LOCUS HUMFIXG 38059 bp ds-DNA PRI 08-NOV-1994 DEFINITION Human factor IX gene, complete cds. ACCESSION K02402 KEYWORDS Alu repeat; Christmas factor; KpnI repetitive sequence; antihemophilic factor B; factor IX; repeat region; simple repetitive sequence. SOURCE Human: genomic DNA library of Maniatis et al., clones FIX-lambda-[6,36,53,61]; fibroblast cell (49,XXXXX) DNA, clone FIX-lambda-4243. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 38059) AUTHORS Yoshitake,S., Schach,B.G., Foster,D.C., Davie,E.W. and Kurachi,K. TITLE Nucleotide sequence of the gene for human factor IX (antihemophilic factor B) JOURNAL Biochemistry 24 (14), 3736-3750 (1985) MEDLINE 86000558 REFERENCE 2 (bases 23487 to 23556) AUTHORS Rees,D.J., Rizza,C.R. and Brownlee,G.G. TITLE Haemophilia B caused by a point mutation in a donor splice junction of the human factor IX gene JOURNAL Nature 316 (6029), 643-645 (1985) MEDLINE 85296286 REFERENCE 3 (bases 23378 to 23387) AUTHORS Graham,J.B., Lubahn,D.B., Lord,S.T., Kirshtein,J., Nilsson,I.M., Wallmark,A., Ljung,R., Frazier,L.D., Ware,J.L., Lin,S.W., Stafford,D.W. and Bosco,J. TITLE The Malmo polymorphism of coagulation factor IX, an immunologic polymorphism due to dimorphism of residue 148 that is in linkage disequilibrium with two other F.IX polymorphisms JOURNAL Am. J. Hum. Genet. 42 (4), 573-580 (1988) MEDLINE 88161064 COMMENT Sequence for [1] kindly submitted on floppy by K.Kurachi, 05-AUG-1985. [1] notes a potential TATA box (2939-2942) and polyadenylation signal (35701-35706); and notes two start codons (downstream of the start codon annotated below) that may be alternative and/or preferred starts for the factor IX prepropeptide. Several tracts of simple repetitive sequence are present [1], including regions with the potential for hairpin and/or Z-DNA formation. [1] describes six long open reading frames in the intron and on the complementary strand. NCBI gi: 182612 FEATURES Location/Qualifiers source 1..38059 /organism="Homo sapiens" repeat_region 1..2596 /note="KpnI repeat copy 1" prim_transcript 2966..35722 /note="FIX mRNA" CDS join(2995..3082,9291..9454,9643..9667,13357..13470, 20634..20762,23328..23530,33004..33118,33787..34334) /note="factor IX prepropeptide; NCBI gi: 182613" /codon_start=1 /translation="MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRP KRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPC LNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEG YRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAEAVFPDVDYVNSTEAETILDNITQST QSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT VVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPI CIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYN NMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRY VNWIKEKTKLT" sig_peptide 2995..3082 /codon_start=1 exon <2995..3082 /gene="F9" /map="Xq26.3-q27.1" /note="factor IX prepropeptide; G00-119-900" /number=1 sig_peptide join(2995..3082,9291..9340) /note="factor IX signal peptide" /codon_start=1 intron 3083..9290 /note="FIX cds intron A" repeat_region 7298..7593 /note="Alu repeat copy 1" allele 8469..8520 /note="t...50 bp...a in FIX-lambda-4243; ta in FIX-lambda-[36,61] [1]" exon 9291..9454 /number=2 sig_peptide 9291..9340 /codon_start=1 mat_peptide join(9341..9454,9643..9667,13357..13470,20634..20762, 23328..23530,33004..33118,33787..34331,9341..9454) /note="factor IX" /codon_start=1 mat_peptide 9341..9454 /note="factor IX-a light chain" /codon_start=1 mat_peptide 9341..9454 /codon_start=1 intron 9455..9642 /note="FIX cds intron B" mat_peptide join(9643..9667,13357..13470,20634..20762,23328..23380, 23487..23530,33004..33118,33787..34331) /note="factor IX-a light chain" /codon_start=1 mat_peptide 9643..9667 /codon_start=1 exon 9643..9667 /number=3 intron 9668..13356 /note="FIX cds intron C" allele 10041 /note="g in one allele; c in another allele (loss of XmnI recognition pattern)" mat_peptide 13357..13470 /codon_start=1 exon 13357..13470 /number=4 intron 13471..20633 /note="FIX cds intron D" allele 14076..14079 /note="tcga in one allele; nnnn in another allele (loss of TaqI site)" repeat_region 18165..20265 /note="KpnI repeat copy 2" mat_peptide 20634..20762 /codon_start=1 exon 20634..20762 /number=5 intron 20763..23327 /note="FIX cds intron E" mat_peptide 23328..23530 /codon_start=1 exon 23328..23530 /number=6 mat_peptide 23328..23380 /codon_start=1 mutation 23387 /note="g in [1]; a in [3] Ala->Thr" allele 23387 /note="g in one allele; a in another allele" mat_peptide 23487..23530 /note="factor IX-a heavy chain" /codon_start=1 intron 23531..33003 /note="FIX cds intron F" mutation 23531 /note="g in [1]; t in [2] (haemophilia patient)" repeat_region 24172..24475 /note="Alu repeat copy 2" repeat_region 25863..26091 /note="Alu repeat copy 3" repeat_region 31537..31809 /note="Alu repeat copy 4" mat_peptide 33004..33118 /note="factor IX-a heavy chain" /codon_start=1 mat_peptide 33004..33118 /codon_start=1 exon 33004..33118 /number=7 intron 33119..33786 /note="FIX cds intron G" exon 33787..>34334 /note="factor IX prepropeptide" /number=8 mat_peptide 33787..34331 /note="factor IX-a heavy chain" /codon_start=1 mat_peptide 33787..34331 /codon_start=1 repeat_region 35948..36262 /note="Alu repeat copy 5" BASE COUNT 12326 a 7397 c 7441 g 10895 t ORIGIN 333 bp upstream of BalI site; chromosome Xq26.3-27.2. 1 gtatatctag aaaaccccat tgtctcattc caaaatcacc ttaagatgga taggcaactt 61 cagcaaagtc tcaggataac aaaatcaatg tgcaaaaatc acaggcattc ttatacacca 121 atagcagaca aacagacagc caaatcatga gtgaactccc attcacaatt gcttcaaaga 181 gaataaaata cctaggaatc ctacttacaa gggatgtgaa ggacctcttc aaggagaact 241 acaaaccact gctcaatgaa ataaaagagg atacaaacaa atggaagaac attacatgct 301 catgggtagg aagaatcaat atcatgaaaa tggccataat gcccaaggta atttatagat 361 tcaatgccat ccccatcaag ctaccaatga ctttcttcac agaattggaa aaaactactt 421 taaagttcat atggaaccaa aaaagagccc gcatcgccaa gtcaatccta agccaaaaga 481 acaaagctgg aggcatcatg ctacctgact tcaaactata ctacaaggct acagtaacca 541 aaacagcatg gtactggtac caaaacagag atacagacca atggaacaga acagagccct 601 cagaaataat gccacatatc tacaactatc tgatctttga aaaacctgac aaaaacaaga 661 aatggggaaa ggaatcccta attaataaat ggtgctggga aaactggcta gccatatgta 721 gaaagctgaa actggatccc ttccttatac cttatacaaa aattaattca agatggatta 781 aagacttcat tgttagacct aaaaccataa aaaccctaga agaaaaccta ggcaatacca 841 ttcaggacat aggcatgggc