LOCUS HUMCRYGBC 22775 bp ds-DNA PRI 01-NOV-1994 DEFINITION Human gamma-B-crystallin (gamma 1-2) and gamma-C-crystallin (gamma 2-1) genes, complete cds. ACCESSION M19364 M19354 M19365 KEYWORDS . SOURCE Human DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Den Dunnen,J.T., van Neck,J.W., Cremers,F.P.M., Lubsen,N.H. and Schoenmakers,J.G.G. JOURNAL Unpublished (1988) REFERENCE 2 (bases 1 to 22775) AUTHORS den Dunnen,J.T., van Neck,J.W., Cremers,F.P., Lubsen,N.H. and Schoenmakers,J.G. TITLE Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region JOURNAL Gene 78 (2), 201-213 (1989) MEDLINE 89378747 REFERENCE 3 (sites) AUTHORS Hearne,C.M. and Todd,J.A. TITLE Tetranucleotide repeat polymorphism at the HPRT locus JOURNAL Nucleic Acids Res. 19 (19), 5450 (1991) MEDLINE 92020260 COMMENT [Gene 87, 225-232 (1990)] sites. [1] for [Gene 87, 225-232 (1990)]. Submitted in computer readable form by J.G.G. Schoenmakers 23-MAY-1988. NCBI gi: 181098 FEATURES Location/Qualifiers source 1..22775 /organism="Homo sapiens" prim_transcript 2116..5653 /gene="CRYG2" /map="2q33-q35" /note="CRY-gamma-B mRNA+introns; G00-119-077" CDS join(2152..2160,2255..2497,5313..5588) /note="gamma-B-crystallin; NCBI gi: 181099" /codon_start=1 /translation="MGKITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWM IYERPNYQGHQYFLRRGEYPDYQQWMGLSDSIRSCCLIPPHSGAYRMKIYDRDELRGQ MSELTDDCLSVQDRFHLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGA PNAKVGSLRRVMDLY" exon <2152..2160 /note="gamma-B-crystallin" /number=1 intron 2161..2254 /note="CRY-gamma-B intron A" exon 2255..2497 /number=2 intron 2498..5312 /note="CRY-gamma-B intron B" exon 5313..>5588 /note="gamma-B-crystallin" /number=3 prim_transcript 18374..20060 /gene="CRYG3" /map="2q33-q35" /note="CRY-gamma-C mRNA+introns; G00-119-078" exon <18410..18418 /note="gamma-C-crystallin" /number=1 CDS join(18410..18418,18519..18761,19723..19995) /note="gamma-C-crystallin; NCBI gi: 181100" /codon_start=1 /translation="MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWM LYERPNYQGQQYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLM MELSEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAM DAKAGSLRRVVDLY" intron 18419..18518 /note="CRY-gamma-C intron A" exon 18519..18761 /number=2 intron 18762..19722 /note="CRY-gamma-C intron B" exon 19723..>19995 /note="gamma-C-crystallin" /number=3 BASE COUNT 6513 a 4984 c 5205 g 5948 t 125 others ORIGIN 1 ctgcagttat ctcagcttta ttttcttctt gtagtggacg ctctggtgct gcctggactt 61 ccactgtgga ctgaagcact ccttctccca gatagctgac ngcttaaagc tgagtttgtc 121 tccaagaatt ttcttctgct ggaggaagct gccttgccca aagttacact tctccatngc 181 agcagcccac atcaaattac ggggcaatgc agaggcacag attcccggtc cacttgccta 241 agttcctgac aactctagcc ctagccttnt gcgggatggg atgaagtcac cattattgca 301 ataggctctc tctcagctca cacttacaac tgcctgcagg ggtcccttct gaccagctga 361 tagagtgggg gaaggctgag cttgatacac taataaattg gcatggcatt tgggtacaag 421 cccaaaatag aatgctgctg cagaatagct cactcaggag tcaccctaaa gacagcagtg 481 agggaaatcc tcccaaaagg caaccttgag gtagtgcacc tggctgctca ctcggtgcag 541 aaagaaaagt agcccaaggt caagcatata tggaattatt gagcagtaat gtgtggcttg 601 gctggctggt ccagggcctg gaaggagaaa gattggaaga ttagggacaa gaaggtctgg 661 ggataggaat gtgcagggag atatgggatt gggcacaaag ggcgaagata gttgtatccc 721 atgtgaaggc ccagtgtagg gcatccacca ttgaagaggc actaaacaac caagtagaaa 781 aaatgatttg gtcatttgat tccagtcagc gtctgccatc agccacccta ctgctggcag 841 tgagctcact aagagagcgt tcatagtggt atggatgaag gctatgcatt aacttctact 901 tattaaggct aatccagcta tttccactgt agaatgtcca atctgccagc aatagggacc 961 aactctgagc ccttttggtc ccatgccttg agaagaccaa tcagccactt agtggtaaca 1021 tttgaggcag agcaggaaca ccaaacagca ggcaggactc tggacagcca ccagcagaag 1081 gagggattag gcccttagga agatctgaaa