LOCUS HUMADAG 36741 bp ds-DNA PRI 10-MAR-1994 DEFINITION Human adenosine deaminase gene, complete cds. ACCESSION M13792 KEYWORDS Alu repeat; adenosine deaminase; long terminal repeat (LTR); repetitive sequence. SOURCE Homo sapiens (human). ORGANISM Homo sapiens Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 36741) AUTHORS Gossage,D.L., Norby-Slycord,C.J., Hershfield,M.S. and Markert,M.L. TITLE A homozygous 5 base-pair deletion in exon 10 of the adenosine deaminase (ADA) gene in a child with severe combined immunodeficiency and very low levels of ADA mRNA and protein JOURNAL Hum. Mol. Genet. 2 (9), 1493-1494 (1993) MEDLINE 94061056 REFERENCE 2 (sites) AUTHORS Berkvens,T.M., van Ormondt,H., Gerritsen,E.J., Khan,P.M. and van der Eb,A.J. TITLE Identical 3250-bp deletion between two AluI repeats in the ADA genes of unrelated ADA SCID patients JOURNAL Genomics 7, 486-490 (1990) MEDLINE 90353944 REFERENCE 3 (sites) AUTHORS Gossage,D.L., Norby-Slycord,C.J., Hershfield,M.S. and Markert,M.L. TITLE A homozygous five nucleotide deletion in the adenosine deaminase (ADA) gene in a child with severe combined immunodeficiency and very low levels of ADA mRNA and protein JOURNAL Unpublished (1993) COMMENT [2] sites; 3250 bp deletion. [2] describes a patient with severe combined immune deficiency caused by a 3250 base pair deletion in the ADA gene. NCBI gi: 178076 FEATURES Location/Qualifiers source 1..36741 /organism="Homo sapiens" LTR 1025..1357 /note="THE O family LTR" repeat_region 1362..1672 /note="Alu repeat" LTR 1680..1717 /note="THE O family LTR" repeat_region 2357..2903 /note="Alu repeat" mutation 2455..5706 /note="g-3250 bp-c in [1]; gc in [2] -> immune deficiency dysfunction" prim_transcript 3936..35975 /note="ADA mRNA" CDS join(4031..4063,19230..19291,26344..26466,28908..29051, 29823..29938,31176..31303,32425..32496,32573..32674, 32851..32915,34354..34483,35100..35202,35651..35664) /note="adenosine deaminase; NCBI gi: 178077" /codon_start=1 /translation="MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAE GLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRY SPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPN WSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEV GSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDT EHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSF LPEDEKRELLDLLYKAYGMPPSASAGQNL" exon <4031..4063 /gene="ADA" /note="adenosine deaminase" /number=1 mutation 4052 /note="The functional significance of this substitution at cDNA position 117 (AA 8 Asp->Asn) is unknown as it occurs in the same allele as a 5 bp deletion in exon 10 which is associated with very low ADA mRN" /citation=[3] intron 4064..19229 /note="ADA intron 1" repeat_region 4907..5227 /note="Alu repeat" repeat_region 5606..5908 /note="Alu repeat" repeat_region 7582..8001 /note="Alu repeat" repeat_region 8179..8484 /note="Alu repeat" repeat_region 10005..10204 /note="Alu repeat" repeat_region 10257..10534 /note="Alu repeat" repeat_region 13452..13777 /note="Alu repeat" repeat_region 14837..15386 /note="Alu repeat" repeat_region 15806..16106 /note="Alu repeat" repeat_region 16913..17224 /note="Alu repeat" repeat_region 18414..18717 /note="Alu repeat" exon 19230..19291 /number=2 intron 19292..26343 /note="ADA intron 2" repeat_region 19605..19902 /note="Alu repeat" repeat_region 22523..22829 /note="Alu repeat" repeat_region 24481..24773 /note="Alu repeat" repeat_region 25143..25453 /note="Alu repeat" exon 26344..26466 /number=3 intron 26467..28907 /note="ADA intron 3" repeat_region 26949..27269 /note="Alu repeat" repeat_region 28032..28333 /note="Alu repeat" exon 28908..29051 /number=4 intron 29052..29822 /note="ADA intron 4" exon 29823..29938 /number=5 intron 29939..31175 /note="ADA intron 5" exon 31176..31303 /number=6 intron 31304..32424 /note="ADA intron 6" repeat_region 31460..31867 /note="Alu repeat" exon 32425..32496 /number=7 intron 32497..32572 /note="ADA intron 7" exon 32573..32674 /number=8 intron 32675..32850 /note="ADA intron 8" exon 32851..32915 /number=9 intron 32916..34353 /note="ADA intron 9" exon 34354..34483 /number=10 mutation 34462..34468 /note="This mutation is found in both alleles of a patient with severe combined immunodeficiency secondary to ADA deficiency. The deletion creates a premature stop codon resulting in very low levels of ADA m" /citation=[3] intron 34484..35099 /note="ADA intron 10" exon 35100..35202 /number=11 intron 35203..35650 /note="ADA intron 11" exon 35651..>35664 /note="adenosine deaminase" /number=12 BASE COUNT 8165 a 9716 c 9721 g 9139 t ORIGIN 475 bp upstream of HindIII site; chromosome 20q13.2-qter. 1 gatctgggta aagggttttc caggtgtcag gatggaagtg actaaggtgc agaggctgga 61 gggctggggc aggtagaagc aagcattcct gttacctact gctgtgtgac aatctccccc 121 taaaacacaa tggcttaaaa taacatccat ttcattacat atctcaatac tataggtcag 181 gaatttgggc tgggcttact tgggtaattc ttctgtccca catggcattg accaaagcct 241 ggttttcagt gggcagctgg gctggatggc ccaacacagc ttcgctaaca tgattgctgt 301 cttcgtaggg atggtggaag cctgggctca gtgggactgt caactggaat ggccatatgt 361 ggactctctt agcatgatgg tctcttctag aagcttgggt tcccagagag aatgttcaag 421 aggccccaaa ggacaccaca aagcttcttt atgaccaagg ctcggaaatc caggaagctt 481 gctcccatca cgctctatta ctccaacaag tcactcaggc cagcccaggt ccaagaggag 541 gaaacctaga ctccatcttg caatgtgaag aattgcaaat aatttgtgtc acccttaagc 601 aaccagcaac tcatctaggt tgattggcat ttcagcaatg tggtgggaag tggtgggact 661 gatgttgaag agggacttga atgtcatgag aggctgggga ggcaataagg tggggagtga 721 agtttctcga gtcagattca aatttaaacc ccagttttgc cacttacaac ccatgagcca 781 agcaggctgt ctctctatct gaacctcagt gtcctcatct gtaaaatgag gagaacacct 841 cctacatctg aggatgactg taaagatgaa atgggatggg tgcttataaa gtgcttccca 901 gtgtacctgg ctccaaacct gtctcagtaa atggcagccc ctattattga acccgagtaa 961 cacagagagc caagaaagga tcttacaaaa aactcccctg gctttgacaa tgtatgagac 1021 ccactgatag ggtttggctt tgtgtcctca cccaaatctc atctagtagc tcccataatt 1081 cctacatgtt gtgggagaga ctcggcggga gataattgaa tcatggggga tggtctttcc 1141 catgctgttc ttgtgatagt aaataagtct cacaagatct gatggtttta aaaatgggag 1201 tttccctgca ggcgctctct ctttgtctac