttaagaaca cactctgtaa aaatgttctg tactagcata ttcccaggaa 54001 cttcgttaaa tttaatctgg ctgaatatgg taaatctact ttgcactttg cattctttct 54061 ttagtcatac cataatttta aacattcaaa atatttgtat ataatatttg attttatctg 54121 tcattaaaat gttaacctta aaattcatgt ttccagaacc tatttcaata actggtaaat 54181 aaacactatt cattttttaa atattctttt aatggatatt tatttcaata taataaaaaa 54241 ttagagtttt attataggaa gaatttacca aaagaaggag gaagcaagca agtttaaact 54301 gcagcaatag ttgtccattc caacctctca aaattccctt ggagacaaaa tctctagagg 54361 caaagaagaa ctttatattg agtcaacttg ttaaaacatc tgcttttaga taagttttct 54421 tagtataaag tgacagaaac aaataagtta aactctaaga tacattccac tatattagcc 54481 taaaacactt ctgcaaaaat gaaactagga ggatattttt agaaacaact gctgaaagag 54541 atgcggtggg gagatatgca gaggagaaca gggtttctga gtcaagacac acatgacaga 54601 acagccaatc tcagggcaag ttaagggaat agtggaatga aggttcattt ttcattctca 54661 caaactaatg aaaccctgct tatcttaaac caacctgctc actggagcag ggaggacagg 54721 accagcataa aaggcagggc agagtcgact gttgcttaca ctttcttctg acataacagt 54781 gttcactagc aacctcaaac agacaccatg gtgcatctga ctcctgagga gaagactgct 54841 gtcaatgccc tgtggggcaa agtgaacgtg gatgcagttg gtggtgaggc cctgggcagg 54901 ttggtatcaa ggttataaga gaggctcaag gaggcaaatg gaaactgggc atgtgtagac 54961 agagaagact cttgggtttc tgataggcac tgactctctg tcccttgggc tgttttccta 55021 ccctcagatt actggtggtc tacccttgga cccagaggtt ctttgagtcc tttggggatc 55081 tgtcctctcc tgatgctgtt atgggcaacc ctaaggtgaa ggctcatggc aagaaggtgc 55141 taggtgcctt tagtgatggc ctggctcacc tggacaacct caagggcact ttttctcagc 55201 tgagtgagct gcactgtgac aagctgcacg tggatcctga gaacttcagg gtgagtccag 55261 gagatgcttc acttttctct ttttactttc taatcttaca ttttggttct tttacctacc 55321 tgctcttctc ccacattttt gtcattttac tatattttat catttaatgc ttctaaaatt 55381 ttgttaattt tttatttaaa tattctgcat tttttccttc ctcacaatct tgctatttta 55441 aattatttaa tatcctgtct ttctctccca accccctccc ttcatttttc cttctctaac 55501 aacaactcaa attatgcata ccagctctca cctgctaatt ctgcacttag aataatcctt 55561 ttgtctctcc acatgggtat gggagaggct ccaactcaaa gatgagaggc atagaatact 55621 gttttagagg ctataaatca ttttacaata aggaataatt ggaattttat aaattctgta 55681 gtaaatggaa tggaaaggaa agtgaatatt tgattatgaa agactaggca gttacactgg 55741 aggtggggca gaagtcgttg ctaggagaca gcccatcatc acactgatta atcaattaat 55801 ttgtatctat taatctgttt atagtaatta atttgtatat gctatataca catacaaaat 55861 taaaactaat ttggaattaa tttgtatata gtattataca gcatatatag catatatgta 55921 catatataga ctacatgcta gttaagtaca tagaggatgt gtgtgtatag atatatgtta 55981 tatgtatgca ttcatatatg tacttattta tgctgatggg aataacctgg ggatcagttt 56041 tgtctaagat ttgggcagaa aaaaatgggt gttggctcag tttctcagaa gccagtcttt 56101 atttctctgt taaccatatg catgtatctg cctacctctt ctccgcagct cttgggcaat 56161 gtgctggtgt gtgtgctggc ccgcaacttt ggcaaggaat tcaccccaca aatgcaggct 56221 gcctatcaga aggtggtggc tggtgtggct aatgccctgg ctcacaagta ccattgagat 56281 cctggactgt ttcctgataa ccataagaag accctatttc cctagattct attttctgaa 56341 cttgggaaca caatgcctac ttcaagggta tggcttctgc