LOCUS HUMGNOS48 23142 bp ds-DNA PRI 30-NOV-1994 DEFINITION Human endothelial nitric-oxide-synthase gene. ACCESSION D26607 KEYWORDS . SOURCE Homo sapiens pre-B DNA, clone gNOS48. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 23142) AUTHORS Miyahara,K., Kawamoto,T., Sase,K., Yui,Y., Toda,K., Yang,L.X., Hattori,R., Aoyama,T., Yamamoto,Y., Doi,Y. et,al. TITLE Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene JOURNAL Eur. J. Biochem. 223 (3), 719-726 (1994) MEDLINE 94333373 COMMENT Submitted (21-Jan-1994) to DDBJ by: Kaoru Miyahara Dept. of Medical Chemistry KochiMedical School Oko-cho, Nankoku Kochi 783 Japan Phone: 0888-66-5811 x2971 Fax: 0888-66-6286. NCBI gi: 558523 FEATURES Location/Qualifiers source 1..23142 /organism="Homo sapiens" /cell_type="pre-B cell" /sequenced_mol="DNA" exon 1423..1602 /number=1 exon 2843..2954 /number=2 exon 4383..4530 /number=3 exon 4741..4903 /number=4 exon 6339..6427 /number=5 exon 6515..6659 /number=6 exon 6925..7064 /number=7 exon 7169..7343 /number=8 exon 8476..8577 /number=9 exon 9208..9402 /number=10 exon 9520..9593 /number=11 exon 9797..9941 /number=12 exon 10176..10280 /number=13 exon 14401..14467 /number=14 exon 14861..14977 /number=15 exon 15074..15248 /number=16 exon 16903..17035 /number=17 exon 17161..17239 /number=18 exon 17370..17557 /number=19 exon 18087..18259 /number=20 exon 18569..18779 /number=21 exon 18871..18958 /number=22 exon 20323..20444 /number=23 exon 21202..21350 /number=24 exon 21694..21888 /number=25 exon 21975..22557 polyA_site 22557 BASE COUNT 4938 a 6990 c 6405 g 4809 t ORIGIN 1 ggatcccatg ccctgcctca ctgggaaggc gaggtggtgg ggtggggtgg ggcctcaggc 61 ttggggtcat gggacaaagc ccaggctgaa tgccgccctt ccatctccct cctcctgaga 121 caggggcagc agggcacact agtgtgcagg agcagcttat gaggcccctt caccctccat 181 cctccaaaac tggcagaccc caccttcttg gtgtgacccc agagctctga gcacagcccg 241 ttccttccgc ctgccggccc cccacccagg cccaccccaa ccttatcctc cactgctttt 301 cagaggagtc tggccaacac aaatcctctt gtttgtttgt ctgtctgtct gctgctccta 361 gtctctgcct ctcccagtct ctgagcttcc gtttctttct taaactttct ctcagtctct 421 gaggtctcga aatcacgagg cttcgacccc tgtggaccag atgcccagct agtggccttt 481 ctccagcccc tcagatgaca cagaactaca aaccccagca tgcactctgg cctgaagtgc 541 ctggagagtg ctggtgtacc ccacctgcat tctgggaact gtagtttccc tagtccccca 601 tgctcccacc agggcatcaa gctcttccct ggctggctga ccctgcctca gccctagtct 661 ctctgctgac tgcggccccg ggaagcgtgc gtcactgaat gacagggtgg gggtggaggc 721 actggaaggc agcttcctgc tcttttgtgt cccccacttg agtcatgggg gtgtgggggt 781 tccaggaaat tggggctggg aggggaaggg ataccctaat gtcagactca aggacaaaaa 841 gtcactacat ccttgctggg cctctatccc caagaaccca aaaggactca agggtgggga 901 tccaggagtt cttgtatgta tggggggagg tgaaggagag aacctgcatg accctagagg 961 tccctgtggt cactgagagt gtgggctgcc atcccctgct acagaaacgg tgctcacctt 1021 ctgcccaacc ctccagggaa aggcacacag gggtgagccg aaggcccttc cgtctggtgc 1081 cacatcacag aaggaccttt atgaccccct ggtggctcta ccctgccact ccccaatgcc 1141 ccagccccca tgctgcagcc ccagggctct gctggacacc tgggctccca cttatcagcc 1201 tcagtcctca cagcggaacc caggcgtccg gccccccacc cttcaggcca gcgggcgtgg 1261 agctgaggct ttagagcctc ccagccgggc ttgttcctgt cccattgtgt atgggatagg 1321 ggcggggcga gggccagcac tggagagccc cctcccactg ccccctcctc tcggtcccct 1381 ccctcttcct aaggaaaagg ccagggctct gctggagcag gcagcagagt ggacgcacag 1441 taacatgggc aacttgaaga gcgtggccca ggagcctggg ccaccctgcg gcctggggct 1501 ggggctgggc cttgggctgt gcggcaagca gggcccagcc accccggccc ctgagcccag 1561 ccgggcccca gcatccctac tcccaccagc gccagaacac aggtaagggc caggcagcta 1621 ggagcaggtg ggcaacaagg gtggtgtcaa ggcctgaagc ctggggctgg gaaggtctgg 1681 aacttgtagc tgagtcggga gggccaggtc acaaatgcaa aagggctatt aatgtgcata 1741 gaacaggaca gtctgggagg