tgccatccat gtaagacgtg acttgctcct 1261 cctttgcctt ctgccatgat tgcaaggcct ccccaccatt gtggaactgt aagtctatta 1321 aagcctcttt cttttgtaaa ttacccagtc tcaggtatgt cttttttttt tttttcatga 1381 gatggagttt cgctcttgtt gcccaggctg gaatgcaatg gtgtaatctt ggctcaccac 1441 aacctccacc tcccaggttc aagcgattct cctgcctcag cctcccgagt agctgggatt 1501 acagtcatac accaccacgc ctggctaatt ttgtattttt tttttttttt ttagtagaga 1561 cggggtttca ccatgttggt caggctggtc tcaaactccc gacctcaggt gatcctcctg 1621 ccttggcctc ccaaagtcct gggattacag gcatgaacca ctgcgcccag gctcgggtat 1681 gtcttcatca gtagcatgaa aataatggac taatacagcc accctctccc tcactcccac 1741 atacaaccaa accccaaatc cagctgattt tacaccctaa atgcagcttg aatatgagtt 1801 tctccacttc ccccactgac atcactatgc cctacccaga ccatggcagt tgcctccttc 1861 ctggtatcct gtcctccctc acccccgctg gccccctgta atgccctccc ctcacagcag 1921 ggagcccagg cttctcaaag tgccctgtgg gtgcgaacca cctgggggtc ctgtttgtat 1981 aaaatacaga ttctacttca gtaggtctgg gatggggtct gaaagtctgc atttgtagtc 2041 agctcccagg tgatgtgggt gctgatgatc cctggatcac actttcagta gctggagaat 2101 attttttcca aataaaaggg tgattttgtc tcgcctccac ttaaaacact ccactgactt 2161 cctaggaatc ccacaccatc gctgggtccc acatccctgg caggattcag ctcccatcag 2221 accttctagc cccttgctct ccactctccc actctctctt tcccccttgt ttatgggttt 2281 gttaatttat ttatgatgaa atgaaatgaa gctaccatcc accccagtac tggaacatta 2341 tcaataacct gtgtgtggcc aggcgtggtg gctcatgcct gtaatcacgc cttgggaagc 2401 cgaggtgggt ggatcatgtg aggtcaggtg ttcgagacca gcctggccaa catggtgaaa 2461 ccccgtctct actacaaatc caaaacttag cagggcacgg tgccacgcgc ctgtaatccc 2521 agctactcgg gacgctgagg ccgagaactg cttaaaatcc aggaggtgga ggttgcagtg 2581 agccgagatt tcgccactgc actccagcct gggcgacaga gcaagagtcc atctcaaaaa 2641 aacaaaaaca aaaacaaaaa aacaaaaaac aaaaattagc caggcgtggt tgtgggcgcc 2701 tataatccca gctactcggg aggctgagac aggaaaatcg cttgaaacgc tgggggtgcg 2761 ggggggcggt ggggaggagg cgggccagag gggcagaggt tgcagtgagc ccagatcgcg 2821 ccacttcact gcagcctccg cgaaagagcg aaactccgtc tcagtaaata aataaataaa 2881 taaataaata aataaataaa taacctgtac ccgcgtgtta tttccctccg tccttacctc 2941 ctcccggctc cttccctttc acctgagata accactcttc tcgtatctat gctcatcttt 3001 cccttgcttt acattttttc caccgatgca tgtgtctaaa catacatact tttggttttg 3061 cttttacaca ttctaaaagt tgcaccattg tatgcagttt tccgcaactt agtttttttc 3121 actcaacatt gtttctgaga cattgtttct gttgttgtct ggctgaagtt cattccgttt 3181 cactgctgtc taacgtttca tggtgtgaat attccggttt atttgcccac tcgcccgtgg 3241 aggggcattt gagggtgttt ccaatgttcc tgttattcgg aatagcgctg gtgtgaacat 3301 tctgcacagg tctctggctg cgcctgggcg ggtttcttaa aggtgaatgc ccaggagggg 3361 actgtctgtg ttctccctcc ctccgagctc cagccttcct cgcctccttt cactcccagc 3421 tccctggagt ctctcacgta gaatgtcctc tccaccccca cccacccctg atgaactcct 3481 gcaggttctg caggccacgg ctggcccccc tcgaaagttc cttaactata caattatggt 3541 gtgtgtttct gcgacgagcg tccgtctatc cggtggaagg cacgccgctc gaggcttgcg 3601 atgctcccgg ggtccccgct tctagcttgg gcctggcgca cagcagcgcc cagactgcag 3661 ggggacgctt gaaagttgct ggaggagccg gggggaaggc agcgcccagc gaggcggctg 3721 gagcgcgcgc ccacaggtgg gtccggtcgg gcgccgcggg gccgtagttt tcgggtcggc 3781 gggcgaggac gccgggtcca gaattccagg aaatgcgcga tccaggccgg cgggcggggc 3841 gggggctccg gcgagagggc gggccccggg aacggcggcg ggcggggcgg gaggcggggc 3901 ccggcccgtt aagaagagcg tggccggccg cggccaccgc tggccccagg gaaagccgag 3961 cggccaccga gccggcagag acccaccgag cggcggcgga gggagcagcg ccggggcgca 4021 cgagggcacc atggcccaga cgcccgcctt cgacaagccc aaagtgagcg cgcgcggggg 4081 ctccggggac gggggtccgg cgcctgggcg gcccgagggg cttagcgggg cccagcccgg 4141 ggcgtccaaa ccctgggaac gaacgggggc tcctgcaggc gagttcttcc ttcggcttag 4201 gccgtggctt gcttgcgggc taatcaggga caatggggca gagaaggtcc agaacccgga 4261 ggcctccaga gtctgcttct gcccctgact tgacccctct gggtctcagt ttcgctgtct 4321 gtcaagtggg catcctagca ccgctgagcg ctgtgtgggc ctgggcaggg acttgaggtc 4381 tctgaagctc agctgtatga tcaggcccga tgtctacgcc ggatagcgac ctagtgctgt 4441 gccccgcgcc tactgagtgc tcagtgaatg gaagcagctt tgtacgccag cgttatggtg 4501 gtgagcgcca aggagctcag gtttgtggat gcgccccggg gaagaaccgt gagccctgcc 4561 agaaagggga gggaggggag cagagcaccc cccttccccc gcgcgggaag aacaggagct 4621 aggtaggccc tgggtttggg gccctagcag ggttcactcg aggccaagcc atggcccact 4681 ggccccaggg gagaatcccc ttgtttctcc gcccaccagc tgtggcgtct tgggactgtt 4741 ggggtcaggg agggtctgga cccccttggc ctgtctcaga gtccgagagg aggggcccag 4801 gagtctgcca agcagggtga gtcagccagt agggtgtgag agtggttggg gaaggagtca 4861 gctgcagtca gcctcaactt acccttctaa gaaataggtg tgagtggccc aggaggttgg 4921 ctcacgcctg taatcccagc actttgtgag gctgaggcgg gaggatcatt tgagtccagg 4981 agtttgagac tagcctggac aacaaaacta gaccccgtct ctccaaaaaa taaaaaaagt 5041 taggggaagt gtgtgtggtg gtgcactccc gtagtcccag ctactcagga ggctgaggcg 5101 ggaggatcgc ttgagcccag gaggttgagg ctgcagtgag gtgtgatggt gccactgacc 5161 ttcagcctgg gagacagagc gagaccctgt ctcaaaaaaa aagagaagaa aaagaaaaga 5221 aaagaaatag gtgtgaatga tgatgacagc tatcacaaaa gtgccggtga gaatccagtg 5281 agtgtgcatg tgtcagtgag ggagacaggc tgtggagagc ccacctacct tctgaggagg 5341 gtgaggcctg gcccccacta ctgatgcccc cagcccaggg aaaatgctca gctactcccc 5401 gtcagaagct ggaacgactg aggtgctgta caagccctcc tacccccacc cctgcctcct 5461 tcacgtctta ctggagctgg ggcccatgat tggcgcctcc cctttgcagt ctttttatta 5521 aatgctctgg gctccctctg cccttgggct ggggacccac tgtaccctga tgtgaatcct 5581 atggcagtag caaagctctt tgattggcgg ggtgcagtgg ctcacgcctg taatcccagc 5641 actttgggag gcaaaggtgg gtggatcatg aggccaggag ttcgagacca gcctggccaa 5701 catggcaaaa ccccatttct actaaaaata caaaaaatta gctgggcatg gtgcgggcgc 5761 ctgtagtccc acgtacgcag aaggctgagg caggagaatg gcataaaccc gggaggtgga 5821 gcttgcagtg agccgagatc tcgccattgc actccagcct gggtgacaga gtgagactct 5881 gtctcaaaaa aaaaaaaaaa aaaaaaaagg ctccttgatt gcgaacatgt tgggagttat 5941 ggagagaaca gcagggccca cttctagagc acttgttgca gacacccatt ggatccttgc 6001 agttcttctg taacagccca tcaagggagg ggctcatatt attatcccca ttttttggcc 6061 ttgctcagtc ctcccatctg attcaagctg gcagatcatt ttccctattg ggacctcagt 6121 gtccacacct ggaggatgga acatcagctg cttatgtggg tgtcccgtgt cctgagtccc 6181 aaggccacaa ggtgatgctt gagagtgaag gtagaatgtt acctgccatg tgtttgaggc 6241 gtgacaaatc ttgtatgatt gtgaggagga acttgtgtga gctggcagga gaagtgggaa 6301 ggagtgtgaa tctcagagcc actgtgacca gagccagctc cctgccctct tgtgggaggg 