ttggacttca tgtctaaaac accaaaagca atggcaacaa 901 aagccaaaat tgacaaatgg gatcaaatga aactaaagag cttctgcaca gcaaaagaaa 961 ctaccatcag agtgaacagg caacctaaag aatgggagaa aatttttgca atctactcat 1021 ctgtccaagg gctaatatct agaatctaaa atgaactcaa acaaatttac agaaaaaaac 1081 aaacaacccc atcaacaagt gggtgaagga tatgaacaga cacttctcaa aagaagacat 1141 ttatgcagcc aacagacaca tgaaaaaatg ctcagcatca ccggccatca gagaaatgca 1201 aatcaaaacc acaatgagat accatctcac acaagttaga atggcgatca tcaaaaactc 1261 aggaagcaac aggtgctgga gaggatgtgg agaaatagga acactttgac actgttggtg 1321 ggactgtaaa ctagttcaac cattgtggaa gtcagtgtgg cgattcctca gggatctaga 1381 cctagaaata ccatctgacc cagccatccc attattgggt atataccaaa gtattataaa 1441 tcatgctgct ataaagacac atgcacacgt atgtttattg cggcactttt cacaatagca 1501 atgacttgga accaacccaa atgtccaaca atgatagact ggattaagaa aatgtggcac 1561 atatacacct aggaatacta ggcagccata aaaagaaaat gagttcatgt cctttgtagg 1621 gcatggatga agctagaaac catcattctc agcaaactat cgcaaggaca aaaaaccaaa 1681 caccgcatgt tctcactcat aggtgggaac tgaacaatga gaacacttgg acacaggaag 1741 gggaacatca cacaccgggg cctgttgtgg ggtggggggc gaggggaggg atagcattag 1801 gggatatacc taatgctaaa tgacgagtta atgggtacag cacaccaaca tggcacatgt 1861 atacatatgt aacaaacctg ctcgttgtgc acatgtaccc taaaacttaa agtataataa 1921 taaaaaaaag atcattctaa aatttataca agcccttaga acagttaaaa atatcttacc 1981 aaaagaagaa taaagttgga ggaatcactc tacctaatat aaagtcttac tacatagcta 2041 cagtaattat gacagtgtta tattggcaga gggataaata catcaatggc acaaagaata 2101 gatagagaaa ctggaagtag acccaaaaca atatggttaa ctgacttacg aaaaaatttc 2161 agaagccatt cagtcgagga aggatagggt ggtattgttg ttttttgttt taacaaattg 2221 tgctggataa attggacata cctatggaaa aaaaaatgaa gtttgaccta aacatcatac 2281 tttacacaaa tattaactca aaatggagca tgggcataaa tctaaaactt caaactgtaa 2341 aacatttaga aaaaaatagg aaaaaaacta tcaggatcta gtgttagtgg aagagttcta 2401 aatgtgatcc ataaaacaaa aacaaataaa ctggactaca tcaaaactaa aaaattctac 2461 tctgtgaaag acctaattaa gaggacaaaa gacaagctac aggctggaga caatatattt 2521 aatccacgta tctatgaaag gattcatatc tagaatatat aaacaacctt aagaatctga 2581 cagtaaaaaa aaaaaatcag actaactgga ccactcatac attgctgatg gaaatgtaaa 2641 gtggtacagc cattttggta aacatcattg ctctctgaca aagatacggt gggtcccact 2701 gatgaactgt gctgccacag taaatgtagc cactatgcct atctccattc tgaagatgtg 2761 tcacttcctg tttcagactc aaatcagcca cagtggcaga agcccacgaa atcagaggtg 2821 aaatttaata atgaccactg cccattctct tcacttgtcc caagaggcca ttggaaatag 2881 tccaaagacc cattgaggga gatggacatt atttcccaga agtaaataca gctcagcttg 2941 tactttggta caactaatcg accttaccac tttcacaatc tgctagcaaa ggttatgcag 3001 cgcgtgaaca tgatcatggc agaatcacca ggcctcatca ccatctgcct tttaggatat 3061 ctactcagtg ctgaatgtac aggtttgttt ccttttttaa aatacattga gtatgcttgc 3121 cttttagata tagaaatatc tgatgctgtc ttcttcacta aattttgatt acatgatttg 3181 acagcaatat tgaagagtct aacagccagc acgcaggttg gtaagtactg gttctttgtt 3241 agctaggttt tcttcttctt catttttaaa actaaataga tcgacaatgc ttatgatgca 3301 tttatgttta ataaacactg ttcagttcat gatttggtca tgtaattcct gttagaaaac 3361 attcatctcc ttggtttaaa aaaattaaaa gtgggaaaac aaagaaatag cagaatatag 3421 tgaaaaaaaa taaccacatt atttttgttt ggacttacca ctttgaaatc aaaatgggaa 3481 acaaaagcac aaacaatggc cttatttaca caaaaagtct gattttaaga tatatgacat 3541 ttcaaggttt cagaagtatg taatgaggtg tgtctctaat tttttaaatt atatatcttc 3601 aatttaaagt tttagttaaa acataaagat taacctttca ttagcaagct gttagttatc 3661 accaaagctt ttcatggatt aggaaaaaat cattttgtct ctatgtcaaa catcttggag 3721 tttgattatt tggggaaaca caatactcag ttgagttccc taggggagaa aagcaagctt 3781 aagaattgac ataaagagta ggaagttagc taatgcaaca tatatcactt tgttttttca 3841 caactacagt gactttatgt atttcccaga ggaaggcata cagggaagaa attatcccat 3901 ttggacaaac agcatgttct cacaggaagc atttatcaca cttacttgtc aactttctag 3961 aatcaaatct agtagctgac agtaccagga tcaggggtgc caaccctaag cacccccaga 4021 aagctgactg gccctgtggt tcccactcca gacatgatgt cagctgtgaa atcagactga 4081 aatgctgaaa taacgataaa aaaaaataca gaggttaaac tagcaaagtg agtaaagtca 4141 agggataaag aaaatttgtt ggaaaactca caaagcagga cataaagcaa ggccattaga 4201 tatatctcat tagtgtgaca tctgggagga caaagcatcc aaaccctttc ttctatataa 4261 gtggtgagat gatgaaggtt gtaagaggct tctgccccct tgaagacttc agatgctggg 4321 gaaaggatag ataagaataa ggatgaacct ggcttttgga gcctgggaaa taatgactag 4381 cgataaacct gaagggaagt taagtatacg atccccagat aatactaagg agaaaggcaa 4441 tgtgattctg cagccattgt agccagagat aataagccct tgaggaaggg gccaggggaa 4501 tttttctaag gatagacagt attaatgcag cactctcttc tgctattaaa ctctcattgg 4561 cttctaaaag gagtttcggt gagtgatttg ctgagatgtt tgcattttca tgctgctgcc 4621 tttaggttat tattgcaaca gtttggaatt ttgaaattaa aacagttctg taaaaccagt 4681 ttagttttgt aaagtgtatg catcaaagat gtccttcatt cagacattac tgagttacaa 4741 ctacggtgcc aggtactgtg tcagggtact aggggtatgg ggataaacca gactccctct 4801 ttgatctaaa gcagcatgag gccaggtgag aggtttcaat atatgtgata aaatgtgcac 4861 taggtactaa gggatcatag agaaaggaac acattaaatg gggaaacaat tgatagagag 4921 agaatatttt catctgggtc ttaaaagatg agtaggcgtt ctctctcttt aaatgtctga 4981 tataagggca ttttatgcaa agaaggatca ctcgtgcaaa gactcagctt tgcaagaacg 5041 tgaggtattt caggagtttt gtatggttcc atatggacta tgacaagtga gacaggtaaa 5101 ctaggcagag ctggtcatca gataatgaag tcattaacct aaggagattg gacaataaaa 5161 tgcaatatgg aggtatcgaa gtataaacat aaggagtacc actgatggct gatttaggat 5221 gcccagtctg gcaacacgct aatgaaatga tagtggggga gggggccgta ccaagactag 5281 gagagagcag tcctgagact attgcaatta tctgcgggag acataaaggc tagaacctga 5341 acagtagcag tacaaaaaaa gaggggagtt caaatgatat taaggaagta gaagtggtat 5401 gacttaacca tctgggtatg gaaggggaaa tggctagagt cttggggact ttgtgtttga 5461 tgtgattatg gaccacagaa taatgtctaa gagaactggc tctttagtct gactgccaga 5521 gtctgaatcc tgaatgtttt agtatgttac cttgcaaagc ccttagcctc tatgaatcta 5581 tcttcctcat ttataaaaat aagatgacag tgcctatctc gtgggacttt tgtgaggatg 5641 aagtgagata atggatgcaa agttactgag cacagtgtcc aacacagcag aagcattaca 5701 tatacattag ctattactgg ctacattatg atatacagtt agggagttgg aaagataatc 5761 tgaaattcag gagacgtatc tgactatagg tgagtatttg gaactcattg ttctgtaaac 5821 agtagttaca gcacgtgtgt gggcatctgg agagtgagca tggatattgt gatacctagt 5881 acagtgcctg gcagtagtgg ttgtatgctc agtaaatttt gttgacaggg tcagggccgg 5941 actagactgt ggtaagcaag gcctgtaggg cataaatata cttgtatgcc ccgagaagtg 6001 aggacctctt aaatattgtg ccctacatgc cttgtttggt tcactcttgt cccagcccta 6061 gcaagtatat ataaggtgaa aaaggaaaaa gctgaggctg gagcctggga gaaccctgga 6121 catttaaggg ccatggagag gaacaggagt taatcaattc aagtgctgga tggataacag 6181 gagttagagc aaagcgggga accagaatag agtgattatt ataaaaagag tttcctaaaa 