gggggaagaa agccacaact ctctgttttt 1141 gctcaggtca gagccaatta ttgaggacct gcaatgtgcc aaccctctgc tctagggctc 1201 agggatagac atgaacaaga aataataccc agcccccaga agcctacaaa ttccaggcaa 1261 gtatcagttt tattcaagac aagcccccaa acaccaacaa tgatgatcac agaatttttt 1321 tttttttttt ttttgcgaca gggtcttgct ctgttgccca ggctggagtg cagtggtgca 1381 atcatggctc actgcaacct cgacctcctg agcttaagcg atcctctcac ctcagcctcc 1441 caaatagctg ggactacagg tatgcgccac catgccgggc taatttttgt atttgttgta 1501 gagatggggt ctcaccatgt tacctaggct ggtctctaac tcctgagctc aagcaatcca 1561 cctgcctcag cctcccaaag tcctgggatt ataggtgtgc accacctcgc ctggctgatc 1621 acagaatttt gaatttgaac taagctttat gggttttaac acactttcac agattacttc 1681 acttgattcc ctcttcttta agattcctta ctatttaaat tctggctttt agaactaaaa 1741 cacacacaca cacacacaaa aacaccacca gtccctgagc agaattcatt acttagttta 1801 atgacttttg agaagtcaat taagcagagt aaactataaa ataaaagcac agagacagaa 1861 tttcgcccgt ccttttgctc aactaaaagt gtactctatt cattttgatg gcaacaacag 1921 ctttagtgaa ttagaacaac ccgaacctac cagaaagaat gagagtaaac cattcagcca 1981 acccagtgac ctgggcacgg agagcagcga gcttgcaaat ccccttactc accaaaatgg 2041 gcccttttgt gtgatttcct gtggaggcag cagtcagggc tgctatacat acagtgacgt 2101 tcctgcagtt cccacacagc aaccagaaaa catctgctca cttccttcaa aatgggaaag 2161 gtaagtcctg ggtaccggat gctcagcctt ggccctaatg cagtggcctc agtgggggca 2221 atcactccat gctcccacat cttccatttt tcagatcacc ttctacgagg acagggcctt 2281 ccagggccgc agctacgaat gcaccactga ctgccccaac ctacaaccct atttcagccg 2341 ctgcaactcc atcagggtgg agagcggctg ctggatgatc tatgagcgcc ccaactacca 2401 gggccaccag tacttcctgc ggcgtgggga gtaccccgac taccagcaat ggatgggcct 2461 cagcgactcc atccgctcct gctgcctcat ccccccggtg agtgtggctc tgtctttgcc 2521 ttccatcttt ttggaaataa aagctatttc atgatattct tttttttttt tttttttttt 2581 ttgaggcgga gtctcgctct gtccccaggg tgagtgcagt ggcatgatct cggctcactg 2641 caacttccgc tcccgggttc aagcaattcc cctgcctcag cctcctgagt agttgggatt 2701 acaggcatgc accaccatgc ccggccaatt tttgtattca tagtagagac gaggttgcac 2761 catgttgccc aggctgatct cgaactcctg gcctcaagtg atccgcccgc ctcggcctcc 2821 caaagtgctg ggattacagg tgtgaactac ggcatccggc ctatttaatc acattattct 2881 taaatcccag ctactcgggc ggctggggca ggagaattgc ttgcttgaag ccgggagatg 2941 gaggttgcag tgagccgaga tcgtgccact gcactccagc ctggcgacag agtgagactc 3001 catctcaaaa cgacaacaat aacaacaaca acaacaacaa caacaacaaa cttttgcttg 3061 ctttgtctta cttttctatt tgattattcc tcctgagaag ataggatcct gtcttctgat 3121 ttctattcta atttaatggt cagtacctat tagctcactt agaggtataa attagagaaa 3181 aggccaaatc tgaaactaaa gtttgagatt ccatattttc tgggcagtac tgcagaattc 3241 ttagaattgt ggtgtgtggg aggcatggga tacagtgtca taaaaacaga agttaatgaa 3301 ggtgatactt cctgctgagg gaaataaata agttgagagc aggaggctag aaaggaagct 3361 taaaagtcag ataggttgaa atttgaactg aaggctgggt gcggtggctc acgcctgtaa 3421 tcccagcact ttgggaggcc gaggtcagga ggtcaggagt tcaagaccac cctggccaat 3481 atggtgaaac cccctctcta ctaaaaatac aaaaattagc tgggcttggt ggcacgcgcc 3541 tgtagtctca gctacttggg aggctgaggc aggagaatcg cttgaacccg ggaaggtagg 3601 ttgcaatgag ctgagatcat gccactgcac tccagtctgg gtgacagagc aagattccgt 3661 ctcaaaaaaa aaaaaaaaag aaaagaaatt tgaactgaaa attagccaga tgtggtggtg 3721 catgcctgta gttccagcta ctcaggaggc tgaggtggga gggtcacttg agcccagaag 3781 gttgaggggg ctgtgaccca tgatcatgcc attgcactcc agcctaggtg acagagggag 3841 accctgtctc aagaaacaaa tacatatatg tgtgtgtgtg tgtgtgcgtg tgcatataat 3901 agtgaacccc aaatatctga gacaggtctc agtcaattta gaaagtttat tttgccaagg 3961 ctgggcacag tggctcatgc ctgtaatccc agcacttttg ggaggccaaa gcaggcagat 4021 cacctgaggt ccggagtttg agaccagcct gaccaacatg gagaaacctc tactaaaaat 4081 acaaaattag ctgggcgtgg tggcgcgtgc ctgtaatccc agctacttgg gaggctgagg 4141 caggagaatt gcttgaactt gggtggcaga ggttgtggtg agccgagatc acgccattgc 4201 actccagcct gggcaacaag agtgaaactc