ctaataaaga atgttcagct 56401 caacttcctg attaatttca cttatttcat ttttttgtcc aggtgtgtaa gaaggttcct 56461 gaggctctac agatagggag cacttgttta ttttacaaag agtacatggg aaaagagaaa 56521 agcaagggaa ccgtacaagg cattaatggg tgacacttct acctccaaag agcagaaatt 56581 atcaagaact cttgatacaa agataatact ggcactgcag aggttctagg gaagacctca 56641 accctaagac atagcctcaa gggtaatagc tacgattaaa ctccaacaat tactgagaaa 56701 ataatgtgct caattaaagg cataatgatt actcaagaca atgttatgtt gtctttcttc 56761 ctccttcctt tgcctgcaca ttgtagccca taatactata ccccatcaag tgttcctgct 56821 ccaagaaata gcttcctcct cttacttgcc ccagaacatc tctgtaaaga atttcctctt 56881 atcttcccat atttcagtca agattcattg ctcacgtatt acttgtgacc tctcttgacc 56941 ccagccacaa taaacttctc tatactaccc aaaaaatctt tccaaaccct ccccgacacc 57001 atatttttat atttttctta tttatttcat gcacacacac acactccgtg ctttataagc 57061 aattctgcct attctctacc ttcttacaat gcctactgtg cctcatatta aattcatcaa 57121 tgggcagaaa gaaaatattt attcaagaaa acagtgaatg aatgaacgaa tgagtaaatg 57181 agtaaatgaa ggaatgatta ttccttgctt tagaacttct ggaattagag gacaatatta 57241 ataataccat cgcacagtgt ttctttgttg ttaatgctac aacatacaaa gaggaagcat 57301 gcagtaaaca accgaacagt tatttccttt ctgatcatag gagtaatatt tttttccttg 57361 agcacatttt tgccataggt aaaattagaa ggatttttag aactttctca gttgtataca 57421 tttttaaaaa tctgtattat atgcatgttg attaatttta aacttacttg aatacctaaa 57481 cagaatctgt tgtttccttg tgtttgaaag tgctttcaca gtaactctgt ctgtactgcc 57541 agaatatact gacaatgtgt tatagttaac tgttttgatc acaacatttt gaattgactg 57601 gcagcagaag ctctttttat atccatgtgt tttccttaag tcattataca tagtaggcat 57661 gagactcttt atactgaata agatatttag gaaccactgg tttacatatc agaagcagag 57721 ctactcaggg cattttgggg aagatcactt tcacattcct gagcataggg aagttctcat 57781 aagagtaaga tattaaaagg agatacttgt gtggtattcg aaagacagta agagagattg 57841 tagaccttat gatcttgata gggaaaacaa actacattcc tttctccaaa agtcaaaaaa 57901 aaagagcaaa tatagcttac tataccttct attcctacac cattagaagt agtcagtgag 57961 tctaggcaag atgttggccc taaaaatcca aataccagag aattcatgag aacatcacct 58021 ggatgggaca tgtgccgagc aacacaatta ctatatgcta ggcattgcta tcttcatatt 58081 gaagatgagg aggtcaagag atgaaaaaag acttggcacc ttgttgttat attaaaatta 58141 tttgttagag tagagctttt gtaagagtct aggagtgtgg gagctaaatg atgatacaca 58201 tggacacaaa gaatagatca acagacaccc aggcctactt gagggttgag ggtgggaaga 58261 gggagacgat gaaaaagaac ctattgggta ttaagttcat cactgagtga tgaaataatc 58321 tgtacatcaa gacccagtga tatgcaattt acctatataa cttgtacatg tacccccaaa 58381 tttaaaataa agttaaaaca aagtatagga atggaattaa ttcctcaaga tttggcttta 58441 attttatttg ataatttatc aaatggttgt ttttcttttc tcactatggc gttgctttat 58501 aaactatgtt cagtatgtct gaatgaaagg gtgtgtgtgt gtgtgaaaga gagggagaga 58561 ggaagggaag agaggacgta ataatgtgaa tttgagttca tgaaaatttt tcaataaaat 58621 aatttaatgt caggagaatt aagcctaata gtctcctaaa tcatccatct cttgagcttc 58681 agagcagtcc tctgaattaa tgcctacatg tttgtaaagg gtgttcagac tgaagccaag 58741 attctacctc taaagagatg caatctcaaa tttatctgaa gactgtacct ctgctctcca 58801 