6241 agggagagat caacaattag aaattattta gagcagccag taaatacata aactcaaaat 6301 tattctttag gtcattcctg attgtgacaa tagtcatttc attatataaa tgtgattaag 6361 gaaggaaaag agctacacag aagttattaa agagctaaag agaattgaga aatttaaaac 6421 agaagaaagt agggccaaca tgaaaggagt agggagaaaa agagataacc agcatattgt 6481 ctcactgatc ctgccaacac ctgtgagata gatattctta ttatactact gttaaaccta 6541 atttacattt gacaaagtta aggttcagag cttgtgtgac ttgtccaagg tcacaggtct 6601 agaggaggca gatacttgat tcaaacctat ttctgtctga tctgattcta aagtctgttt 6661 tttcactcaa ccacactgta cagtcagctc tccttgtgag ttccacagcc acagattcaa 6721 ttaactgcag atcaaaaata ttcaagaaaa aaatggatgg ttcgatctct actgaacatg 6781 tacagactct tttatctttc attattccct aaacaataca gcataacaac tatttacata 6841 gcatttacat tgtattagct attaagagaa acctagagat gatttaaagt acaaaggagg 6901 atgtgtttag gttatatgca aatagtaagc catttttata tcggagactt gagcatccac 6961 agatcttgat atttgcaggg ggtcttgcca ccaattttcc atggatactg aggaacgact 7021 gtaaatggat gcaggcatgg atgctattta ggagtgtcca gggccaagta aatgagttgc 7081 tgagcagaga ggtgggtgga ggctgtgagg catcaatatg tggtggcatc catctgcatt 7141 ttggtgattt ttttccttca cagtcctcgg ctgtctggga agagaaggat gaaggcagat 7201 ggctgctcca atttaggggc taggattgca gggtgggcac agcattgcaa acgagtgaag 7261 gaaattgaga aatatggcca atgaagagtt gaagagaggc ctggcatggt ggctcacacc 7321 tataatccca gcactttcag aggcccaggc aggcagatca cttgaggtca ggagttcgac 7381 accagcctgg ccaacaaggt gaaatggtga aaccccggct ttactaaaaa tacaaaaatt 7441 agctgggcat ggtggcgggt gcctgtaatc ccagctactt gggaggctga ggcaggagaa 7501 tagcttgaac ctgggagatg gaggttgcag tgagctgaga tcgcaccact gcactccagc 7561 ctgggcgaca gagcaagact ctgtcaaaaa aaaaagagtt gaagagaaaa agtctaggct 7621 aaattcaaag aaaaaaagtg agcccaaaag gaacttgcag agcaagggaa aagcagggat 7681 gtcaagggac tagaacactc cataaagtga acagctgcaa tgaaaataag ggaagaaagt 7741 ttagttcatc tccgtttctt tcctttcctt tttactttcc tttctcttcc tttttggagt 7801 tagtcaggaa gtagtcccaa ataccccaga aagttcatct tataagccct tggtcctctt 7861 gagatggtat cagatatatt gctagaccct tgaagaaagg aacaactcca ggcaacttct 7921 tgagtccctg ttattaattt tatacataca cacacatata tgtatataca tgaaaacaca 7981 caaacacatg tgtgtgtata cagccatgca ttccttaaca atggggatat attctgagaa 8041 atgtgtcatt aagcaatttc atcattgtgc gaacataata gagtgtactt acctaaacct 8101 aaatggtata gcttactaca tacctaggtt gtattgatgt ggcctattgc tcctaggctc 8161 ctgggctgca aacctgtaca gcatgtgact gtactgaaca ctgtaggcaa tggtaacagt 8221 ggtatttgtg tatctaaaca tagaaaaggt acagtgaaaa tacagtatta taaccttatg 8281 ggaccactgt cgtataatgt ggtccatcat tgaccaaaat gtcattgtgc agcaaatgat 8341 tatctcatat atatatatat atgatatgat atatatgata tatatgtgtg tgtatatatg 8401 tatacatata tatgtgtaca tatatgtata catatataca cacacatata tatgtacaca 8461 catatatgta tatatatgta cacacatata tgtatatata tgtacacaca tatatgtata 8521 tatatatgta cacacatata tgtatatata tatgtacaca cacacacata gagagagaga 8581 gagaggagag gagaggaagg agggagggaa ggagaaatat gattcagata gagacatcta 8641 tcctccagag ttcaggagtg tctcttcaga ctaggtagat gtagcttaaa aaaaacatat 8701 cctggaattc tagagagatg cttaaatcac tgcaattcct ataacacttg ccaaccaaag 8761 gtgctgttga tctgaaattg cttttttaaa ttaatgcagt gatttttctt taacatctag 8821 tgacagacac tggggtcaca tttgcagctg gaccataatt aggcttctgt tcttcaggag 8881 acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc agggtgatgg 8941 atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg tgaagttaac 9001 cgctcaattt gagttctttc tttttcatcc aaagtaaatt caaatatgat tagaaatctg 9061 accttttatt actggaattc tcttgactaa aagtaaaatt gaattttaat tcctaaatct 9121 ccatgtgtat acagtactgt gggaacatca cagattttgg ctccatgccc taaagagaaa 9181 ttggctttca gattatttgg attaaaaaca aagactttct taagagatgt aaaattttca 9241 tgatgttttc ttttttgcta aaactaaaga attattcttt tacatttcag tttttcttga 9301 tcatgaaaac gccaacaaaa ttctgaatcg gccaaagagg tataattcag gtaaattgga 9361 agagtttgtt caagggaacc ttgagagaga atgtatggaa gaaaagtgta gttttgaaga 9421 agcacgagaa gtttttgaaa acactgaaag aacagtgagt atttccacat aatacccttc 9481 agatgcagag catagaatag aaaatcttta aaaagacact tctctttaaa attttaaagc 9541 atccatatat atttatgtat gttaaatgtt ataaaagata ggaaatcaat accaaaacac 9601 tttagatatt accgttaatt tgtcttcttt tattctttat agactgaatt ttggaagcag 9661 tatgttggta agcaattcat tttatcctct agctaatata tgaaacatat gagaattatg 9721 tgggtttttt ctctgcataa atagataata tattaaactt tgtcaaaagg actcagaaag 9781 atcagtccaa ccctctaacc catattggat ggtgatatac tacagggtta tgccagtgtg 9841 ggaactatcg ctggtaaata agtttaatcc tccctagggc ttcacaaaga acattgttcc 9901 accccaggag ggtggaagga agaaactgaa atgattgtgt cttagaacct aatgaaagtt 9961 tgcattcctc agtaaaatca gagactgctg attgacttaa atgtttatag cttcaaagtc 10021 ctcctcatta tcatggccca gaagcccttc catgattgtc cttccccacc ctccccatta 10081 cccttcttgc ctcctctgct acttctctcc tcgcacactg ggctccagcc accctggcct 10141 tcctgtcact tcttgcacac tctaggaatg ctcccacttt ggaggcttta tctggctgtt 10201 tctcttattt ggctgttccc aacttcctgt gggctgactc cctcacctcc ttcgggtctt 10261 tgcccaaatg ttaccatctt aatgaggcct accttcacca tctattaata cttcaacctg 10321 ccccagtagc cttaccactc tagacacctg tacagaactc cactctactt tttaacagag 10381 cttttcacca tctaatgtat catataattt cttactcata ctatttatca tttattttct 10441 cctactccac taaaatgcaa gtttcatgtt ggcagggata ttcaattgtt ttgtttattg 10501 atatattcct agcacctaga acagtatctg gaaaagaggt actcagtaaa tatttatcaa 10561 atgaattgac caaaagaagg aaaactcaaa actttaatga caactaactt taaagctaca 10621 ataacttaaa attcagagta ggattttgag ggagggtaag tttcaaagat tgacttacct 10681 aagactatct gcataaataa aaagaaatta atccagacaa caaattcacc aacttccatc 10741 aattggaaat ccaattctat tttctacagt ttatgttctg gagacactac tggacactct 10801 tttactctca taactcataa ctcctccact tttgttttta aatcatgaga gaaaaagagt 10861 tgactctgtt atattgtttt atctaccttt ccttgatctt agaaacgaat actaccatac 10921 cagcttctac tgaggtgccc cctaaagtta gtccaaatag gtctttgcaa tctccattcc 10981 cgcagaattt agaactttga atcacatgat ttatttctaa aagtaaatcc atgccgattt 11041 tccccaccaa aaaattcctg actattaaac tcctacaatc ccttcattgc tcactcccca 11101 cccccaggat catattttaa agttgggccc ttgccttttg ggtcacatag gtacactgtt 11161 tgctatacca caggtatagc tatctggaaa acatggaggg tattattctg ttactactgc 11221 ttcgtcaacc aaaaaataaa acaaaacaag aacaaaaaag aaacaaactc cctgcctctt 11281 ttcacttgca gtcaaggttc ctaaccacta caaaattagc ctatgtttct tcttgcacat 11341 agtagaaacc caagcttctc actgctgtgc tattctgtac catcaactca tcacataaag 11401 agcctggttg aagaatgatt gtccaaccac attactagca tctgtcaaga ctttccagtt 11461 tacaaaaggc ctatcacatt taaccctcac accatccttg tgaccaaagc attattaact 11521 ccattttaca ggagagtaaa ctgaagctta gggaagttaa aagaactgcc aaaggtctcc 