LOCUS HUM17BHYD 21788 bp ds-DNA PRI 30-OCT-1994 DEFINITION Human 17-beta-hydroxysteroid dehydrogenase (EDH17B1 and EDH17B2) genes, complete coding regions and flanks. ACCESSION M84472 KEYWORDS 17-beta-hydroxysteroid dehydrogenase; Alu repeat; estradiol 17-beta-dehydrogenase. SOURCE Homo (tissue library: Lambda EMBL13) DNA. ORGANISM Homo Eukaryota; Animalia; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Peltoketo,H., Isomaa,V., Maentausta,O. and Vihko,R. TITLE Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA JOURNAL FEBS Lett. 239 (1), 73-77 (1988) MEDLINE 89031223 REFERENCE 2 (sites) AUTHORS The,V.L., Labrie,C., Zhao,H.F., Couet,J., Lachance,Y., Simard,J., Leblanc,G., Cote,J., Berube,D., Gagne,R. et,al. TITLE Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta JOURNAL Mol. Endocrinol. 3 (8), 1301-1309 (1989) MEDLINE 89384667 REFERENCE 3 (sites) AUTHORS Luu-The,V., Labrie,C., Simard,J., Lachance,Y., Zhao,H.F., Couet,J., Leblanc,G. and Labrie,F. TITLE Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes JOURNAL Mol. Endocrinol. 4 (2), 268-275 (1990) MEDLINE 90231340 REFERENCE 4 (bases 1 to 21788) AUTHORS Peltoketo,H., Isomaa,V. and Vihko,R. TITLE Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements JOURNAL Eur. J. Biochem. 209 (1), 459-466 (1992) MEDLINE 93011163 COMMENT [4] reports bases 6601-21788. NCBI gi: 177126 FEATURES Location/Qualifiers source 1..21788 /organism="Homo" /cell_type="leukocyte" /sequenced_mol="DNA" /tissue_lib="Lambda EMBL13" repeat_unit 907..1187 /rpt_family="Alu" /rpt_type=direct repeat_region 907..21622 /rpt_family="Alu" /rpt_type=dispersed /rpt_unit=10904..11038 /rpt_unit=11417..11674 /rpt_unit=13232..13514 /rpt_unit=13544..13818 /rpt_unit=13835..18937 /rpt_unit=13938..14073 /rpt_unit=17126..17260 /rpt_unit=17636..17897 /rpt_unit=1898..2178 /rpt_unit=19461..19739 /rpt_unit=19755..20038 /rpt_unit=20086..20280 /rpt_unit=20297..20570 /rpt_unit=20571..20849 /rpt_unit=21100..21300 /rpt_unit=21332..21622 /rpt_unit=2481..2760 /rpt_unit=3984..4128 /rpt_unit=4146..4428 /rpt_unit=4429..4562 /rpt_unit=4577..4858 /rpt_unit=6655..6809 /rpt_unit=6816..7097 /rpt_unit=7569..7888 /rpt_unit=907..1187 repeat_unit 1898..2178 /rpt_family="Alu" /rpt_type=direct repeat_unit 2481..2760 /rpt_family="Alu" /rpt_type=direct repeat_unit complement(3984..4128) /note="right arm" /rpt_family="Alu" /rpt_type=inverted repeat_unit complement(4146..4428) /rpt_family="Alu" /rpt_type=inverted repeat_unit complement(4429..4562) /note="left arm" /rpt_family="Alu" /rpt_type=inverted repeat_unit complement(4577..4858) /rpt_family="Alu" /rpt_type=inverted repeat_unit complement(6655..6809) /note="right arm" /rpt_family="Alu" /rpt_type=inverted repeat_unit complement(6816..7097) /rpt_family="Alu" /rpt_type=inverted repeat_unit complement(7569..7888) /rpt_family="Alu" /rpt_type=inverted repeat_region 7754..20180 /note="duplicated regions D1 and D2" /rpt_type=direct /rpt_type=tandem /rpt_unit=13938..20180 /rpt_unit=7754..13937 repeat_unit 7754..13937 /gene="EDH17B1" /map="17q11-q21" /note="G00-119-860" misc_difference 7826..7829 /note="present in clone lambda17-HSD5; absent in clone lambda17-HSD3" misc_difference 7833..7839 /note="present in clone lambda17-HSD5; absent in clone lambda17-HSD3" prim_transcript 7840..11038 /gene="EDH17B1" /map="17q11-q21" /note="G00-119-860" misc_difference 8119 /gene="EDH17B1" /map="17q11-q21" /note="G in clone lambda17-HSD5; A in clone lambda17-HSD3; G00-119-860" misc_difference 8202 /gene="EDH17B1" /map="17q11-q21" /note="C in clone lambda17-HSD5; T in clone