catctcaaaa aaaaaaaaaa aaaaacccag 4261 aaagaaggtt tattttgcca aggttgagga atgcacccat gacacagcct cagaaagtcc 4321 tgagacatgt gcccaaagtg gtcaggggta cagtttgctt ttatacattt tagggagaca 4381 tgagacatca atcaatacgt ataagttgta aattggttca gtctggtaag acaggaagta 4441 ggggcttcct ggttagacat ggataagaaa cagagctggg cacgtggctc acccctgtga 4501 tcccagcact ttgggaggct agaggtgggt ggatcgcctc aactcctgac agagtttaag 4561 accagcctgg ccaacatagt caaagcccgt ctctactaaa aatacaaaat attagctaat 4621 cgtggtggtg ggcgcctgta atcccgctac ccgggaggaa tcacttgaac ccagaaggtg 4681 gaggttgcag tgagctgaga ttgcgccatt aaaaaaacag tagataagag acaaaaggtt 4741 ctttgagccc ttgatcagct ttccactgaa tacacaattt agtctggctc gatgactctg 4801 catctttaca taaacaatag gggagaggaa gcaatcagag atgcatttgt ctcaggtgag 4861 cctcagaggg atgactttga atagaatggg agacaggttt gccctaagca gttcctggct 4921 tgacttttcc ctttagctta gtgattttga ggtcccaaga tttattttcc tttcactgta 4981 tatacataat atgacattta actttccaat gactctcagt tttctccttt gagaaaggct 5041 ttctcaaata acaggcacta aagtgatgtg atattttatt gtaagcaaat cttaattccc 5101 aaagccctag ctctgcccat gaatcattag actcagcggt gggtgactgg ggagtgtgac 5161 agccccttaa ctttgcaaca gggttgttct agaagcaaac ttggcctggg agaacttctg 5221 ggcaggtgtg gccagggagg tgtagggact ggagctttaa tttccatctg tttttgtttg 5281 tttactcttg cgttttctgt ctgccactcc agcactctgg cgcttacaga atgaagatct 5341 acgacagaga tgaattgagg ggacaaatgt cagagctcac agacgactgt ctctctgttc 5401 aggaccgctt ccacctcact gaaattcact ccctcaatgt gctggagggc agctggatcc 5461 tctatgagat gcccaactac agggggaggc agtatctgct gaggccgggg gagtacagga 5521 ggtttcttga ttggggggct ccaaatgcca aagttggctc tcttagacga gtcatggatt 5581 tgtactgaag tatttacgtt ttccactttt ctcctttaaa atctaataaa atatttagct 5641 tgtgtttctg gcactagtag agccctgtct ttctttcaat ctattaagca tttataagtg 5701 ataatggcac tcagccaaac ataataacat gttttcatga tgggaagcaa tcttttataa 5761 ggggaataat gcagagatat tatttccagc actcttgtaa tgactaaaac actgtaggct 5821 caaataaaag ctcagttcac ttggactcag gccaattgta gttagtctca ccaggctaga 5881 tttgcagcta cggtggtgaa ttggtacttt ttgaaacacc tccaagttat ccctccaggt 5941 tatccctatt gtcttcccta atagtccagg ccttagctga tgaggaaagt tgttctcagc 6001 ctctagactc ctacctcagc tccataaaca aacaaataaa tgaactggtc cactcttacc 6061 tattgcactc ctgtcctcct aacagtcacc atccctttcc tctcacttcc actgccaata 6121 tctcattcca ctatgagatt tccagtccaa atagaattca ctgtgttttc gctatatgtg 6181 ctttgtggaa taatttcagg acatttacaa aaaccacatg cgcacgggaa gctcagcctc 6241 atgtcatttc agtagagagt aaaatattat gattacacat aataatacta agtggccggg 6301 cgtggtggct cacacctgta atcccagccc tgtaaacctg cgtctccagg gctcaagcga 6361 tcctcccacc tcagcctccc aaatagctgg gattacaggc gcacaccacc atgctcagct 6421 aatttttttt atttctagta gagacagggt cttgccatgt tgcccaggct ggtctcaaac 6481 tcctgagctc aagcgatcct cttgtctggg cctcccaaag tgccagaatt acaggtgtga 6541 gccaccacac ccagtcataa actcggtcat ttgttttgat tttgggtttt tttttttttt 6601 tttttttgag atggagtctc actctgtcac ccaggcggga gttcagtggt gcaatctcag 6661 ctcactgcaa cctctgcctc ccagttcaag cagttctcct gcttcagcct cccaagtagc 6721 cagaactaca ggcgtgtgcc accacgcccg gctaatgttt gtatttttag tagagacaga 6781 gtttcaccat gttggccagg ctggtctcaa actcctgacc tcaggtgatc cacccacctc 6841 ggcctcccaa agtgctggga ttacaggagt gagccaccac gcctggccta cactgggtca 6901 tttttgagag tgaaagtata tactattaat aattacactg ggacaagaga catgaaccag 6961 gactgttcta ggcaaacttg gatgcaagtt taccctactg tgtgtgtgtg tgtgtgtgct 7021 aaatattact acaaaagtgt caaaaaggtt taaaatgtta aaaagtttat gttacaaagt 7081 tacagtatgc taatgttagt ttattattga agaaagcaag cattttaaaa aaatgtgtag 7141 cctaagttta gcctactgta tgtatatgta tattagccta ctgtatgtgt gtatatatag 7201 agaacacaaa tacatataaa gatttatttc ctgaaaaaca gtcagaatct aggattattt 7261 agtgttaact cttcctaaat cttgggtctt taacctttaa actcgcaaca atagtgatgg 7321 cttcctggag ctattaatca gagtcctctg