ctcagaaagg agaccaggat cagagtcggc aggtgaagct 1801 gggagtaagg gtgccagcta tagaatctgg ccagggtttg aatgctgctc tgccgccagg 1861 agctgtttga ctttgagcaa gttacttaat ctctctgaac ctccatttat ataaaacgag 1921 atatggcaat acttactcca tggggaagta agtttctagc tcacagcaag ccttcaacag 1981 cagcgatgat tatttagctg gagaagaaag gagctgacag cagtggttac aggagtgaga 2041 aagtggggtc tcccagaaga gggagagagt tgggcaggaa actcgggccc ttggggtaag 2101 caggctgaga agacagagcc accaggcttt tttcccctgc tccagccccc tctcctcgtg 2161 gctgtcaccc gaaaactgga ccatgcagtt cccacaagag tcctcccggg ggtagaggtc 2221 ccaggaggga ggaaagaccc ggaggcctgg tggggtgcca ggccgggggc aggctggggc 2281 tgcaggcagc tatgcaggga aggctgaggg ccggggccct gctgctcagg cgcacccttg 2341 gcctgagtcc ctcccttcct ccctgccgct ggtggctctg ggaggaagtg ataaggcctg 2401 cgaggcttcc cttcacacat ggggctgctg tcaggagggg ttgtgagtgc ggagggaaat 2461 cagagctgag gaatccctgc agggcttccc tccactcaag caccaggctc tgtccccctc 2521 agggtagggc ttatagcagc tttgcggggg gtggacaccc catctccaga agaggtgagg 2581 tgggcgctgc aggtgggatg cgaacttagc ctcgggtcag gggctcagga gctcagcacc 2641 agcagcccct gcagcccagg accctggtct ataaacggag gcacagctcg cctctagctc 2701 ctaaggcatg gggaacgcca gaaggcatgc ggcaggtggg ctgtgagatc gccagtgctg 2761 taacaggggc ctccgggtga catctgggaa ggctgaaagg aaacaaaccc ttcctgatga 2821 ccctatccct ggctcccaac agccccccga gctccccgct aacccagccc ccagaggggc 2881 ccaagttccc tcgtgtgaag aactgggagg tggggagcat cacctatgac accctcagcg 2941 cccaggcgca gcaggtaagg ccggcatgcc ctgtccccat cgtctccagg gaaagggtgg 3001 gtaaggcctg gcctcagatg gggccggaga gggaagctca acccttcttt gaattggtcc 3061 cttgtttcca aaaagaggag aggactggga agaaccagag gagttgaggg acatgcacgg 3121 gacttgggtg accctcagcc tccagcctta cccccaaccc tggctcaaac ttttccccca 3181 tcccacccct gcaccccttt tccccctccc acccctgcac ccttcctccc tctcccccac 3241 cccacccctg ccccccctcc catcccagct ctaaacccct cctccctctc ccccgtccca 3301 cccctaaacc ccacctccct gtccccctct aaacccctcc tccctgtccc cctctaaacc 3361 ccacctccct ctccccatcc cacccctgca cccttcctcc ctctgccccc gtcccacgcc 3421 tgtactcctc ctccctctcc cccgtcacac ccctgcaccc ctcctccctc tccccatccc 3481 atccctgcac ccctcctccc tctgcccccg tcccacccct aaacccctcc tccctctgcc 3541 ccaccccacc cttgcacccc tcctccctct tcccccgtcc cctgcctgca ttcctcctcc 3601 ctctccccat ctcacccctg cacccctctt ccctctccca cccctgcacc cctcctccct 3661 ctccccgtcc caccctgcac tcccgccctc tccagcgtcc cacccctaca cccctcctcc 3721 ctctgcccca ttccacccct gcaccccctc ctccctctgc cccgacccac ccctgcaccc 3781 ctcctccctc tcccccgtcc cacccctgca tccctcctcc ctctgccccg tcccacccct 3841 acacccctcc tccctctccc ccatcccacc cctaaacccc tcctccctct cccctgtccc 3901 atccctgcac ccttcctccc tctccccgtc ccatccctgc acccttcctc cctctccccg 3961 tcccatccct gcacccctcc tccctctgct cccatcccac ccctgcaccc ctcctccctc 4021 tgcccctacc ccacctctgc acccctcctc cttctcccca tcccacccct gcacccctcc 4081 tccctctgcc cctaccccac ccctgcaccc ctcctccttc tccccatccc acctctgcac 4141 ccctcctccc tctcccctct cccacccctg tacccttcct ccttctcccc gtcccacccc 4201 tgcacttctc ctccctctaa cccatcccac ccctgcaccc ttcttccctc tcccccatcc 4261 caccactgca cccctcctcc ctctccccct gttccacccc tgcacccctc ctccctgccc 4321 ccaactccca tcccacccct gcaccctggc ctgtcctgac ctttgcactc cctcgaccca 4381 ggatgggccc tgcaccccaa gacgctgcct gggctccctg gtatttccac ggaaactaca 4441 gggccggccc tcccccggcc ccccggcccc tgagcagctg ctgagtcagg cccgggactt 4501 catcaaccag tactacagct ccattaagag gtgacagctt cccggacgcc acagcctccc 4561 ttgtcccact gaggccccag aaaccccgtg acgaccttcc catgaccccc tcccttccca 4621 gatcctaaca ccacgtgggc ccctcccgcc ctcccccagc acttgcacaa agcctggagg 4681 agggcctccc tgtcccacac aacttcctgc ttgtcccctt cccacccctc tcctccccag 4741 gagcggctcc caggcccacg aacagcggct tcaagaggtg gaagccgagg tggcagccac 4801 aggcacctac cagcttaggg agagcgagct ggtgttcggg gctaagcagg