LOCUS HUMTPA 36594 bp ds-DNA PRI 14-JAN-1995 DEFINITION Human tissue plasminogen activator (t-PA) gene, complete cds. ACCESSION K03021 KEYWORDS Alu repeat; KpnI repetitive sequence; repeat region; tissue plasminogen activator. SOURCE Human fetal liver, DNA library of T.Maniatis, multiple clones. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 36594) AUTHORS Degen,S.J., Rajput,B. and Reich,E. TITLE The human tissue plasminogen activator gene JOURNAL J. Biol. Chem. 261 (15), 6972-6985 (1986) MEDLINE 86196143 REFERENCE 2 (sites) AUTHORS Thomas,W. and Drayna,D. TITLE A polymorphic dinucleotide repeat in intron 1 of the human tissue plasminogen activator gene JOURNAL Hum. Mol. Genet. 1 (2), 138 (1992) MEDLINE 93244777 COMMENT Sequence and draft entry of [1] kindly submitted by S.J. Friezner Degen, 08-APR-1986. There are two genes for plasminogen activators in the haploid human genome: the tissue plasminogen activator gene (t-PA) on chromosome 8, and the urokinase-type plasminogen activator gene (u-PA) on chromosome 10. The t-PA gene spans 14 exons. [1] notes a partial KpnI repeat and 28 complete or partial Alu repeats (see FEATURES table), a long (ry)*n run (7170-7225), and a 'tgataga' tandem repeat region (23888-24458). [1] also notes a number of potential regulatory signals. NCBI gi: 339817 FEATURES Location/Qualifiers source 1..36594 /organism="Homo sapiens" repeat_region 740..1033 /note="Alu repeat" repeat_region 1684..2113 /note="KpnI repeat" prim_transcript 3531..36250 /note="t-PA mRNA" intron 3713..17969 /note="t-PA mRNA intron 1" repeat_region complement(5669..5958) /note="Alu repeat" repeat_region complement(6319..6462) /note="half Alu repeat" repeat_region complement(6471..6744) /note="Alu repeat" repeat_region complement(7212..7510) /note="Alu repeat" repeat_region 8864..9176 /note="Alu repeat" repeat_region 10067..10365 /note="Alu repeat" repeat_region complement(10502..10801) /note="Alu repeat" repeat_region complement(10802..10937) /note="half Alu repeat" repeat_region complement(11745..11868) /note="half Alu repeat" repeat_region complement(12704..12985) /note="Alu repeat" repeat_region complement(13027..13142) /note="half Alu repeat" repeat_region 16794..17125 /note="Alu repeat" repeat_region 17170..17466 /note="Alu repeat" sig_peptide join(17996..18067,19767..19790) /note="tissue plasminogen activator signal peptide" /codon_start=1 sig_peptide 17996..18067 /codon_start=1 exon <17996..18067 /gene="PLAT" /map="8p12-q11.2" /note="tissue plasminogen activator prepropeptide, (first expressed exon); G00-119-496" /number=2 CDS join(17996..18067,19767..19809,22105..22242,23160..23270, 23603..23777,26008..26099,28291..28462,29470..29555, 30806..31001,31113..31249,31425..31565,32428..32594, 35337..35495) /note="tissue plasminogen activator prepropeptide; NCBI gi: 339818" /codon_start=1 /translation="MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDE KTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALY FSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKP YSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFG NGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKP WCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRR SPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKY IVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYG KHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDA CQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP" intron 18068..19766 /note="t-PA cds intron 2" repeat_region complement(18628..18796) /note="half Alu repeat" repeat_region 18879..19178 /note="Alu repeat" exon 19767..19809 /number=3 sig_peptide 19767..19790 /codon_start=1 mat_peptide join(19791..19809,22105..22242,23160..23270,23603..23777, 26008..26099,28291..28462,29470..29555,30806..31001, 31113..31249,31425..31565,32428..32594,35337..35492) /note="tissue plasminogen activator" /codon_start=1 mat_peptide 19791..19809 /codon_start=1 intron 19810..22104 /note="t-PA cds intron 3" repeat_region 20946..21259 /note="Alu repeat" repeat_region 21280..21578 /note="Alu repeat" repeat_region complement(21640..21938) /note="Alu repeat" mat_peptide 22105..22242 /codon_start=1 exon 22105..22242 /number=4 intron 22243..23159 /note="t-PA cds intron 4" repeat_region 22253..22545 /note="Alu repeat" mat_peptide 23160..23270 /codon_start=1 exon 23160..23270 /number=5 intron 23271..23602 /note="t-PA cds intron 5" mat_peptide 23603..23777 /codon_start=1 exon 23603..23777 /number=6 intron 23778..26007 /note="t-PA cds intron 6" repeat_region 25620..25911 /note="Alu repeat" mat_peptide 26008..26099 /codon_start=1 exon 26008..26099 /number=7 intron 26100..28290 /note="t-PA cds intron 7" repeat_region 26524..26821 /note="Alu repeat" repeat_region 26941..27239 /note="Alu repeat" repeat_region 27880..28145 /note="Alu repeat" mat_peptide 28291..28462 /codon_start=1 exon 28291..28462 intron 28463..29469 /note="t-PA cds intron 8" repeat_region 28804..29100 /note="Alu repeat" repeat_region 29297..29431 /note="half Alu repeat" mat_peptide 29470..29555 /codon_start=1 exon 29470..29555 /number=9 intron 29556..30805 /note="t-PA cds intron 9" mat_peptide 30806..31001 /codon_start=1 exon 30806..31001 /number=10 intron 31002..31112 /note="t-PA cds intron 10" mat_peptide 31113..31249 /codon_start=1 exon 31113..31249 /number=11 intron 31250..31424 /note="t-PA cds intron 11" mat_peptide 31425..31565 /codon_start=1 exon 31425..31565 /number=12 intron 31566..32427 /note="t-PA cds intron 12" mat_peptide 32428..32594 /codon_start=1 exon 32428..32594 /number=13 intron 32595..35336 /note="t-PA cds intron 13" repeat_region 32921..33220 /note="Alu repeat" repeat_region 34234..34525 /note="Alu repeat" exon 35337..>35495 /note="tissue plasminogen activator prepropeptide" /number=14 mat_peptide 35337..35492 /codon_start=1 BASE COUNT 9621 a 8696 c 9145 g 9132 t ORIGIN 25 bp upstream of NcoI site; chromosome 8p12. 