taaattgaca ccatggccca cttaatgagg ttaaaaaaaa gctaattctg aatgaaaatc 58861 tgagcccagt ggaggaaata ttaatgaaca aggtgcagac tgaaatataa attttctgta 58921 ataattatgc atatacttta gcaaagttct gtctatgttg actttattgc ttttggtaag 58981 aaatacaact ttttaaagtg aactaaacta tcctatttcc aaactatttt gtgtgtgtgc 59041 ggtttgtttc tatgggttct ggttttcttg gagcattttt atttcatttt aattaattaa 59101 ttctgagagc tgctgagttg tgtttactga gagattgtgt atctgcgaga gaagtctgta 59161 gcaagtagct agactgtgct tgacctagga acatatacag tagattgcta aaatgtctca 59221 cttggggaat tttagactaa acagtagagc atgtataaaa atactctagt caagtgctgc 59281 ttttgaaaca aatgataaaa ccacactccc atagatgagt gtcatgattt tcatggagga 59341 agttaatatt catcctctaa gtatacccag actagggcca ttctgatata aaacattagg 59401 acttaagaaa gattaataga ctggagtaaa ggaaatggac ctctgtctct ctcgctgtct 59461 cttttttgag gacttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttgt ggtcagtggg 59521 gctggaataa aagtagaata gacctgcacc tgctgtggca tccattcaca gagtagaagc 59581 aagctcacaa tagtgaagat gtcagtaagc ttgaatagtt tttcaggaac tttgaatgct 59641 gatttagatt tgaaactgag gctctgacca taaccaaatt tgcactattt attgcttctt 59701 gaaacttatt tgcctggtat gcctgggctt ttgatggtct tagtatagct tgcagccttg 59761 tccctgcagg gtattatggg taatagaaag aaaagtctgc gttacactct agtcacacta 59821 agtaactacc attggaaaag caacccctgc cttgaagcca ggatgatggt atctgcagca 59881 gttgccaaca caagagaagg atccatagtt catcatttaa aaaagaaaac aaaatagaaa 59941 aaggaaaact atttctgagc ataagaagtt gtagggtaag tctttaagaa ggtgacaatt 60001 tctgccaatc aggatttcaa agctcttgct ttgacaattt tggtctttca gaatactata 60061 aatataacct atattataat ttcataaagt ctgtgcattt tctttgaccc aggatatttg 60121 caaaagacat attcaaactt ccgcagaaca ctttatttca catatacatg cctcttatat 60181 cagggatgtg aaacagggtc ttgaaaactg tctaaatcta aaacaatgct aatgcaggtt 60241 taaatttaat aaaataaaat ccaaaatcta acagccaagt caaatctgta tgttttaaca 60301 tttaaaatat tttaaagacg tcttttccca ggattcaaca tgtgaaatct tttctcaggg 60361 atacacgtgt gcctagatcc tcattgcttt agttttttac agaggaatga atataaaaag 60421 aaaatactta aattttatcc ctcttacctc tataatcata cataggcata attttttaac 60481 ctaggctcca gatagccata gaagaaccaa acactttctg cgtgtgtgag aataatcaga 60541 gtgagatttt ttcacaagta cctgatgagg gttgagacag gtagaaaaag tgagagatct 60601 ctatttattt agcaataata gagaaagcat ttaagagaat aaagcaatgg aaataagaaa 60661 tttgtaaatt tccttctgat aactagaaat agaggatcca gtttcttttg gttaacctaa 60721 attttatttc attttattgt tttattttat tttattttat tttattttgt gtaatcgtag 60781 tttcagagtg ttagagctga aaggaagaag taggagaaac atgcaaagta aaagtataac 60841 actttcctta ctaaaccgac tgggtttcca ggtaggggca ggattcagga tgactgacag 60901 ggcccttagg gaacactgag accctacgct gacctcataa atgcttgcta cctttgctgt 60961 tttaattaca tcttttaata gcaggaagca gaactctgca cttcaaaagt ttttcctcac 61021 ctgaggagtt aatttagtac aaggggaaaa agtacagggg gatgggagaa aggcgatcac 61081 gttgggaagc tatagagaaa gaagagtaaa ttttagtaaa ggaggtttaa acaaacaaaa 61141 tataaagaga aataggaact tgaatcaagg aaatgatttt aaaacgcagt attcttagtg 61201 gactagagga