6361 acagatgaca gttataatta ttagcattac tagctgcagc taatggagtg ttgatgtttc 6421 tgccaggcac cgttctaaac acattatctg cattttttat ttaatccagg cacagagagg 6481 ttaactaggc ccaagatcac acagctagga aatgtccaac tctggggttt gagtccaagg 6541 gaggctggct tcgaaatccc atgcctctaa ccatctttcc taaactacct ctgcagaagc 6601 ctttggggat agaggtgcca gtgccccagg tgcaaacctc ctgagacagg agcctttgct 6661 gtgtccttca gcttctcata cctgccacca gctgaggcct gggacctggt cagctagaag 6721 aaagcagagc agggcagcgc ttttcaaact gcactcaagt ggcctgactt ttaatgttca 6781 cactgtgatt ctgtgtgggt cgggttgggg cctgcgatgc tgcactgctg accagctccc 6841 aggaaatgct aatgtcaacg atccaggaac acactttgct tagcaaggcc ctaggcagct 6901 gccttctgtt gtgcgggacc cctattgact ccaatggata tagcaccagg ttcaagaggc 6961 taccttcttt ggaagaggta gcaaacaaga tacggggttt tactgggggc ttagacacag 7021 ggaagagagt ccagtggcgg cagactgagc agaagaaccg caaccacttg caaatcatgc 7081 agtttatgta gcattttcat ttaacacctt ctcccaacca tctccaccta gtaaccttca 7141 tttaacccaa aacaaagggc ctcggtccct atacccctgt atggtcagtg tcccgtggga 7201 atggggtggg gctcagatgt tcctcataga taacgactgg atctccaggt tggccactct 7261 tggattcctt cgctcagaac tctgaacacc cattcaagtg tgcctgccat gcagggtcat 7321 cgtcagggga tgcccaagtc aagtttgcct gtcgggtgtg cctcccatac ccccacctgg 7381 tttgacttag cacctgctgg gcactggaag aagtgcaaag gggggttgca ggggtggccc 7441 ttatcagcct atgttcacag gtggcaccag gcactcaggc attctgcatc ctggaggcca 7501 gtgctgatca catgcctgtt acaataatca taacaatagc tgtccttgaa gtagtcctgg 7561 gtaccaggtg ccttcagtga ctttttcttc tttgccagaa tctcactctg tcgcccaagc 7621 tggagtgcag tggcaagatt ttgggtccct gcaacctctg cctcctgggt tcatgcgatc 7681 ctcctgcctc agcctcccaa gtagctggga ctacaggcgt gtgccgcagt ctcactctgt 7741 tgcccaggct ggagtgcagt ggtgtgatcc tggctcacta caacctccac ctcccgagtt 7801 caagccattc ttctgcctca gcctccggag tagctgggat tacaggcgtc caccaccacg 7861 cccggctaat ttttgtattt ttagtagaga cagggtttca ccacgttagc cagctggtct 7921 cgaactcctg atctcaggtg atcctcccac cttggcttcc caaagcgctg ggattacagg 7981 tgtgagccac tgtgcccggc tagtaacttt tatctcacgg aatcctctgg acgacttgac 8041 aaggcatggg tcttcatccc catttacaga tgaagaaact gaagcttagg gagtggaggg 8101 acttgccagg gctacacaaa atctgagagc cttgaagctg tagactggca agtgaacagg 8161 tacaggctgg gacagcagtt tctttctttt tttctttttt tagacagagt ttcgctcttg 8221 ttgcccaggc tggagtgcaa tggcacgacc tcggctcact gcaaccttcg cctcccaggt 8281 tcaagtgatt cttctgcctc agcctcccaa gtagctggaa ttacaggcat gcaccaccat 8341 gcccggctaa ttttttgtat ttttagtaga gacggggttt ctccttgttg gccaggctgg 8401 tctcgaactc ccgacttcag gtgatccgcc cacctcagcc tcccaaagtg ccgggattac 8461 aggcatgagc caccgcaccc ggccaaggga cagcagtttc taaactgtcc ctctctgatg 8521 cagaggggaa ttggggctaa atcagcaatg tgccttttct gtctcatatt tgaatgtcta 8581 ctctgcacga ggcgctgtcc tgctttgcat acagtgactc atttaatgtt tatgtcagcc 8641 ctctgaggaa ggtcctgtcc tattattaac ttcacttatt atgaggaaac tgagactcag 8701 agaggggagg gaacttgcca aagtcacaca gctggcaagc agcagagcta gacttgaacc 8761 cagatctgcc tgcactcaag tagaagctgt tcattgcttt gctcatttgc caattccact 8821 ttatgcaaaa aagagggggc agtgtggggg gaagagttag aatcagggtg gcagggtggg 8881 ccagtgcatt agccctgggc ttcagatgta ctggggttga attcctgcct gccgcttagc 8941 agctagggta cctcaggtag acaactcctg aaactcagct tccccctctg taaaatgggg 9001 tgacaaaacc aagatcttgg ggttcttggg gaaactgaca tgctgattgg tttttgtaca 9061 gtgcctggct ggtaacagca ggccctcagg ggtgcgtttc cttcctgggg actggagtgg 9121 gggttgcagt agactctggg aggcctctcc agctgcagaa tctccctcct ccctcctcct 9181 ttttgtcttc ctgacacaaa acccaccagc tgcacttctt tgggcttgca gtggctttca 9241 gttaccagag ccacctgtta aaacaaaaat gtgcctagga agagcctgcc ttacccattt 9301 tgactcacat ggcagttggt ggtggagggg aacaaaggag actgagtttc atcgaagcct 9361 tttgcttcgg aggaggaagg gaggatcaga gagaggaagt ggtctgtgtt cacacaggga 9421 ggcaggggag gccaggcagc ttcccaatcc tgcattcaac ctcagggtgg gcttgacctg 9481 ggtggctggg ggccctgtga tccaggagag acttgtccac ctgctcaggt gtcttgaagg 9541 ggtccctgtg gtaccccctg ggcggggcaa ggtagtagga ccatggtctg gctggggagg 9601 tggagaggag caggctgtgg gcgcagagtg aggttggaat ctgtatttac ccaaggtgtt 9661 gggggtaggc ttgccctcag cccttaatgt tctcaggccc ctgagcagtt gtgggggata 9721 acctctgcac tcctagtgac cagggagcta gaacagcaag gaatttgaac ttggacacca 9781 gctggggtca ggctctctgg gtctgagtcc tgatttccca ctttccagct agaggagctt 9841 gaatgagtca tttaacttca cggtgcctca gtttcccctc tctaaaatga gaattatacc 9901 catacccacc tctcaaacac caagtgcagg cctggctcag agcaggtgct gcagcaatag 9961 ctgccattgg tcagcatcat catcatggtt ggtaatggtc ctactttgac ttttgagaca 10021 gagtctcact ctgtcgccca ggctggagtg cagtggtgca atctcggctc actacaacct 10081 ctgctcccgg gttcaagtga ttcttctgcc tcagtctccc aagtagttgg gattacaggt 10141 gtgcgccacc atgcctggct aatttttgtg tttttagtag agacagggtt tcaccatgtt 10201 ggccataaca atggctgtcc ttgaagtagt cctgggtacc aggtgccttc agtgactttt 10261 tttttttttt tttttttgag ctggagtctt cctctgtcac ccaagctgga gtgcagtggc 10321 acgattttgg ctcactgcaa cctctgcctc ctgggttcat gcgatcctcc tgcctcagcc 10381 tcccaagtag ctgggacttg ggatacactt gcccccgctg gtcctccctt ccacctctgt 10441 gaagaggagg tctcaaactc ctggcctcaa gtgatccacc cacctcagcc tcccaaagtg 10501 ctgggatttc aagagtgagc caccgcacct ggcccctgtt tagatgttag catcagtgac 10561 ccagcacctt gctatgtggc atgcagggag cgtgctgcta gacctccggg tttagagtca 10621 aatagcttcc tggctgtggt gtgcattaga ctttctaact caaggtcctc ccactctctg 10681 agcctcagtc ttgttgcctt taaaacgagt ttaagtgtgc tgagtcccta tgctgtggct 10741 ccacaggaat ttccccaggt ggaagacaca tcttgccttc tgtgaaacct ctcagcagca 10801 gagctgtcag gccccgtcag caggagacac tgtggggact gctcagtccc ttccactgtg 10861 tacctcggag ctggcggagc ctagatgagg ctgagcatag agggcttcct ggaggaagtg 10921 gagctgaaac agtttctcag cccagggctg ctctgtctcc tggcctcaca ctaaaagtca 10981 gttgagaggc catagtggca taagtcactg accctggcac tgcccagctc atcaccaaaa 11041 gcagggctag ggagggaggg gacattcgat tggcagtggg cacctgtggc tcatctgggt 11101 tctggccacg gtgctcaggt tctgtgagct gaccaggcag ccctggctcc tctgcccccg 11161 tgtgggttct gccaggtccc atggggcagg tcagcccctt ccttgttgca gggagagcac 11221 ccagcattgc tgacatggga cagggaaacg aggaaataac ggtgtggtca ttgaacacag 11281 agagcactag gtgctgtgcg aggtgctgag gacacgacat gatgacacag acaaggtccc 11341 ccctctcagc aaacggctca tgagggagac agacatgtta catacatgaa cccaaaaagt 11401 cagacgaaaa caaaacagag cgatgtgttt gggaggcaaa cccaactgcc ggagggcgag 11461 