tttgtcaaca ataatatgtc aaacataatt 7381 cagaaaacca aaagcttctt aacgtgctga atttttacac tatttcctag aagacataaa 7441 atcacatatt ttggctgggt gcagtggctc acgcctgtaa tcccaacatt ttggaaggcc 7501 aagacaggcg gatcacttga ggccaggagt ttgagaccag cctgaccaac atgccgaaac 7561 cccgtctcta ctaaatttaa atacaaaaat tagctgcacg tggtgacaca tgcctgtaat 7621 cccagctact acagaagctg aagcacgaga atcgcttgaa cctgggaggc ggaggttgca 7681 gtgaggtgag atcacgtcac tgcactccag cctgggcaac agagagagac tctatctcta 7741 aaaataaaaa taaaagtaaa tcaccgtctt taggcatgaa aattattcta aaacatctga 7801 actgaaaggg attagagtcc ccgaatctct ttgatcaagt cattattctt agaaattttt 7861 tgctcctatc cctgggatac aggcaaagaa aaagatgtcc tgtcctcctc ctaaatccaa 7921 cataaagaga aagtcaatac tcaggtggtc cgcctgcctc ggcctcccaa agtgctggga 7981 ttatagtgtg agccaccgtg cccagcttgc tatactatac tttttatcat cactttagag 8041 tattctcctt ctacttatac ttttttaaaa aaaaaaaagt taactgtaaa cangcttcag 8101 cagagccttc aggaggtact acagaaggaa gcatcatcat cataggtgac agttccatgt 8161 gtgtttttgc ccgtgaagat cttccagtgg tacaacatgt ggaagtggta gacagtgata 8221 ttgatgatcc tgaccccgtg taggcctaaa ctaatgtgtg tgtttgtgtc ttagtttttc 8281 acaaaatttt aaaaagtaaa agaataggcc aggcgtagtg gctcacgcct gtaatcccaa 8341 cacgttggga ggtcgaggca ggcagatcac ttgagcccag cagtgtaagg ttcttgtatc 8401 agttccaacc ccaagagcgc gtccacagac aacacgagga ggtgtggagc aataagctgt 8461 tttaaggagc gcctgggtgc gcctgagtgc aggaaggccg aggcttaaaa tggcgtcagc 8521 accaagtgag gacggggcaa aggttttaca gtctcctgta aacaggaagt gtcctagtct 8581 gacgtaactg ctacgttgta cccggatggc ctctttctcg atcttcgggg gtacgtgtct 8641 tccagccggc tctcttcctg cttctgctat cctgctggcg cacactgctg acacaagtga 8701 ccttgcgcct tgggactggg cctgggaagg gaggggttac tcatcccctt aagctttcag 8761 actctgggga gaatcataca aggagtttga gaccaccctg ggcaacatag caaaacgcca 8821 tctctattaa aaaaaaaaaa aagaaaaaag tttatatagt aaggataaaa agaaaatatt 8881 tttgtacagc tatacaatgt ttgtgtttta agctaccaca aaggtgtcaa aaaggcttaa 8941 aatgttaaaa agtttataaa gttacaaagt tacagtatgc taatgttagt ttattattga 9001 agaaagaaaa gcattttaaa aaaatgttgt gtaccctaag tgcacagtgt gtataaagtc 9061 tacagtggtg tacagtaatg tcctaggcct tcacattcat tcaccctcct cactgactca 9121 cccagagcaa cttccagtcc tgcaagctcc attcaatggt aagtgtccta tacaggtgta 9181 caatcttttt tttttttttt ttgagacagn gtatcactct gtcacccagg ctggagngca 9241 gtggtgtgat cgcggctaac cgcaagctct gcctcctggg ttcatgccat tctcctgcct 9301 cagcctcccg agtggctggg actacaggca cccaccacca cgcccagcta atttttttgt 9361 atttttagta gagacggggt ttcaccgtgt tagccagaat ggtctctatc tcctgacctc 9421 gtgatccgcc ttgccttggc ctcccaaagt gctgagatta cangcgtcag ccactgtgcc 9481 tggccaggtg tacagttttt taatcattta taccatattt cttgttggga acaggccccc 9541 ccaaatctgc cataaactgg ccccaaaact agccataaac aaaatctctg cagcactgtg 9601 acatgttcat gagggccata acgcccacgc tggaaggttg tgggtttact ggaatgagga 9661 caaggaacac ctggcccacc caggtcggaa aaccgcttaa aggcgttctt aaaccatgaa 9721 caatagcatg agcaatctgt gccttaaggg catgttcctg ctgcagataa ctagccagac 9781 ccaccccttc atttcggccc atcccttctt ttcccataag ggatactttt agttaatcga 9841 gtatctatag aaacaatgct aatgactggc ttgctgttaa taaatacatg ggtaatctct 9901 gtttggggct ctcagctctg aaggctgtga ggccctgatt tcccacttta cacctctata 9961 tttctgtgtg tgtgtcttta attcctctag tgccactggg ttaggctgtc cccagtcgag 10021 ctggtctcgc atttctactg taccttttct atgtttagat ttgtttagat acacaaatac 10081 tagtgtagta ggctgatcca tctaggtttg tgttagtaca ctctatgatg ttcacacaac 10141 aatgaaattt ctcaaaatgt atcccattga taagagatgc atgggggaag aggaggctag 10201 agaatgtagg catgggccgg gcgtagtggc ttactcctgt aatcccagca atttgggagc 10261 ccgaggcggg aggattgctt gagcccagga gctcgagacc agcctgggca acatagtgag 10321 acctcatctc tacaaaaaat aaacaaaatt agccgggcat ggtagcaggc acctgtggtc 10381 ccaaattctt gggaagctga agtgggagaa tcccctgagc cagagagata gaggctgcag 10441 tgatccaaga tcagccactg