aaaaaataat ctgagccaag tagaagacct tttcccctcc tacccctact 61261 ttctaagtca cagaggcttt ttgttccccc agacactctt gcagattagt ccaggcagaa 61321 acagttagat gtccccagtt aacctcctat ttgacaccac tgattacccc attgatagtc 61381 acactttggg ttgtaagtga ctttttattt atttgtattt ttgactgcat taagaggtct 61441 ctagtttttt atctcttgtt tcccaaaacc taataagtaa ctaatgcaca gagcacattg 61501 atttgtattt attctatttt tagacataat ttattagcat gcatgagcaa attaagaaaa 61561 acaacaacaa atgaatgcat atatatgtat atgtatgtgt gtatatatac acatatatat 61621 atatattttt tttcttttct taccagaagg ttttaatcca aataaggaga agatatgctt 61681 agaactgagg tagagttttc atccattctg tcctgtaagt attttgcata ttctggagac 61741 gcaggaagag atccatctac atatcccaaa gctgaattat ggtagacaaa gctcttccac 61801 ttttagtgca tcaatttctt atttgtgtaa taagaaaatt gggaaaacga tcttcaatat 61861 gcttaccaag ctgtgattcc aaatattacg taaatacact tgcaaaggag gatgttttta 61921 gtagcaattt gtactgatgg tatggggcca agagatatat cttagaggga gggctgaggg 61981 tttgaagtcc aactcctaag ccagtgccag aagagccaag gacaggtacg gctgtcatca 62041 cttagacctc accctgtgga gccacaccct agggttggcc aatctactcc caggagcagg 62101 gagggcagga gccagggctg ggcataaaag tcagggcaga gccatctatt gcttacattt 62161 gcttctgaca caactgtgtt cactagcaac ctcaaacaga caccatggtg cacctgactc 62221 ctgaggagaa gtctgccgtt actgccctgt ggggcaaggt gaacgtggat gaagttggtg 62281 gtgaggccct gggcaggttg gtatcaaggt tacaagacag gtttaaggag accaatagaa 62341 actgggcatg tggagacaga gaagactctt gggtttctga taggcactga ctctctctgc 62401 ctattggtct attttcccac ccttaggctg ctggtggtct acccttggac ccagaggttc 62461 tttgagtcct ttggggatct gtccactcct gatgctgtta tgggcaaccc taaggtgaag 62521 gctcatggca agaaagtgct cggtgccttt agtgatggcc tggctcacct ggacaacctc 62581 aagggcacct ttgccacact gagtgagctg cactgtgaca agctgcacgt ggatcctgag 62641 aacttcaggg tgagtctatg ggacccttga tgttttcttt ccccttcttt tctatggtta 62701 agttcatgtc ataggaaggg gagaagtaac agggtacagt ttagaatggg aaacagacga 62761 atgattgcat cagtgtggaa gtctcaggat cgttttagtt tcttttattt gctgttcata 62821 acaattgttt tcttttgttt aattcttgct ttcttttttt ttcttctccg caatttttac 62881 tattatactt aatgccttaa cattgtgtat aacaaaagga aatatctctg agatacatta 62941 agtaacttaa aaaaaaactt tacacagtct gcctagtaca ttactatttg gaatatatgt 63001 gtgcttattt gcatattcat aatctcccta ctttattttc ttttattttt aattgataca 63061 taatcattat acatatttat gggttaaagt gtaatgtttt aatatgtgta cacatattga 63121 ccaaatcagg gtaattttgc atttgtaatt ttaaaaaatg ctttcttctt ttaatatact 63181 tttttgttta tcttatttct aatactttcc ctaatctctt tctttcaggg caataatgat 63241 acaatgtatc atgcctcttt gcaccattct aaagaataac agtgataatt tctgggttaa 63301 ggcaatagca atatttctgc atataaatat ttctgcatat aaattgtaac tgatgtaaga 63361 ggtttcatat tgctaatagc agctacaatc cagctaccat tctgctttta ttttatggtt 63421 gggataaggc tggattattc tgagtccaag ctaggccctt ttgctaatca tgttcatacc 63481 tcttatcttc ctcccacagc tcctgggcaa cgtgctggtc tgtgtgctgg cccatcactt 63541 tggcaaagaa ttcaccccac cagtgcaggc tgcctatcag aaagtggtgg ctggtgtggc 63601 taatgccctg gcccacaagt atcactaagc