cagttgggaa cgtggaaaca tgagtcagat ctgggagtat ctgtcccagg agtccaagac 11521 ctgggtcctc atggtagctc tgccaccgac acactgagtg accttgggta agtgaaccca 11581 ccgccctgga cctctctggc acgcatctct tgagagcagg gacttagtgc atttcccgag 11641 ggcctccacg gtgcctggca catagtgggg cttagtaaat atttgttggt aactgaggat 11701 gcttcctgtt cacatcagcg ctgggaggat ttcctgctgt tcagacaaat gctgggctgg 11761 ctgtgagtca gccttgcaga gagcaaaggc agtgggaagg ggcgtgagat tcccctctgg 11821 agaggtcagg aggccaggca ctgtctcgac atgagtgcca gggagggggt gtggcctgtg 11881 ggcagggctt gggctgaggc agagggactt gagttccacc ctagctctac caccatcaat 11941 tttgtgtaac tctggacagg ccactgaact tctccgggct tagcctggca agtccatttc 12001 cccatctgta acatgggccg atatgtacat tgcctaggga ttaaatgaga taaagggtct 12061 gaaaacagta ggtagctgct ttatcattat tattatttct gtattattga tgtctgaggc 12121 taggcccaca gaggcagtac agtagagtgg ttaggagctc aagaatcaga ctagggttca 12181 aattctgact ccatcactga ctgttttggg gtacttcttt gaacctcagt ttcttcatca 12241 gtaaaatggg agtgaagtct ctaccttgct ggttgtaagg atgaaataag ataatgcata 12301 tagatggtct agcacatagt agatactcaa aagtttgagg ccactgctga cccttttccc 12361 tgaaaggaga caggagagcg gggtcgccac cccattgtca ttgtcatctg gaataggctg 12421 acagacttcc catggtgtgt tgcagttttc tagaaaattc agtaggaggc ctgcctgagc 12481 ttgagccacc tgtggaggtg cttcctgcct ctgctccaca cctgaaacgc gtctgggcct 12541 cttctcaggc agccgtgaga agggatgagt gctactggtc atggtgggca gctggctctg 12601 ctttccccct tcccagaggc gctcctgcct cctgcccagc tccctgaacc cctagcttct 12661 gcaccccggc actgtctggc ttctgccccg ctgagcaccc actgtctctg acgctgcctt 12721 gagtacttcc cgcatgttat tcaaatccca atcagatctt ccctccccca gtagctggtc 12781 ttctgttctg gcttcctgcc atcctgtcct ccacacagca gccgggaaag gtttttttaa 12841 aggggactct ccgatttaac acacttgggt ggaaaaccct ttgcttcggc ctctgcaatc 12901 tccctgcccc ctctccactt tgccctggcc tcatttctca ccactaacct cactctgcac 12961 tctggccaac tccccgcctg cttcctgatt cagacactaa gcacacgcag ctcccctgcc 13021 tggagccatt ctccctctcc ttctttcttc tccctggaga actccccctt taagtgatct 13081 tttcccaaca cactttctaa attgccccca ccccagtgtg atttttcttt atctcatagc 13141 acttggtctg cttcttatca cagtttgcaa ggctgagttc agaaaggtgt gtttgctcat 13201 tctgaggcag gagaggctac cttgtgctgc tgtggtaaca aacagccccc aggtctgagg 13261 ggtctgcaga gacccaggtt gacctcatac tgcttgtccc tccagggcct ccagtgaggt 13321 ttcggctcct tggatcactc agggccccag gcagatggga agattccact ctgaacattg 13381 ccaattgttg tgccagagta aagcagagct gggaggtggg ctcttgaatt ggcatttaaa 13441 tacttttgcc aggcagggta aggcagctca cgcctgtaat cataacactt tgggaggcct 13501 aggtgggtgg atcacctgag gtcaggagtt caaaaccagc ctggccaaca tggtgaaacc 13561 ctgtctctac taaaagtaca aaaattagcc gggcatggtg gtgggcgcct gtaatcccag 13621 ctacttggga ggctgaggca cgagaatccc ttgaacctgg gaggcagagg ctgcaatgag 13681 ctgagatctt gccactgcac tccagcctgg gcaacagagc cagactccat ctcaaaaaaa 13741 aaaaaacaac aacaacaaat aaataaatga ataaatactt tagccagaag tagccatgca 13801 gacctccccc caccagtccc acccacaagc ggacgtgact accgccccca ttcactgcct 13861 gatcctcctg ttctcagggg ctccaaggcc aggcctggtt tgaccttctg actttctgac 13921 ttcctcctac cttcccagta acctcatgca actcctttca ctcagcctca atcatcccca 13981 tgggtgttta aacttgccca agacatgccc ctttgaaaaa gcctgccatt ctcttgaccc 14041 acatgcacgt cctgccccct ccaaggctgc tagttccttt aggggcaaaa ttgtgaaaga 14101 gtagtctaaa ccttcttcct cttcttacct ccacttcttt cttaccttat tcccatgtgg 14161 attctaccct cactcaggcc tctagaacgg ttcctctacg gcagtggttc ccaatcttga 14221 ctacgtgttt ttttaaaaaa agtcctccac ctgggcctgc caccaaggat ttttctttaa 14281 ttgacctcag atggggttga ggccttggga actggccaga acttcccgtg ctcctaactt 14341 gcagccgggg ttaagaacta ctcctctgaa gcccccagtg cctgcgcttt tagcccgacg 14401 gacaagtttc tgcccttcca tcctgtgacc tccagcaggg cctgaccatg tgagttttct 14461 gtggctgccg tgacaagttg ccacaccctg catggcttca accaacagaa acgtgtgccc 14521 tggcagttct gggggccaga agtccaacat caagatatca tcagagccac atgcccactg 14581 aaggctctcg ggggaatcca ttccttgcct cttctggttg ctggtggctc taggcattcc 14641 ttggcttgtg gctgcatcat tccagtctct gcctctgagg tcacgttgct gcttcctctt 14701 gtgtgtgttt ctcttaaaac tctctgcttc tgtcttataa ggatacatgt gattgcatct 14761 agggcccaac cagataatcc aggataaact cttcctgtca agacatttaa taatcacact 14821 ttgccatata aggtaatttt tttttttttt tgaggtggag ttttgcactt tcacccaggc 14881 tggagtaaag tgatttaatc tcggctcact ggaatctctg cccccaggtt caagcaattc 14941 tcctgcctca gcctcctgag tagctgggat tataggtacc tgccaccatg cccagctaac 15001 ttttgtattt ttagtagaca tggggtttca ccatgttggc caggctggtc tcgaactcct 15061 gacctcaggt gatccacccg ccataagtta atattttttt tttgagaggg agtattgctc 15121 tgttgcccag gctggagtgc tagtggctca atctcggctc actgcaacct ccgcctccca 15181 ggttcaaatg attctcctac ctcagtctcc tgagtagctg ggactacaga tgcatgccac 15241 catgcctggc tgatttttgt atttttaata gagaggggat ttcaccatgt tggccaggct 15301 ggtgttgaac tcctaacctc aagtgatcca cccacctcag cctcccaaag tgttgggatt 15361 acaggcatga accaccacgc ccgacccata taaggtaata tttacaggtt ctggggatta 15421 ggattagcat gtagacagct ttgtgggggc caccattcag cccactatgc taaccctgtg 15481 aaccgttgct cgcttctcct tgacatctga cggcctggcc ttctgcatac cacacaccct 15541 cccacctctc tggccacagt tctgtaggct cagcctcctc cgtaaggcca ttaagtgctt 15601 gtgctggtca aagtttcatc ctaggccttt tccttacctc ccttgatatt ttctccctag 15661 gtgagctcct tcaagcccac agcttctgtg cttacccaca ctcctaccta cattcccagc 15721 ttgggcttct caggccagct ctagactctt gtatcccact gggttcttcc acttaccttt 15781 ggatatctca aaggcatctc cagttggctg ggcacgatgg ttcacacctg taaccccagc 15841 actttgggag gccgaggtgg gcagatcact tgaggtcagg agttcaagac cagcctggcc 15901 aatatggtga aaccccatct ctactaaaaa tacaaaaatt agctgggcat ggtggtgggt 15961 gcctgtagtc ccaactactc gggaggctga ggcaggagaa tcgcttgaac ccgggaggtg 16021 gaggtttccg tgagctgagc tggagccact gcactccagc ctgggcaaca gagtgaaact 16081 ccgtcttaaa aaaacaaaaa acaaaaggtg tctctagtgt aacataacta aaaccaaacc 16141 aatcatgcct ccctcccccg catcctccct cctggaggga gctccaggac ttggtcttct 16201 cttccagagt tctctgtctc aaactgcggg aattgctccc cacccaggcc taacctgaag 16261 tgtgagcctt ggcatctctt tctatccacc tgtttttcct ctatgcacct cacaaccctg 16321 gtccaagcca ccgtcatctt tcaaatggct gcagtagcct ctaactggcc ttggaggagc 16381 catcctcttt ctctaaccag ctgccaaccc tgcaatggcc tctgtgtgct ttccagataa 16441 agcctgactc ctcgtggccc gcacagccct gcctgggtgg tcctatcctg cagcctctcc 16501 agtaccatga accctccctt