lambda17-HSD3; G00-119-860" repeat_unit 10904..11038 /note="left arm" /rpt_family="Alu" /rpt_type=direct repeat_unit complement(11417..11674) /rpt_family="Alu" /rpt_type=inverted misc_difference 12291 /note="C in clone lambda17-HSD5; T in clone lambda17-HSD3" repeat_unit 13232..13514 /rpt_family="Alu" /rpt_type=direct repeat_unit 13544..13818 /rpt_family="Alu" /rpt_type=direct repeat_unit 13835..13937 /note="truncated" /rpt_family="Alu" /rpt_type=direct repeat_unit 13938..20180 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" repeat_unit complement(13938..14073) /rpt_family="Alu" /rpt_type=inverted prim_transcript 14023..17268 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" mRNA join(14023..15086,15180..15347,15495..15674,15850..15943, 16460..16637,16724..17268) /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" exon 14023..15086 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=1 CAAT_signal complement(14889..14892) /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" protein_bind 14921..14922 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /bound_moiety="transcription factor AP-2" GC_signal 14926..14939 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" TATA_signal 14949..14955 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" CDS join(14990..15086,15180..15347,15495..15674,15850..15943, 16460..16637,16724..16993) /gene="EDH17B2" /standard_name="estradiol 17-beta-dehydrogenase" /map="17q11-q21" /EC_number="1.1.1.62" /note="NCBI gi: 177127" /codon_start=1 /gdb_xref="G00-127-970" /product="17-beta-hydroxysteroid dehydrogenase" /translation="MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQG RLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEA LGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASK FALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQ YLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNY VTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRSAVGDPELGDPPAAPQ" intron 15087..15179 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=1 exon 15180..15347 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=2 intron 15348..15494 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=2 exon 15495..15674 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=3 intron 15675..15849 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=3 exon 15850..15943 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=4 intron 15944..16459 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=4 exon 16460..16637 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=5 intron 16638..16723 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=5 exon 16724..17268 /gene="EDH17B2" /map="17q11-q21" /note="G00-127-970" /number=6 repeat_unit 17126..17260 /note="left arm" /rpt_family="Alu" /rpt_type=direct repeat_unit complement(17636..17897) /rpt_family="Alu" /rpt_type=inverted repeat_unit 19461..19739 /rpt_family="Alu" /rpt_type=direct repeat_unit 19755..20038 /rpt_family="Alu" /rpt_type=direct repeat_unit 20086..20280 /note="truncated" /rpt_family="Alu" /rpt_type=direct repeat_unit 20297..20570 /rpt_family="Alu" /rpt_type=direct repeat_unit 20571..20849 /rpt_family="Alu" /rpt_type=direct repeat_unit complement(21100..21300) /note="truncated" /rpt_family="Alu" /rpt_type=inverted repeat_unit 21332..21622 /rpt_family="Alu" /rpt_type=direct BASE COUNT 4889 a 5920 c 6091 g 4888 t ORIGIN 1 gtcgacctgc aggtcaacgg atccaactca tgggcagctc tagatctgcc tccctggaag 61 cttctgtgct gcaatggctg ctccaggctc tgcttaagct cttcacacag ttgccctgcc 121 cttccatctg gcactcttgc tccatgaagc