1 ttcacacaac tggtgctgtt accaccatgg gcgtctagtc tggatcagtg gtcctcagtc 61 ttttttgcac cagggaccag ttttgtaaag atagcttttc cacggacaga gggaggggag 121 atagtttcgg gatgattcaa gaggattaca tttattgtgc actttattta tattactatt 181 acattgtatt atataatgaa ataatggtat gactcagcat aatgtagaat cagtgggaac 241 cctgagcttg ttttcttata actagatggt cccatctggg ggttatggga gacagcgaca 301 gatcatcagg cattagattc ttataaggag tgcacaacct caatccctcg catgtacagt 361 tcacaatggg gtttgcactc ctatgagaat ctagtgccac tgctgatcca accggaggtg 421 cagctcaggc agtaatgcga gtgatgggga gcggctgtaa acacagatga agcttcactg 481 gctctccagc cactcacctc ctgctgcgca gcctggttcc taacaggcca cggacagata 541 ccagcccatg gccccagggc cggggattcc cagtctagat ggagacctag acaaggcgtg 601 cgacaataac accgatttta gatccatcat gacatttacc ccatcccctg caaagccaga 661 tggctaccaa aattaaatct tagtttagac acagaatgtc cgtcttctgg tccaaaacat 721 ccttgtcata agtttcttgg ctgggcgcgg tggctcacac ctataatccc agcactttgg 781 gaggctgagg caggtggatc acgaggtcgg gggtttgaga ccagcctgac caacatggtg 841 aaaccccgtc tctactaaaa tacaaaaaat tagctgggcg tggtggcggg cacctgtaat 901 ctcagctact caggaggctg aggcaggaga attgcttgaa cctggtggag gttgcagtga 961 gccgagatca caccactgca ctctagcctg ggcgacagag caagactctg tctcaaaaaa 1021 aaaaaaaaga aaataaaaaa aaaaaaacaa gtttcttgcc cactcttcct ttctctgagt 1081 ttccagagac atcacatcat ttcttaccca gctgagcaga gtcccagcat ggctctcgtt 1141 cgaataccca tcctgccacc tgccccagtg agaagggttg gagcagcccc tgttctctgc 1201 ccccgccacc tccatgactc atgcattctg tgggggaggc gcccactgca gaaacagcca 1261 ggctggctgg gaaaagccct gcagcaattc cccgtccagt ttctctgtgc ccactttgtc 1321 tccgtgttat ctaggcctgg atttatttct cttttttgaa aatgaagggc tttgatgaaa 1381 tgttcacagg atgtgaggtc accaagattt ttttcctttt tttctgttct tttcttttcc 1441 tcgaagtgat cccttgacta aaatcaaggc tcccattgtc accttatcag cctgcccatg 1501 cctaattctg cactctcagg cttccccaga atctgtccga gggaaaccaa tctcaattca 1561 gaaggaacac agaggcccca gtttctaggg ctgcaggata ttgctgggtc ttaatcattc 1621 gggtatattt cagcaaagct cagggcccct gctaatgatc tgcaaaccct ctcctctcag 1681 tctcccgttg tttagcccct atttataagt gagtgcatgt ggttgttcac tttctgtttc 1741 tgagttattt cagttaggat aatggtctcc agtttcatcc atgttgctcc aaaagacaga 1801 cttcattgtt ttttacggct ttgtcgtatt cctcggtgta tatgtgcatt ttctttatcc 1861 agtcctccat tgatggacac ttaggttaat tctgtgcctt tgctattgtg aattgtgctg 1921 ttgtgaattg tgtgtgataa acgtgtgagt gcaggtgtct ttttgatgta atgatttctt 1981 tttctttgaa tagatactca gtagtgggat tgccgggtca aatggatgtt ctatttttag 2041 tttgggaaat ctccatattg ttttccatag aggttcagga tccaggattt aagtgcaacc 2101 attcagtgga aaaccatcct ctcaagagtt caaatgagag tcctcatgac cagcactccc 2161 tgctgaacgg caatgcccca ccccccaaaa aagcctccat cctcaccatc ttagaccaca 2221 ttgcaggaaa gcagccccat gcccaccaga caggcccaca gctgctgctg ctcatgggag 2281 gtctacctcc cgtgctcagc aggcaaccca ccccagtgcc ccttttctac aatgaccatc 2341 agcagggctg cagcttcata aaaatgtgaa aaacagtttg aaagcaatgt gaaaagcagt 2401 taggtgcctt tcaacttcaa actcagcact catggtttga caaatatgag tatatttagg 2461 atcagaatgt atgaaatctg gcctctcctg aatagtcggt catcccacaa tttcctctgc 2521 caagcttctc ttccctccct gcgttctttc tttcacctct ctctcatttt tacaaggtct 2581 ggtctcagcc agacatgaac caatgatgat agatgctcct gctgagccct gtgatgtgcc 2641 agggccctga catgcgtggc ttctctctga tcctcacgtg acctgcagat gcaaaagcca 2701 gagctcagca tagttgaaaa tcttgattga ggtcatatcc cagttactgg cacagccgga 2761 tttaaaccta agactttccc ctacacgaca gggcttttat ttctcagtca tctgaaaagg 2821 tgtcagcaag ggaaatggct tgtctatttc caggggcatt ttacaagcaa atactgaaag 2881 gcttcggtgg gcttaagggc tgatggcttt gatcgaattt caggcatgtt ggccccaagg 2941 ccctgtgtat attccctggg cccactcaag gggatgctgg agccggaaag ttcccggagg 3001 ccacctactg cagccctgca ctttacaaag aagagaaaga ttctccctaa aattacagaa 3061 cagggccaaa gatgcctacc ggagcaaacc cccatggggg cacctcctac cgcaggtgag 3121 cccaaggctg gtcctgcctt ctcagtggct acccccctga gctcccgcac cacacaaagt 3181 gttccaatcc ttgtgcatcc tccagtccct ttaacctctc atgtcctgag aggccagagc 3241 tacagccaca gattccagaa gacaccccac tcccagcccc aacctgctgc ctttagaatt 3301 ataaacactt cttgtcatca cagggtcctg aaagtccctt ttaagcctgg gacactagga 3361 ctctaaagga agatgattct taaggtccca tcccacttcc aaattcctgc gattcaatga 3421 catcacggct gtgaataatc agcctggccc gaagccagga tgggctgtgc tgcttccacc 3481 gtgaacttcc tccccctgct ttataaaaac aggcctgcct cagctccctc atggccctgt 3541 ccactgagca tcctcccgcc acacagaaac ccgcccagcc ggggccaccg accccacccc 3601 ctgcctggaa acttaaggag gccggagctg tggggagctc agagctgaga tcctacagga 3661 gtccagggct ggagagaaaa cctctgcgag gaaagggaag gagcaagccg tggtaggtcg 3721 ggtttctgta ccttggggtc tgtctcctct tctttctctt aaaagtcttt ccagcaagct 3781 gagccagtga aggaatgctt taaccaaggg accaactttg taattcaggc aactagagga 3841 tccgctagaa tccactccag aggggagatg tctgtttgca tttgcatgtg attgggatag 3901 gctggagtgt tttggagggg agaggcagtc ggggaaaggg agactaggga ggttgcattc 3961 attggagaag cctctgctga cagagtaaag gggaaagtga aaagaacgat acagaaaagc 4021 cccaaatagc ctatgggagt acctcaagac gagcaagcaa taaaagcaaa atcggctgcc 4081 ttgggacacg tgcctgtgac agctgggagg gcccgctggg tcccctagtt tcctccctcc 4141 cccgatgaac ccccagaaag gaactgaggc tgtggatggg gcagaggggg acttacttcc 4201 agagcactat ttgctaggtg ctgggagaga gaagcaggtg gctttcacac cccacattac 4261 cccgtgggat agagaaatgc ctctgatctc cctaggtgcc acccctacaa gtctccacag 4321 gtcagtttgg ccctctggct ttttgcccag ggtgcatcag tcaagtgtgc agtcctcctt 4381 aaaggacatt ttaattacag gggaaaaaac tgacattaat gtcttttatt cctaaagcac 4441 tctgcaggaa gcatgtgggg ttctccagat tttcactgtt attatcttta ttttcttaac 4501 ctcacaggga gggagagagg aagggaggga gggaagacga aaacacgccg aggtcccagg 4561 taactaatga caactcaagc tcaaagaagt gtggtaacaa ggatgtgttt ggtggccaat 4621 tgggaataat atggtggtct cctgtagctg cttgatgaca gaaaaaatgt cgtgtgtgtg 4681 tgtatgcgtg tgcattgcag tcccgggaag gggtcttgca aataccattg tcaggtggag 4741 tcccctcaaa ggtgacttcc tagcagtact tgctgtggca agaacgctca ttctgggatc 4801 tagactcaat ccatgacggt cagcatgagc tgctgggtgc gtgcttcctg tgcaggcaga 4861 gtcagactcc agcactggca gggacactgt gagtattgag atatgaatag ctccatcctg 4921 cccacccatt tattccacct aaaatgttct caaagatgca agcctccaag ctctggatca 4981 aatgataaag ccccagatca aaatctcagg agcaaatgaa agctgccctt gtctccaaaa 5041 tgctccttct ctgcccgact ccccaagacc agcttggttt atttcacaat gactcgcgtc 5101 ggattctccc agtgtctgcg gctcccctgc ttcatcacag gcctgggaca gtccaggcag 5161 ccagggaata gctgggaata gcagttcccc tttgttggtt tttgagttca ctgaggcttt 5221 gatttccccc agggcctgac gttgctgagc agagccagcg gccagtagat ttcaaaggat 5281 tccaaaaaac agtcaggcac tcctttgtga acccaaaagt atctgagaca ggtctgtcaa 5341 tttagaaagt ttattttgcc aatgttaaga acacacatgt gacacggcct ctggagatcc 5401 tgaggacata tgtccaaggt ggccaaggta tggcttggtt tcatacattt cagggagaca 5461 tgagacatta atcaatgtat gtaagatgtg caccggttcg gtctggaaag gcaggacaac 