tgctccagcc tgggcaacag agcgagacct tatctcaaaa 10501 aaataaaaat aaaaagagct agagaatgga ggtgcaagtc agtagcggtg gtgcaggcga 10561 gcttgcagcc caagaccctg cctctgccct cagcaaggcc cctggcaggc aacgactgca 10621 agctgcatgg tgagggccca ggtcataagg aatgggcaca tctggatgtg agagtggggt 10681 tgaaaaatat aggccagtaa agctgaatga aaatgacagg aatgaataca ctgtgggcag 10741 gctggagatc tttgcaagag aagggaatat gcctcacatc atctttgctg gcccctggaa 10801 ctgacaaagt tataagcatc ctgggcccag cactgaagga tgccatgctg gaactcagtg 10861 cttcaaatgg caagggcatt gacgttgcga ggaataaaat caaaatgttt gcttgacaaa 10921 aagtcatcct tcccaaaggt caacataaga tcatcttcct ggatgaagca gacagcataa 10981 ctgatggagt ccagcaagcc ttcaggggaa ccattgaaat ctgctctaaa acgactcact 11041 gtgttcttgc ttttaatgct tcagataaga tcaccggaag gcccatgtga cagcagcata 11101 gatgaaggat cagagagagg ccaaattggg gtttggacat catgaagaag ctgttgtagt 11161 agtctaagga gaagaaaaag gagagtttta gaattctaca tttgtctgac tggtggttct 11221 tagctccagc tgcaggcagc acctccagtg gagctttaaa gaaactgtga gtgtcctgtt 11281 cctaccccca gccagaccga attgtcatct gcccagaagn nnccaacgcc cagcatacat 11341 tgtgattcca gagtcttcct gggcctgaat tgactcactg agggcttgtg gcacatggat 11401 gtctgccttg gaggatcatt tctccatctg aaaagccctg gccagccaag gccattgctg 11461 gggcagtgct ggctgaggcc tctgtctgat ttgcacttca actgggtgat ttggggaagg 11521 atcttaaaaa gctggagttc actctagatt agatgttagc agaaagcagg gttaattttg 11581 tgattagtta tctcaaggaa tcttacccat ggggagggga gactagaaca cggataaacc 11641 tgtaatccat aaagaagtag cagttaatca ttttggctga gagagagagg gcttggaatt 11701 ttgagagtgg agcattgact ttgtttttgt ctgcgcttag acaaagttaa gaagtggctt 11761 tattttatct catttcatcc tggtctcgga gtagccttgt ctgaagttgt tattctgtga 11821 gattgtttat gtctaatagg ggagtaacat gtcctcactg tgagtgccag gccagcatct 11881 gaatgtcaga gcctgctctt ttttctcact ttttttctca ttaatcagac tacagtccat 11941 agagataact catgctctgt gtggttatgt aatttgccat ggagctaatc agtgggcctt 12001 ctgagtgtag gcggcctgag tccaaagctc acactcttgc ccgtgaagct ttatagcctc 12061 cctcatgctt ggaaaaggaa aagcaattta taaagcaata ctttatactt tggttaatac 12121 tttgacattt agccttgttt ttactgcatt tctcttaagc acctgctgcc aaagaggagt 12181 cgcaccacca gcatggctgg gctttgtgga ttatgcagct gcatcctcgt aatcaaagca 12241 ctaatagggt gatgccagcc tctgagggaa acctcactgc cttcccgtct ctgttcagag 12301 gccactggat cccagtgcat agtcctccgc tacacaaagc tgaccgatgc ccggagcagt 12361 gtgaggccga tgaatgctag agagaagggt acagttctgt acactgactt tggcctagaa 12421 gccatcatcc tcatgggtca gggagacatg agacaggccc tgaacaactt gcagtccatc 12481 ttcccaggat ctggcttcag ttacagcgag aagtatgttc agggtctgtg acgagcccca 12541 ccccctgctc atgaaggaga tgatccagca ctgtgtgaat gcccatgtca aggaaaccta 12601 caagattcct gctcacctat ggcatctggg ctactcacca gaagatgtca ttggcaacat 12661 cttccaagtg tgtaaaactt tccaaatggc agaataactg ataaagtgga gtttgtnaag 12721 gaaattggat acactggtat gaaagcagag gaggagtgaa ctcccttctg cagacaacgg 12781 ggctcctggc caggctatgt cagaagacaa tggccccagt ggcatagagc agaggcttta 12841 ttgattgagt tacaagagcc ctaatccctg taatacagga ggtgcagcct tctgaagtgg 12901 agggggaagc gtgggtgggg aatgccacct taagctggtg ccagcataca ccatacttta 12961 aaccctcgtg gttttcacgt tgcttctagc tgatctctgc tccatgagtg tttgcattca 13021 acctcagact cactgacgag tgatggagca gggcagaaag gctcagagaa gctcagggca 13081 ggcacctgat ctgtgtgtga gttgacattt agctcataaa gccttgcagt gtttgttgta 13141 aggtgaccac atgaggcctc aaggaaaacc agcttcctgt ctctgccctt gcttgttcct 13201 cccctttcta cttgtggccc ctagcagcct gcaagtagga agatgactag agagtagatt 13261 ggacaagcta atctcaattc ttctagaagc atgaagggac cagttccctg gggtgagggc 13321 agagtttgct gtaatttatt tagatagact tctcaaaacc aggcaataag ccttcaggaa 13381 gggcttgctg agggggtcga ctggcaaagc accacacaaa aaccccagca tgatgccttt 13441 cccatgtcct cgagggaact cttggccttc gctttagaat tccccagtga attttatatt 13501 aatttgtaga attgcctttt tatttgcaag ggtactattt