ctctgaacct ctatttaatc catttcatat accccgtttt 16561 ctcctgccat agggccttgc acatgctgtt ccttctgcct ggaattttct tcctgcctcc 16621 ctccgcaccc ctgccttgtg ttgtgggttc ctcgctatcc tctagctttt cgctcaggct 16681 cattgttggc cctctagatg tattcacttc tcttgtttgt taccctctgt cataggactg 16741 tgttcgtact tcccaaggag tcgtcttggt ttgtgactgt acattttccc atgtgacatt 16801 tgcttaatgc ctctcccact ctggggcctg tacaagcccc aggaacagga cttggaccct 16861 cctgtttaac tctacaatct agcatccagc aggcgcgcag gccttcgttg acttttattt 16921 tattcttatt ttttattttt gagatgcagt ttcgctcttg tcgcccaggc tggagtgcag 16981 tggcgtaatc tcggctcact gcagcctctg cctcccaggt tcaggtgatt ctcctgtctc 17041 agcctcccaa gtagctggga ttacaggtgt gcgccaccac gcctggctaa ttttttgcat 17101 ttttagtaga gatggggttt caccatgttg gccaggctgg tctcaaactc ctggcctcag 17161 gtgatccacc cacctcggcc tcccaaagtg gctggattac aggggtgagc ccccatgccc 17221 agccttcatt gacttttagt tgacaactat ttagcatttg ctatgtgcca agaactccct 17281 gcctactaat gcagttaacc ctcatgaagc ctagaaggaa ggactgccat tctccccact 17341 taacagatga ggatgccgag gcacaggaag tgaagtgact ttctcagggt caagcaggga 17401 gtgagtggag gagccgagat tccagctcta accgcatgat gctctataca gtgtgactcc 17461 ggctctctgg ctgggccctc tccatagccc tgtgagggtt aaggatagaa aacagaggct 17521 cagagagttg aggtcccttg cctgaggtca cacagctggt tggccgttcc ctgggctata 17581 agcttcagta ttcccaatgc tgagcatatt ttgagaaccc gagaaacaga cgtttggctg 17641 ggtgggaact gaactcattt tgtcagggaa ttcaacaact aagttggccc tgagactggg 17701 tgtgaagacc gctctgtccc ctgccagctg gatgacctca ggagagatct gatgactctg 17761 aggtcctgct gataggacct ctggtgtctc tgttccctgc tggcctcccc tgggcctggg 17821 ttgggtttcc tctgcaggag gcagctcatg tatgtgctcc tagacgccct tgggccagca 17881 gctccttggc tgttcctccc tgagccaggg cagccaactt tcttatccag ctctccatgc 17941 tccccacccc agcatgagat gtcagctgag agttttctgg atctccccta gctaggggga 18001 aagcttccat catttggaac aggaacagca ggaacagcaa agtccctttc cccaccatct 18061 cccactgcct gctgtgcttc tcctaacagc tcatggtaaa caccctgact gagcggcagg 18121 ggctgtttcc tttgggctat ccatgtccac ctacactgcc ctttttaatc cttacaattt 18181 ttcttggaca cgggggcata atattccatt gtttttcagt tgaggaaact gaggctcaga 18241 gaggtcaagt gtcttgtctg aggtcacaca gcagaactgg gagtcaagcc agatgggctg 18301 cctccaagga tcctactctt aaactctaga gtactagaaa gatcttccgt tgcctaatat 18361 tgattcctga taggctatgc ttgagtagca tctgcttttg aaaatggagc ctgggtcggt 18421 tgcggtggca catacctgta atcccagcac tttgggaggc tgaggtgggt ggacacctga 18481 ggtcaggagt tcgagactag cctgagcaac atggtgaaac cctgtctcta ctaaaaatac 18541 aaaaattaac tgggtgtggt ggcacctgcc tatagtccca gctactccgg aggctgaggc 18601 acaagaattg cttgaaccca ggaggtggag gttgcagtga gaggagatca cgtcactgca 18661 ctccagcctg ggagacagag cgagactcca tccgtctcaa aaaaaagaaa acgaaaatgg 18721 atcctgaatt ttgaaatatg ctgtgactct tccctagttt gggacatctg ggtcaatccc 18781 ttttgttaaa gtagtttatt tagttggctg agagcgggag ctgcctacgt gacctggagc 18841 acaagctttg gaattgggct tgggttagaa ttccgcctct gccactcacc agctgcgatt 18901 aagaacaaag atactgggtt gggctcctgc ctctattact tgcaatctgt gtggccttgg 18961 atgagatatt taacacctcc gaacctcagt gtcctcaatt gtgaaagaga tcgagataac 19021 agctgaaccc acatcccagg agcggattaa atgagatagt gcagtacaga gtttaccgaa 19081 gtatatgggg tcagcagcca gccagtaaaa tggtggctaa tggttatcat gattaatgtt 19141 aacattaagc tctgaaaggt ccttcgtgaa ctcataggta tttgttctct ctctcccttt 19201 ctctctctct tccccctgcc cccttgcagg tagaactgca tgtccaccta gacggatcca 19261 tcaagcctga aaccatctta tactatggca ggtaagtcca tacagaagag ccctctctcc 19321 ctgggatttg agtggggtcc ccagctccac ccagaggccc ctggggaatt ccagggtcac 19381 tgttccttcc tgtctccctg tgggaatcaa gccagctcca ggccagaagt gggactgtga 19441 ggacatggag gcctcggcac tgagctgcag acccgcagac caactcctga gctttctggg 19501 cctctgagtc ttgtcctcct ggtgtcaggt gagccaggcc tgagcctgct ctccccaccc 19561 acccacatac gtgcatgaag gtagttccca gggctgaatc cgtctttttt tttttctttt 19621 gagatagagt cttgctctgt cgcccaggct ggagtgcagt ggcatgatct cggctcactg 19681 caacctccac ctcctgggtt caagtgattc tcctgcctca gcctcctgag tagctgggat 19741 tacaagcaca tgccaccaca tccagctaat ttttgtattt ttagcggaga tggggtttca 19801 catgttggcc aggctggtct cgaactcctg acctcaagtg atccacccag cttggcctcc 19861 cacagtgctg ggattacagg catgagccac tgtgcctggc tcctgtcttt tgacttaact 19921 gagagcctat atatagcagg tgatgtgctc acatgagatg ccagtacaat ttcttgagca 19981 tctcctagag ctgggctggg ctttatcagc tcattgaatt cctccacgct tggaagagga 20041 ggatacgctc tctgcatttt actgaggagg gaatgggctc agccaagaca gttgtccacg 20101 gtcacacaaa ttaatagcag atcaagagtt gaacccaagg ctgtctgacc cctaaggctt 20161 tactacatca tcagggtcat aacctgctag gagtcacgga aaagtggctc cccaactctg 20221 ggcctaaatc tctgcatctt ccaagtgaga acacacttcc tgcctcagct ctcagagatg 20281 ctagggggcc agagggtccc cctgttcccc agcgaggaag gttcttccct tcctacccag 20341 acctcaaggg ctcacagcag ctcctctctt aggaccagct tttaagggca gggactttaa 20401 aggccagtgg atctggattc aaatttggac atattatctc ctgtctgcga acttggtctc 20461 tatcaactga ggctaagaac aggccctccc tagagagatg acctaggagc taggggctcc 20521 ttgtccaccc agccctgccc ccgcagacct gtgttcctcg gatgtttgca caacactcat 20581 tttgtttgga gctgaaagaa ctcagcctct ctgtcacagt cttgaaattc agctcgggac 20641 ccaaatttga acatttctgc tccataagcc agaatcctgt tattcagagg cctgccctca 20701 tggagagaat gagggatccc gggggttgcc cccaactctc gggagcatct ccaccaactc 20761 cctgagagat ttctggtaag tccactattc tccatctttt cacacttcca gggaccttct 20821 tctgccccag gaagctgcca ttgatttaat tcctatttaa ctgcaaggca taagcacagt 20881 agcacctcct gtgtgccaaa cactccttta agtgcgttac ccgggttaag ttattgaagc 20941 ctcacaacaa tttgtaagat aggaactcta ttgccgtcat ttacagatga ggagactgag 21001 ccgtggtagg tggagtaagg tgcccagtaa gcacagggcg gaggtttgaa cccagatagt 21061 ctgcccccga gtccatggcc ctggccatta ccccctgtca gttagaggtt ttggtaagtg 21121 atgcccgtaa aatgcttagt tcagggccta gcacacatta atgtgctcca taaatgtcac 21181 ttaatgataa tattcttatt aattggagct tatatctcta agtggggtga aacctcttgg 21241 cttatctctg cctggccttt gcccatgtca agccgccaac ttgccacaag gcccctaatg 21301 aggtcgttca gtggggcacc aagatgagat cgaacccagg cactcattaa ggggtcacgg 21361 agggctcatc agctgcagcc aggggctggg agcgccgggt ggggctaaga gaaaggggaa 21421 aggagccgcc gggaggggca ctggtctgat cgtccattcc tcacaccacc tctgggcctt 21481 ggagatggcg tgcggcaggt gccagctgga gcttggcctg aagtcagcag gcaggggact 21541 ggggagtttg tcacactcag atatgggtgt ctgtaaatgc