5521 tcgaagtagg ggcttccagg tcataggtag ataagagaag gcttcattct tctgagtctt 5581 tgtcagcctt tcactgaata cacaatttac atatgagagg ggggcagagg aagagtcact 5641 tatgccttag ttggctcagt gaatctactt ttttttttga gacggagttt cactcttttt 5701 gcccaggcta gagtgcaatg gcatgatccc ggctactgca acctccacct cccaggttca 5761 agtgattctc ctgcctcagc cttctgagta actgggatta caggcgcctg ccaccacacc 5821 tggttaattt ttgtattttt agtagagaca gggtttcacc atgttggcca gactggtctt 5881 gaactcgtga cctcaggtga tccacccacc tcggcccccc gaagtgctgg gattacaggc 5941 atgagccaac atgcctggcc tgaatcttca tttttacaaa aacaataggg cagaggaagc 6001 aatcagatat gcgtttgtct caggtgagca gagggatgac tttgagttct gtcctttgtc 6061 ctgtacccat ttgcattgcc aaggtgaagt tcagcagaac tgttttaggg taaagatctt 6121 gaagtccaca aggagtttcc ttgtgggtaa attgtgagag aggtatgtag ccttttatct 6181 ttgtagccgt cttatgtagg aataaaatgg gaggcaggtt tgcctcatgc agttcccagc 6241 ttggcttttc cctttggctt agtgatttgg gggtcttgag atttattttc ctttcatacc 6301 ttggtagtgt cacttgaagc caccacgccc ggctaatttt tatattttta gtagagacag 6361 ggtttcacca tgttgatcag gctggtctcg aactcctgac ctcgtgatct gccctcctcc 6421 tccaaagtgc tgggattaca ggcatgagcc accatgcccg gccaattttt cttttctttt 6481 tttttttttt aagatggagt ctcgcttttt cacaggctgg ggtgcagtgg cacaatcttg 6541 gctcactgca acctccacct cccaggttca agcgattttc ctgcctcagc ctcccaaata 6601 gcttggatta caggcgcccg ccaccacacc cagctaagtt ttcaccatgt tggccaggct 6661 ggtcttgaac acctgacctc aagtgatctg cccgccttgg cctcgcaaag tattgggatt 6721 acaggcgtga gccaccatgc ccagacaggt ttttctttga ttatttggca ttatgcacct 6781 gcagtctcag aataaatttt ttactttctc tgagtgattt tcgcttctgc tttgatgaga 6841 ttgttgggac ggacaataag ggaccagtgc attctgctca ttccttcttg gggccatttc 6901 ttttgtatat acgggagaaa atgtctgtct atagtgtcag gctataaacc tcgtcctagt 6961 caagcagctc acaaaaccat atggtgggtc tcacatcaaa ccaggtaaaa gagtgaggat 7021 gatttagact caaagaaaat tagagctaga aataaattta aagctcatcc accctgctcc 7081 aaccctaagt caagccacat ggtcttccga tagtggctca gttttctact tacataaaaa 7141 gacagcacat tctcttagca atatgtgttt gtatgtgtgt gtgtgtgtgt gtgtgtgtgt 7201 gtatatatat atatatatat atataattta gagacaaggt ctgactccat cacccaggct 7261 ggagtgcagc agtgtgatcg taggtcactg aaccttcaaa ctcctgggct caagtgatcc 7321 tccatctcag cctcccaagt agctaggact acaggggcat gctgccatat ccagctaatt 7381 ataaaatttt tttgtagaag cagagttttg ctttgttgcc caggctagtc tcaaactcct 7441 ggcctcaagc aaccctcttg ccatggcctc acaaaatgct gggattacag gcaagagcca 7501 ctgtgcccag tccctcttag tgatattttg catattatat attcaaaaaa tattttctat 7561 gtatgccact tgggaaactt ctgtagaatg ggatagaggg acagataaac ccaattcttg 7621 atccactcaa aaataacacc tgtgacagag tgaagatgaa acaggtgctg ggcacacagc 7681 aagtgtttta gaaacatttt tgaactcaac tttgcctgag ttgtggtgct gatcatggct 7741 gccaggaaat gctagccagc tgttcttcct atacaagtat atgactgggt gtctgcagca 7801 gctgcccggc tgtgaattgc acacaccaat ggccaagacc cagcagcgac ttggctaaca 7861 ggcccagccg atgtgcatgg gtgaccacgc gatgctcctg acacacgcac tggtggctta 7921 gggaagtttt tttgaggatt gatcagaaga tctgattcca cctggagcct ctgaagtgat 7981 cacttccagg ttaggctgaa cccagatacc aggagacctg tgtattgaga gccttttgtt 8041 ttttttatgt agtcacaact attccattaa catacagcta ggcattagag aatccatgct 8101 ggactcctac aaaggcccct agatccttag aacactcaga gattccaaag cacacgtcct 8161 cccaggacac cctggcagaa gagcccgggg gcgactgtca cctttgcctg ctgtcgggag 8221 ctgtgctgat gggtaggggg ctctgtgctt gctgtggccc agagccaagc cgtggggatg 8281 tgctctgtct ggagcagacc ccttcactgt ctgcctaact ccttcgtgtg ttcccggaac 8341 agcttctgtg ttatgcattc cagaaagcct gcctgaccac cccaacctca acaagcctgg 8401 gatggacaac ctcctccaca ttccactcca agcccacccc cgtccccacc ctgctgcgtg 8461 gtatggcgct gctctgctgt accctgagtg tctagttatt catcaggccc cttcctaact 8521 atgagctctt tcaggataag agctgtgtct ttgcatcacc agagcctgtg ccagggcacg 8581 gctggtgctc catacacgtt gatggtgaat atatagcatg ggtagatcat tgtctgtgaa 8641 tgcttaacag agaagcagct catgtgggtg cttgagggct gggggggcag ggtgggggtc 8701 tggtaggcgc tgggaggagg acatccctgc agcttctcca gccccataga tgggactctt 8761 gatgtgggca gtttttattt cagctgagtc tccagaaggc aggggacagg gactgggagg 8821 ggatgctaaa cccgataacc cagtatggat gagctaacag aggccgggca cacagctcct 8881 gcctgtaatc ccagcacttt gggagcccga ggtgggcggg ttgcttgagc caaggagttt 8941 gaaaccagcc cgggtcttga acatagcgaa gactctgtct ctacaaaaaa atgaaaaaaa 9001 aaaaaaaatt agccagacat ggtggcacgc acctgtagtc ccagctactt gagaagctga 9061 ggtgagagga tcacttgagc cagggaggtt gaaactgcag tgagctgtga tcacgccact 9121 gcactccagt ctgggtgact gggcgagacc ctgtctcaaa acaaataaat aagaaagaga 9181 gactactggt caacttgatt tctgctggtt attctctttc tgtcatgttc accaaaaaga 9241 gaaacccgtt gtattttatc ttgttgtagc aagagccggt gtctaacacc tgggctactg 9301 agagaaagcg aagggttttt ttctgggaag ctccaatttc cttatttctc tcacatgatg 9361 cctctgactt tcatagtgtg gcttggtcag atgggcctta tcaatagaga tggcctgatg 9421 tctcagctgt gtcatctcag ctgctagttc tggcttctgc tgggagtcca cagtggcctc 9481 tgcatgcatg gtgtgggaaa ggcaaataaa aaagcagatt aaaaaccaga ttaaagacat 9541 caccctgtat tcaggaaata atggctcctg ttgatactgt tctacgaaca cagatgaagg 9601 cacaaaattc tacatcaatt gcagagaatt ggttataggc taacacaggt ggtcggatga 9661 tctaggaagc aggattcagt attaacgggg atccatgagg accccatgaa gcgtggcatc 9721 tcttctgcat cagcagcttc aagttgttcc agggagaagc gggaagcctc agtgcttttg 9781 ttgaggaagg atgttcatga cagtaggtgc aggtcgctcc tgccgtgcac ctaggtgtgg 9841 gggaagaact ttcctgcttc ttttccagtt accttacaat tcagcaagac ggaaatgatt 9901 agcccatgac aaaaactagg aaacaggctc agagagagtg agttgcccac acagaatgtg 9961 tgctgtaaat gcagttagat ttccaggttg agaatccagt gaccacgccc cttctttgtg 10021 gcattctgct gtcgtatacc atgtggaaca cattaagaac gttatggcca ggcgtgttgg 10081 ctcacgcctg taatcctagc actttgggag gccaaggtgg acagatcacc tgaggttggg 10141 agttcgagac cagcctggcc agcatgccga aaccctgtct ctactaaaaa tacaaaaatt 10201 agccaggcat ggtggcacac acttgtaatc cgagctactc gggaggctga agaaggagaa 10261 tcgcttaaac ccaggaggcg gaggttgcag tgagctgaga ttgcaccgtt gcaatccagc 10321 ctgggcaaca gagtgaaact ccatctcaga aaaaaaaaaa aagttacaat tgggtgtcac 10381 atagacagtg aggagtagtg gaaagagtgt tagatttggg gtaagagaac tgtgtctcct 10441 gggcttgagt cctgatgcca actctcacaa gatgtgtcac cgtacagcac gacgcttata 10501 cttttttttt tttttttttt gagacaggat cttgctctgt ctcgagctgg agtgcagtgg 10561 tatgatcaca gctcactgca gcctcaaact cccaggctca ggccatcctc ccacctcagc 10621 ctcccaagta gctgggacta caggcatgta ccaccatgcc caaataattt tttgtatttt 10681 tttgttgaga tggggttttg ccatgttacc cagggaggtc tcaaactcca aggatcaagc 10741 cacccaccct