tcgctttctt gctgtccaat ttctattaaa 63661 ggttcctttg ttccctaagt ccaactacta aactggggga tattatgaag ggccttgagc 63721 atctggattc tgcctaataa aaaacattta ttttcattgc aatgatgtat ttaaattatt 63781 tctgaatatt ttactaaaaa gggaatgtgg gaggtcagtg catttaaaac ataaagaaat 63841 gaagagctag ttcaaacctt gggaaaatac actatatctt aaactccatg aaagaaggtg 63901 aggctgcaaa cagctaatgc acattggcaa cagccctgat gcctatgcct tattcatccc 63961 tcagaaaagg attcaagtag aggcttgatt tggaggttaa agttttgcta tgctgtattt 64021 tacattactt attgttttag ctgtcctcat gaatgtcttt tcactaccca tttgcttatc 64081 ctgcatctct cagccttgac tccactcagt tctcttgctt agagatacca cctttcccct 64141 gaagtgttcc ttccatgttt tacggcgaga tggtttctcc tcgcctggcc actcagcctt 64201 agttgtctct gttgtcttat agaggtctac ttgaagaagg aaaaacaggg ggcatggttt 64261 gactgtcctg tgagcccttc ttccctgcct cccccactca cagtgacccg gaatctgcag 64321 tgctagtctc ccggaactat cactctttca cagtctgctt tggaaggact gggcttagta 64381 tgaaaagtta ggactgagaa gaatttgaaa gggggctttt tgtagcttga tattcactac 64441 tgtcttatta ccctatcata ggcccacccc aaatggaagt cccattcttc ctcaggatgt 64501 ttaagattag cattcaggaa gagatcagag gtctgctggc tcccttatca tgtcccttat 64561 ggtgcttctg gctctgcagt tattagcata gtgttaccat caaccacctt aacttcattt 64621 ttcttattca atacctaggt aggtagatgc tagattctgg aaataaaata tgagtctcaa 64681 gtggtccttg tcctctctcc cagtcaaatt ctgaatctag ttggcaagat tctgaaatca 64741 aggcatataa tcagtaataa gtgatgatag aagggtatat agaagaattt tattatatga 64801 gagggtgaaa cctaaaatga aatgaaatca gacccttgtc ttacaccata aacaaaaata 64861 aatttgaatg ggttaaagaa ttaaactaag acctaaaacc ataaaaattt ttaaagaaat 64921 caaaagaaga aaattctaat attcatgttg cagccgtttt ttgaatttga tatgagaagc 64981 aaaggcaaca aaaggaaaaa taaagaagtg aggctacatc aaactaaaaa atttccacac 65041 aaaaaagaaa acaatgaaca aatgaaaggt gaaccatgaa atggcatatt tgcaaaccaa 65101 atatttctta aatattttgg ttaatatcca aaatatataa gaaacacaga tgattcaata 65161 acaaacaaaa aattaaaaat aggaaaataa aaaaattaaa aagaagaaaa tcctgccatt 65221 tatgcgagaa ttgatgaacc tggaggatgt aaaactaaga aaaataagcc tgacacaaaa 65281 agacaaatac tacacaacct tgctcatatg tgaaacataa aaaagtcact ctcatggaaa 65341 cagacagtag aggtatggtt tccaggggtt gggggtggga gaatcaggaa actattactc 65401 aaagggtata aaatttcagt tatgtgggat gaataaattc tagatatcta atgtacagca 65461 tcgtgactgt agttaattgt actgtaagta tatttaaaat ttgcaaagag agtagatttt 65521 tttgtttttt tagatggagt tttgctcttg ttgtccaggc tggagtgcaa tggcaagatc 65581 ttggctcact gcaacctccg cctcctgggt tcaagcaaat ctcctgcctc agcctcccga 65641 gtagctggga ttacaggcat gcgacaccat gcccagctaa ttttgtattt ttagtagaga 65701 cggggtttct ccatgttggt caggctgatc cgcctcctcg gccaccaaag ggctgggatt 65761 acaggcgtga ccaccgggcc tggccgagag tagatcttaa aagcatttac cacaagaaaa 65821 aggtaactat gtgagataat gggtatgtta attagcttga ttgtggtaat catttcacaa 65881 ggtatacata tattaaaaca tcatgttgta caccttaaat atatacaatt tttatttgtg 65941 aatgatacct caataaagtt gaagaataat aaaaaagaat agacatcaca tgaattaaaa 66001 aactaaaaaa taaaaaaatg catcttgatg attagaattg cattcttgat ttttcagata 