cctggcgcaa 4861 cgctccccgc tgcgtgggcc ggatccagtg ggggaagctg caggtgcggc tggccagcga 4921 ctgagagacc cgggcgctac caaaagggga gcggggtggc ggggcagttc ctaaggcttc 4981 ccgggggctg ggaggtccca aactgtgggg gagatccttg ccttttccct tagagactgg 5041 aaaggtaggg ggactgcccc accctcagca cccaggggaa cctcagccca gtagtgaaga 5101 cctggttatc aggccctatg gtagtgcctt ggctggagga ggggaaagaa gtctagacct 5161 gctgcagggg tgaggaagtc tagacctgct gcaggggtga ggaagtctag acctgctgca 5221 ggggtgagga agtctagacc tgctgcgggg gtgaggaagt ctagacctgc tgcgggggtg 5281 aggacagctg agcggagttc cctgggcggt gctgtcagta gcaggagcag cctcctggaa 5341 aagccctggc tgctgcttct cccccaagag agaaggcttc tcccgccagg ccagtccagt 5401 gcagcccctc acccacaccc actgctaccc cagttcccct gcttcggccc gcaccctccc 5461 tcacacccca gcccacagac tcggggctgg ccttagttac tggaacgcct gtgaccacag 5521 cactaagaga agcaagctgc cccatggggg acttggtccc catggccttg gcctccttca 5581 ccatcactgg ccgccaaaga gtttgaaata aagccacgtg cccagtgaat cccaaaggaa 5641 cctcaactaa aataaaaaca atcctatctg acacttgcct gaccctctaa gtcattcaaa 5701 gctttagctc aacttcgatc catctgagct gccatagtgg accccactca gagctgcgtc 5761 cctcccttga ccccaggttg gtccctgcca ctcccctgcc cctgtcactg acacatgttt 5821 cctcctccct caggcaggag tgggacctcc cagcctcctc ctggggcctc cactcagaat 5881 gtcaggatga gcagggtcct aggaggcctc tggtgcagcc ttcccttccc accatccatg 5941 tgctcaaaga gaatcacccg tcctttcttg aatgccatgg atcatggggg atttgctgcc 6001 cacactccta ggcggcctct tagacatccg ttggtgccta acccaagcat cagtttggca 6061 gaggccgagt ccctcctctg tactggatac caagtcagct tccataggga tggggagaca 6121 cctggcccag ggaggagatg agaagcagcc cggatggtgc tacatatgtc agagagcagg 6181 gcaggaaggg atcagtgtgg ctgccaatgg tcaggagggc gccatggagt gaaccatggc 6241 ccctgcctcc tcaaccaaga agtcctctgg agctgatact caagaccccc cgtctctctc 6301 ctcaccctcc tctcccgctg cctcggctgg ctcaggtgtt cgatgcccgg gactgcaggt 6361 ctgcacagga aatgttcacc tacatctgca accacatcaa gtatgccacc aaccggggca 6421 accttcggtg agtgcccccc accatgccag gccccagcct tcttccccaa ggcagggaag 6481 gcggggctct gaccagctct ttccccatgc gtgccagctc ggccatcaca gtgttcccgc 6541 agcgctgccc tggccgagga gacttccgaa tctggaacag ccagctggtg cgctacgcgg 6601 gctaccggca gcaggacggc tctgtgcggg gggacccagc caacgtggag atcaccgagg 6661 tgggcaccga gggccaccca tgagggtgtc cccaaggtgg agaatgagga aaccagtggg 6721 agaaggctcg ggggatccag gcaggaagag gggagcctcg gtgagataaa ggatgaaaaa 6781 caccaaagga ggggtgcctg ggtggtcacg gagacccagc caatgaggga ccctggagat 6841 gaaggcagga gacagtggat ggaggggtcc ctgaggaggg catgaggctc agccccagaa 6901 ccccctctgg cccactcccc acagctctgc attcagcacg gctggacccc aggaaacggt 6961 cgcttcgacg tgctgcccct gctgctgcag gccccagatg agcccccaga actcttcctt 7021 ctgccccccg agctggtcct tgaggtgccc ctggagcacc ccacgtgagc accaaaggga 7081 ttgactgggt gggatggagg gggccatccc tgagcctctc aagaagggcc tgcaaggggg 7141 tgctgatccc acaccccaac acccccaggc tggagtggtt tgcagccctg ggcctgcgct 7201 ggtacgccct cccggcagtg tccaacatgc tgctggaaat tgggggcctg gagttccccg 7261 cagccccctt cagtggctgg tacatgagca ctgagatcgg cacgaggaac ctgtgtgacc 7321 ctcaccgcta caacatcctg gaggtgaggt gcgggatggg gctcgggcac cgaatgcacc 7381 tgtccaaggc aggagtctgg ctctcactcc atccccaaaa tgccagccac ggggacaatc 7441 agagcaggtc cagggttgcc tcctaaatgg gaactgagga caagctctag aaccactgaa 7501 gcaaaggggt agggggtggc aggggtgtgt gtgggggtgt gagtgggtga gtgtgagagt 7561 gtgggtttct ggggtgtgca gtgggtgaga gtgtgggctt gtggggtgtg tagtgggtgt 7621 gagactgtgg gtttgtaggg gtgggtgagt gtgggtgtgt gggggtaggt gggtgtgggt 7681 ttgtgggtgt gtataggcag tgactgtgag actgtgggtt tgtgggggta ggtgactgtg 7741 ggtttgtggg gtgtgtaggg gtgagtgtgt gtgggtttgt aggggtaggc gagtgtgggt 7801 ttgtggggtg tgtaggggtg agtgtgtgtg agtttgtagg ggtaggcgag tgtgggtttg 7861 tggggtgtgt aggggtgagt gtgtgtgagt ttgtaggggt aggtgagtgt gggtttgtgg 7921 