ccttggcctc ccaaagtgtt gggattacag atgtgagcca ccacaccttg 10801 caaatttttg tattttttgt acagccgagg gtctccctat gttgccgagg gtgatcttga 10861 actcctgggc tcaaatgatt caccctcctc agcctcccaa agtgttggga ttacagacgt 10921 gagccaccgc tctcagcccc ttacactttt tgaagttcag ttctcccatc tgtaaaaacg 10981 aggtaataat attgcctcaa atgacttaat ggatgtgaaa gggtttagta aactctgtgc 11041 ctggaaaggt agaagctact caaatatctg ttgagtgagt ggcattcatc catgtgtaca 11101 tttctcaggc aacaataatg tcactttcac ctaaggccag taaaatgtgg gtaaagtcat 11161 ataatgatac aatgaaagtt tctgatcagt atttcctaat tcaagtgtgt tgaaatgtgg 11221 agttgggctg gagaattgtc aaatcattgc gtatttaatt accttgtggt gatgtttgct 11281 ttagggagtg gaaggaacat gaggaacgaa cgaccttcat cacggaagat gacattcatt 11341 tcgattcact ttagatttca gggcttgttt agatgcagac tttgcagtta acattttatt 11401 gcactgactg atttagtttt caccaggtgg tccttgtgtt tgcttcagaa ggatctaagt 11461 gtattaggac agggtttctt ctgttttgat tgtgggagga ggcgggatag acttctgttt 11521 tcctagaccc acaaccaaaa ttccccactc ctccaaataa ccgggattac caggcagagg 11581 gtggagcatt gaggagatga cagctggaca tgcctgctgt agctttttct gagtttaatt 11641 ccatatagct tagacacagg ccatatgcct acatttggaa gatgttttgg agaaaattct 11701 gctctgatgg gtggggggca gggtctgcca ggaaaatatt ctattctttt gaagacatgg 11761 ggtcttgcta tgttgcctag gctggtcttg aactcctcgc ctcaagtgat gctcctgcct 11821 cagcctcctg agtagctagg actacaggtg caaaccacca cacccagctc tgagaggatg 11881 ctatactctt cacttcattg gaattggtga aaattagata agaaacagac tcttcctctc 11941 ttctccccag ttataaacag ttctgttaag agagggaaaa taaccattta gcctatagaa 12001 aatcaccttt tcgaaaagtt aagaattact tatgtgatgg tagtttttga aagtggtttt 12061 tattctgaga tcatggcctc tgtactatgc agggcctaga gaagtgggat gagagctacc 12121 aggctcaaag ctcctgttcc gaacaaaggg ttgctttcgt gggagcacgt caccctttcc 12181 aaggctagtt cctctcccag catctcactt cagctctcgt cctgctctag aaacgtgcct 12241 ttgctggtcc aaggaatcct ggccgtttct tttcttaatt gttggcattc atctgggcta 12301 tggtggttgt ggcgggggtg gcagtggaga gtgtgttgtt ttaaatccat gagtcatttt 12361 agggtattgg tactcttgaa gactgacttt ctcttgctca ggttttcaga gagacctttt 12421 gctaagcaac aataacctaa gaatctcctt gaccaaagat aaatgtagca aactttgcac 12481 atggtgcaac atttgataat agtatcaatt tacgtttgtc tttcccttgc aatttccctc 12541 ctcctctagc ttgctcacgt ttctgccttc ttcttgctgg caagagtaca gactataatt 12601 ctccagttca ctaacatctg gagcgactgc actgtttgca atttcattga ttgactacat 12661 gtgtacagtt cctttattgc aagtcacttt tctgtataat cttttttgag acgaagtcct 12721 gctctgtcgc ccaggctgca gtagcgcaat cttggctcac tgcaacttcc gcctcccggg 12781 ttcaagcgat tctcctgcct cagcctcctg agtagctggg attataggcg cccgccacca 12841 tgcccagcta atttttttgt atttttagta gagatggggt ttcactatgt tggccaggct 12901 tgttttgaac tcctgacctc aagagatctg ccagccttgg cctcccaaag tgctgggatt 12961 acaggtgtga actactgtgc ctggccatat aatctatttt taaaatgttt ttatatgaaa 13021 ataaacagag acagagtctc actgtgttgc ccaggctgat ctcgaactct tgggttcaag 13081 tgatcctccc accctggcct cccaaagtgc tggggttaca ggcgtgaacc acctcatgtg 13141 gcctcgcttt cctatataat ttaaacaata gaactatagt gccatttgta gagtttccca 13201 gtttatactg catgtagcac tccccatagt cgtatgttct cacagcagaa cggaaaccgc 13261 aggatgtcag caccggaggc gaccttggag catccagccc acttggtttt gcattgctgg 13321 caggagattt tatgcctcaa aatatagatg ctttttggaa ggacagcaca ttaattattt 13381 ttcagtcatt tttaccttat gcgaacaagc tgattagttc ctttcctagg agctggtttt 13441 tatggaggga agatggggcc ggtagaggca gatagagggg gatgtaatac acaggcactg 13501 agacagcacc ccactgactt tcccctgtcc ctcctccagc tggcctcctc ctttccaggg 13561 gctgtaccca atccagaatc agttactcac tggtgcccat cgaccatcat ttccccatgt 13621 ggccaccaaa gaaatgaaca ccacctttct ggttggcatg atcatcaatt tctcagccaa 13681 aacggcatgc atccttggct ctgggaaaca gtacatctcc caggaaagtg agcttacagc 13741 acggtacccc acttcctggt taccagacta ttgttcccgt tttccccaag aacagtcatc 13801 attcacaggt tgtttggcag ggcccaggaa cagagtcact ctggttgcta cagccaacag 13861 accaaacacg gcttccaggc aggaaggtca gagctgctct gcaggatgca catgcaggtt 13921 ggaagcagac agggctggcc gagcacagat atgctggctg tgtcctacac acaggtgcct 13981 acacacacat ccttcagatc cgggctgcac tctatcagcc aacccacgga ctctgttttt 14041 tctaatttgc acagattctt tgtcaacctg ccatgccctg agactgctga acttcatcca 14101 acagagaggg taccttttgc aaatctgcaa aaatcaactt tgtgtgctag ggtggcctgc 14161 agggctaggc cttggggtct tggggaccag cattccacct ctcctctcat acagtgattc 14221 tggattccag cccagcaaaa gtcagccaac cttggggcct tcctttcttt catcctttct 14281 tttttttcct tttctatcct tctgtgcctc ccttcctacc cccttccttc cttcttctca 14341 tttgcctttt tttttttcag ttctttgatg atcctgagaa gctactaaat atagcaaaag 14401 ggagataaca cagaacaaaa ttagaagtct atttataaaa atgagcctct tccatccctt 14461 ccgccaatgt catctctcac ccgggctcgc cagagcactc atggacctcc ctttggtgag 14521 gcccaaagtc catcccagcc acgccctgcg gtcccgagtc tgagtccatt gttctggctt 14581 tcactctgct ctgcatcccg tcactggccc cagacctcga cgcccacctc ttcagcgaag 14641 gcgaaacaag gactcatttt tcctccctct cttcgctctt tcttgttttc agactgcact 14701 gtttttctgc tggccggatg actcatttct ttgtcatctc ttaccccact tggccttttc 14761 agctgctcga atcgcctctg tgtgatgcgg acagagctat cgccctgctg gggtgagatt 14821 cacttgcatt gaatcagctc aaggcgcagg aaggtccagg gaagccaagg aagagaagag 14881 ccaagtctcc aactctctca ggagcaaaga caaaaatacg ctcccgctct cctatctctt 14941 attcagaccg ttcagttgca aaagggctcg aacatcgatg cagcgggtgg tatgtgtgga 15001 ccagccctag gtcgtgcttc tcctccatct ggtcccccac ccctagttat ccagaaaggg 15061 ggatgttccc aggcaatgcc aacatgtcca tactgcactc ttcacattgc agtttcccgg 15121 catctgggat tgcattcctt ttggaaggac tttgagttct tgaaataaag aagtaacttg 15181 gtgggcatct ggaaaaaaca cccaaactgt atcccaggct ggggtgcagg agcctatcga 15241 gagggctggg tggtgtggac agcgtgatga agaaggtcaa gttccttgta ctcactcgtt 15301 tgctgtttca ttcacaattc ctgtgaggtg ggagctctca ccatccttgg gtcttgctta 15361 agagtaagga gtggggcaac ctagagatac atgaacatca aggagaaatg gggagggagt 15421 ttcacatgag ctatttttac aagattaagt aatgggataa aatttaaaag gggaatttaa 15481 gaggaatttt gggcagtttt gagaaacagg aaatttgagg aaagctgaga aagagaagat 15541 ctggagtaag tctctgtgat gagaagattc caccccgcac tcctgttctg ggtggccttg 15601 gctcctggct ccctttcttc tgaaactgcc tggagccagg gagtagcaca gctgcttcct 15661 cccggggaga aagggacacc caaagagcgc actccaggga gaccttgggc actgcgggct 15721 caaaggctgg agatggcact tctgttccct cctgatggga caggtgcagg gaggctgaga 15781 ggatgccacg ctggcgagcc tccctctgag ctgtgttttc tcattggaat tgctgtaccc 15841 ggagcctcct gcaggtttcc ctcgccctct ccctaagctc ctctgcctga cacaggagcc 15901 cgggagaatc tgtcaggcat