acacaaatat gggctaagaa 21601 tggaaggagg aggggagccc ctggcctgag ccctgctagg cccaattcag tggccctttt 21661 tccagctctg ggactcaggc ctgcctcatt aactgtcctc acccatttct ccttcctcca 21721 gttcccagga ttctggcctt ttcaggggcc tctccaacct ctttctcagt cttgtttata 21781 accctgtcaa ctatttctac agagattctg aaactggctg ctctttcctc cgatcactgc 21841 cctggtctgg gccaccactg cccctccctg gtgctgtggc ctcctgattg gtctcagcca 21901 tctactctgg ccttcctctc tacgggccct gcagtgctgt agttggagca agagccttaa 21961 cccatggtct tcccagctca ttccccagct tccccatctc actcagagtc aaagccaaag 22021 tccacacatg ggccttaaag ttctgcaaag cctgcattgc ctctctgacc tctctaaggc 22081 tccttgctta gtccacactg gatgtttttc aaacatgcca gacctaggaa acagagagtc 22141 tgggttactt gcccaaggtc acacagcctt taagtcacag agctgggatt caaacccaga 22201 ccactgggct tcagagtctg ctctttctca tgacacacaa agtttcattt cttcctctgt 22261 gcacccctac atggaaaata ttatgtttta ctgacaaggg caccaagggc cttagagggg 22321 agcgctcctg cctgggatga tgtggtaaat aggggtggga gatggacttg acctgcaacc 22381 cctgcgctca tcctccctcc ctccctgggc tcctgatggt gggcttcttg tgactgtgtt 22441 gcccaccaag gccggaagag gaccagacag tgccccagca cagcagctgt ggctgaccag 22501 ggagtaggga tcatctaaga acagagcgtg catggtgctc acgcctgtaa tcccagcact 22561 ttgggaggcc aaggcgggtg gatcacctga ggtcaggagt tcaagaccag cgtggccaac 22621 atgggaaacc ccgtgtctac taaacataca aaaaattagc caggcatggt ggtgggcatc 22681 tataatccca gctacttgag aggctgaggc aggagaatca cttgaaccag ggaggtgaag 22741 gttgcagtga gtcgaggtcg tgccattgca ctccagcctg ggcaacaaga gcaagactcc 22801 gtctcaaaaa aacaaaacaa aagaaaaaac agagggtggc cctatgagga gccttcgctt 22861 gtgtgggtgg ccagggacag caagaggtgc cagggcccta ggaacagctc tttcctgctt 22921 caactttggg ctccagatgg gcgctttcca gctcagtctg agcagcttcg ggaagctgtg 22981 tcccatggga gacactggga gtcccctgtg ctctttgtct cctgtcgggc ccccacatta 23041 gctctctggc ctcagctctg gcttccctcc aatttgtttc ccacgcagca gccagaggag 23101 ctttcaaaaa ggtaaattat ttcatgctag tcccctgctt gaaatcctac agtgccttcc 23161 cagtgctttc agccaaagcc ccagtccctt cctaagccca gcctggccct gcctccctgg 23221 tgcatcatct gcacaaatgc ctgctctctg acctccagcc accctgcact tccaatgccc 23281 gcggcttcct gcctgcagct ttagtacaga cccctcccct gcccagaact gcccccaccc 23341 caaggcttct gctgaaatgt cacctcctca gagaggcctt ccctggctgc tctgtctaaa 23401 ctctgtgttg agaagttcct tcttgatggt tgttgaggag ggaggctgga gaagaagaat 23461 caaagaggag aaatagaaag caaaataatt tgttcttggg gacgggctgg tgctgggcac 23521 ggggaggcgc ccgtctctgg tgtgggcagc tgggtagatg gaggagccgt atttggaaat 23581 gtggaaccca ggaagggagt gatctagagg gaggggaaag gtggcgcgag atgcctgcct 23641 ctcaacaggt agccagacac atgggtctgt cttggtcact gctatctgcc cagtgcccag 23701 cacatcacag gccctcagtg gtggtgtgtg ggcatagaga attagaagct gtggacctct 23761 ggatccggag ctgaaaacca ccaaaggaga tgagttggcc tggccaggtg tgtaaaaggc 23821 agagtctgag agagaacgac cagagggcag agccccgcag gtggagtcct gggggctgga 23881 gggagaccat taggagaatc gcacatggct ggcgcagcag gtcccaggca aatgtggcca 23941 ctgggtttgg caatatggga gccagagccc tagtgtcatc tccctgcctt ctacccagca 24001 gttcccagag tgatatcccc aacagtgttt gacaactggt acaggctctt cagcggccac 24061 agttactggg caaggccttg tgagggtgac tttggggcag ctggccagca gtgggagggg 24121 aagcagtctc aggggtacct gaggcactga gctccgacct ccaggtgcca atgccgcacc 24181 agggcaccgt tcccctgcag gctcttacag ggattagggg ctggtaagga gcagtgatta 24241 ggggctgact agcaggctgg tgggcaccag catgacccct tggtggtacc ctctgggcac 24301 tcatggggac ttgggctaac agatggggaa gggagcacat tcagggggct taggaaacat 24361 atttatgtag ggaagcattt taatatttta gtaacagaag ctattaaagg acttacaaac 24421 ttacttacat acactaaaac actatttggt caaacttctg tttctttggc actttcctcc 24481 tttattcttt tttatttttt tgagacaggg tcttgctctg tcacccaagc tggagtgcag 24541 tggtgcaatc ttggcccgca gtagccttga cttccaggct caggtggtcc tcccacctta 24601 gcctcccaag tagctgggac tacaggtgca cgccaccacg cctggtgaat ttttgttttg 24661 aaggggtttc actgtgttgc ccaggctggt ttcaaactcc tgggcttaag tgatccgcca 24721 gccttggctt cccaaagtac tgtgattaca ggtatgagcc actgcacccg gcctcctatt 24781 tttctgcttc tgctttgtgg ataattggat gcttggacct cctgatttaa tcttctaatt 24841 tccttaactg tttactccta tttttcatca tcttgtcttt ttgttctact ttgtggagga 24901 tttcttcact tttagcttcc agttcttttc ttacatcgtg acagttgctg ccgcattctc 24961 ttgtaaattt ccgagggctc gttcttgggt tctgaatgtt ccctcctttc aaggatcttc 25021 tcatctcttt gaggatattc atgtcttttt tgttttggtt cttaggtttt catctgttct 25081 ctgtgctgtt tcctcggagt gcttttgtct attctgttgt tttgtccctc atgttagaag 25141 catttctttt ttttttcttt ttttttttgt gatacagagt cttgctctgt caccaggctg 25201 gagtgcagta gcatgatctc ggctcaccac agcctctgac tccctggttc aagtgattct 25261 cctgcctcag cctcctgagt agctgggatt acaggcacac accaccacac ccaactaatt 25321 tttgtatttt tggtagagac ggggtttcac catgttggcc aggatagtct caatctcctg 25381 acctcatgat cctccgacct tgcctgggag gccaaagtgc tgggattaca ggcgtgagcc 25441 accatgccca gcctagaagc atttcttaat gtctggtgtt ctctggctgt tgtatcttaa 25501 aaaaaaaagg ggggggaaac tgaggctcga ggtgaccttg tgagctggag cagagccggg 25561 atgggatgag gaggcaggag cgtgtgcaga agagagggag cccccctgag ctcgcaccct 25621 gcttcccgtg gctgggaggg gaggccgaga tgcttgggga gaaatggagg ctccaagcca 25681 gaggggctgt ttccagcacg ctcttactga gcgctgctgt agtccagctt ggtgtggcgg 25741 ctgtgggcag ggaggggaga gaggtctgag ctggctggcg gcccactggg cccctcccct 25801 gagcctccac cggccctctc ccagtgcgct gggctgggca agcctctgat gtgccagcca 25861 gatggagggt gaagtcctga tgcctgcccc taccctggga attgtgatgc tgcagttact 25921 gcccctgata acccctgact gggcatagga ccagctggct gagccagctc ctggggctga 25981 ggaggaagcc atgaacttga cctggcactt tccttgtctc caagcatcag tcaaccaagg 26041 atatggaggg ggtgtgtgca tgtgtgcaca catacacaca cacacacaca cacacttcaa 26101 cctgtttatc ccccttgaga tttgctgact tgtgcattgg gggtagaagg tgctggaaaa 26161 attccggtcc tggttctcag tttccccatc tgtccagtgg gagcagctgg actgagagac 26221 gcccatgtct cctgctgtgg tcctgcaagg aggctggcgc tcctgagtct gctccatcct 26281 ggcctgtcag gcctgcctgg atcctgcccc gggttggtcc accactcact gttttgtttc 26341 caggaggaga gggatcgccc tcccagctaa cacagcagag gggctgctga acgtcattgg 26401 catggacaag ccgctcaccc ttccagactt cctggccaag tttgactact acatgcctgc 26461 tatcgcgtga gttgccccca acccacaggt cctagggcag cattgatccc tatgactagg 26521 accaggcctg tccctcagcc tgtgggggcc agagaagttg ctctgaaacc acagctgtct 26581 ttctcaccat tgtgtacact tagtgagtct ctccagtgcc tttaggcctc