ggtgtgtagg gggtgtgtgt gggcttgtag gggtaggcga gtgtgggttt gtggggtgtg 7981 taggggcgag tgtgagagtg taggtatgtg ggtgtgagtg tggatgtgtg taggcggtga 8041 gtgtgaaatt gtgggtttgt gggggtgggt gggtgtgagt gtgtgggttt gtgggtgggt 8101 gtgggtgtga gtgggtgggt gaggggggca tggggatggg tgtgaacatg tagttgttct 8161 ttcaggcata ggacccatag ctctagagct ttcatcagat tctcaaaggg gaccttgact 8221 cggaaaaggt taagacccat tttagagatg agaaattaaa gcctggagct gaggagcgac 8281 tggcccaaag tccctctctg ctctgaggtg cttcgcaggc aaaaacctga accagccccc 8341 taggcagcca ggcctcccaa tggacaccac tcacctcact ccttccagcc atgtacggga 8401 aacagagata gtctccccac cccacccccg tgatcacctc tgtccctacc gatgccacac 8461 acccttctgc cccaggatgt ggctgtctgc atggacctgg atacccggac cacctcgtcc 8521 ctgtggaaag acaaggcagc agtggaaatc aacgtggccg tgctgcacag ttaccaggtg 8581 cagaggccca gactggccag gaaggcaaag ggtttgcata cgggggcagc aggggcgggg 8641 gatggaggag aggcagccat ttagaaacta gggcaggatt tggacaggca gaagaagttc 8701 cgtagtccca gtgccatggc gcacactggc tgcggttcgg ggacagggca ggtactattc 8761 caggcgctgt catctggtgg cttactgtgt gccagggacc ttgctgttta ctgcatgccc 8821 agtcatgctg attctcaggg catattgggt attgcagttt gtgggacccg ctggatcctg 8881 gaaacaaata ccaggatcaa gggcacacca ggagtcgtag tttgaggaag ccggggcctg 8941 ctgagaattt ctgtgggcta tttggtttgg ggaccaggca tgcagatgct ggagattaga 9001 gctgcttgtt gcatgttgaa cctgcagcat gaccatgcat gatgtggttt ggggtgaggg 9061 tgacattgtg gtttgagggg acacagggtg tgttagatat ggggtaatcg agggcacatg 9121 tggtttgggg tgaccggagt ggtggaggaa gaatgggcga ggtctgtggg tctggtttga 9181 gcctctcccc ctctctctcc cttccagcta gccaaagtca ccatcgtgga ccaccacgcc 9241 gccacggcct ctttcatgaa gcacctggag aatgagcaga aggccagggg gggctgccct 9301 gcagactggg cctggatcgt gccccccatc tcgggcagcc tcactcctgt tttccatcag 9361 gagatggtca actatttcct gtccccggcc ttccgctacc aggtgcccac cctaatggct 9421 ctgccagcct gggcccagct ctaattctaa gcagcccctg gggacctcta acctttcctt 9481 ttctttacct cccctcccaa ccccatcatc tctctgcagc cagacccctg gaaggggagt 9541 gccgccaagg gcaccggcat caccaggaag aagaccttta aagaagtggc caagtgggtc 9601 ccctgggagc cccgctctcc cacacacacc ctgggggccc cactctcccc cacacaccct 9661 gggggaccct gccccagcag tgttctggac ctaccactca gtatcccaaa accctgttgt 9721 gagggggttg gacccttgcc tggggaggcc ctgcctctgt gcacccggga caccctcaca 9781 ccttcctctc ccgcagcgcc gtgaagatct ccgcctcgct catgggcacg gtgatggcga 9841 agcgagtgaa ggcgacaatc ctgtatggct ccgagaccgg ccgggcccag agctacgcac 9901 agcagctggg gagactcttc cggaaggctt ttgatccccg ggtagggctg agcccagggg 9961 agcagggagc tagaaagagg gggctctatc agcatcttca ggggtgccct ggaggacagg 10021 aagtgttaca agtcaggact catgaggaac ccggaaccac aggtgttcag agatcaagtt 10081 ggggcctgaa tcttgcactg ccagggaggc cagagtgagg agggcagggc ctccgggggc 10141 cacagcaccc aggacatctg tcttcccacc cacaggtcct gtgtatggat gagtatgacg 10201 tggtgtccct cgaacacgag acgctggtgc tggtggtaac cagcacattt gggaatgggg 10261 atcccccgga gaatggagag gtgagaactt ccaggaaagg ggctgctggg aatgaggaga 10321 gactcagaat tggagtgact gggcaggaac ctctgcccaa cacacacaca cacacacaca 10381 cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cgccaggatg 10441 gaaagggaga tgctaagaga cccctggagc ctgaaacccc acacaacgta cgctcccagc 10501 ccacccatgt ggctgcctcc ctgcaagcac atttgcttaa ctgcgcgtcc ccaagtcatt 10561 tccattatca gtgcaagttt ttaatacaag gaaggcacat cctggctgac caagaggtta 10621 gactgtgctc gggcactgac aagaaaaaca gggatacgtc actgagggcg gcttctagga 10681 tgcgggtaat gtttcttaat gggatactgg ttacacaggt gtgttcagtt tgtaaaaatc 10741 cacagagctg tacatttaca acatgtacaa cactattcca gcattttatt ttatttgttt 10801 tatttatttt gataacctat ttacgttgcc caggctggcc ttgaactcct agcctcaaga 10861 gatcctcctg ccgcaggctc ctttttcaaa agaagaaatt gagcgctgtt tagatgccaa 10921 catagattaa ataacttcac tttttaaaaa gaaacacaaa gctagagtac catcattgaa 10981 ttccttctct