gaaatgtagc gaggcaagga gggtgatcag cacctcccac 15961 gggggagttc gtttcgaagt aacaatcaaa gatccagagc cggacccagg cagggaggca 16021 aggtctggaa gcccctgtgc ctccaagccc ctaggacgct cgggggaggg ggagggggag 16081 ggtgggacct gaagttgttg tgaccgaagg gaaatgagtc agggaaagaa atgccatgct 16141 ttaatttttg tggatgaagg agggaacagg ccgccagacc acaaaataac acccggccga 16201 ctaacctact tttagctgcc gagggcagga tcacagagga gaggcagatg gaaactgggg 16261 ctctggggtc caggaagatc tgagtcttcc gaccaaacat catttgcctc ccctccttcc 16321 tgcaaatatg cacattgccg gatctgctgc agtctatgaa aaaggagaca gatgttctgg 16381 cagagcggtg ggggggtggg cgtggaggtt gggttggggg gcctctgctt tgtggggaga 16441 acctcaggca ggggagtagg ctccatcctg cgtggaggaa cctgagcagt ctaaggcagg 16501 ctggctctat gatgtgctgg caataaaatc ccaatgcttc cgctgcagaa gtccaagagg 16561 acatgactgc ggctccatct agtcaagccc agggcaggaa ttcccttcca ggaaaccaag 16621 ccagagcgct gtggtctctg ggctgccaag atgtctcaga caatggtcta gcccttcagc 16681 ccacagaaat ctctgggcaa aattatctcc cagcattgac agacgaatgg ataaacaaaa 16741 tgtgttctat cccacagtgg agtattattc agctttaaaa aggaaggaaa aatgctgggc 16801 gcggtggctc acaccttgat cccagcactt ttgggaggct gaggaaggag gatcatttgt 16861 gcccaggagt tcgagactag cctggacaac atagagaaac cttgtctcta cacacacaca 16921 cacacacaca cacacacaca ctctctctct ctctctctct cagccaggca cagtggcaca 16981 tgcctgaagt cccagctctg ggaagctgag gcaggaggat ctcttgagcc tggtgggtca 17041 aggctgcagt gaaccatgtt catgccactg cactccagtc tggatgacag agcgagacct 17101 agtctcaaaa aaaaaaaaaa aaaaaaaaaa aagaaagaag aaagaagaaa ggaaaaagaa 17161 aaaaaggcag cggggcgtgg tggctcacgc ctgtaatccc accactttgg gaggccaagg 17221 cgagcggatc acgaggtcag gagatcgaga ccatcctggc taacacggtg aaaccccgtc 17281 tctactaaaa atacaaaaat tagccgggcg tggtggcagg cgcctgtagt cccagctact 17341 caggaggctg agacatgaga atggcatgaa cccgggaggc ggagctgtag tgagccgaga 17401 tcacaccact gcactccagc ctgggcgaca gagcgagact ccatcttaaa agaaaaaaaa 17461 aaaaggacat gctacagcat ggatgcacct tgaagacatt tgcaaagtga aacaaaccag 17521 tcgcaaaaga agaaacactg tctgattcca cttctaggat gtatgtagag cagtcaggtt 17581 catacagaca gaaagtagca agcgtggttg ctgagggaaa aggagaatgg gagttattct 17641 ttaatagtta cagagtttca gttaggggtg atggagaagt tctggagatg ggcggtggtg 17701 acggtcggtc gcacagcgat atgacgtgct taatgccact gaactgtgca ctgaacatcg 17761 ttaaggtggt aaattttgtg ttatgtatat tttgcaacaa taaaaaatat gtagtttcta 17821 gaatcctctt ctagatgcat gtctggcgtt tctgccgcgg ggctggcact ggaggaagcc 17881 agacaggaca acattgcggc ttatcctcct ctgttgccat catggacctc tcgcaccccg 17941 tgatcaagct gttttttctc tccttccaga atttaaggga cgctgtgaag caatcatgga 18001 tgcaatgaag agagggctct gctgtgtgct gctgctgtgt ggagcagtct tcgtttcgcc 18061 cagccaggtt ggtgtgcagg atccctgtgt cccgcccctc aaggctgtga tgcttccgga 18121 ggctccaggg gtctgtgtcc atctgggcca cggaggttgg aatgctgtca gggagcagag 18181 aggcacaggg acgaggggct ggcattgctg tggagcacac agcacacact cccttctgta 18241 cagcaaactc tgtatttggg ggcccagtgt gtagctgggc cctaggcact tattttgacc 18301 tgagtaagcg gaattaacat gccactccct gcctgtgact gccttttttt gcagctgttt 18361 ttaaagaatg tattcaaatt aatccataaa gtacagttgt ccctcatatc tatggggtat 18421 ttgttccagg acccccaagg ataccaaaat ccagggatac tcaagttcct catatagaat 18481 ggtgtagagt ttgcatatcc tatgcacacc ctcctgtata ctttaaatca tctctaaatt 18541 acttataata cctagtacaa tgttaatgct atgtaaatgg ttgttataag gtatttttta 18601 atttgtgtta tttttattgt tgtattattt atttatatat tttttggaaa cagggtctca 18661 ctctgtcacc caggctggag tgcaatggca caatcatagc tcactgcagc accaaactcc 18721 taggcttaag ccttggcctc ccaaaactct ggggttacag gtgtgagcca caagcccagc 18781 ttatattatt attttttatt tttctgtttt ggttgaatcc acagatatgg aacctgcaga 18841 tatacaaagt ggactgtatt tataaaagac aatgcaggac agggcacagt gactcacacc 18901 tgtaatctca gcactttggg aggccgaggt gggaggatcg cttgagccca ggagttggag 18961 accagtctgg gcaatatagt gagatgctgt ctctacaaaa aatttaaaaa ttagccgggt 19021 gtactagtat gcacctgtgg tcccagctac tcaggaggct gaggcgggag gatcgcttaa 19081 gttcaggagg ttgggacttc agtgagatat gattacgcca atgcactcca gcctgggtga 19141 caaactgaga tcctgtctca aaaaaaaaaa aaaaaaaaga aaaaggcaat gcaagtgcca 19201 tgagccacag cagaggcaaa ctgccctcat ggtgcctact ctctagctga gatggaagcg 19261 ctacacacac tctctgaaaa tgcctagcaa taaagggcct cacggaagtc caaactaacc 19321 acacctctcc aacaggaccc tacagcgggg agagccaggt gactgcgtgg agtagacagc 19381 cagctgcaac tccattgccc aatatggtgg tcacttacct tgtgcaactg tttaaattta 19441 aaataattaa agttaaaaat tgtttctcag tcccactggc cacattcaaa gcactcggtg 19501 gccctgtgtg gcttctgtcg tggacagcac agacagaaaa catttccacc aagcagaaag 19561 ctcttctgga cagagccagt caggaaggag aggaagaatt ggactagaag gcaggagatg 19621 gactttcact tgggccagtt acccgagggg gtctctgagc agaggtatct ggccggcagg 19681 ttcacatggg cttctgggtt ggccgccttt actcttagta cacctggcat gtgctgatcc 19741 ttcctccacc tctggtttct tcgcaggaaa tccatgcccg attcagaaga ggagccagat 19801 cttaccaagg tcgggtgaag ctgaggggtg catggggtca tcagggaggg aggcagggcg 19861 gggtgcaggg tgcatcaccc acccaccacc tgccttcttc cacccaccac ctgcctacgg 19921 tgtgacagtg ccattgcagc atggttctac agagatgcct gtgtcggcac cattctccca 19981 tcagctgcgg ccactgggcg ggttctgatt ctgaggggag cagaaacagg tgtttccccc 20041 ccaaggggcc aggctgtcag ggatcacaac ctagcggggc tgggggggcg tcactggtcc 20101 aaggttctag ttatacagat caaaggcaga gcccaggaga gagcaagtgg cttgcccagg 20161 gtcacacagc cgccagcagc acggccaggg cagtcacagc cgaggccagg cccatgctct 20221 gggtctcatc ctaggctgtg atcccaccac agtgcaccgg cagctttggt aacaacatcc 20281 ctgtgtatcc atttccctct gttgatccaa ccgggatgtc ccaactggga tgtcccaccc 20341 aggcaacccc tcgacatggt ggggtctcta agtccacatc tagagttgac tctagaaggc 20401 tgaggaatgc gaggcccagc ttcaggtcca aaactaccaa cttaggccct cgatttccct 20461 ccttcacgac ccagttcctt cgagtctgga agactctgca ataccctttg tgaaggtgtt 20521 aaaaagggtg actcactccc cagagcgagt cacacctgga ctcttaatgc cttcgttgtt 20581 ggatggcatc ctgcttccta ccaggttatc ctggcctcag tgacctcaga agcagcaagg 20641 gtctgactta cagtgggcac gtgctacttc tttaattaat tgaaagtaaa gttgttgttt 20701 ttaagttggc attctggctt gaaaacagaa agatggcatg aaaatattaa tgggagtact 20761 tcaactattt tcattatgcc aaaaatactt ggagaagtag cacattttct gcaaagtcta 20821 aaatgtcaat tttctttggg gccaaaaatg catcatttct gtgtggtaat acttatgtgg 20881 ataaaaaact ctggtagaca gttatgcata tatatatttt ttggtgaatt acaatgagaa 20941 aaagtccagg tgcaatggct cacatctgta actccagcac tttaggaggc ggatccagga 21001 ggatggcttt agcctaggag ttcaagacca gcatgggcaa catagtgaga cacctctgcc 21061 tcccccaccc caccccgcct ctacaaaaaa