11581 cagttgggga gtcatgaagc ccagaagaga agccaaattc tctgctgctc aaccccttgc 11641 tttcactatt acacctcagg gccttcaaat ctaaatgcag ttattcatta aacaggaacc 11701 tggtagtctt aaacaggaat ctctcacttg gtaagatctt gtctcttgtt gtatttgacc 11761 ccaactgtct atggctttgc ctgaacccaa agtacacaca gcctagaaac caaaggagaa 11821 ccaaatgtgg gataaaatga cactcatttt aacgacatgt ctcagcaaat gagttcctgt 11881 gtagctggct gaaagcccag accctttcag taaaacatcc tgaataattc acatttgttg 11941 gtctataata taaagggcaa atgtagctca tttttagacc agttctgaac atcaatagta 12001 acaaaccaga gataaccgat tttgttttca tagaattgga acaaattaga gtatctgtgc 12061 aaaagcatat cagatctagg agcagagggg acaaggtcta atttttaaat aagcaaattt 12121 tccagggagg gactacttat gataaaggga tattagtctc ttagtcaacg gaacctggat 12181 acacgcttct gacagagaag agggagaata ggcaggaatc tacacaccag atgtcaagga 12241 gatttgcttt aaaatacgac tgataattag aaatttctca gtttccccct tttccctcat 12301 tctttgattc ttattgttat ctttatctct tactcctttg tttctcatat attgagtctt 12361 acagatcaag ctcccatttt tttcttcagg ggtatttttc tagttcaaag tgcctaccat 12421 ctcccttctg gttctattca tccttctctc ccaaagctcc tttagaagtg tggattaagg 12481 cagagcacta agaaaccaga cttaaagatt cccttctcat tctgactttt ctcctttcac 12541 ctattccttc ctcctgtttt cttaccatca gtgtcttcaa aggctttcaa gtacacggta 12601 aatgcagaaa cttcaagaaa ggcagaatgg aaacataacc aatgcataca taaataaagc 12661 acactgtaga atctttttaa attctgtatg atatatcgaa tgctgtctct cacattacct 12721 agaccatttg aaaccgaatt tgtaaaacat agactatctt taagtagtaa cagatgcttc 12781 tgacatgttt tctattgtct tgaaccatta ctgcatatga tacatcaaag ttaagtgaca 12841 atacaagaaa gcagattcat ttgctccctg cctaggccgt cagttcctaa agtggaaacg 12901 ccatatatta tctagctcag tttgctctac aagacctgca atagagcctt gtgtgacata 12961 gagataatat ttgttgaagc aattaaattt gacttggaat taactctgcc atcattctat 13021 aaggaaggat tgaaaatcct tctcaccctg tgctgatata gtacctttct atacaaaaac 13081 gtccttctcc ctcttccctt ggattgcata aactatgtac atgccttcct caggggcact 13141 tttctaggac agtgtcagcc taaggatctt tgtttgggtg gcttttagaa actcaggaag 13201 acaggagcat catatgccta taggcagctg gcttccaggt cagtagtttt gctctgaccc 13261 taaaatcaga ctcccatccc aatgagtatc tacaggggag gaccgggcat tctaagcagt 13321 ttacgtgcca attcaatttc ttaacctatc tcaaagatgg agatcagtgt gagtccaatc 13381 catgtttaaa tggcggcagt tgcaaggatg acattaattc ctatgaatgt tggtgtccct 13441 ttggatttga aggaaagaac tgtgaattag gtaagtaact attttttgaa tactcatggt 13501 tcaaagtttc cctctgaaac aagttgaaac tggaaaatgc aatattggtg tatcataatt 13561 tttcttaaaa acataccttt gatgcttata aacatttcat ttgtagtgat agttttcagg 13621 atatgagttc aagaagctac attaaaatca ataacaatat ttggtaacta atattaagta 13681 ataatgatgt tccgactcac cttattaatc tttaatacaa ccgtatgtgg ttagtactat 13741 cattatgcgc attctatgca gatgagaaaa ccgcaactcc aacggccaaa aattacagag 13801 gcataaatgg tttagacagg acttaaactt cagtgtgacc aaaacccatg cttctaacta 13861 ctatattcaa aactcagaga aaactgaacc cagaaaattg aaatcatgac taaattgcta 13921 tcaacatagg tgaaagtcaa ttaagtacag aactggagta tgactggcca attatcccat 13981 ataatgggaa ttctccacat gtacaaacca cttcatatgc taaacttgtt gacaacattc 14041 aaagctcatc cctgaatttg actatattga ttacatcgaa aatgttacat agcaacctta 14101 gaatccttgt gtaccttttc ttctcaaagc ctagattatt tctttttccg acgttttcag 14161 taattggagc agtaaacccc agtgtccctt acctacttgt ttattacctc cagatgcaat 14221 attactggta ctgtgattga gaaacgcaca cagtgctaat gaggaattca ctttctactc 14281 tgacactctg gaagaataga gatgcaatcc taaggaagaa tttaacacca caggctacat 14341 gactaaggat aaagagtaga aaattagcag gactctatta accgattaca gcaatccacc 14401 tgacagatga aaaaggcatg aaatgaaatg aaatgtagca gctacactcg tcctattgag 14461 aaaggaaaaa agtcacctgt aatgttgttc agaaatcctt tcagtactaa aaaattcatt 14521 gaccatcttc ctttagtctc gaaaatttct tagaaggtaa aaaaaggaaa aggtgacagg 14581 gcaaagacat ttgaaaagaa agaaaagagt gaatgaactt gcacacctgg cttggactcc 14641 ccattcccct taggtttcca ttgtggggga caaactaatg cctgggttac ctttcttgag 14701 agtgtgttaa ttgattcaat atctctgaag tgctactttc atctgaaagg ttataatttg 14761 aaattcagat ttacctggat aaatttgatc ttgctattat ggaaacctct agaaatcctt 14821 ggagtagtta ctcattatca gcttaaataa tatagccggt ggagctgagg gaatgagtaa 14881 ctcaattagt ctcagttaca actgaagggc acattgttgt aaactataat tgaaaacata 14941 aatatcttta cctagtttaa aaaataaaga tgctttaaaa ggaggaaggg aatagccctg 15001 aggaatgtaa atataagcac aaaacttcta caacagagtt tgctacgtgt gtggctgtgt 15061 tccacccagc aaaaatgcta agtctacaac tgacacaact tggatactct catgttccca 15121 cattttggtt tggtcaaggc tgtgcagttg tactgcaggc caccaccact cctggcctct 15181 acagtatatt gatctgaccc accaatctga tcaaggttta gaaaaatatt ttcagcccag 15241 ttagctcaca aacaaaatga gaattcccac aaattgctct ttatctcaga caacagagga 15301 aagctacagc aaaagcataa acaaattacc atttaagttt gttgcttcaa attaaagact 15361 aattgcaaca gctactagat agcacagttt atggggcatc tcggccccaa gtcttttgtc 15421 ttataaggtc ttgaaaaaaa gaaaggagat tttcatcaat aagagttttt tgttatcttt 15481 ttcccttgtt catcaggccc ttcactgcga gagagaggtg taaacgttca gggcatgcat 15541 tctagttaaa gaatattaat tggctattgg gtccctttgg ttagaataaa gacctctgta 15601 tgatgtccct agctgtacat caaacccaaa tatctctcag ataaatgaag gtctgtaaga 15661 atttggtcat tcctgtctct tctaaagagt aacagaggca ttttcccgca gtaaagtaga 15721 atggaaagaa aacaaaaatc acaagcctat aaacaccttc ttcaattttc ccagcatgtc 15781 acagacacta ctgtcttatt tactacgtat ttctgaggag taaaaaaagg aaatatgttg 15841 agtttagctg aagcacagca tattttgtgg taaacttgtt aaataaaaca tcttttgtcc 15901 aagctttggt tgtcacacaa gtggatatat caggaaatat aaaggcagaa taaactaaag 15961 cagaacatac taacatttgt agtaggcatg aagggaatta gaaagtgttt gtgttaacat 16021 ggagggaggg agaacagatg ctttgagatg ttcttcaaca gatattctag gcactgagac 16081 ccccttcggg accagagaga gcccatatcc accacagtac ctgacacata aatgctcagt 16141 aattgataaa tgagtcccat tctaactgtt ccttagccct gctctatgga actctcccct 16201 gaattccttg tgccattatt ttatttctgg aatcttcagc cttttagctg agggcaaaag 16261 attgctgatt aggaagcaat atttcccacc tcctgcgcaa aacaagccaa agatcaacag 16321 cagcagcaac atactgagcc ctaaagggca atgacaaatg tggagaatga tacagaggtc 16381 tggttacttc ttagccaatg acacagaatc acaattgaga aaacacagag tttattcatt 16441 cccattgtgc atgccctgga caaaccaagc tgcacctttc gtaacttatc acaatctcat 16501 attgacggaa cactttctac aggtaatgtt tgatttggct gaacacttta gcattgcttc 16561 gtagcaacaa aatgatagct agtaacagaa aaagatccag ggatattacc actgttagtg 16621 aggagaaagg ccttttaatt aattaattaa ttaattaata ggaccaagtg ccatcttttt 16681 ggatcatgcc cttagtggat tattggtagc aaaggttaaa gctcaagctg gttcctttgt 16741 ccccctggca acagttgatt tgcctccctt atctcctgaa gtaccgtaag gactaagagc 16801 caattattac atttggctat gctagcatat gtaaaataga gtttaaaagt ttagattcat 16861 cactcaaaaa