tgcaagctta ggtatctctg aggtgcccca ggctaggctc atttctgagt 11041 cttacctgct ccagcttcta ggtgttaaag gccttattag cactaagtac ttcctcagta 11101 ctcttttttc ttttttcctt tgagacaggg tctcactttg tggcccaggc tggagtgcag 11161 tagtacaatc acggctcact gcagcctcaa cctcctagac tcaagcaatc ctcccacttc 11221 aacctcccaa gtagttggga ctacaggcgc atgccatgat gcctagctaa tttttgtatt 11281 ttttatagag atggggtttc gccatgttgc ccaggctggt ctctaactcc tgggttcaag 11341 caatccacct gcctcggcct cccaaagtgc tgcgattata gacgtgagcc actgcacctg 11401 gcccgcagta tcttaagcaa gttggaatct cgtgaaaccc tttttgctgc cttagtgtcc 11461 gtttcagccc tcattcttac ctaccttttc aagaaaaata gcaccagcaa ttgacttttt 11521 tttagcataa aggtgtatag aacccatata acctacagcc ttcacaaggc atagcacatt 11581 ttcaccaccc tggaaagttc cctcatcagt tcctcacgtg aatcccttcc cagtctgtct 11641 ccctgccaga agtgtctgtc accacagaat agtttcgcct gctctagaac ggcacctaga 11701 tggaagcacg cagtgttgcg gcgtctcctg ctgaggctgt ttttgaggcg cactcgtgtt 11761 gctgcgtgac tcagtatttc actcattctg ctgctgagtg ccgttcattg tgtgaatatc 11821 cccagtttgt ttacccattc tcttgttggt gacacttggg ctgtttccag gtcggggcta 11881 ttatgaataa acctgttatg aacattctgt acccggcttt tgtgggctta tgtttttatt 11941 tctcttgggt aaaacctagg agtagaattg gtaggtcata gggtagatgc atgtttaatc 12001 tttcactttt ttaaaaaata aaactgccag gccaggcgcg gctgctcacg cctgtgatcc 12061 cagcactttg ggaggcccag gtgggtggat cacttgaggt cagaagctca agaccagcct 12121 ggccaacatg gcaaaaccct gtctctacta aaaatacaaa aattagctgg gcatggtggc 12181 gcacgcctat agtcctagct actcaggagg ctaggcggga gaattgcttg aacctgggag 12241 gtggaggttg cagtgagccg agatcacgcc actgcactcc agcctgggtg acagagcaag 12301 aattctactt aaaataaaat acaaataaat aaaataaaac tgtcaaacag caaagcaaat 12361 taaactgccc tttaacatct gtgcagttca atgtatgtta attttatccc aaatttttaa 12421 caaatctagg aatacagctc acagaaaatg gggtatattc actaaaaata aggaatattt 12481 atagcaaatt tgtttgtaat accccacact ggaaacaatt caaatgacca tcgacaaata 12541 ctgataaatt gtggtatatt caagtgccat atcgcactaa gtgtgaacga aacacaacca 12601 cacacaacag tgcaggtgaa tctgaaaaaa tgtgaagaga agaaaaagcc agaccaaaga 12661 atacatactg tactacaggg ttcactttat ataaagttca gaaacaggca gaactaatcc 12721 acggagttag aaattaggag aggagttagt cactgggatg ggggtggcag tgacaggaag 12781 aaggcacgaa gttggcttct aggatgcggg taatgtttgt ttgtttgttt gtttgtttgt 12841 ttttgttttt gagctggagt ctcactctgt tgcccaggct ggagtgcaat ggcgtgatct 12901 cggctcactg caacctccgc ctccccggtt caagcgattc tcctgcctca gcctcccgag 12961 tagctgggat tacaggtgcc cgccaccatg gccagctaat ttttgtgttt ttagtagaga 13021 cgcgtttcac catgttggcc aggctggtct tgaatccctg acctcagcct cccaaagtgc 13081 tgggattaca ggcgtgagcc accacgccca gccacgggta atgtttctcg atgggatgct 13141 ggttgcacag gtgtgttcag tttgtgaaaa cttacagagt tgtacattta caacatgtgt 13201 gcacctctgg acttgtgttg cacgttgaca aaacattcaa aaatgaaatt caaatcgttc 13261 ttgctaactc tggcgcactt gggaaccagc acccagaggc atctgcagtt gagcaccaga 13321 tgcagttcct tccagcttcc ttccccctgg gaggtccgct tgatgccact tcttcatggc 13381 agcacaaaca aggccatggt cttctgagga gggcaacctg cacaatgtct gctagtgacc 13441 aggacactgc tgaaggaact gagagtttgt ccacccatga aatccactaa aacaggaaag 13501 attttgctct agccgttgtt agccaggagt gaggaaagag ctgtgccctc ccctgcagct 13561 gcgaggacga tctgcctgcc ccaacaagtg gggattcagc aactccactt ctaaggatta 13621 cccagctgaa gcatttaaaa gtgggagcaa ggcacacgta caagggcgtt tgagagagca 13681 cctgttccca gaccaccgag ctgcccttca gtctcagtga agtacaatgt agccactaaa 13741 aagactgagg tcatgttttg gaaagtccag gccggaggat cgcttgagcc caggagttca 13801 aggccagact gaacaacaca gcgagactcc atctcttcag aaaatttaaa aattaaccaa 13861 gagtggtggc acgcacctat agatctagct actaggaagg cagaaaaatc ccttaagccc 13921 aggagtttga ggttacagtg aatgatgatg gagccactgc accccaacct gggcgacaga 13981 gcaagaccca tatctaaaaa caatactact acttacgtca atattgttgt