cttctaaggc cttcctcttg ggggaaagcc 181 cctttgtgcc ccatctcctc acccatgcga caaaggcaac acagtgaact cacctactca 241 caggtctctt tcctctgggc tgtgggctcc ttgatggcag cgttcggatt ttgtctcagt 301 agccctagcg cccagcacaa agaagcaatg agtgaatggt tgttgaatga atgaatgaat 361 gaatgaagat gaatatattt ctatgtgtgg gcccttcttc ctcaggtgta cctggccttg 421 ggcctgaccc aggcagagat caatgagttc tttactggtc ctgccttcct ggcctggggg 481 cgaatgggca acctgcacac ctgggatggc cccctgcccc cctcctggca catcaagcag 541 ctttacctgc aggtaaaagg atggaaaagg gaaggggcag aatcggtgat agatggtcat 601 gggcccagga agggtggtat taggccggcc ccagggctct taactgaggc ggggggctgc 661 gtgtatcctg ggagatgagg gccttctcat aggacagcag tggccatgct caccaccctt 721 ccttctgttc ctccagcacc gggtcctgga ccagatgcgc tccttcggca tgaccccagt 781 gctgcctgca ttcgcggggc atgttcccga ggctgtcacc aggtgaggtt ccgctcaccc 841 cctccactta gctcagagag ggaattttat tcccttctag aacatgactt aaaaacttaa 901 gctctgggcc gggcgcagtg gctcacgcct gtaatcccag cactttggga ggccgagttg 961 ggcggatcac ctgaggtcag gagttcgaga ccagcctggc caacatggtg aaaccctgtc 1021 tctactaaaa atataaaaat tagctgggca tggtggcacg cgcctgtaat cccatctact 1081 taggaggctg agacaggaga attgcttaaa cctgggaggc agacgttgca gtgagtcaag 1141 atcacgccat tgcactccag cctgggtgac gagcgaaact ctgtctcaaa caaacaaaca 1201 agctctggac gtaggcctgg gtttgatttc tgactctgct actaattagc tgtgtgactt 1261 cgggcagatg acatgactgc tctgtgcctc agtttcctta cttgtaaaat gggatctcta 1321 cccactcgct gtagggtttg taattatctc tcgatctatc tgtgactttg cacagagtgc 1381 tagcaaatgg cagcccctgg gagtggccgc aggggtgctc cagtgtccct tgtcccttcc 1441 tgttcctcgg gctttcccag ccatcctgta aatgtcttgg gaaaagtctt caaggctcac 1501 ctgagacctc ccctccttca ggaagccttg ctagtgcccc gcatgacctc ctttgcacct 1561 gctaatgtct ggctcccata ctctcgtagg acttaatgca tgccagtggc ctccctgccc 1621 gcctctttgc ccccatcacc aggtggcagg aaactcactc attcattcaa taaacttggt 1681 ccagctgtct gaggctgcca gaactggctg tgctgggtcc tgggaggcgg caagaaaggt 1741 gcccaagggc ttacccctga taggagagat atgttggctg aaggatacaa tgtggggaca 1801 aggacaggaa tatatgtggg ttccgctctc ctctgccggg agagaggggc aggaagggct 1861 cagggcagag cccagccttg aaaaatgagt gttgcttgga cggacgcttg gctaatgctt 1921 gtaatcctag cgttttggga ggctgaggcg tatggatcac ctgcggtcag gagttaaaga 1981 ccagcctggc caacatggcg aaaccccatc tctactaaaa gtacaaaaat tagccaggcg 2041 tggtggcggg ctcctgtaat cccagctact cggtaggctg aggcatgaga atctcttgaa 2101 gccaggggcc agagactgca gtgagccgag atcacaccac ttcactccag cctgggtgac 2161 agagtgagac tccgtctcaa aaaaaaaaaa aaaaaaagga aagaaaatta aacacctcat 2221 gttctcactc atagtgggag ttgaacaatg agaacaacat ggacacagga aggggaacat 2281 cacacaccgg ggcctttcgc ggtgtggggg tcaaggggag gagtagcatt gggacagata 2341 cttaatgcat gcggggctga aaacctagat gatgggttga tgggtgcagc aaaccaccat 2401 ggcacatgta tacctatgca acaaacctgc atgttctgca cagaactgaa ctgaaagtat 2461 aattaaaaaa aaaaaaaaaa gctgggtgcg gtggcccaca cctgtaatcc cagcactttg 2521 ggaggccgag acgggcggat cacaaggtca gcagatcgag accatcctgg ctaacacagt 2581 gaaactcagt ctctactaaa aatacaaaaa attagccggg tgtggtggcg ggcacctgta 2641 gtcccagcta ctagggaggc tgaggcagga gaatggcatg aacctgggag gcagagcttg 2701 cagtgagctg agaatgcgcc actgcactcc agcctggggg acagagtgag actctgcctc 2761 aaaaaaaaaa aaaaaaagaa agaaaaagga gcgttgcttg tttcaggcca caggaagggg 2821 agagatagtg aaagtttttc agagaaggtg gccagggaag gagaagaaag gactgtaggc 2881 agagagcata gcctgtacaa agccatagag gcaagagaaa ccaggagctg tagagaagtt 2941 ggcaaggctg ttgaacacta tggtgaacac tatggcggct tccatgaaat atctgagctt 3001 ttgctcccca ctagggtgtt ccctcaggtc aatgtcacga agatgggcag ttggggccac 3061 tttaactgtt cctactcctg ctccttcctt ctggctccgg aagaccccat attccccatc 3121 atcgggagcc tcttcctgcg agagctgatc aaagagtttg gcacagacca catctatggg 