ttcatattct ccaaaaccat acagtcactc tgttagcctg tgttccccca 16921 gaaaaaaagt cacaagctta ttattaacat gtgcaatcca ggggcaagag aaaggaactg 16981 aagatgaggc agaaaggaaa agaaagccaa taagaggatg agttatcaaa ctactcgttt 17041 cttaacagca actgattgct taacttcctg ggactgtctc caataagtca aattggcctc 17101 aggttagtcc acctgagtgg gaagaagcgg tgaaagaatt tgtctgtcag tatctgtctc 17161 tcattggtta gaagttcgac ttatggggaa ttaactccct cacatttcct agttggatag 17221 cttgggtacc agaggcatat ggcatccatg ctcagcatga acagggaagc ttcaaggcaa 17281 aagacacata gtgcagctat gagccaaggc aattcaagga tacacccata ggaggctggt 17341 tgacatccac ccagagctaa tcaccaccat gctggaaaaa gacacaggtg aagctgagaa 17401 gaatgaaggt ggtgcatagg aggtatctaa tacagtcact cattttcaaa ctttccatgt 17461 tatgattgca ctgaccactg aggatttcta ttgaaagttt tactgttgtc aaacacgtac 17521 acaaggggaa aggtgtctta cattgtttat gttcctgtgc tgctctagaa acagaaatag 17581 gctcaagagc agagcctgtt tttcttaatt cagcaggtct aagctaacaa gtcctgaaac 17641 atggtacttc ctgttattgg tattgcatag gagaaacaaa gggaaagcac agtaattaga 17701 aaatacaaac aagatggcag gaataagcca aaaatatcag gaaacacaat tattgtgaat 17761 tgggattaaa ctaatctatt aataatgaca actttcagct tggagttaaa aatttaattg 17821 tatactgtta acgaaagtga tacctaaaat aaaattacac tgggaggcca aaatgaaggg 17881 atgtgaaaag aactatcagg taaaaactaa caaaaagaaa ctagcaaagc aatcttaata 17941 tcagacaaaa tagaatccaa gaggaaaatc atttcaaaag acaagagatt ttttttatta 18001 ataaggggaa ttgcatagga gagtaaagaa aatgtgggcc actggaatgc ttagcactaa 18061 tgacatattg gtctttggtc ttcagttacc ttacaggacc ctatttcatt ctcttatgtt 18121 tgatatgtaa ccacctcagc cagcttcaag ttgctttttg gccctaatgg acttcctagc 18181 actataattt cttttttttt aaatgtttta ttttaggttt aggggtacat gtgaaggttt 18241 gttacataga taaacatgtg tcacaggggt ttgttgtaca tattattaca tgacgcagat 18301 attcagctca gtaccaaata gtgatctttt ctgctcctct gcctcatccc accctcctcc 18361 ctcaagtaga ctccagtatc tgttgtttcc ttctttgtgt ttataagttc ttaacactta 18421 gctcccgctt acaagtgaga acctgcagta tttgattttt gttcctacgc tagtttccta 18481 aggatgatag cctccagctc cattcatatt cccacaaaag acataatctc cttcttttct 18541 atggctgcat aatattccat ggtatatatg aaccacattt tctttatcca gtctgtcatt 18601 gatgggcatt taggttgatt ccatgtctgc tattctaaca ctgtaatttc taaagacttc 18661 cagattctac ttttataggt aacctgttaa acagtctagc tctggaagcc aagcaatttc 18721 tagaataact aagcaataga aattacactt caatgcagaa aggcagtatc tacatgagat 18781 tatgaaattg cggttgcttt ttgtgttcac tgaaaaaaat aagtaaaact gtaactttca 18841 gaaaaaatga ttgtacatat agaaaaccca aagcatctaa acaattaaaa taaataagta 18901 tagaaagatt actggataca gagtcaacat acaaatatca attgtatgtc tatataccag 18961 caacgattca aaaatgattt ttataatagc attaaaaatt agacgcttag taataaatgt 19021 gagaaagatg tgcaagaact ctacataaaa aattatgaga cgttattgag aaaaattaag 19081 gaaaacctaa ataaatgaat gaataggcaa tgtttatcat taaaggatac aatatagtaa 19141 atatatcaaa tgtttactaa tggattcaat gcaataccaa agtgccagca ggcttttttg 19201 gtggtgggag gtcgggcagg attcataagc taattataaa atgcatatgg aaatgcaaag 19261 agccaaggat agccaagaca gttttgagga agaataaact tgtactactt acactaccag 19321 atgtcaagac ttattatcga gttacattta ttaagacagt gtggtactga cacaaggata 19381 gacaaataga tcagtgaaac acactagagt gctcagaagc acacctgtac atatataaag 19441 gcttgattta tgatagaggt gccagtgcag tagagaagga aattattggt gttttcaata 19501 aaaagtgata ggtcaattag atattcatat ggcatgaagt atgaaacaat aacaatttat 19561 attcataact tgcagaaagc aaaaatttct taaaatacaa aaagtgatca ccataaagga 19621 aaagattgat aaactggact atattaaaac taaggactcc tgttcagcaa aagacactac 19681 ttcgactgaa aagacaagtc acagagtgag acaagatatc tgcaatacag atacctaata 19741 actgaacccc atacagtgat ggtgggaatt taagttcgta caatcatttt agaaaattgc 19801 ttggcagtat ctactagatc tgaacatgtg atccagtaat tacactcata attataagcc 19861 agtaaaaagg catgtttatg tcaccaaaag atatatacaa gaatgttcat tacactatta 19921 tacataagag ccaaaaactg gaaacaaacc aaatatccat taacagtaga atgaataaat 19981 aaaagctgta atagtaatac agtggaatac tacacagcaa tgtaaatgaa ctactgctgt 20041 acaaaacaac atggtttaat ctcacagaca aaatgttaaa tgaaagacac agacgagtac 20101 atattgcgaa cttctgttta taattcaaga actggcaaga actgtttact gtgttagaag 20161 tccaggtaat ggtaacctat aaaaaggaaa aagggtggaa tgattgggag ggggcatctt 20221 ctggggtctt gataatgtgc tatgtattgg tcagtttagt gtttaaacag gctcatttac 20281 tttgtgaaaa cttacactaa aattgtgtgt attttttgaa tatatgttat acattaataa 20341 atagggtttt taaacctgta gttcataatt tagtgaaagt agaatatcca aacatttagt 20401 tttaaaccaa tcaattatag tgctaccatc atttttatgc attattgaga agtttatttt 20461 acctttcttt ccactcttat ttcaaggctc caaaatttct ctccccaacg tatattgggg 20521 gcaacatgaa tgcccccaat gtatatttga cccatacatg agtcagtagt tccatgtact 20581 ttttagaaat gcatgttaaa tgatgctgtt actgtctatt ttgcttcttt tagatgtaac 20641 atgtaacatt aagaatggca gatgcgagca gttttgtaaa aatagtgctg ataacaaggt 20701 ggtttgctcc tgtactgagg gatatcgact tgcagaaaac cagaagtcct gtgaaccagc 20761 aggtcataat ctgaataaga ttttttaaag aaaatctgta tctgaaactt cagcatttta 20821 acaaacctac ataattttaa ttcctacttg aatctgcttc cttttgaaat catagaaaat 20881 atcagtagct tgaattagac caattaattt tctagattgc atcatatttt aaatataact 20941 atgtaatcat ctacaacctg aattctttct gtgtccaatt tgtccaattt ttttctctaa 21001 catttatatc acaaagcaat taatttgtgt gatttctgca tatgtatttg taattcatca 21061 agtcaaatca atgtagtaat actatatcat aaaatataca caaataattg agtgataggc 21121 ttctagtata aggacggtaa gtttgaagca tgattctatc tgggctggct agtttactct 21181 gagaaagtta ttttttattg ttgggtctta agctgagttt acacacttgg tgtcagaatg 21241 attccggcaa tgaactgttt tatgttctgc taggctgatc agcacaatct atatggctgt 21301 gaacaaaaca atgtttccca gtcataccaa ccatgccacc attttaacag ctgattagtg 21361 tattcagaac atctccactc catgttcgta tggctgttat ctaaagatga aagcagtaga 21421 cacttttatt ttttgaaaaa tttaggctct gcagggtcaa ttatatttga taaatgaggg 21481 gcttttttga agcaaactag atataatttc ttttgcattt ctaaagcctg atatcttatt 21541 aattggtaca ttaaattgtg caccatttct ctgtaactgt ttcagtacct gtctcagcac 21601 tataccaggc agaagaaata aagaaagaac cagtgccaga tcagcttggt caggagaccc 21661 taatcctgcg gcactagagg aattaaagac acacacacag aaatatagag tatggagtgg 21721 gaaatcaggg gtctcacagc cttcagagct gagagccccg aacagagatt tacccacata 21781 tttattgaca gcaagccagt cataagattt actgaaagta ttccttatgg gaaataaagg 21841 gatgagtctg gctagttatc tgcagcagga acatgtcctt aaggcacaaa tcacttatgc 21901 aattgtctgt ggtttaagaa cacctttaag cagttttccg ccctgggtgg gccaggtgtt 21961 ccttgccctc attctggtaa acccacaacc ttccagtgtg gatatcaagg ccatcacgag 22021 catatcacag tgctgcagag attttgttta tggccagttt tggggccagt ttatggccag 22081 atttggaggc ctgttcccaa caaaccagaa gctaggaata tatatcctgc aaataaaatg 22141 aagaatctct aaggcttcag ggcctgccca