attgacctgg 14041 agggatgtct gcaataaatt attgattaaa accaaggaag tacagtatgg taccactttt 14101 acttaaaaaa aaactataaa tatgcacgtg cacgtaagtt caaggaaaaa gggctggaag 14161 gttaacacct gtgaatggcg catatgcccg gaggaagatg gggtggtctt tgtcttatca 14221 ctttacacat ttctgtaatg tcatttttca aaaacatcag atcgcttttg aaattttcaa 14281 aacaaataaa aattaagtga caaatcaata ataatgagga tcagctggta cagttttaaa 14341 cttctatgta gtttgaaatg aaacaaaact aaccctgatg caaacactcc cctcgccaga 14401 gctttgcagc tgccctgatg gagatgtccg gcccctacaa cagctcccct cggccggaac 14461 agcacaagtg agttgggtga gagtttgggg gagctggggg agctgatgca tttggagaca 14521 caaacagaaa gggggtctga aaagctctcc ctctgtgcct caagtcgttt tcccaccaaa 14581 agccagggct ccaggatgcc ctccattcca ggctgcaatg gcagtccaga cctgcctgct 14641 tctgagagcc gggacagtcc tgaggtcttc agagatgggg gtgtggtgtg tcagggcccc 14701 aggctcggaa ccccagggat gctggccctc agcccctccc aagggcaggg cctttcctgt 14761 ccagaggcag agaccctgaa gccgtccctg gggctgggtc tgggcctagc ctgtatcccc 14821 agggccctgt gacaaccttg tctttgtcct ctcttgccag gagttataag atccgcttca 14881 acagcatctc ctgctcagac ccactggtgt cctcttggcg gcggaagagg aaggagtcca 14941 gtaacacaga cagtgcaggg gccctgggca ccctcaggtc agggcctcac caagaggggt 15001 gcaacgggtg ggcaagctgc ctgggcaaac gtggcctgca aagggagctc cactgacgac 15061 ccctgcaccc caggttctgt gtgttcgggc tcggctcccg ggcatacccc cacttctgcg 15121 cctttgctcg tgcggtggac acacggctgg aggaactggg cggggagcgg ctgctgcagc 15181 tgggccaggg cgacgagctg tgcggccagg aggaggcctt ccgaggctgg gcccaggctg 15241 ccttccaggt gagcccagcc cagcccctgc tctgactcct gccccctggg atgcctcctc 15301 ctgcctcact ctgccctgat tctgtttggt tctttggtcc cttcctgttc cttccaaaat 15361 ccaccctcat ctctccatgg catagccagc tcttctgggt caggggcaga ggatgacatg 15421 gccctgccga ccacaggggt gcctagccca ggcagaagtg cagccgaaag agagcaggca 15481 gggccctggc aggagggagc ttcagccagg cacaggctgg gcctcacaag tgggcgcaca 15541 aagggagggg gtgcagggca gggcagggga ccccacccag gatgggcagg atggagggag 15601 aaggaaggga cagagagaag gtcagacaga ggcaagggct gaagctgagg ccagcacaga 15661 agccacagga agccagaggc cagacagcct ggggcggtgc ctgcaccaga actggtccgg 15721 gccaggcaag caagcacagg gagaggtgga tccctggggg ctgtggcttt ttaagcctgg 15781 gcttcctcag gggcagtgct gcctgtctgg ggatcatgtc tgcagttgac aagggctcgg 15841 tctccccagt gccacactgt tcagggcagt gctgctgtcc cggggcccag gctggagctc 15901 agcagatttg ccttgattgg aggaggaggg catcctagga ggagagggag tgggggctac 15961 ctcagggacg gggaggtcag gctgcagaaa cacataggcc ctgattggga agaagggaca 16021 cggtaaaata agctctaaaa gaatttaaaa caaaaagagc cattgcagcg ggatgagacc 16081 acatcatcag gttttgggaa taggacttta gaggcgtagg atccattaca gcatcaccga 16141 accagaagca ggaaggctga gctaagcaga gcagcagcag tggagatagg aaggaaggga 16201 gggaggggcc gaggaaggaa ggaagagata taagacttca cacgcaccac aaaagaaaga 16261 ttaacgggac ttggtgatat gaggctcagc caatcacggg tgagccctgc atttcaagcc 16321 tgggactggc ccagcagttt tccagctgtg tgcctgacca ggagtagacg ggatccacac 16381 cctcccaggg atctgccccg tggggtcccc tctgccgccc gaattgtgcg tcccttccca 16441 ggagcactta ctatctgcac gcactttgtg gaaagctaag ggctttacat aaagtatctc 16501 atttaatctt caccagaaca caatgaggtg taaagatggg gaaactgagg catgtcactg 16561 taagtacggg attcggaatt tgaatgcagg tctgaacaca cagacgcctt cacagagcta 16621 ccgtgtgcca agcactatgc ttctcggatc acgggattaa cacgcaccag ataaggaacg 16681 atgcaccaat caggacgtgc agagaaagag ccagccgggt ccctgggccc agcggccaat 16741 ccatgaaatg ggctggcgga aaaggtgctg tccttggcgc cggcctcagc cactggggct 16801 gccaaccccc caggagcaag acgcagtgaa gccgcccagg cgcctcacta gggcgacccc 16861 tggtggcggg aggtcctcag ccctcaccgg cctgtcccgc aggccgcctg tgagaccttc 16921 tgtgtgggag aggatgccaa ggccgccgcc cgagacatct tcagccccaa acggagctgg 16981 aagcgccaga ggtaccggct gagcgcccag gccgagggcc tgcagttgct gccaggtggg 17041 ccctgcctca ccctaacccg gctggttctc