66061 caaatatcca tttgactgtt tactcttttc caaaacaata caataaattt tagcacttta 66121 tcttcatttt ccccttccca atctataatt ttatatatat atattttaga tattttgtat 66181 agttttactc cctagatttt ctagtgttat tattaaatag tgaagaaatg tttacactta 66241 tgtacaaaat gttttgcatg cttttcttca tttctaacat tctctctaag tttattctat 66301 tttttcctga ttatccttaa tattatctct ttctgctgga aatatattgt tacttttggt 66361 ttatctaaaa atggcttcat tttcttcatt ctaaaatcat gttaaattaa taccactcat 66421 gtgtaagtaa gatagtggaa taaatagaaa tccaaaaact aaatctcaca aaatataata 66481 atgtgatata taaaaatata gcttttaaat ttagcttgga aataaaaaac aaacagtaat 66541 tgaacaacta tactttttga aaagagtaaa gtgaaatgct taactgcata taccacaatc 66601 gattacacaa ttaggtgtga aggtaaaatt cagtcacgaa aaaactagaa taaaaatatg 66661 ggaagacatg tatataatct tagagataac agtgttattt aattatcaac ccaaagtaga 66721 aactatcaag ggagaaataa attcagtcaa caataaaagc atttaagaag ttattctagg 66781 ctgggagcgg tggctcacac ctgcaattgc agcactttgg gaggcctaga caggcggatc 66841 acgacgtcag gagttcaaga tcagcctggc caacatagtg aaacctcatc gctactaaaa 66901 atataaaaac ttagcctggc gtggtggcag gcatgtgtaa tcccagcaat ttgggaggct 66961 gaggcaggag aatcgcttga tcctgggagg cagaggttgc agtgagccaa gattgtgcca 67021 ctgcattcca gcccaggtga cagcatgaga ctccgtcaca aaaaaaaaag aaaaaaaagg 67081 gggggggggg cggtggagcc aagatgaccg aataggaaca gctccagtct atagctccca 67141 tcgtgagtga cgcagaagac gggtgatttc tgcatttcca actgaggtac caggttcatc 67201 tcacagggaa gtgccaggca gtgggtgcag gacagtagtg cagtgcactg tgcatgagcc 67261 gaagcagggc gaggcatcac ctcacccggg aagcacaagg ggtcagggaa ttccctttcc 67321 tagtcaaaga aaagggtgac agatggcacc tggaaaatcg ggtcactccc gccctaatac 67381 tgcgctcttc caacaagctt aacaaatggc acaccaggag attatatccc atgcctggct 67441 cagagggtcc tacgcccatg gagcctcgct cattgctagc acagcagtct gaggtcaaac 67501 tgcaaggtgg cagtgaggct gggggagggg tgcccaccat tgtccaggct tgagcaggta 67561 aacaaagccg cctggaagct cgaactgggt ggagcccacc acagctcaag gaggcctgcc 67621 tgcctctgta ggctccacct ctaggggcag ggcacagaca aacaaaagac aacaagaacc 67681 tctgcagact taaatgtccc tgtctgacag ctttgaagag agtagtggtt ctcccagcac 67741 atagcttcag atctgagaac aggcagactg cctcctcaag tgggtccctg acccccgagt 67801 agcctaactg ggaggcatcc cccagtaggg cggactgaca cctcacatgg ctggtactcc 67861 tctaagacaa aacttccaga ggaatgatca ggcagcagca tttgcggttc accaatatcc 67921 actgttctgc agccaccgct gctgataccc aggaaaacag catctggagt ggacctccag 67981 taaactccaa cagacctgca gctgagggtc ctgactgtta gaaggaaaac taacaaacag 68041 aaaggacatc cacaccaaaa acccatctgt acatcaccat catcaaagac caaaggtaga 68101 taaaaccata aagatgggga aaaagcagag cagaaaaact ggacactcta aaaatgagag 68161 tgcctctcct tctccaaagt aacgcagctc ctcaccagca atggaacaaa gctgggcaga 68221 gaatgacttt gacgagttga gagaggaagg cttcagaaga tcaaactact ccaagctaaa 68281 ggaggaagtt cgaacaaacg gcaaagaagt aaaaaacttt gaaaaaaaat tagatgaatg 68341 gataactaga ataaccaatg cacagaagtc cttaaaggac ctgatggagc tgaaaaccaa 68401 ggcaggagaa ctacgtgaca aatacacaag cctcagtaac cgatgagatc aactggaaga 68461 aagggtatca atgacggaag