cttgttcttc tgcctggttc ttcacataca 22201 ctgtctcaaa gctagtctac cttgagagga gcatgaatat gtgtgtgggt gtgtgtctgt 22261 gtattttaac cttaaaaacc taacttccag tatagacaga tggcatacta gctaaaccct 22321 tacaagttct tctatgctat aaaagagaaa cagaattgag aaccacctcc aactattaag 22381 tgttatattt gaatatagcc ttagctttag cagaataagt aggccaaact taaaataagc 22441 ttttctgcct tttcaatgat aaaggtccct tttctgtagc cattgttgat tgtgtacact 22501 tatacataag tattttgaac taatttcctg ttttctcaac cacttgctgt cttcatgata 22561 ctttgtcgca gctggttgct atagaaatgt ctgttacaag gaatgtggct tgaaggaaag 22621 tgataaatga aaatgaaatg tgaagtgact ttgtttgact acaaattccc attctggtag 22681 tccccagtgt atcaatacat tatttttctt tagaaaataa accaacccaa ggaaaaatgg 22741 tgggcaggtc ctggtgaata tggctgtgat aattatatta gcaatctctt tggctaatat 22801 ttgaagccca aataattgaa tcacaatgat ctctccccag aaaatatata aaatgcacct 22861 tggaatctag aaggcctttt agtctgcaaa agaaaccttc ttaatcataa gcagcagaag 22921 tcccatttac caaattggaa agttaaagtt acaaagcatc aatcatcaga cttccattca 22981 gggatggcaa ttgggagtaa gactttttag taaagaaact aaacacaaag tcattagact 23041 ctgtaaaagt cttaccaaat ttgattctgg aacacctatt ctatttccgt aaagatgatg 23101 aattcggagc caaatgttct tttcatgaag gatttgaaaa ctgtccatga aaataacgca 23161 atcaaccttt tagcttgaga ctctattcac tgattagatt tttttaaata ctgatgggcc 23221 tgcttctcag aagtgacaag gatgggcctc aatctcaatt tttgtaatac atgttccatt 23281 tgccaatgag aaatatcagg ttactaattt ttcttctatt tttctagtgc catttccatg 23341 tggaagagtt tctgtttcac aaacttctaa gctcacccgt gctgaggctg tttttcctga 23401 tgtggactat gtaaattcta ctgaagctga aaccattttg gataacatca ctcaaagcac 23461 ccaatcattt aatgacttca ctcgggttgt tggtggagaa gatgccaaac caggtcaatt 23521 cccttggcag gtactttata ctgatggtgt gtcaaaactg gagctcagct ggcaagacac 23581 aggccaggtg ggagactgag gctattttac tagacagacc tattgggatg tgagaagtat 23641 ttaggcaagt ttcagcacta accaatgtga gaaggcctcc agagatgagc agttggtgaa 23701 agagaggctc aaaaccagct accatacagg tcaagaagaa tttggcatta aggaaacagc 23761 atagcaggat tccagacagg caactggtca acaacatgaa ggtctggaag aaaggtcgca 23821 gtactcaggt tcagggcact acttcagctt cagcccttgc aaaaactggt gagagttgga 23881 aagtctttag gctaagaaaa attggattat ttaaaagggg taaagaaagg gactcaagga 23941 ggaaggatta aggcaagaac taggttccaa gaaacagggc atgagagaga gtcttgatct 24001 accactatag ttctcgtggt agcatcagaa tcacctggga acgtagaaat gcaaattctc 24061 ctgctctaca ctagacctac caaatcagaa tatctagggg gtggggccca gcagtctgtg 24121 cgcaaacaag cactgcaggt gattttgatg cacattatag tttgaaaact aggccaggtg 24181 cagtggctca tgccaataat cccagcactt tgggagactg agacgggagg attgcttaaa 24241 cccaggagtt tgagaccagc ctgggcaaca cggcgaaacc ccacctctaa ttaaaaaaaa 24301 tacaaaaatt agctaggtgt gatggctccc acctgtgctc ccagctattc aggaggctga 24361 ggtgggagaa tcacctgagc ctggaaagtc gaggctgcag tgaattgtga tcacaccact 24421 gcacttcagc ctgagtgaca gagtaagacc ctatctcaaa aaacagaaaa agaaaaacac 24481 tggcccaaag gaaatgaact tgttacagaa gccggggttc aaaacaccaa ataatgcact 24541 tgtacctagt ccttcccggg tgctctgcag acatttctcc aagcgtagtc tgcaaacaac 24601 ctacatatgt agaattacct atgcacattt ttcatttaac aaccaagagc tacatttgta 24661 gcaaaatctg ggttgtaact tagcctacag ctgaagccta agagattccg tctgtgagaa 24721 gaaataaccc acctctttgg cccccctccc caggcaggaa gccaggatgg tccttatata 24781 aagttgtgct gtccaatagg taaccactag ccacatatgg ctatttaaat ttaaattaac 24841 tacaattaag agaaattaaa aattcaattc ctcaattgca cctgccaaat tttaagcaca 24901 taacaaccac atgtggctag taactactgt attggagagt gcaagcggag atagaacact 24961 ctattactgc agaaatttct attggatagc acttataata gtttagtgta acttaaaact 25021 ccctagttgc cacagtcatg atttagtagt aatttcatgg atttctctac tgaggttaga 25081 atctctgcca ttagagactg ataaatttaa agtttgcaat tatcaaactg gtgacaattt 25141 aagccagaat caggtaatgt cctcagtttt aacagcattg gaattttctg ggactagctg 25201 tgtatctatc caggattctt gagaatgcct gccatttttc aacataatgg atgtaaggta 25261 ttacacatat acctggggat ggggaggtag gtataattgc acaagcattg tggagaatgg 25321 tatcaaagag tggcagaaca tcacaatcaa ggttttccct ttcttttacc tttgcttttt 25381 aaaaagacaa tatttgctgg acctgatctt ataactcata aatgggacac tgtatgttcc 25441 tttttacctc ctctgtttct acttaattgc accctatgag gactgcttcc cttacctacc 25501 ataacccctt ccttcactca tccatatctt tactcttctt cacaactctg taatattgac 25561 cttctttatg aacctttcct ggaacaatcc ctcttaatgc aagcactgtt attatgcctt 25621 caatgtattt aatatccatg tatctattct ctctaatttt gtcattttgt gttctcatgt 25681 attttcattc attatgtgtc caacttccat ggataacatg gttacaacaa aagatcctac 25741 tttatgacaa ttatcttcct tgggtttgtg ggacatagaa cagtgcacag agtaggggat 25801 ccaagaaccc aggagaatat attagctaag aagataactt ccgtttttaa aagtccaaga 25861 ttcaggagat caaaaccatc ctggctaaca tagtgaaacc ccgtctcttc caaaaataca 25921 aaaaattagc ccggcgtggt ggcaggcgcc tatagtccca gctacacggg aggctgaggc 25981 aggagaatgg cgtgaaccgg ggaggcggag ctggcagtga gccgagatcc cgccactgca 26041 ctccagcctg ggcgacagag cgagactccg tctcaaaaaa aaaaaaaaaa aaaaagtcca 26101 agattttaaa aaaaaaaaaa aaaaggatgt ctgctttgtg agtttagcat tgtctccttg 26161 tcattccaga aatgaaatgg caaatacatt taaatcagaa ctaaaaaggg gaacagggta 26221 taaaggctca atttagtcac atcatttccg tttctcaccc acccccttta aaccagatgt 26281 ttgccaatgc attaacaatg cagatgtttc ctgaaagaaa gtttagtaac tcaagcagac 26341 accttatttt cttttcaagc agaaaagact atgagatggt ggttgtggtt gttccgggag 26401 ggagaagata taaatgatac acattatttc aaatcatttc atgacctcac tgcacactta 26461 tagttattgt acctgttgtc tttttgctgt caagcctagc taagatcatt tggaatgttc 26521 aagatcactc atacatgcat gtgcacacat acacatgcac atatgttcac tccctatttc 26581 atccacatga actaagatta ctgatgtgta cagattcaaa gcacttttat tcttttccaa 26641 aggcaagaag ctgagctact ttccagaata gttgtgaaag accctgtcat acttctgcat 26701 tgtttcctcc acaccacctc catccagttc cttatgaatg gttactggtt ttcaaaaata 26761 tgagataaat tgagtgtata aaagtcattt ttagacaaaa tgaaacagga aatgaaagaa 26821 accagaatct ctcctcattt gtggatgggc cagctccacc atgtcatggt taatctgcag 26881 ggaggaaata ctagatttga ttgcagatca gactgcagca aacctgctgt gactaaggca 26941 tcaagagaaa gcaagcaaca gactggggct tcagtggtga aaacattata tatctagctt 27001 tgaaatatga aatactgttt agcagtgtca cctagaaaag agtgtttcaa aatgctgatg 27061 cttcataaga acctttctct tcagagttgg tttcttttat ctttcaaatt agccagggtg 27121 ggaaataaag tgatcacttg gtgaagaaat ctcacaaaga agaacataga gagttcactt 27181 tcatctggag taatgaacag attgaacaaa ctagaaatgg ttagtctgtt aaagaaaagg 27241 tgtaggtgag ctgtttgcaa gagccacaag ggaaagggga agacaacttc tttgtggact 27301 taagggtgaa agttgcaagc aggcaagacg attctgacct ccattaagaa agcccaaacc 27361 aaccaacaac cactgggttg gttacgcagg ttgggcagca ttgggagcaa atgttgattg 27421 aacaaatgtt tgtcggaatt gttgacttaa agagctgttc tgtcactggg