tgaggccccc acaccccggg actaaagcac 17101 tctggggcca ggccctgctc cctagctcag gctgcctcat ttgcccctcc ccgcccccag 17161 gtctgatcca cgtgcacagg cggaagatgt tccaggctac aatccgctca gtggaaaacc 17221 tgcaaagcag caagtccacg tgaggacgac ggctttaccg ccccccaacc cctgtcctga 17281 acaccctgac cctggaccct cctcctccca cattctcccg cccccacccc tctctgactc 17341 cccataagtg cccctctccc cacccccagg agggccacca tcctggtgcg cctggacacc 17401 ggaggccagg aggggctgca gtaccagccg ggggaccaca taggtgtctg cccgcccaac 17461 cggcccggcc ttgtggaggc gctgctgagc cgcgtggagg acccgccggc gcccactgag 17521 cccgtggcag tagagcagct ggagaagggc agccctggtg aggggcagcc tgggaagcaa 17581 cagggcacac cagccccatg cccagcccca cccccggccc caggcctcca ggagctcagg 17641 acccgaccca gggggtggcc acctcctcca cagctcagca ggcaggctca gagctggctg 17701 tgctgcccac tgccgggctg gccttgttgc tggaccatcc ccacaccctc aaatgcaccc 17761 ccaccaaaag gctgtcccct ccctctgggc tcctctccaa ggctccccta gcaatctagc 17821 ttgctctgga gctggcactg gggctatttg ctgccacatc aatgcctggg ctttatttaa 17881 aataaggggg tggagtcaga ggcagaggag cccagaccaa cccagtccgg ccaggggccc 17941 ccgaacaata cactgaggct acctagacag gccgaccccg ctgctcaagg gcaggctctc 18001 taacagtcac caaaacacaa acatcagccc aggtactgca gtcctgctgg gccctgtcct 18061 cagagctccc tgtgcactat ccccaggtgg ccctcccccc ggctgggtgc gggacccccg 18121 gctgcccccg tgcacgctgc gccaggctct caccttcttc ctggacatca cctccccacc 18181 cagccctcag ctcttgcggc tgctcagcac cttggcagaa gagcccaggg aacagcagga 18241 gctggaggcc ctcagccagg ttgggggcca ccccaatgag gcacaggggc tagagagacg 18301 ggatgagctg gggggacccc agtggcagga aacccccatg caaagtcccc cctggacttt 18361 cttctcctgg ctgacatgca ctggtgcttt aagacccagc tcctcaggga ggaattcatg 18421 gctggattct ccaggtctta gagaaaactc tattggcctg aactgagcag ggagaaaccc 18481 taaagaggct cagtggggga ggggtcaaga agggaggtta ctaggaaggg ctatggggcc 18541 tccaacccac tgcatcctgc cccgccagga tccccgacgc tacgaggagt ggaagtggtt 18601 ccgctgcccc acgctgctgg aggtgctgga gcagttcccg tcggtggcgc tgcctgcccc 18661 actgctcctc acccagctgc ctctgctcca gccccggtac tactcagtca gctcggcacc 18721 cagcacccac ccaggagaga tccacctcac tgtagctgtg ctggcataca ggactcaggg 18781 tgaggcaaca agcaggagca ggcctggcca cagcagggtt gggaccggcc cctctctggc 18841 ccctcaccgg cctctccttc ccacccccag atgggctggg ccccctgcac tatggagtct 18901 gctccacgtg gctaagccag ctcaagcccg gagaccctgt gccctgcttc atccgggggt 18961 aagtgagatg gaggacttgg tggggagctg cccagggtca gggtggcagc tttggtgagg 19021 agtgtcactg gtgaggggtg tcactggaaa caggaaggag ctctgtaaca tgtcaagggt 19081 gtggtgtcat taggtcactt cagaactctg gctaagcttt ggctctctca ttcatttaga 19141 ctcagagttc tgccctgaaa ctatagctcc cagagccaga gctggtatca aaccggctgg 19201 ccctgtggct ttctgaaagc ttctgtgttc ctctctatgt ccctgggctg tctgatgttg 19261 ggcagcatgg cacctgggaa ctacagtcac taaatcctca ctcaatccag ggagaactac 19321 tagttagggt taagaccacc ctttggcctt ggtgtcacca aggactcaaa gaaggtgaag 19381 gttttggttt ttttttcccc cagagatgga gtcttgctct gtcgcccagg ctggagtgca 19441 gtggtacgat ctcggcttac tgcaacctcc gcctcccggg ttcaagagat tctcctatgg 19501 cgtgaacctg ggaggtggag cttgcagtga gccaagattg tcccactgca ctccagcctg 19561 ggcgacagag ccagactctg tctcaaaaaa aaaaaaaaaa tattctcctg tctcagcctc 19621 ctgagtagct gggattacag gcacccacca ccacgcccag ctaatttttg tatttttagt 19681 agagacggtg tttcactatg ttggccaggc tggtctcgag ctcctgacct cacaatcctc 19741 ccacctccgc ctcccaaagt cttgggatta caggtgtgag ccaccgcgcc cggaccgagg 19801 gtgaaggatt ttaagagacc cttccttcat gctgtgtcca gaagtcttgc ccgctctcgc 19861 agccaggaac caaaagtcct ggtaggactg agaacagttc ctaggctgcc atcagctggg 19921 cctggtgatt caaatccacc caggtggcta aactacaaat aaaccgtacc catctactga 19981 acataaacta aataccacta ttaaggatac ttaaaataaa cacacttagt gaacccatta 20041 tgaactgaaa gtgtctttca cccttcccac gttttctaaa tcccctgagt catctaagta 20101 