agttttccct 26641 tctgagatgt gggtgtgatg gactgaaatt gcttcaagtt ctacagagaa atggcagaat 26701 atgggagcta agaacacagg gtcagaggca gtgcagggct tgaacccggg ccatctatct 26761 cctagttcag ggcttcgtgt tgtgagggga ggagaggcct gaatataggg tgggggcggg 26821 gagatgtggg gaagattctc caaaaggctt tttctttttc ttgtcttgag tcgccaggga 26881 acagcactag gtaccgaaaa ggccagaagg ggtatgggcg agtactagag agaaatttcc 26941 atgactgctt tatttattta tttatttatt tatttattta tttattgaga cagagtctca 27001 ctctgttgcc caggctgaag tgcagtggtg cgatctcagc tcactgcaac ctccacctcc 27061 cagtttaagg gattctcctg ctttagcctc ccaagtagct gggatcacag gcacccacca 27121 tcacacccaa ctaatggttt tgtattttta gtagagatgg ggttttacta tgtttgccag 27181 gctggtctcg aattcctgac ctcaggtgat ctgcccgcct cggcctccca aaatgctggg 27241 attacaggcg tgagccactg cgcctggcct ccatcctcat cctgaagatg caagaacttc 27301 tggtgacccc ttctcctgag agtggcctga tctcccctgg gcagggcact ttcttcccac 27361 gctgggctct cccacgactt gtgtgccttc cctcacacat tctagtaacc acttcatttt 27421 cactcttcat ggtgggaact tccagctaag cacagtccac cgttacgtga tcaacacagt 27481 ggccctggca ggccaatttg tgccttgctt ctggaacaaa catgcagtaa taacaacgaa 27541 aatgttttga gcatttgtcc gctctgctcc aagcactgac ccgggtgggg tttatgaagt 27601 ttgactcatt tgtccccgca ataactcctt gacctaggtg tcagagggtg actaaccagg 27661 ggtcacacag cagataagtg tgggcacaag gatccaagtc catgactgta tcccacgtgt 27721 ctcccacatc caggcatccc tctggacttg tccagctgtg tccttttctc tcatttctct 27781 tccctgccag ccttaactcc atcaccaaca aatattgggc tactctgtcc taggcatggt 27841 cctcagctga gaggtcgcag ccatcccaag acagaggggt ccttgccaca tggagactgc 27901 attctagtag ggaatacagc aaactggctg ataagccata tgacacacaa tgttgagtag 27961 tgataaggac ctgggagaaa aagaaagccc aggagaatgg tggaggggcc gttttaagat 28021 aaggcggtct gggccaggta cagtggctca cgcctgtatc cccagcactt tgggaggctg 28081 aggtgggcgg atcatgaggt caggagatcg agaccatcct ggctaacaca gcgaaacgct 28141 gtctctacta aaaatacaaa aaattagccg ggcgtggtgg catgcgcctg taatcccagc 28201 tacttgggag gctgaggcag acgaatcact tgaacccagg aggcagaggc tgcagtgagc 28261 tgagatggcg ccactgcact ccagcctggg cgacagagca agattctgtc tcaaaaaaaa 28321 aaaaaaaaga taaggtggtc agggaaggcc tctctgagga ggtgaagctt cagctggctc 28381 taaaccaggg gagcgggaga gacgcagtgt aggacagtat cggggaagag caggcctgtg 28441 tcttctccgg tggcctcagg gaatgaggga gaaggaaggt gctggggagg ctggcaaggc 28501 tggaggatgc aggcttgtgg gcaggacctg ggagttgcga tgtcactctc cgtggcagga 28561 agctactggg gcttcgaggg gagaagtgat atgctttgat ttaccttctt aaaagattgc 28621 cccaactgct gggtggagaa caggatgaca ggggcaagca tggagacagg gaggccagtt 28681 agagatggcg tgattcaggc caggatgagg ggtgagaact ggtatgcagt tccaaagtag 28741 agctgatagg acttgcccag tgtctggatc ttatccagtg gatgcccaga gcttgggtct 28801 ggggatgaag tgggtttaat ctgccaaggg ttggggatgt catttgctcc tggagctccc 28861 aagggacttg gggaaggttg ttcccaaccc ctttcttccc ttcccagggg ctgccgggag 28921 gctatcaaaa ggatcgccta tgagtttgta gagatgaagg ccaaagaggg cgtggtgtat 28981 gtggaggtgc ggtacagtcc gcacctgctg gccaactcca aagtggagcc aatcccctgg 29041 aaccaggctg agtgagtgat gggcctggaa ggggccatgc tgagggtgtg gctgggaggc 29101 tcagctctga gactggaagg gcgaactgct gggaatccct gacccaagca agaccttgtt 29161 cttgccccca gtctggtcca tggcctcaga aagatgggtt taactctgtc acaagagacg 29221 tggttcccat cctccctttg ccgttatgtt cttaccttgg gcacaagtgt ttggctgtgt 29281 cttgctctgg ccacaggcct gctgtccagg aatgttaacc tgcttagcca cccaggattt 29341 ctgaggggtc tcccttgtca ctgatgctga tcagatctct aaaggcccta aaggtcctgc 29401 tctaacttca taactgaagt gagtctggcc catttctagc cccctgcctg ggcccccatg 29461 gatctctaag tggtatcaca aaaccaccct gccccatttt ctgagccatg attctgatac 29521 atatagaatg tgaacatcat ggcaggccca agcttagcaa tgctgtccat ctgggggtgg 29581 ggagggccat gttgacaccc cacacctccc actaagatct aggagcaccc agctgcttta 29641 agagctagag ggacatgcta gggcctgggg gcatctctgc cagtctttcc tctgaggcag 29701 tgggtcagtg ggggaggagg gtcctcccca aagcctcctc ttcctcctct gtcccagtcc 29761 cagagctgcc ctttaggcct tccttttgcc tcaggcccat ccctactcct ctcctcacac 29821 agaggggacc tcaccccaga cgaggtggtg gccctagtgg gccagggcct gcaggagggg 29881 gagcgagact tcggggtcaa ggcccggtcc atcctgtgct gcatgcgcca ccagcccagt 29941 gagtaggatc accgccctgc ccagggccgc ccgtctcacc ctggccctga cctcctggcc 30001 tagcagtggg gctgtacctg atctcccctg tgccccacag ccccatggtg tccccttgag 30061 cccactggca tgaacttggg gcttcatgaa acaactggag acctcctagg caggctcaga 30121 acttctggag atgttctccc cagggacacc atgcctttat agccaccctg caggaagctc 30181 aacaccaaat aggaacgtaa ctattgaaaa aaaaatctag gctagattct gatcagccca 30241 tagtcctccc tcgagaccca gtggaccagg ccccatcctg tctgggcctg aataggtctg 30301 atttccaaga tttctgaggg gtctcccttg tcactgacgc agatcagatc tctagagttt 30361 gtgcctcatg gtgcacagcc tcactgtgtg atattgggca ggtcacactg ctgctctggt 30421 tatgcaccaa gacacctcag ttgtgcactg tcacaaggag atgatcacac ttacttcatt 30481 cctctaccct caggattagt aagaaccaaa gagctacctg cacgcatttc ctctaatcct 30541 cgcagcagcc tgcaaagcag aactaccatt gcttagtccc atttgacaga tgaggaaact 30601 gaggtggagt gaggtgcagc ctcttgcaag gcacaaaccc tggatttgta tccggggaca 30661 tctagttcca aagcctgtgt tcattcattc tttcttaaac acttcagaat aactttattg 30721 gttaagagta cctaatacat tagcgagata cttcccaata ctagtgtgag ttctatttta 30781 gatgacgtgt taaacggtcc tccgtttcct catctgcgca tgggaataag cctaccatga 30841 gtgttgttgg aaacaccagg tgagagaagg gtccgtgtca tttactgagc tcaggccccg 30901 tccttggtgc tttacacaca tggcctcggc aaagcctggc cgtgaccctg tgcaatagct 30961 ggcagggttc tttctgaaaa gggcggaaac tgaggccata agcagagcag ttttccgcag 31021 ccatgtggtt aggacatagc agttaggatt tgaagacact gagccctgtt ttgtgctggc 31081 ctcccatggg gggtttgggt gggacagcag gcaggtaggc tgggaggtct ctccatggtg 31141 ctggtgacag agcctgggtg ggcatctgcc cacagactgg tcccccaagg tggtggagct 31201 gtgtaagaag taccagcagc agaccgtggt agccattgac ctggctggag atgagaccat 31261 cccaggaagc agcctcttgc ctggacatgt ccaggcctac caggtgggtc ctgtgagaag 31321 gaatggagag gctggccctg ggtgagcttg tctcccaccc atagttggga gaaatcacaa 31381 gaaccaggga ccatggtgtc tcctgagttc tgaagtgtgt ctttgttggg tcttaaggct 31441 tggaactgga atccccctgg gccaggcgtg gtggttcatg cctgtgatcc cagcactttg 31501 ggaggcgagg caggaggatt gcttgagcct aggagtttga gaccagccag ggcaacatag 31561 tgagatccat ctctgcaaat acaaaaaaaa gtagtcaggc atggtggtgc atgcctgtag 31621 tcccagctac ttgggaggct gaggtgggag aattgcttga gtccaggaag tcaaagctgc 31681 agtgagctgt