tttcccattt tttaaaatta 13561 aaattgcaat catataaaaa agagatgcat gactgcatag gataccaccg tatattaatt 13621 gctaagaagc aggaaggtgg gtggtaaaat caactgctgg ctggacctca gacaccagca 13681 aaactctaga attggctacc gctgttgtaa cattaatttc tcatctcaga agaaataaaa 13741 attagaatta ctaaggagtg ggaggactta gggcacaaca cagcattcct ggtttttccc 13801 ttttgcttat tatctccact gttataaagg cccattatgg ctgggtgtgg tggctcacac 13861 ctgtaattcc agcatttggg aggccgaggt gggcagatcc cctgaggtca ggagttcaag 13921 accagcctgg ccaacatggt gaaaccctga ctctactaaa ggtacaaaaa ttagctgggc 13981 gtggtggcag gcgcctgtaa tcccagctac tcgggaggct gaggcaggag aatctcttga 14041 acccaggagg cagaggttgc agtgagccaa gatcgcacca ctgcactcca gcctgggtga 14101 caagagcaag atttcatctc aaaaaaaaaa aaagaaggcc tggcacagtg gctcagtctt 14161 gtaatcccag cactttggga ggccgaggcg ggcggatcac aaggtcagga gatcgagacc 14221 atggtgaaac ctcgtctcta ctaaaaatac aaaaaattag ccgggcgtgg tggcgggcgc 14281 ctgtagtccc agctactcgg agaggctgag gcaggagaat ggcgtgaacc ctggaggcgg 14341 agcttgcagt gaactgagat tgcgccactg cactccagcc tgggcgacac agcgagactc 14401 cgcctcaaaa aaaaaaaaaa agccccatta aatcgatctt gtgcagggtg cctgtgtcat 14461 cctacacacc gaaagttgca catcctgaac ttcaatgtga gtgtgttatg cctgtgtata 14521 ttgaacattt gaaacaggct ccatagacca ttataataat aaatttcaga caaggaataa 14581 caatcacaca tccccccccg ggcatttatt gagtaacctt tatgtgccag tcctctaagc 14641 caattagtga gaacacaaaa ataaagatgg aatagactct gcctttatgg ggctctccca 14701 tctattttga gggactgatg tctaaacaaa ataattagat aagtgatagt tacccttata 14761 gtggtatgaa catgaggagc cacggaggca gtatttaatt cagcccagaa gattaggaag 14821 ggttcaggaa aatcttttac agacaaactg acgcttgagc tgagacttga agaaagggta 14881 aaatttctct ggttgaaaaa taaactggtg tctcattgag aaggatcaat atgttgaaaa 14941 acaagaacaa catgaaataa cattgtgcat ttgggaaatg acaagcggtt cggcgtgatc 15001 aatcagaaag cgtggggaca gacagcggag gccaggtcta ggatgccgcg ctaagggatc 15061 aatattggat cctgagacaa tggagtccag taaattttca agcaaatgaa cagcatgatt 15121 tgatgtgttt tagttctcat cactccagca tctgtctgag tgcagcttgg aggaagacaa 15181 cactgggcag agtcaggagg ctgttgaaag tccagctgag atatgataag accctatgta 15241 aggcagctac aatggcaggg gtttgggggt gggaggtggt tggggnagag gagagaagga 15301 gaaagatttg aaaaaaggtt agagaaatac aagactacgc cattaggaac aagagcgatg 15361 ttctgtaata tgcactttct ggccccttta ttgcttttcc tgtcttctta ccagtgctct 15421 aatttaagtg ctggtatctc tgctccgatt ctctcactgt gtacatatga aactttatag 15481 aacaagaaag agtgctggcc aggcgcggtg actcatgcct gtaatcctag cactttggga 15541 ggccgaggtg ggcagatcac gaggtcagga gatcgagacc atcctggcta acacggtgaa 15601 accctgtccc tactaaaaat acaaaaaaaa aaaaaaaatt aaccaggcgt ggtggtgggc 15661 gcctgcagtc ccagctactc aggaggctga ggcaggagaa ctgcttgaac ccaggaggcg 15721 gaggttgcag tgagctgaga tcacgccatg gcactccagc ctgggcgaca gagcgagact 15781 ccgtctcaaa aaaaaaaaaa aagagtgcta caaaacagag agcacatctg cctttaagtc 15841 taacgagaat gttaggcagg gcacagtgac tcacgcctgt catcccagca ctttgggagg 15901 cagaggaaaa tggattgctt gaggagatca agaccagact gggcaacata gtgagccctg 15961 tctctacata aagaaaatac aaaaaattag ctgggatgtg gatgacctgc agtcccagct 16021 actcaagaga ctgaggtggg agcttgagct tgagcgtggg aggcagaaac tgcagtgagc 16081 tgagattgtg tccctgcact ctagcctgga caacagagca gaactctatc tcaaaaaata 16141 aataaataga attaagagaa tgttagtaca attcctaata aggcattgcc tagggatggc 16201 taaaatacat gatttccttg tcaaaacatg aagggataaa ccacagcagt gttttggccc 16261 aagaactatt tggtgcttat taaaaatgta ggttctgggc tgggcgtggt ggctcatgcc 16321 tgtaatccca gcactttggg agaccgaggt gagtggatca cctgaggtca gaaattcgag 16381 accatcatgg ccaacatagc aaaaccctgt ctccaataaa aatacaaaaa ttagccgggc 16441 atggtgaccc gggcctataa tctcagctac tcaggaagct gagacagaag aatcacttga 16501 acccgggagg cagaggttgc agtgagctga gatcgcacca ctgcactcca gcctgggtaa 16561 cagagcaagg ctccatctca aaaaataaaa taaaataaat aaaataaaaa ataaaaatgt 16621 