gacagcagcg 27481 gctagatagc cccattcagg gagagggcat ttgttcacct ggccagagat cagagcaggc 27541 taagggactg ctgggatcct gtccagcttt gagaccctac agagccatgt tcacctagca 27601 cgtatcccgt ctgcggtcac ggtcatttct taccttattc cagggctttc acctcagctt 27661 gccaggctgg agccaagggc caacgcagcc gcgccttgtt cgcgatggta gcttcccagg 27721 agccccctat ggttccggaa cgcgctgccg gccccatcct gtttgctacc tcctaaagcc 27781 aaaggcactg gcgggccggg ccagcttcta aagtcgcgca aggttagaag gttccggaca 27841 ggaacggcgt gaggccaatg gaaggaggta cttcagtttc cctccagatg cccagcgatg 27901 ggctcagagc tccttgagaa ctcgggaaag gaagcagggt ctctgaagaa atacttcagg 27961 agtagaaaga ggaagctaga gggttaaatg cactacacag gaacagaaat gagtttttct 28021 tagagttagt atatgtctag aggtgtagta aactaaaaca agtcttgaat tgcataccgc 28081 cacgtaggga agaaatgaaa acctttgaat attagtgaaa aaagggaaac tgcaacgcct 28141 gtattactag atagctttca tcaacagctc aaaaccgaca gatttaaaga agcaacaccg 28201 cattttggct ttctaaagct ttaatttggt ttggatccca tgcccatgac cctgccagct 28261 gacaattcta agcatgcgca aactggcccc aaaaattcct cccacatttc cgaagaacta 28321 tttggccctt tatgtgaagt acctggtttt tccattttct gttttaccat aggcctcagt 28381 tcggtgtgtg gcgtatttat tctacattta acaatttgaa gatcattcta ttagattaaa 28441 aaaaaagaat acaatggaag ccaagtgatt aagctttcct tatgcttata ttaagttgta 28501 gcatatgcat ttaccgatag ttaaccgtat taacctacag aaaatgtcca gggaaatggt 28561 ctatttctta ttctattttt gacctaaaga aaatctttaa aatgtcttag cattttcccc 28621 agtctccatc cacttccctc agctttggcc tgaagctatc tttaaaggta ccctgtacaa 28681 gctcttgccc tgtacagcta gctacagaga ttcaatcctt tctgttcgat taggacacat 28741 ctcagtggca gataacatgc aaagttatta tatgtatgaa ccagaacttg tttttcctta 28801 ggggccagga tgttacacta aggtcttaag actatagtaa tatcttcact tgaaaaagcc 28861 ctctattatt cctatctcag atgataaaaa ttcaattaag agaaataaga acgtgacatg 28921 tgtaatcgca cctggctcta caaagctagt ctggacagac atttaaacaa ttatcctcta 28981 agattatttg atgaaatgca tttcaatgac tagttaacca ttaaaaacca aagtgagcat 29041 cccatctgtt cccagtcaaa tgacctagag caaaggacta ggcaaaccac atctgtgggc 29101 atagcaagct gtacatcaca aacaaatgaa tttgctttgt atatgagtga gagcaaacac 29161 tctttattgt acaacttggg tgggtaagta gggagaataa tggttttact gaaatcgcag 29221 gtaacggtta cgttggagtt aaaggttagg aagaaaacca aagggtaaga gctgttgttc 29281 tgggctggca ttgtcaatga agagcataaa ttcagatgtg aatgtatatt ttgtagaagc 29341 atgtgtgttg ttggtttttg tgtatgtgtg agtctgaaag agggaaaaca ggctcccatt 29401 agactatgac taacaaaaat gtttgacaga ttataactca gatgtcttac tcagagcata 29461 tgccttccca ttttccccat tattccccaa catgatgtct ttaagaactt gtccttgacc 29521 gagcagacat ctcatacccc aaatagctaa tattttgata gctatgatcc tgaacggcca 29581 aacattccaa aaccaagtag tttgtaatat ctttaatgca aatatatttt aggccttttc 29641 cttggcaagg atgtttggtc aggggttggc aaaaataatg ctcttcagac ttaaaagaac 29701 acaaccatat ttcttagcca tccaccagaa agtagtagaa cgctccagga agcaagtctt 29761 tgtcaggagt cagactagct acatcataat ctctctgccc aggggctgtg gatgtcatcc 29821 atcctggcct aactagccta ctgagctgag agatgtccaa tttcccccca atacactaac 29881 cagaggagaa ggaccgtgat atcattgcat gtgaattctt aattccaatt gcttaaacaa 29941 atatgttcag ttgtaactat caataccagt atataacagt gttggccaag ttttattgat 30001 gctgacaatc aattggagtt acagccagac acatggtctt atgaccggcg tacttacgca 30061 gggctttgca ctgagacagg tcgtgcatct gaggtttact gctttgcatt tttgttttgt 30121 aactgaagtc tgatgagaca gccagagcat gtgctaccta gggacttgaa tccctgcagc 30181 cccatttcac ttctcaccac cttccggggt ggtttctcga cctcccactc ccctaccacc 30241 tggtgcctta gccagccctg gctctccctc caaacacctg cccaatgagc actgccaccc 30301 catggtgccc agacatgctc tccctcctca tccctaccta gctaccattg ccactcccct 30361 cccccagcgg ggacatgggc ataggagcag ggagagttaa ggttggtcag gtgcacgtgc 30421 cctatgctat cttggaaggg ggcttggcca tgtggcatct ctggaccaag aatgcgccac 30481 agcacatttg gagggtgaat ggtgggggca caccccttgt ccacctctat ttcaggcatg 30541 gaacacatcc tggcatgaaa gttgcagtcc cttgggaatc acctctccac cttgattgcc 30601 acagtaggcc agtgacaagg gaagattgac acatcatccc tgctggggcc cagtgtcctg 30661 tggctggcag gcaggggatc ctaaggacat gtgggtctta aattgtaggg tgcacttcct 30721 gggcaccttt gagggtctgc actgccccag caaatatccc catgctagaa ggagcaaaat 30781 attaaatggc aaattttaaa aatgtaacaa gatgggttgc aaaagagact acagaggaaa 30841 gcaaaagttt tgtattttag tatcttccat ggcacttttc ttcctagctt ttgaacaagg 30901 ggccccacat ttttatttct cactgagccc cacaaagtat gtagccattc ctgcccggag 30961 tgaggacttt taaaacataa agattatcaa gtcttggaaa ttctgattca gtagatatat 31021 aacaggtctc aaacttaatt atgtaaagaa tattctggag agcttccttt tacccagtcc 31081 cacccaccaa atattctgat aaattaagct tcgattagcc cccagatctg cattttataa 31141 ggatccccag atgattctac tgcaattggt ccacagacca tgcctggacc gaatttgggt 31201 gcttaggagc acaaattctg gagccgggca gacttgagtt tgcttcctag ctttaccaac 31261 tgatctcagg ggagttaatg tttacctcta aactttagct catgcatcta taaataaata 31321 tattaatatc atgtcataag gatattatgt tgtattaaat gtctttaaaa caccacaatg 31381 attagcccaa agtaaacact caataaatgt tcaaaaattt aggaaaattg ttaagactgg 31441 gttgtatgca cactggtgtt tattatatta tgtagttttt tctgtatttt tacaacattt 31501 cagaattaaa agcaacagct agaaaaagag ggaaatggcc gggtgcagtc gtcacgcctg 31561 taatcccagc actttgggag gccaaggcgg gcggatcacg aggtcgagag atcgagacca 31621 tcctggccaa catggtgaaa ccccatctct actaaaaata caaaaattaa ctgggcatgg 31681 tggcatgcgc ctgtagtccc aggagaattg cttgaacctg ggaggcggag gttgcagtga 31741 gccaagatct caccactgct ctccagcctg gtgacagggc aagactccgt caaaaaaaaa 31801 aaagagaggg agagccagag tatgaaaaag gaagtcagag ccctttaatg agtcagcttt 31861 gtaggtctcc aggtaggagg ctagtgcttc agtgtctagg acatagtagg tgttcagtaa 31921 attaaattca ggacaaaaag aacatgcccc aaggaccatc tgatatccac ttaaagtgat 31981 ggactacctc gtttcccttg tttatgaatg ggttcatgcc taagactgtg tgcactttaa 32041 tacaagggca gtcgttcaga actagtcagg tcctgaaaag gatttaccaa atgttgagtg 32101 tgccctctag tgttcacact tcccagcttt cttcctataa aggtggatca aggcacttgc 32161 ttacaactgg aactgaaatc ctccaagtcg atctagacat tgagatggag aaaatattca 32221 ttgtcgactg taattatgca acgaatatcc agttgagata atggacttgc ctcttatcta 32281 ataataccca ggctcaatgc gtcactgctt tgtccacttt gcccaaaatt caagcacagc 32341 taagttgata ttttaggaca aaggcagctt actatccagc cagaggggag tagaatatgg 32401 ttaagagaga gtggaaagaa tgaatgagcc ctgctattcc tcactgcctg gatggctata 32461 agcacagccc ttatggaggc cttaggtctt gcttcacaat attccagttt gaaaagggtt 32521 tgaaaagacc tcctagaaaa atcagtagtt tttctctttt gagtaacatg tagcaaaaaa 32581 aatttcatca tgtaggtaca gggaacaccc tagtaactat taatctcaag gagtcaagcc 32641 agtgtgtttc ctaatgtatc tgctgtatcc ccatgaagca aattttgcca tcagagaaac 32701 tgactcatgg ggaaaaaatc caaggacctc aaatcaccaa aagaagccat tcctcagatt 32761 