gataatgcga ctgcactcca gcctgggtga cagagggaga ccctgtctca 31741 aaaaaaaaaa aaaggaagaa agaagaaaga gaaaagaaag agaaagaaag agaggaagga 31801 aggaaaaaga ggaagggagg gagggaggaa ggaaggaaag aaggaaggaa gggagagaga 31861 aagaaaagcc tccacttggt gttgggagtc ctgtgctgag cctgcttctg gctgtgattt 31921 gctgtgtgaa cctgggcaac actgtgtctt ctctgggcct ctgtttcttc tattgggatg 31981 actgagttgg agccgacatc tcaaaagtcg cttccagcgt gatgatgaat gggcctcctg 32041 tggagggtgc agcatggtgg agaagtcagg gctctggagt cccactgccc gggctcagag 32101 cttggttcca cacttcctgt ctgaccttgg tcacattact tgaatctcct gagcttcagt 32161 ccttcatcat aaaatgggtg ggataatagt tgtgaatatt agataatgta tacaagtcac 32221 ttcatatact acctgacaca tggtaactgg ctaatgagtg acagctacca cttagataag 32281 gacttggagg gtaaaagacc aggtttcccc atgctgttga agcaggcagc atgactagga 32341 tggttcaatc tccacagcat ggtcaaggca ggctgccggg gccctcccgc tagggcaccc 32401 atgacctggc tctccccctt ccaggaggct gtgaagagcg gcattcaccg tactgtccac 32461 gccggggagg tgggctcggc cgaagtagta aaagaggtga gggcctgggc tggccatggg 32521 gtccctcctc actgcctcct cccatacttg gctctattct gcttctctac aggctgtgga 32581 catactcaag acagagcggc tgggacacgg ctaccacacc ctggaagacc aggcccttta 32641 taacaggctg cggcaggaaa acatgcactt cgaggtaagc gggccaggga gtggggagga 32701 accatccccg gctgtcccaa cttcctgtat agagaggcag aaagcagggc gggtcccagg 32761 aactcgaggg gtggccccag gcccagacat ggggggagga atcagcatgg cctggggcca 32821 tccctgccag ccacacacct gctcttccag atctgcccct ggtccagcta cctcactggt 32881 gcctggaagc cggacacgga gcatgcagtc attcggtgag ctctgttccc ctgggcctgt 32941 tcaattttgt tccaggaagg ccaaagaggg aagaaacttt agggattggg catcagccca 33001 tgccgcgtct tttagatatg aaatctcttc gacaccctgg gaagcaggca ttgccgtcct 33061 catcttacaa atgaggaatc cgaggcccag atgtgctgtg gcttgactgg gattacccag 33121 ctgctaacca gcagagctgg ggccctacag ctcatcagct ggagcagaac gctccattac 33181 tctgagggaa gcttccacac ttccaattct cccaactctg ccccctgggc atcgcatagg 33241 aagcaggagt ccctctggcc agcatgttct ctcttcctga cacctggccc ttgggacccc 33301 tgggcattcc cctgagcgcc atcttgaagc tttccaccgg aggtctgttc caccctgcct 33361 ggctcccatc ctggagtcta accagggtca aggccctcct tccgtcctgt cgccaagcca 33421 caggagcagt atcaggcctt aggaaaaagc cgccttcccc aagacaagga cagcaagaac 33481 tcagggtgac catggtcagg ccagcactta tccatctgcc aggcatatga gaaggggagg 33541 ggcttcggct ctgatgttct gatgacaagg gggtcttggg gcttgcttag ggacacgtgg 33601 cacctgtgga ggttcttgga ggcatgtggg tataccatgg gctggaaaaa gatccaggag 33661 tcatctgcac agatatggtg gctgaaggag aagcagtggc cccaggaggt ggtggagcaa 33721 gaagggccta ggatagaacc cagaaggaca atggtattta agggaccagc aaaagagaca 33781 agtaggagga aagtcaaaag tgtggtgtca cagaaatcca gggaaaaggt ttcaagaaac 33841 agtcaacagt gtgaaattct gctatgcaag tcgattatgg tcagagctag gaaagatcca 33901 ttagatacaa caagatggtg gtcagggatc gtgccaagaa cagcttccat ggtatgttgg 33961 agtagccagc tcccagtggg actgaggaac aagcagggta gggtgcagag gggaaggctg 34021 gagagggtgg cagccggagg gggatgttgc tttcttggct cccaccccca cgcccccacc 34081 ggctgccatt ctgcctggtt cccatgtctg gcccctctgc tgcctttgcc cagctctggt 34141 cttcaggatg ggctggattc tggactttct ggttacatag acttgaacaa gtcacctaag 34201 ttctgaattt atttccccct ctgcacaagg atcagatctt tcagatctgt ttgaggctgc 34261 tgtgaggatc aaaggcgggt gaacgtcaat gtgttctgac tatttatgta agagtaaaag 34321 gaggctgatt ctctcctcct ccctcttctg caggctcaaa aatgaccagg ctaactactc 34381 gctcaacaca gatgacccgc tcatcttcaa gtccaccctg gacactgatt accagatgac 34441 caaacgggac atgggcttta ctgaagagga gtttaaaagg ctggtgagtg ggtgtgagcc 34501 atactggcct tgactcgggt ttgggagtat ggtatctaca ggtccagtcc ggggcctgga 34561 atctttggag agagggagtg agtctgcctc aacagtccaa gacaagccca acctagacac 34621 tttccacaga gaagacatct ttgtgttgac gtcctgacct aggaccaggt ttttgatcct 34681 ttgcttgggt tgagtgcctt taaagaatcc agtgaaagct gtcaaccctc tccccagaaa 34741 ggtgtgtgca gcagctatga agtcttgcac actctcttca ggttgttctt aaatcccagg 34801 ctgaataagt ccattcctgc acgtgtctgc gaggtgtctc tggcccccta catgccaccc 34861 tgtctctcaa aggtttctcc aacttccttc tcacagccct ttttcatgta atgacaaatt 34921 aagaacacga cctcatggtc tctactctgg cacttgctgc cgtgtgacag tggacaaatc 34981 cttccccctc taagcgtatc tgcccatgtt gagtgaagag gatggactat cactacattg 35041 ctaagagctg ccttctttgt tctctggttc catgttgtct gccattctgg cctttccaga 35101 acatcaatgc ggccaaatct agtttcctcc cagaagatga aaagagggag cttctcgacc 35161 tgctctataa agcctatggg atgccacctt cagcctctgc aggtaggttc ctgtctgggc 35221 ttctgggcag ttgcctgtcc tggccccagt gtggctttct gtgggacttc tagcaagatg 35281 cccttccatt cttgggcagc gcatgaatgt gtgatgactc cctggtttct gggccctggc 35341 tgggagcagc gtctcattag atcggtttgt tttctataaa agttcttgag aggctgttct 35401 aaggggagac tttctgaagc ccagtcccaa aggtctgggc agttggggac acctccatgg 35461 ctgcccaaag ccaagggcag ggagaggggc ccaggctgtt ctgctccttt cttcctatgt 35521 ggtcttggca aggcatcttc ttgccatcat aggaaggagt tcctttctgg ttctggtgtt 35581 ctatgatttt tacaacatcc tgggtactac aagttgcctg atctttttgc ttctctgaac 35641 caacgagcag ggcagaacct ctgaagacgc cactcctcca agccttcacc ctgtggagtc 35701 accccaactc tgtggggctg agcaacattt ttacatttat tccttccaag aagaccatga 35761 tctcaatagt cagttactga tgctcctgaa ccctatgtgt ccatttctgc acacacgtat 35821 acctcggcat ggccgcgtca cttctctgat tatgtgccct ggccagggac cagcgccctt 35881 gcacatgggc atggttgaat ctgaaaccct ccttctgtgg caacttgtac tgaaaatctg 35941 gtgctcaata aagaagccca tggctggtgg catgcagcag gtggcatgta atttggtggt 36001 cttgggcggg ccgatgtggg caggatgagc atggagggag ctgggtcagc ctgctcagca 36061 gcagggcctg agcctaaggg tggctgtgaa tgccaggcca gagatcccaa tgctgtgggc 36121 caagaggggt ccagaggctg tcctccttcc agaagaaata aggcttctct ggttgttgct 36181 caaacattcc ctgaactctc agcccctcct aactctaggt tttaaggagt aaagcttcct 36241 tttgggttcc tgaagctggc agttggggtg agagcagatg agatggaaga gggctcatca 36301 gacactggcc ttggagggtg ctggcctctg cagaacgcca gcatcttctc agaatcgtat 36361 gttctagaag cctgggcgaa gtccggctaa ttgtggactt ggggaaaata aggcccaacc 36421 cctgtttttg caaggttaag gagaaataat cttaaaccag tcacacaaat catcggcatt 36481 tatttcctgg gtcctaggtg tcacttatcc tggtggacag ggcagaggtg gtcagatcgt 36541 tttgagccaa aatcccttcc ctaaaaatgg atctgtggag ctccatgagg gaacctcaga 36601 gatgcacaat gacagtttag ctaaaatggc ttaaaaaatg tgaattgatt gtcagctctc 36661 tccatatctg ctgaaaaaag gtttaaaatt tttaaaaagt ttaaaagtgt tttctaaaaa 36721 agggacaagc aggtctggac c //