atgaaatgaa tgaaatgaag catgaagaga agtttagaga 68521 aaaaagaata aaaagaaacg aacaaagcct ccaagaaata tgggactatg tgaaaagacc 68581 aaatctacat ctaattggtg tagctgaaag tgatggggag aatggaacca agttggaaaa 68641 cactctgcag gatattatcc aggagaactt ccccaatcta gcaaggcagc ccaaattcac 68701 attcaggaaa tacagagaac gccacaaaga tactcctaga gaaaagcaac tccaagacac 68761 ataactgaca gattcaccaa agttgaaatg aaggaaaaaa tgttaagggc agccagagag 68821 aaaggtcggg ttacccacaa agggaagccc atcagactaa cagctgatct atcggcagaa 68881 actctacaag ccagaagaaa gtgggggcca atattcaaca ttgttaaaga aaagaatttt 68941 cggcccagaa tttcatatcc agccaaacta agcttcataa gcattggaga aataaaatcc 69001 tttacagaca agcaaatgct gagagatttt gtcaccacca ggcctgccct acaagagctc 69061 ctgaaggaag cactaaacat ggaaaggaac aactagtatc agccactgca aaaacatgcc 69121 aaattgtaaa cgaccatcaa ggctaggaag aaactgcatc aaggagcaaa ataaccagct 69181 aacatcataa tgacaggatc aaattcatac ataacaatac tcaccttaaa tgtaaatagg 69241 ctaaatgctc caattaaaag acacagactg gcaaattgga taaggagtca agacccatct 69301 gtcgttatgt attcaggaaa cccatctcac gtgcagagac acacataggc tcgaaataaa 69361 aggatggagg aatatctacc aagcaaatgg aaaacaaaaa aaggcagggg ttgcaatcct 69421 agtctctgat aaaacagatt ttaaaccaac aaagatcaaa agagacaaag aaggccatta 69481 cataatggca aagggatcta ttcaagaaga agaactaact atactaaata tatatgcacc 69541 caatacagga gcacccagat tcataaaaca agtcctgagt gacctacaaa gagacttaga 69601 tgcccacaca ataataatgg gagactttaa caccccactg tcaacattag acagatcaac 69661 gagacagaaa gttaacaagg atatccagga attggactca gctctgcacc aagcagacct 69721 aatagacatc tacagaactc tccaccccaa atcaacagaa tatacattct tttcagcacc 69781 acaccacacc tattccaaaa ctgaccacat agttggaagt aaagctctcc tcagcaaatg 69841 taaaagaaca gaaactataa caaactgtct ctcagaccac agtgcaatca aactagaact 69901 caggattaag aaactcactc aaaaccactc agctacatgg aaactgaaca gcctgctcct 69961 gaatgactac tgggtacata acaaaatgaa ggcagaaata aagatgttct ttgaaacaac 70021 gagaacaaag acacaacaca ccagaatctc tgagacacat tcaaagcagt gtgtagaggg 70081 aaatttatag cactaaatgc ccacaaggga aagcaggaaa gatctaaaat tgacacccta 70141 acatcacaat taaaaaacta gagaagcagg agcaaacaca ttcaaaagct aacagaagac 70201 aagaaataac taagatcaga gcagaagtga agaagataga gacacaaaaa acccttcaaa 70261 aaaatcaatg aatccagaag ctgttttttt gaaaagatca acaaaattga tagactgcta 70321 gcaagactaa taaagaagaa aggggagaag aatcaaatag acgcaataaa aaatgacacg 70381 gggtatcacc actgatccca cagaaataca aactaccgtc agagaatact ataaacacct 70441 ctacgcaaat aaactagaaa atctagaaga aatggataaa ttcctcgaca catacactct 70501 gccaagacta aaccaggaag aagttgtatc tctgaataga ccaataacag gctctgaaat 70561 tgaggcaata attaatagct tatcaaccaa aaaaagtccg ggaccagtag gattcatagc 70621 cgaattctac cagaggtaca aggaggagct ggtaccattc cttctgaaac tattccaatc 70681 aatagaaaaa gagggaatcc tccctaactc attttatgag gccagcatca tcctgatacc 70741 aaagcctgac agagacacaa caaaaaaaga gaatgttaca ccaatatcct tgatgaacat 70801 cgatgcaaaa atcctcaata aaatactggc aaactgaatc cagcagcaca tcaaaaagct 70861 tatcctccat gatcaagtgg gcttcatccc tgccatgcaa ggctggttca