tgcctaagct taagcttccc tgtctctcat tgtgtgttgc tttcaatgca gttacataaa 32821 tggctttttt gtttatgcac caaaaacact aattcatctg caaagctcac atttccagaa 32881 acattccatt tctgccagca cctagaagcc aatattttgc ctattcctgt aaccagcaca 32941 catatttatt tttttctaga tcaaatgtat tatgcagtaa gagtcttaat tttgttttca 33001 caggttgttt tgaatggtaa agttgatgca ttctgtggag gctctatcgt taatgaaaaa 33061 tggattgtaa ctgctgccca ctgtgttgaa actggtgtta aaattacagt tgtcgcaggt 33121 aaatacacag aaagaataat aatctgcagc accactagct ctttaatatg attggtacac 33181 catattttac taaggtctaa taaaattgtt gttgaataaa ttgggctaaa ggcagaaggg 33241 tcataatttc agaacccacg tcgcaccgtc ctccaagcat ccatagttct tttgatatac 33301 ccctattatc actcatttca gtgaggtaca attagttctt gatgtagcca tttccatacc 33361 agaaggcctt cccaaaaatc agtgtcatgt caccgatcct tttatctctg gtgcttggca 33421 caacctgtag caggtcctca gaaaacaaac atttgaatta atggccaaat gagtttgtgc 33481 tcaaaaaagg ggtgaggata cttgaaattt ggaaaatcta ggataattca tgactagtgg 33541 attcattatc accaatgaaa ggcttataac agcatgagtg aacagaacca tctctatgat 33601 agtcctgaat ggctttttgg tctgaaaaat atgcattggc tctcattaca tttaaccaaa 33661 attatcacaa tataagaatg agatctttaa cattgccaat taggtcagtg gtcccaagta 33721 gtcacttaga aaatctgtgt atgtgaaata ctgtttgtga cttaaaatga aatttatttt 33781 taataggtga acataatatt gaggagacag aacatacaga gcaaaagcga aatgtgattc 33841 gaattattcc tcaccacaac tacaatgcag ctattaataa gtacaaccat gacattgccc 33901 ttctggaact ggacgaaccc ttagtgctaa acagctacgt tacacctatt tgcattgctg 33961 acaaggaata cacgaacatc ttcctcaaat ttggatctgg ctatgtaagt ggctggggaa 34021 gagtcttcca caaagggaga tcagctttag ttcttcagta ccttagagtt ccacttgttg 34081 accgagccac atgtcttcga tctacaaagt tcaccatcta taacaacatg ttctgtgctg 34141 gcttccatga aggaggtaga gattcatgtc aaggagatag tgggggaccc catgttactg 34201 aagtggaagg gaccagtttc ttaactggaa ttattagctg gggtgaagag tgtgcaatga 34261 aaggcaaata tggaatatat accaaggtat cccggtatgt caactggatt aaggaaaaaa 34321 caaagctcac ttaatgaaag atggatttcc aaggttaatt cattggaatt gaaaattaac 34381 agggcctctc actaactaat cactttccca tcttttgtta gatttgaata tatacattct 34441 atgatcattg ctttttctct ttacagggga gaatttcata ttttacctga gcaaattgat 34501 tagaaaatgg aaccactaga ggaatataat gtgttaggaa attacagtca tttctaaggg 34561 cccagccctt gacaaaattg tgaagttaaa ttctccactc tgtccatcag atactatggt 34621 tctccactat ggcaactaac tcactcaatt ttccctcctt agcagcattc catcttcccg 34681 atcttctttg cttctccaac caaaacatca atgtttatta gttctgtata cagtacagga 34741 tctttggtct actctatcac aaggccagta ccacactcat gaagaaagaa cacaggagta 34801 gctgagaggc taaaactcat caaaaacact actccttttc ctctacccta ttcctcaatc 34861 ttttaccttt tccaaatccc aatccccaaa tcagtttttc tctttcttac tccctctctc 34921 ccttttaccc tccatggtcg ttaaaggaga gatggggagc atcattctgt tatacttctg 34981 tacacagtta tacatgtcta tcaaacccag acttgcttcc atagtggaga cttgcttttc 35041 agaacatagg gatgaagtaa ggtgcctgaa aagtttgggg gaaaagtttc tttcagagag 35101 ttaagttatt ttatatatat aatatatata taaaatatat aatatacaat ataaatatat 35161 agtgtgtgtg tgtatgcgtg tgtgtagaca cacacgcata cacacatata atggaagcaa 35221 taagccattc taagagcttg tatggttatg gaggtctgac taggcatgat ttcacgaagg 35281 caagattggc atatcattgt aactaaaaaa gctgacattg acccagacat attgtactct 35341 ttctaaaaat aataataata atgctaacag aaagaagaga accgttcgtt tgcaatctac 35401 agctagtaga gactttgagg aagaattcaa cagtgtgtct tcagcagtgt tcagagccaa 35461 gcaagaagtt gaagttgcct agaccagagg acataagtat catgtctcct ttaactagca 35521 taccccgaag tggagaaggg tgcagcaggc tcaaaggcat aagtcattcc aatcagccaa 35581 ctaagttgtc cttttctggt ttcgtgttca ccatggaaca ttttgattat agttaatcct 35641 tctatcttga atcttctaga gagttgctga ccaactgacg tatgtttccc tttgtgaatt 35701 aataaactgg tgttctggtt cataccttgg ctttttgtgg attccattga tgtgaatcag 35761 tcaccctgta tttgatgatg catgggacta ctgacaaaat cactctgacc ctgccaagct 35821 gctgccttct cctgccccaa cctcaccccc agccaggcct cactcttgct agttccttta 35881 gttcttttag tcaatatatt tttgtcttcg catataagta taaataaaca tatttttaaa 35941 tttcttggct gggcccagtg gctcacgcct ataatcccag cacttctgga ggccaaggtg 36001 ggcggatcac ctgaggttag gagtttcagg ccagcctggc caacatggtg aaaccctgtc 36061 tctactaaaa atagaacaat tagctgggct tggtaatgtg cacctataat cccagctact 36121 ggggaggctg aggcaggaga atcacttgag cctggggagc agggggtgcg ggaggttgca 36181 gtgagacaag atcgcaccag tgcactcccc atcctgggtg acagagtgag actctgtctc 36241 aaagaaaata aataaataaa tacatttctt gaggcgtttc ttgttaaatc attcatggag 36301 aggcatccca aacaccacat tcaacaaaac actctgaaaa atgttttcaa atgcaatata 36361 acacagcaga gatttgatgc tctgttatcc agttttcata taaggctgtg tgagctgtgt 36421 cccagagagg acagtggtct gaatccacct gagacagaat tgggtctaac taactgtgag 36481 tatggccttc aataagtcac tctccatttg ggaatttgat ttctccactt gtataatgag 36541 agtatttgac aggatgctct cccaaatccc ttgcaatttt gttagtctgt gatttcatgt 36601 ttttattttt attccttcat ccaacaaata gtcaaggagt aattgctgtg tgccaaatac 36661 caacagtatt cattaaattg taattcagat tttatatata tataaataat gtataatgtg 36721 tataaattgc tttgtgagtg cctactacac tgctagacag tagttgctca ataacttgtt 36781 agctgaatca gaatccatgt ttatcccaga gtagcaatta gtcttgcatc gagtatcgtg 36841 aaagaaggcc acacttaaat aagaataatg cctggggttt aggttttatg aaaaaatgaa 36901 aggaaattag ttctgctttt gttgactaaa ggaagggaag agagaagaga cactataatt 36961 gtctgcctca gatttaagga ggaggctaat tcatgcatta aacacgttac ttcaaatttg 37021 aatgaccaaa ggtctgtagc ctcagcactt caaaattggt aaaagtaaga cactctggcc 37081 ttgtttccat agagaccacc ccttacaaag gcaccaatgg gaaactggcc tcaggactcc 37141 tgttattggt cttctctgtg gcagagaaag gagctcttgg acccataaat ctctgagcca 37201 cagttctttt tgccatgggc tcaaaaatga ttgaattcat catgagccac ctgtggcata 37261 ttgccacact aaacatgtgg ggcctttaag ctcactaaga gccaatgtct tcagagccag 37321 ccctggcttg attctaccta gggcatttgc agttgccata taagaatcat tagtgctttc 37381 aaaattactg tagatacttt gcctaaatag actaaaacat gctgccgtca tattggaagt 37441 gacagattaa aatagaactc ttgccaagtg aaggaaagtg tgctaatata atgcagtcat 37501 tttaacttgc tgtttaagtg tgattgtttt tagttctttt gaatattatt tgttttatac 37561 tgacaggaac gaagtactgt ccaattttct ctgccaagga aaaaagaaaa ggtgttcttc 37621 cttacttacc tgaaccaaaa cagaccagtt tacaaaattg cctaattata attgctaaac 37681 aagttccgaa tgcttacagt ctaatccaag aatgtcagag ctgcaagggc ccttaaacac 37741 catccaatcc actccactca tttagcagat gaagagattg agggcaacat aaggccaggc 37801 ccaagataac acaatgacag ccaggactag agctcaagtc tcccaccctg cactttgaaa 37861 gaataatgct ttcaactgga gtacattaac tctactgtct atatttttag ggcagctggg 37921 gcattctgca ttggtggcaa tcctctcaac aaccctggga ctgaaaactg cctggaattc 37981 ttactaacaa ttctctaatt gaccaaaagg tgacgaaatc aaggagacca ataaggtagc 38041 cttggaaagc aagagtggc //