ttcttcaatc caaaatgaac tatatttcct ttggtgcaat ctccagaaac cacagatcca 20161 aggagtttca gcaagtagag ttgttttttg ttttttgttt tttttttaat ttttttttga 20221 gatgggaaga acttgggtcc tccttgctcc acccaccctg catggtgaga atggtggagc 20281 aggaaaggca aaggggacct gatggagtgt ctctcctgcc agggctccct ccttccggct 20341 gccacccgat cccagcttgc cctgcatcct ggtgggtcca ggcactggca ttgccccctt 20401 ccggggattc tggcaggagc ggctgcatga cattgagagc aaaggtgagg ctggtgacta 20461 aaggactgcc tgaagggagt cacacaatct agggacagag gggtggggct ggaaggcagg 20521 aaataggaaa gagagggcag gaaacaaagt ccacaaagct gaaaagacgc tcatgagacc 20581 aaggggaggg caggtaccaa aggcaagggc tgggccctga gcttctggct tcctggtgcc 20641 tggtacatag taggtgttga ctggattgag gacaaaggaa aatagaattt tcaaagggat 20701 tagggctaag actcaaagaa gaactgccca aggtggattc ttgactgtgc cagagctgac 20761 cgaggtctgt ccaagaccta aggatgctac aaggtgttca tattgagcat ggggtgccca 20821 gggtggtctg tcaatcaaaa gaagagggct gtgactggga ggagagttat aagtatggga 20881 gaatatgaag tgggagcggg gaaggggact gcgatgtcac acaatgcaaa gggcatggaa 20941 ttctgagtcc gaagccgcgc attctagcgc actccaccag gggccaccac ctcacccgcg 21001 cttcccttcc ctctgtaaat cagggctgtg cagggtctct gtgaaagcat tctacactct 21061 cttagagatg aaacagccaa agtaatggtg gtttcagccc aaaacgctgg gctgccaggc 21121 tgggcgacgg tggcctgtgg ggaggcccca ctagcactgt gccccggaga agagccttcc 21181 caagcgcggg gttgcttgca gggctgcagc ccactcccat gactttggtg ttcggctgcc 21241 gatgctccca acttgaccat ctctaccgcg acgaggtgca gaacgcccag cagcgcgggg 21301 tgtttggccg agtcctcacc gccttctccc gggaacctga caaccccaag gtgtgagacc 21361 ctgagggcgc aatggtaacc tgaagatagg gagagagggg aggactcgcg ctctccagcg 21421 gggcacacca accacggccc tcccgtggcc tcccacgacc actcagccac ccctgcacac 21481 tctggcccac ccttgtgccc cggcccctct aggccccgcc tcctcccgcc cctgccccgc 21541 ccctttggct ctgccctgtt gacaacgccc cagggcacgc aggccccacc aggcccgctc 21601 cggagaattt caaggtccag ggccagccag cagccccggg ctgcccccgc gcccaccccc 21661 accagggccc gccctaaccc cgccgccccg cagacctacg tgcaggacat cctgaggacg 21721 gagctggctg cggaggtgca ccgcgtgctg tgcctcgagc ggggccacat gtttgtctgc 21781 ggcgatgtta ccatggcaac caacgtcctg cagaccgtgc agcgcatcct ggcgacggag 21841 ggcgacatgg agctggacga ggccggcgac gtcatcggcg tgctgcgggt gcggaggggc 21901 gggccgggcc tgagcgtgcg gggttcctgc taaggtctcc gagtcgggtt ctgatccact 21961 gtgctctttt ccgacaggat cagcaacgct accacgaaga cattttcggg ctcacgctgc 22021 gcacccagga ggtgacaagc cgcatacgca cccagagctt ttccttgcag gagcgtcagt 22081 tgcggggcgc agtgccctgg gcgttcgacc ctcccggctc agacaccaac agcccctgag 22141 agccgcctgg ctttcccttc cagttccggg agagcggctg cccgactcag gtccgcccga 22201 ccaggatcag ccccgctcct cccctcttga ggtggtgcct tctcacatct gtccagaggc 22261 tgcaaggatt cagcattatt cctccaggaa ggagcaaaac gcctcttttc cctctctagg 22321 cctgttgcct cgggcctggg tccgccttaa tctggaaggc ccctcccagc agcggtaccc 22381 cagggcctac tgccacccgc ttcctgtttc ttagtcgaat gttagattcc tcttgcctct 22441 ctcaggagta tcttacctgt aaagtctaat ctctaaatca agtatttatt attgaagatt 22501 taccataagg gactgtgcca gatgttagga gaactactaa agtgcctacc ccagctcatg 22561 tggattacag tttttttttt ttgttttttt ttttttgaaa cggagtctcc ctctgccgcc 22621 cgggctggag tgcagtggcg tgatctcagc tcactgcaac ctccacccca caagttcaag 22681 tgattctcct gcctcagcct cccaagtagt tgggattaca ggtgcctgcc accgcgcccg 22741 gctaggtttt gtatttttag taaagacggg gtttcaccat cttggccagg ctggtcttga 22801 actcctgacc tcgtgatcca accgcctcag cctcccaaag tgctgggatt acaggtgtga 22861 gctactgcac ccggcgtgga ttacaattat aaaatgacaa gatttctgtt ttaacctgtg 22921 cagttgtggg tatgtggtgg ggaaaggggt cattctttta acagagtcct acacgccact 22981 tgaccctgca ctctgaaaac atggtttcca gccagtctgg gctgctcccc cgtgcagttc 23041 tcaggctcgt aatcgagaag gcaggtgcag cactcagctg ccaggagtgg ggcctgccag 23101 aaacaagagt cacagagatg tgcaacagcc atgagcaagc tt //