atttaaaaat tagctgggtg tggtggtgtg 21121 cacctgtagt cccagctact tgggaggttg acgcaggagg actgcttgag cctgggaggc 21181 agaggttgca gtgagccaag acagcaccat tggactccag cctgggtaac agagaccctc 21241 gaaaaaaaaa aagaaaaaga aaagaaaaga aaaaattagg ctgggcacgg tggctcatgc 21301 ctgtaacccc agcactttgg gagaccgagg tgggtggatc acttgagtca ggagttcgag 21361 accagcctgt tcaatatggt gaaaccccgt ctctaccaaa aatacaaaaa ttagccgggc 21421 atggtatcgg gcacctgtaa tcccagctac tcgggaggct gaggcaggag aatcacttga 21481 acccaggagg tggaggttgc agtgagccga gattgtgcca cttcactcca gcctgggcga 21541 cagagtgaga ctttgtttca aaaataataa taataaataa ataataaata aataaatcat 21601 atgagaagat actcaatggc actcagaaaa gaaatgcaaa tttattttat tttattttga 21661 gatggagtct tgctctgtcg cccaggctgg agtgcagtgg tacaatctcg gctcactgca 21721 acccccactt cctgggttca agcaatactc ctgcctcagc ctcctgagta gctgggatta 21781 caggcacctg ccaccatgcc tggctcattt ttgtattttt agtagagata gggtttcacc 21841 atgttggcca ggctggtctc gaactcctga gctcaagtga ttcacccacc tcggccaccc 21901 aaagtgctgg gattaccagc atcagtcacc gtgtttggcc agtattcatt atcttgttgt 21961 cttccagttg tgtctcttca ataagggagt atgcaatgga gtctatagaa agcaagtgag 22021 ggagttttct cagtaggtgc aagggtagtg aggcatttca ttttgagtca tactctgatg 22081 aggctggcct gtcttttctc atagtgatct gcagagatga aaaaacgcag atgatatacc 22141 agcaacatca gtcatggctg cgccctgtgc tcagaagcaa ccgggtggaa tattgctggt 22201 gcaacagtgg cagggcacag tgccactcag tgcctgtcaa aagtatgtgc tgaggctgga 22261 aggtggtgca tgcctgtgat cccagcactt taggaggcca aggtgggagg gtcgctggag 22321 cccgggagtt caagaccaat ctgggcaaac atagcaagtc ccctgtctct acaaaaaata 22381 aaaaaattag ccagacctgg tatgtagtcc caactacttg ggaggttgag gcagaaggat 22441 cacttgagcc caggagttgg aggctgcagt aatctacgat tatgccactg catttcaacc 22501 tcagtgacag ggcaagccct cacctctaaa acaaaacaaa acaacacaaa caaaaacaaa 22561 aacacagaaa agcccagtac aaatcgactt caaactgaga cttcgagttc aggggtccag 22621 tcatgaaccc tgtctttcat ggtccccgga aagttcaaat cttcaaaagg agcctccagg 22681 cctgttcggc cttaggcgga ggtgaaggta caagcagaaa agggagcaag accaagtgac 22741 cttgggcaaa tgcccgcttg cctcagtttc ctcatctgta aagaggtggg aataacagta 22801 cacacttcat ggtttgctgt gaggattaaa ttagctaatt tttgtagact gtacaacagc 22861 gcctggcaca tagagcacat tcttaatatt ttaactcaca tcatccttgg agctgctttg 22921 aaaatacagg ggacccttga acaacacttg tctgacctgc agggttcact tatgtatgga 22981 tttttttcaa ccaaaggcag gatgaaaaca gtatttgtag gatgcagaac tggtatacac 23041 gtgttccacg ctgcaggact tgagtgtgtg tggattgtgg tagacagggc tcctggaacc 23101 atggcctgag cacacagaag gaggctgtca ttaggggctt ccttttttat acttgacagg 23161 ttgcagcgag ccaaggtgtt tcaacggggg cacctgccag caggccctgt acttctcaga 23221 tttcgtgtgc cagtgccccg aaggatttgc tgggaagtgc tgtgaaatag gtgagtaggt 23281 gagagcacgt gaaacgagct gaaatcccac ctctccagtc tcccccgccc ccggaaggaa 23341 aggcagggtg cgatggcagg gccaggggtg ggggccaggg acagggaagg cgcttctgcc 23401 atgggtcagg aagcacagtg ccacacagca agcagagccc aggtgtgacc ctgaatccag 23461 gctggcaccc ttgccaccca gcctgtggct ccgagccagc ctgcatcagg cccgggggag 23521 gacggggcag agaggggagc ctcctgaggg ctgaatgaaa ggggactccc atgtgaggca 23581 tccatgccct gctctctgtc agataccagg gccacgtgct acgaggacca gggcatcagc 23641 tacaggggca cgtggagcac agcggagagt ggcgccgagt gcaccaactg gaacagcagc 23701 gcgttggccc agaagcccta cagcgggcgg aggccagatg ccatcaggct gggcctgggg 23761 aaccacaact actgcaggtg agggcacatc cccaaggagg gattccccct gtgagaagct 23821 gctacagctg gggaaagatt ctgtcagatc cgtcagggtt ctcccaagaa acataaccaa 23881 tacaggatgg atagatggat agatgataga cagataatag atgataggtg atagatgata 23941 gattgataga tgatagatga taggtgatag attagataaa tagatgatac atacatgata 24001 gatagatgat aaatagacgg tagatggatg acagatagac agatgatagg tgatagatag 24061 atgatagatt gatagatgat tgatagataa atagatgata gatacataga tgatagatgg 24121 tagatagatg atagatggat agatgataga tagatgatag gtggtagatg atagacagat 24181 gattagaaag atagatgata gatacataga tgatagacac atagatgata gacagattga 24241 cagatgatag atgattgata gatgattaaa tagatgatac atagatgata gataatgata 24301 aatagatgat agatgataga tgataggtga tagatagatt gatagatgat agaagattga 24361 tagatgatag atacataggt gatagtagat gtaagatgat agatgataga tagatagatg 24421 atagacagat tgatagatga tagagagata gagatagaga aagaggagag agaaatagag 24481 agagagagag aatgtgtgtg aacccaaagt atctgagaca ggtctcaatc gatttagaaa 24541 gttgattttg ccaaggttaa ggacaccccc gtgacacagc ctcaggaggt cctgaggaca 24601 tgtgcccaag gttgtcaggg cacagcttgc ctttagacgt tttagggagt catgagacat 24661 caatcaacat gtgtgagatg tacatcggtt tggtcgggaa agttgggata actcgaagca 24721 agggcttcca ggccataggt agataagaga caaaaggctg tattctgagt ccttgatcag 24781 cttttcactg aacacacaat tgagtctggc tcagttcatc tgcattttta cataaaaaat 24841 agggcagagg aagcaatcag atacgcattt gtctcagatg agcagaggga tgattttctg 24901 tcctgcacct gggaagataa gctatccatt tacaatgcca aggtgaaagt caacagaact 24961 gttttagggt aaagatcttt aggcctgcaa ggaatgtcct tgtagagaat taaaaaaaaa 25021 aaaaaaaact ttgcagctat cttattgagg aataaatgag aggcaggttt gcctgacgta 25081 gttcccggct tgacatttcc cttggctcat gacgttgggg tcctgagatt tattttcctt 25141 tcacactaga tagatagaca tttatgttaa ggaactggct gacaggatcg tgggggctgg 25201 caagtctgaa acatcttggt aagccaggct ggaagtgcag gcagaagctg aggctgctct 25261 cttaaggcag aatttcttat tcaggaaacc tcatatttgc tcttaaggcc tttaagtgat 25321 tggacgaggc ccaactacat tatctaggac aatttccttt tctaaagtca actggctgta 25381 gatattaacc acatctataa aacactttca caactcctag atgaatgttt ggttaactga 25441 ctgggtgcca cagcctggcc aagttgacat ataagactat tccagtccac accttgtcaa 25501 tttggcaccc atgtgcatct ccttaaacca tccttcacct ccaagtaaac acaggaacaa 25561 aatcatactc ctgcctaaca tgatagaact accagtgtac aaccaaaaac gcactcccgg 25621 ctgggcgtgg tggctcacgc gtaatcccag cactttggga agccaaggca ggtggatcac 25681 ctgaggtcag gagttcaaga ccagcctggc caacatggtg aaaccctgtc tctactaaaa 25741 atacaaaaat tagccaggca tggtggcagg cacctgtaat cccagctact cgggaagctg 25801 aggctgaaga attgcccaaa tccaggaaac ggaggttgca gtgagaggag atgcgccgct 25861 gcactccagc ctgggataaa cagcgagact ctgtcaaaaa aaaaagcacc ccccattcct 25921 ccagaaaagg ataccaaagt ccttgggtcc taaaggagag gcttcacctt tgacctaccc 25981 tggcccttcc cttggctgat ttttcagaaa cccagatcga gactcaaagc cctggtgcta 26041 cgtctttaag gcggggaagt acagctcaga gttctgcagc acccctgcct gctctgaggg 26101 taagtggcag ccaccccgcc tttccctgaa tgtccctggg ggaggaaagt ccaggaggac 26161 aggccgatag ccctcctgca cctgagggga gaaaggggga ggccaggagt gagtcatttt 26221 ggttgcagag ggaagaaaga caggacttag gtctgcgcct