aggttctgag gtcttctcct gatctaatga tgcaggattt agccaaaaga tcaagatggt 16681 aatttgcatt tttaataagc aaggtgattc ttaggcacac tggagtttga aaaccacccg 16741 atggtttcga aagtcccttc caagcctaat ttnnctttaa tcacaaaatg gcttcataga 16801 ggataaattt tttcaggaat ctttgagagg attaaatatc tttgagaggg ataaacagga 16861 tgaagcaagc cttaacaatg tcactctatt actaataaca acatttattc agtgttcatt 16921 tgtgccaagt atgtgccaaa ttcgcttata cacataatcc cacttattca tgtcaatgtc 16981 cttnagctaa agaccaccag ggacacacct gtctttaaac aagttgagct tattacttgt 17041 tgcagcaagg gaggacatgc tccttgggga agcatggact gtctcagtaa cagagcttag 17101 aaagaaattg ttataggatt tgcacttcag ttgtgcgatt tggggaagga gctaaaaaag 17161 ttggagttca ctccagatta gatgttagca gaaagcaggg ttcaattttg tgatttagtt 17221 atctcaagaa atcttanccg tagggagggg gagactagaa cacggataac ctgtaatcca 17281 taaagaagtg gcagttaatc attttggctg agagagtgag ggcttgggat tttgagagtg 17341 gagcattgac tttgtttttg tctgcgctta ggcaaagtta agaagtggat ttattttatc 17401 tcatttcatc ctggtctcgg agtagccttg tctgaagttg ttattctgtg agactgttta 17461 tgtctaatag cggagtaaca tgtcctcact gcggagtgcc aggccagcat ctgaatgtca 17521 gaggctactc ttttttctca cttttgttct cattaatcag actatagtcc atgagatact 17581 cctgctctga gtggttatat aatttgccat ggagctaatc agtggccttc tgagtacagg 17641 cggcctgagt ccaaagctca cactcttgcc cgtgaagctt tatggcctcc ctcacgcttg 17701 aaaaagggaa agcaatctat aaagtagtat acggtacttc tcagtcttgg gcccagtgac 17761 catagaaacc tttcccttgc ttgttatcgt aagttcacta ccagggactg atctctagtt 17821 agacgacgtg cccacgaaag gcatagttaa aagctgtctt aaagcattgg gttaacgaag 17881 tcaaaactag ccaagataag aatctagatt tgtgtccggc cctggactgg aaaattgtgt 17941 aaagacaaaa atgtaaggta gagcagtctc tgccatccag ggaaatgagt cagtgctttt 18001 ggcattctac ctcagcaacc tctctggaat cctggagcaa ttctataatg gcatagatct 18061 ttcccagaaa attcacgggg aataattcaa tcatatagac agagccacga atttcaggtc 18121 aaaagttcag actgactgca cagataaatt tagaaaacac taacaatcca aataaaagca 18181 acacagagca gtatgtacag gcagcgttag aatataccag agaacaagaa cacaatctac 18241 aatcatttcc agtgaatgca ggatgttaaa gagatgcata aaatcccctt accgctgagg 18301 gccccttttg tgttgttctt gccaacgcag cagccatcct gctatataga ctggctgtgc 18361 agccgcaggc cccatcacac tgaactcgca tcatccgtgt caaccagcca tggggaaggt 18421 gagcagaaca caaattaaat aaaatgaaaa aaaagttgcc tttatataat gcctgttagg 18481 agcaaataat gtaattcgga acgattcttc ctttgcagat caccttctat gaggacaggg 18541 ccttccaggg ccgcagctac gaaaccacca ctgactgccc caacctgcag ccgtatttca 18601 gccgctgcaa ctccatccgg gtggagagcg gctgctggat gctctatgag cgtcccaact 18661 accaaggtca acaatacttg ctgcggcgag gggagtaccc cgactaccag caatggatgg 18721 gcctcagcga ctccatccgc tcctgttgtc tcatccccca agtgagtttt ctagatttcc 18781 atcatgccgc cagagtcccc actgtattgt caatgtgggt tacagggagg gaggtttgca 18841 tttaaaaaca cctaagggtt agatggacat cagagacctg aataagccag atagataaca 18901 tgcacaaaaa cagcagagaa tgtaaggaag aacccactta gaggaagaat ccgtttttac 18961 ttgaaatttt tgcatccaat aagtcaatta aaagaggtct gtaacaaatg taatatcata 19021 atgggatata aaacaaaact tgcaaatggg aagctggttg ggcataaaaa gacggtattt 19081 ttaacaaatt attttgtcta tagtaaaaga atttctaatg aatgaattag atagattcca 19141 ccatggacta gtaaacctca aagctgtatt gttaatatag gctattcaaa ggttgtgtcc 19201 aactttggaa aaggtaattt ttcttaattt ggaaaatcag ttaaattctc attccaaatg 19261 actatttaac tttacactga agtacaagat tttttaaatc ttactttagt ggtaatttat 19321 atgtttgtaa tttgggagat aataaccctt actaaagaaa tactagtgaa ataaattatt 19381 tctatttttc cccccaaatg tagtttgaat taacacaggt aattaggatc agatatctca 19441 gttcttgatg gattctaact cagagtttga acctcttaaa aattccatct cctaaataag 19501 aatgaatttc aggtcaaata gaaaatgagc gtgccagtat ttaggtgcta gtggaagaca 19561 gatccatgcg cagcaaccac agtaatctac attttacact gtctaaattt tacaatgaca 19621 attccatgcc acaacctacc aagttcatct gttctttggt tggacaaatt ctggaagaga 19681 ctcatttgct tttttccatc