acatacgaaa 70921 tcaataaaca taatccagca tataaacaga accaaagaca caaaccatat gattatctca 70981 atagatgcag aaaaggcctt tgacaaaatt caacaatgct tcatgctaaa aactctcaat 71041 aaattaggta ttgatgggac atatctcaaa ataataagag ctatctatga caaacccaca 71101 gccaatatca tactgagtgg acaaaaactg gaagcattcc ctttgaaaac tggcacaagg 71161 cagggatgcc ctctctcacc actcctattc aacatagtgt tggaagttct ggccagggca 71221 atcaggcagg agaaggaaat aaagggcatt caattaggaa aagaggaagg tgaaattgtc 71281 cctgtttgca gatgacatga ttgtatatct agaaaacccc attgtctcag cccaaaatct 71341 ccttaagctg ataagcaact tcagcaaagt ctcaggatat aaaatcagtg tgcaaaaatc 71401 acaagtattc ctatgcacca ataacagaca aacagagagc caaatcatga gtgaactccc 71461 attcacaatt gcttcaaaga gaataaaata cctaggaatc caacttacaa gggatgtgaa 71521 ggacctcttc aaggagaact acaaaccact gctcaatgaa ataaaagagg atacaaacaa 71581 atggaagaac attccatgct tatgggtagg aagaatcata tcgtgaaaat ggtcatactg 71641 cccaaggtaa tttatagatt caatgccatc cccatcaagc taccaatgac tttcttcaca 71701 gaactggaaa aaactacttt aaagttcata tggaatcaaa aaagagccca catcaccaag 71761 gcaatcctaa gccaaaagaa caaagctgga ggcatcacgc tacctgactt caaactatac 71821 tacaatgcta cggtaaccaa aacagcatgg tactggtacc aaaacagaga tctagaccaa 71881 tggaacagaa cagagccctc agaaataatg ccgcatatct acaactatcc gatctttgac 71941 aaacctgaga gaaacaagca atggggaaag gattccctat ttaataaatg gtgctgggaa 72001 aactggctag ccatatgtag aaagctgaaa ctggatcctt ccttacacct tatacaaaaa 72061 ttaattcaag atggattaaa gacttaaaca ttagacctaa aaccataaaa accctagaaa 72121 aaaacctagg caataccatt caggacatag gcatgggcaa ggacttcatg tctaaaacac 72181 caaaacgaat ggcaacaaaa gacaaaatgg acaaacggga tctaattaaa ctaaagagct 72241 tctgcacagc taaagaaact accatcagag tgaacaggca acctacaaaa tgggagaaaa 72301 tttttgcaat ctactcatct gacaaagggc taatatccag aatctacaat gaactcaaac 72361 aaatttacaa gaaaaaacaa acaaccccat caaaaagtgg gcaaaggata tgaacagaca 72421 cttctcaaaa gaagacattt atgtaatcaa aaaacacatg aaaaaatgct catcatcact 72481 agccatcaga gaaatgcaaa tcaaaaccac aatgagatac catctcacac cagttagaat 72541 ggcgatcatt aaaaagtcag gaaacaacag gtgctggaga ggatgtggag aaacaggaac 72601 aacttttaca ctgttggtgg gactgtaaac tagttcaacc attgcggaag tcagtgtggc 72661 aattcctcag gaatctagaa ctagaaatac catttgaccc agccatccca ttactgggta 72721 gatacccaaa ggattataaa tcatgctgct ataaagacac atgcacacgt atgtttattg 72781 cagcactatt cacaatagca aagacttgga accaacccaa atgtccaaca acgatagatt 72841 ggattaagaa aatgtggcac atatacacca tggaatacta tgcagccata aaaaatgatg 72901 agttcatgtc ctttgtaggg acatggatga agctggaaac tatcattctc agcaaactat 72961 cacaaggaca ataaaccaaa caccgcatgt tctcactcat aggtgggaat tgaacaatga 73021 gaacacatgg acacatgaag aggaacatca cactctgggg actgttatgg ggtggggggc 73081 aggggcaggg atagcactag gagatatacc taatgctaaa tgacgagtta atgggtgcag 73141 cacaccaaca tggcacatgt atacatatat aacaaacctg ccgttgtgca catgtaccct 73201 aaaacttgaa gtataataat aaaaaaaagt tatcctatta aaactgatct cacacatccg 73261 tagagccatt atcaagtctt tctctttgaa acagacagaa atttagtgtt ttctcagtca 73321 gttaac //