gggctcggcc tctgactggc 26281 tatttgtctg acctggagct gatctcctca cactctgacc ctcaatttcc tcctctatgg 26341 aggagaggat ggggctgaat cagtggtttt cagtcctttt gagaatgaat ggagattctc 26401 ccttttttga ttaatgggtg aatggggctt tgtctctctt tcgctccctc tcaaactttt 26461 taatgcaaaa aaaaaaaaaa aaaaaacttc caagattgaa aaaatatata ttaagttaca 26521 agaccaggca cagtggctta tgcctataaa cccagcactc tgggaggctg aggcgggcgg 26581 ctcacctgag gtcaggagtt tgagaccagc ctggccaaca tggcgaaacc ctgtctctac 26641 taaaaataca aaaattagcc ggatacggtg gcaggcacct gtaatcccag ctactcagga 26701 ggctgaggca ggagaattgc ttgaacctgg gagatggagg ttgcagtgag ccgagatcat 26761 gccactgcac tccagcctgg gtgatagaac aaaaaactgt ttcaaaaaaa agaaaaaaat 26821 gaaatgctaa gttacagaaa ggtactatga attcagtggt gcttatacaa atcattacgt 26881 tacttatcac atttatcaca gcactatgaa agattttttt taagttctaa atatatatag 26941 ggccaggtgc agtggctcgt gtctataatc ccagcacttt gggaggctga ggcgggagaa 27001 ctgcttgagc ccaggagttt gagaccagcc tgggcaacaa agtgagactc catctctaca 27061 aaaaatacaa aaattagtca ggtgtggtgg cttgtgccta tggtcccagc tgcttgggag 27121 gctcaggtgg gaggatcgct tgagcccagg aggttgaggc cacagtgagc aatgattgtg 27181 ccactgcact ccagcctggg tgacagtgag atcctgcctc aaaataaata cataaatatg 27241 tgtgtgggtg tgtgtatata tatatgtaat acacatatat taaatttata tatgatatat 27301 ataaacacgc accagctata tgcattcagc acccaggtcc acgggtgatg cctgtgactc 27361 tgaagacttt acagtcactc tacaatatcc tccccatccc ccatggtctg gtctaaatga 27421 ggactcgcag atctagataa tcttgaaaat cccttccatt tatggtattt atgtatagag 27481 gtatgctttg tcagtttcag gtcgggagaa aaaaatggaa aaatggggga aataaatgaa 27541 aacaggcagc actccacggc tcataccctc ctccttccca agcccatcat cagatcctca 27601 ggacactggc agacacagtc cgagaaataa cccccacccc agccccactg aagcacgttg 27661 gttcactgca gcctgttaag taacacaagg aaacccctac tggctttcaa agcagcttca 27721 gaaacagccc ccactcatgg aagtggttct tcctgctgaa cctgaagatg tccccagact 27781 ctctctcaac atagcaatct agggagccac ttccggtgga gatgaaaccc ccctgccatc 27841 tctaagtaaa aggactcaaa gagggggaaa aaggctcagg ccgggcgtgt tggctcacac 27901 ctgtactccc agcactttgg gaggctgagg cgggcagatc acctgatgtt aggagttcaa 27961 gaccagcctg gccaacatgg tgaaaccctg tctcaactaa aaatacaaaa ttagcgtagc 28021 atggtggcgc atgcctgtaa ccccacctac tcgggaggct gaggtagaag aatcgcttga 28081 acccaggagg tggagattgc agtgagccaa gatcgcgcat tgcactccag cctgggcaac 28141 aaaaggggaa gtgtgaggtg ttacactctt ctcagtgccg ggctagcggc ctccagcttc 28201 ctcgaccggc agctccgctt caagccccag ccctgacttg cgtgcttcag aatttgtttt 28261 tgtttcagtt tgagaattct tttcttctag gaaacagtga ctgctacttt gggaatgggt 28321 cagcctaccg tggcacgcac agcctcaccg agtcgggtgc ctcctgcctc ccgtggaatt 28381 ccatgatcct gataggcaag gtttacacag cacagaaccc cagtgcccag gcactgggcc 28441 tgggcaaaca taattactgc cggtaggtag cacaggggtg gggggttcag gtcttggcag 28501 aacgtgggat tagggtgtga gacgggggaa gatccaatgt ctcaagttgc atgacagacc 28561 cagtgcgtgg gaagcaccca tggatattat ctaatccaac ctcttcactt gctagaataa 28621 cacatattgt gaaaagcaag gtctaccagt tttccaacct aaatcccaag ttaagggtcc 28681 tggcctgtaa ccatttagtc ctcagctgtt ctcctgacat ctttattgca atgatttgta 28741 agagttccgt aacaggacag ctcacagttc tgtctgacaa ccctatgaga ttagaacact 28801 acggccgggc gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg 28861 gatcacgagg tcaggagatc gagaccatcc cggctaaaac ggtgaaaccc cgtctctact 28921 aaaactacaa aaaatagccg ggcgtagtgg cgggcgcctg tagtcctggc tacttgggag 28981 gctgaggcag gagaatggca tgaacccggg aggcggagct tgcagtgagc cgagatcccg 29041 ccactgcact ccagcctggg caacagagcg agactccgtc tcaaaaaaaa aaaaaaaaaa 29101 aaaagaacac tacattactg actgggtaac aaagttaaag agaagttctc ctagggtggg 29161 ggtgtgctgc aaggtcaaga tgaactcggt gtcctccctc ccagctcagt ggttttcatt 29221 ggttgactga gtctccttct actcttacat ggcctgtgat gtggctgaaa atgggattga 29281 aaatcttaaa ctcctggcct ggtgtggtgg tgcatgcctg taatcccagc actttgggag 29341 gctgaggcag gaggattgct tgagcccagg agttcaagac cagcctgggc aacatggcaa 29401 gaccccatct ctacaaaaat taaaaaataa gaagataaaa aggaaacctt aaactctctt 29461 atcatttagg aatcctgatg gggatgccaa gccctggtgc cacgtgctga agaaccgcag 29521 gctgacgtgg gagtactgtg atgtgccctc ctgctgtaag ggctgggccc cggctgcctc 29581 cctgcacctg tctcccttct tcaccatctc ctcgccactt tctaggcctt catggctgtc 29641 tggtgcagac tgtgtgccta ccagacttcc aggctgggtg gggagggggc ttccatgact 29701 gaagccacgg tgggtgggcg ggtgtccatg acccatgcat gggggtggtg gggaggggca 29761 agaagaaaga aaagaacaca gcaacctctc tgagaagtca gtaggctcta cccggctctc 29821 tctagacgcc tctattggtg ttgctgagag taatggggaa tgaggaggag gcctcgcatg 29881 catggctcct tagataataa agtgccttca ccacatttgt ccaacagcgt ggtggaggtg 29941 gtcttcctac ctccagttta ctgagtagga agcagtctcc cagacgccag gtggcctgcc 30001 caagctcgct gggcaccggg aggtaaagct agggcctgcc ctcatgccct ctgaccccaa 30061 tggcatgtac ttccactgtg agatcttcca cgtttcctgt tgacctattt cacacagggg 30121 agctggctca tgatgtgggt gagagatagg agattcaagt tggtgcatat tgctaaaaaa 30181 tgaaacttta gtttggaaat ggccagagag taggttatta atcacctcct gtgaacacag 30241 atcagccaga atgttcccca aggaacacaa gttcaactgg gacgatgaga cacagaccac 30301 cagctaactc acacccaagg gcattagtgt gagtcctcag tggtccgtgt ccctaagctc 30361 ctcagagctg agcaggtggg gacgtcagga aagctttgcg aggaggcagg attgcacctg 30421 ggccttgaag catgggtaag gttggacaga tggaaaagaa atgagcagac attccacaga 30481 aggaagctgc aattcttcat ttcttaggcc aggaaatggc tgtaggaaaa cattagaagg 30541 aatgaaggat ggcagatccc cagttttgga gtcaaacata cttgggaact aatccaggtg 30601 ccattgcaac cttgggcaaa aacgtctccg cctcctgaaa cttatcgctg tgggaactaa 30661 agagaatgta tggacaacat tcggcatgct gatcccacca agtgaaagtt gtggttttac 30721 agccatgctg atggcctcct cactctacct acacacgtgc aggaggcctg tgggactgac 30781 tgcctcctcg tcctttcctc cccagccacc tgcggcctga gacagtacag ccagcctcag 30841 tttcgcatca aaggagggct cttcgccgac atcgcctccc acccctggca ggctgccatc 30901 tttgccaagc acaggaggtc gcccggagag cggttcctgt gcgggggcat actcatcagc 30961 tcctgctgga ttctctctgc cgcccactgc ttccaggaga ggtaggggct cggaaaccca 31021 gttggttttt ccaccctcta acgcctagaa accaagccct ttaggggaaa tcccacagca 31081 aaaaaagcat tctaaggctg tttctccacc aggtttccgc cccaccacct gacggtgatc 31141 ttgggcagaa cataccgggt ggtccctggc gaggaggagc agaaatttga agtcgaaaaa 31201 tacattgtcc ataaggaatt cgatgatgac acttacgaca atgacattgg taagagctcg 31261 tcattcccgg ctccagttca tacagatcac acaacacacc cacatgcact cacctatgtt 31321 tacacacacg ggcctcctcc tccagcccct gcccctcctg cgtgttcctc ccctcccggg 31381 gacgcggccc tcacgccagc tcactcctcc tttctccctc ccagcgctgc