cttctttctg tggaccgagt agacagtctc ccacaggctg 19741 cggctgtacg agagggaaga ccacaaaggc ctcatgatgg agctgagtga agactgcccc 19801 agcatccagg accgcttcca cctcagcgag atccgttccc tccacgtgct ggagggctgc 19861 tgggtcctct acgagctgcc caactaccgg gggcggcaat acctgctgag gccccaagag 19921 tacaggcggt gccaggactg gggggccatg gatgctaagg caggctcttt gcggagagtg 19981 gtggatttgt attaaaatag cttaacacta ccaatttccc attttggaac ctaataaata 20041 tttagtctgc attgctggca attgctgact tctgtcattc tttcattgtg caaatcagtt 20101 cacctttaaa tgctccttgt caaaagttaa gaagtgaatg gggtggggga cggggtctat 20161 tggagaagag cttcaaggta gagtgagttt gaacaagcct cagacgttgg ggtggaggca 20221 gggtgtagcc tgnccgagaa agaaaacgca gggcaatgcc agagacctgg gagaggctga 20281 ctggtgagag gggaggcaat tcaactangc accttgagga caatgattgg gaagtttcct 20341 tctaaccaaa atgggttagg acnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 20401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 20461 ggccaccgca gccattgccg tacctttgaa caaagttaaa gactattcat cttcttttga 20521 aaatggctcc tgtccagaag tgtagctctt ggtcagtact acccctggcc caaatgctgt 20581 gtcaattata gaaactgcac atcagtttca tggtgaccag ctattgcaaa taaattaata 20641 ttaagagata cacatcaatc ttttaaatag attttcatgg tatagtgtaa cccaaacata 20701 aaaaataact acaaaaaaca tcgttctggc ataaggacgc atgtatgcat atgtttatca 20761 cagcactatt catgacagca aagacatgga atcaacctaa atgcccatca atggtaggct 20821 ggttttacaa atgtggtaca tatatacaat ggaatactat gcagccataa aaaagaatga 20881 gaccctgtcc tttgcagcaa catagatgga gctggaggcc attatcctaa gcaaactaac 20941 acaggaacag aaaacaaaat acctcatatt ctcgcttcta agtgggacct aaactttgag 21001 tacatgtgga caagaagaaa acaagagaca ctggggcctg cttgaggttg cagggtgggc 21061 ggttggagag gatcaaaaaa ctacctgtca ggtactatac ttatcacctg ggtgataaaa 21121 taatctgtac accaaacctt cacaacatgg caatttacct gtattacaaa cctggatacg 21181 tgcccctaaa tctaaaataa aagtttaaat aaacaaatac gtaagtcctg taattacaaa 21241 atgggctcaa atttaaaggt gctttaaaga agccataatt tctggagcct tttattaaac 21301 taaaatctgc ttgctcataa gcaaagccct aaaaagtaaa aataaaaaaa aaaaaaagaa 21361 agcaattacg agtcttttca tcagcagaga atttatttat tttaacttaa aaatctccct 21421 tcaaagtaaa aggcctccca taatcttact actgtacaaa ttctataaag aagttgaggg 21481 gagtccttct gacgcccctc attgctaact cttgtttata gttggtgggc acccttctgg 21541 gattttctcc ttgtttatat agctctctta taaacacatg cttcttttct ttacaaaaat 21601 ggaatcatgc tatacatatt agtctgcaac ttgcttttaa aatgtattat aatatggaca 21661 tatatctagg tcagtatctt attctgtttg atggttgaat tgcatcccat tgtttggagg 21721 tcccttagac catttcacca tttgtccact taagtgactg ggcttttcca atgttgcttt 21781 taccaacaat gctgcaaaga ataacattgt acatatacgc taatcctgac atgccataat 21841 tttaaaaaga tagcgaccta gaagtgagac taccggctca tagtgcaagt ttattttatt 21901 ttatttattt attttttgag acatggtcac actctgttgt ccaggatgga tgcagtggca 21961 caaacccagc tcactgcagc ctcgacctca caggctcaag cgatcctccc atctcagcct 22021 cctaagtagc tggggctaca ggcgcgcacc accatgcctg actaattttt tcactttttt 22081 gtagagaagg ggctcactat gttgccaggg ctggtctcga actcctgggc tcaagtgacc 22141 ctcccacctt ggcctccgaa agtgctggga ttacaggtgt gagccaccac acccagccac 22201 aagtttattt tccatttcaa tagcctccaa ttattagcca ctagagactc ttaacttcct 22261 tgagttagga tccttaccaa tttttgagca cctaccatac gcctgctata tgtagcaatg 22321 gggatgaaga aaacaatcaa aacaaaacaa aagaaaaagg tatttcccta ccaccgtaga 22381 gctctatata gaaagaatac aaaaaaaaaa aagcagccag aaaataagaa ttaaaataat 22441 ttgtattgca catagttggt gtttaattca taaataccac ttacaaagat ttatgactca 22501 aagacaagac aaagtacttc catgggttga cacagggctg taagcaattc tttaaacatg 22561 aaagaagctg gacacatagg tcatattcca ctccagtact cttcccagtc catcaaactg 22621 ctctcttcca ggccaataag tactttctga agtcttcctc gagtccaact tctagannnn 22681 nnnnnagctc ccctttgtgt tcatgcatta atttcgtctg agtcaaaggc cttgtgtact 22741 ctcgctcgtt caggggtaaa ggtgtattct agatc //