tgcagctgaa 31441 atcggattcg tcccgctgtg cccaggagag cagcgtggtc cgcactgtgt gccttccccc 31501 ggcggacctg cagctgccgg actggacgga gtgtgagctc tccggctacg gcaagcatga 31561 ggcctgtaag tggaaggaag cctcggcccc atcctgtctg cgggacagca ggggaggctg 31621 cggtccacca gaggaaaatg gggtcaggag accgaagttc cagccccggg tcaggcactg 31681 acgccagtcc cgtctccctg tgtcgtgggg gcccgtctct gctgtctctg cctcacaggg 31741 acactgcagg ccaggaaagg acacaacagt atgagggcct cgaagtgctg caggtgttgg 31801 gaaggttctg agtaggaagt ggagtacagt cgctaagcgt gtgggttctg ggaagctgga 31861 gttacaaaga cccgatttca aatcccactt gctgagctgt gtgaccgtgg acatggattt 31921 ttattttgaa ctgctcccag cctcagtttc ctcgttggta aagtggagat agaactatct 31981 ccctaattag attaggaggg ttaaatgaga taatattgaa cgaatggatg tcagctgggg 32041 tgattttgtc ccccaggaaa cgtttggcga ggtctggaga cgtttttggt tgttacagtt 32101 tagggtgagg gttaacgccg gccttcagtg agtgcagcca gggatgctgc acactgcagg 32161 gctcgggact gtccccatcc cccacaacag ggacctccct ggtccgaagc atcagcagtg 32221 ccactacgga gaggctgtgg gttcaatccc ggaatcctgc tgtttttgtg ggtcaaaacg 32281 ataaaatacc agcagtgtca taggattcga cctaatacat gttgaatctt gatcaatgtt 32341 agctattatt ggaaaatttg gctttctctt tcaaaaacgt ttataaataa ctttccctaa 32401 aaccatatga tggttctccc ctttcagtgt ctcctttcta ttcggagcgg ctgaaggagg 32461 ctcatgtcag actgtaccca tccagccgct gcacatcaca acatttactt aacagaacag 32521 tcaccgacaa catgctgtgt gctggagaca ctcggagcgg cgggccccag gcaaacttgc 32581 acgacgcctg ccaggtaacc aggagtggcg gcccatgctg ggcacaaccc aggggagaat 32641 gcccctggga caacaggttc ttcaccaaag aaaaaagtta tcaccagagt ggagtgattt 32701 cctcttagtg atacccctag ggattctaga tgagggcctc acagaataaa gcaactggag 32761 gaagatcaaa gtcacctaaa cctaagaatt ctaaactgca ggaaatttcc ccaggatctg 32821 cacaggcaac tccacctgta caggatttcc tttcagccca ggcaattgat tgactattga 32881 agtgatggag agagccacac aattaagaaa cgtttgcctc agcctggtgt ggtggttcac 32941 gcctgtaatc ccagcacttt gggaggctga ggtgggaggc tcacctgagg tcaggagttc 33001 gagaccagcc tgaccaacat ggagaaaccc catctctact aaaaatacaa aattagcctg 33061 gcatggtggc acatgcctgt aatcccagct actcaggagg ctgaggcagg agaatcgctt 33121 gaacccggga ggcagaggtt gcagtgagcc gagatcgcgc catcgcgctt cagcctgggc 33181 gacaagagcg gaactcgatc tcaagaaaaa aaaagaagag gaggggaaga aatgtttgcc 33241 tctgttggca ctagagaatt ggagtctgct ttgtagaagg agaaggaaga aaggcaactt 33301 actgggaagc aggatctaga tgatgtgaga aagaagtttt caaaactcac attcagccct 33361 aataccctgg gaaagcacac tatttgaggt cctttgtgtg ggcaccttat cagaattagt 33421 acttatattt catgattagc cagatactgg ggtatgggag gaccaggcca gcctgctggt 33481 attaagacct gcacagagcc aaggaattga tcttcctcag acatttcagt gcctgcagcg 33541 tgcgaagctc tcctttaggg gctgggggta gaagagatac aaagagaagt gaggccaggc 33601 tctggtgctg aaggatgtgt gggctttgtt ttcgcaaggc agtcatatcg gcggtttccc 33661 ctctgattcc ctgacaggat ttagtttctt tttgaatggt ttcttcagca acctcagctg 33721 taccagctta cagtccagaa acaaaaaggt tgtaccaaag tgaaaccatt atctatctgc 33781 aagcttagtt aaaagcaaaa ccaaatcatt ttaattcaat ataagaacag ctaacaatta 33841 ccaagagttt tactagatgt cttccagtgc ttttcatgca ttcttctact gaatgccata 33901 accactctat gggtagtatg aatattatct ctatggtaca gataagaaaa ccaaagcatg 33961 gttagtctaa ggccatcagc tagtaagtga tggagccaag ccagggtttt tgaggcctga 34021 aacgtttgag taattaactc tactttacca gaatagatac agcctaatcc tccatgggac 34081 caagataact gagatacaat ctacccactc ttcagtaagt ctccacttaa cagcatgcct 34141 ggaaaaaata ggttcttaga aactgcaact gtaagtgaaa tgacgtataa caaaaccaat 34201 tttaccacca gctaattgat ataaacaaga gttggtcagg tgcggggctc atgcctgtaa 34261 tcccagcact ttgagaggct gaggaaggca gatcacctga ggtcaggagt tcgagaccag 34321 cctggccacc atggtgaaac cctgcctcta ctaaaaacac aaaaattagc caggtgtggt 34381 ggtgcgtgcc cataagcacg agaattgctt gaaccccgga ggtggagggt gcagtgagct 34441 gagattgcgc cactgcactc cagcctgggt gggtgacaga gtgagactct gtctcaaaac 34501 aaaaaaacaa aaaaaaacaa aaaaagaaga gtgaagttct tgtggcaata tttctagtca 34561 taaaaacatc agcaaacttc taaataaaga cccaaaacac ttctaacatt caatattgaa 34621 ataaatgtga gctatacaac atttaagaaa ggttaataaa aacaaacatg gtatttattt 34681 acccaatttt tggagaataa gtggatgatg gcggccataa tagtggtggg ttaattcagg 34741 gaataaatgt ttgcaaggca ggaatggtaa ggaacacctc ttactaccat gaagttcaaa 34801 aacaatcaca aatagggcag gctccctgac tgcctccaca cctcacagtt tatcatgcat 34861 tcgtgtattt agcacagact agacagattt ttactttata acactttgta ttcattcatt 34921 ttccaacgtg cttattccgg ttcagggtct tgggtggggt ggccagagcc acctggcagc 34981 tcagggcgcc aggcgggacc agccctggac agacgccacc atcctattgc agagccacta 35041 acacccacac tcactcagac tgggcccacg tagatacatc ctcagttggc ttaatgtgca 35101 agctttggga tgtggaagga aaccggggta cctggacaaa acccaggcag acagtgtccc 35161 cagacaggaa ttgatttttg ttttcctcat caaagttata atgaaatgac actgaatgga 35221 atattattga agggcctgct gtattttgaa gattacgatg ttcatgctac acatactgac 35281 tttctccaga tagtctgctt tttttgcaaa cgccaaacct gctatctcct ttgcagggcg 35341 attcgggagg ccccctggtg tgtctgaacg atggccgcat gactttggtg ggcatcatca 35401 gctggggcct gggctgtgga cagaaggatg tcccgggtgt gtacaccaag gttaccaact 35461 acctagactg gattcgtgac aacatgcgac cgtgaccagg aacacccgac tcctcaaaag 35521 caaatgagat cccgcctctt cttcttcaga agacactgca aaggcgcagt gcttctctac 35581 agacttctcc agacccacca caccgcagaa gcgggacgag accctacagg agagggaaga 35641 gtgcattttc ccagatactt cccattttgg aagttttcag gacttggtct gatttcagga 35701 tactctgtca gatgggaaga catgaatgca cactagcctc tccaggaatg cctcctccct 35761 gggcagaaag tggccatgcc accctgtttt cagctaaagc ccaacctcct gacctgtcac 35821 cgtgagcagc tttggaaaca ggaccacaaa aatgaaagca tgtctcaata gtaaaagata 35881 acaagatctt tcaggaaaga cggattgcat tagaaataga cagtatattt atagtcacaa 35941 gagcccagca gggctcaaag ttggggcagg ctggctggcc cgtcatgttc ctcaaaagca 36001 cccttgacgt caagtctcct tcccctttcc ccactccctg gctctcagaa ggtattcctt 36061 ttgtgtacag tgtgtaaagt gtaaatcctt tttctttata aactttagag tagcatgaga 36121 gaattgtatc atttgaacaa ctaggcttca gcatatttat agcaatccat gttagttttt 36181 actttctgtt gccacaaccc tgttttatac tgtacttaat aaattcagat atatttttca 36241 cagtttttcc aaaatcagag tggaatggtt ttgttataga tgctgtatcc cactctttat 36301 tcatgttcac attttaaaat catttggaat tcgccccgct aactttccca cacctgtaac 36361 atacaggtca tggctggtgc tccggaccgg aaaaggaggg acagaatgct tggtctgatg 36421 ggctaatatg gcatttagag aagtaccaag gtacagtgga gccggtcaca aaagggcaga 36481 cttgtagtag aattcagttg caagagggat tggggaatct taaggaaaaa atagaatctt 36541 aaggaaaaaa taactgggtg agacgtggac tgtggacagg cgcggaaaag gcac //