3181 gccgacactt tcaatgagat gcagccacct tcctcagagc cctcctacct tgccgcagcc 3241 accactgccg tctatgaggc catgactgca ggtacagtgc ctgggtgggg tgggagagcc 3301 ccccagaccc tcaaaaagaa gggagtagca gatgtcagta ggggtaggca gagggactgg 3361 aataatgcct cgccataaca cacagtactt tatagtttac caagcacgtg tacacatgcg 3421 ttgtctcagt gaatcccact gtggttgaga ggtgagctct ggaagccaac aacctgggtc 3481 acacctcgcg ctcctatttc ctggccgtgt gacttatgac tcatgacctc cttcccagtg 3541 tctcgtttgc ttttcctgta aactgggact acctcatagg tagaataacg cctggcccag 3601 agcaaaggcc actaagagct agctatgaac aaggattttg tttcatctct gcgtggttgc 3661 tgaagtaggc actgcaggca ggaggtgagt ggatgtgcct aaaggcacta agtgcgcatc 3721 ctgctacaaa actgtgaagc cagggctcct tcctgccact taaaggagga gtggagcaga 3781 gggcgcccaa gtcaggaatg acttagtgga gaggcgtctg tgttggccag gaagggaaca 3841 gatcagctca gcctttcttg agcagtactg ctccaagtgt gacccaaaac cagcagcagc 3901 agcagcagca gcccgagctg tgagatggca aattctcagg ccctacccaa gacctgaagg 3961 agaagctaca tttttttttt tttgaagaca gatttcactc tgttgctgag gctggagcac 4021 agtggcacaa tctcatctca ctgcaacctt cgtctcctag gttcaagcga ttctcctgcc 4081 tcagcctccc gagtagctgg gactataggc acccgccacc acgcccggca atttttgttt 4141 gttttgagat agagtctcgc tctgtcaccc aggctggagt gcagtggcac gatctcagtt 4201 cactgcaacc tctgcttcct gagttcaagc gattctcctg cctcagcctc ctgagtagct 4261 gggattacag gcgcccccca accacactcg gctaattttt gtatttttag tagagacggg 4321 gtttcgctat gtaggtcaag ctggtttcaa actcctgacc tcaaatgatt cgcccacttc 4381 agcctcccaa agtgctggga ttacaggtgt gagccacctt gcctggccaa tttttgtatt 4441 tttagtagaa acaggtttca ccatggtggc cagactggtc tcaaactcct gacctcaggt 4501 gaactgccca cctcagcctc ccaaagtact ggtattacag gcgtgatcca ctgcgactgg 4561 ccttgatttt gtttttgaga cagaatctta ctctgtcgcc cagactggag tgcagtggca 4621 caatctcagc tcactgcaac ttctgcctca tgggttcaag tgattcttgt gcctctacct 4681 cccgagtagc cgggattaca ggcacctgcc attacgctag gctaattttt gtatttttag 4741 tatagacagg gtttccccac attggccagg ctggtctgga actcctgggc tcaagtgatc 4801 cacctgcttc agcccctcag agtactggga ttataggtgt gggccaccac gcccattcag 4861 aaacctccat gttttaagga gcctctgggt aactctcatg ttcacccaag ctgctgaacc 4921 ctgtcttgga gttttcagag ggacgcgtat gtgccacaga cgtcccgctg gtgggggtca 4981 tgggaagcca tgacctggga tagacagtcg tctgtagagt ggggtgaaca ttccctgggc 5041 cctctgtttc atcactcctc ttctctgttc cccctacctc ctgtccacag tggatactga 5101 ggctgtgtgg ctgctccaag gctggctctt ccagcaccag ccgcagttct gggggcccgc 5161 ccagatcagg gctgtgctgg gagctgtgcc ccgtggccgc ctcctggttc tggacctgtt 5221 tgctgagagc cagcctgtgt atacccgcac tgcctccttc cagggccagc ccttcatctg 5281 gtgcatgctg cacaactttg ggggaaacca tggtcttttt ggagccctag aggctgtgaa 5341 cggaggccca gaagctgccc gcctcttccc caactccacc atggtaggca cgggcatggc 5401 ccccgagggc atcagccaga acgaagtggt ctattccctc atggctgagc tgggctggcg 5461 aaaggaccca gtgccagatt tggcagcctg ggtgaccagc tttgccgccc ggcggtatgg 5521 ggtctcccac ccggacgcag gggcagcgtg gaggctactg ctccggagtg tgtacaactg 5581 ctccggggag gcctgcaggg gccacaatcg tagcccgctg gtcaggcggc cgtccctaca 5641 gatgaatacc agcatctggt acaaccgatc tgatgtgttt gaggcctggc ggctgctgct 5701 cacatctgct ccctccctgg ccaccagccc cgccttccgc tacgacctgc tggacctcac 5761 tcggcaggca gtgcaggagc tggtcagctt gtactatgag gaggcaagaa gcgcctacct 5821 gagcaaggag ctggcctccc tgttgagggc tggaggcgtc ctggcctatg agctgctgcc 5881 ggcactggac gaggtgctgg ctagtgacag ccgcttcttg ctgggcagct ggctagagca 5941 ggcccgagca gcgcagtcag tgaggccgag gccgatttct acgagcagaa cagccgctac 6001 cagctgacct tgtgggggcc agaaggcaac atcctggact atgccaacaa gcagctggcg 6061 gggttggtgg ccaactacta cacccctcgc tggcggcttt tcctggaggc gctggttgac 6121 agtgtggccc agggcatccc tttccaacag caccagtttg acaaaaatgt cttccaactg 6181 gagcaggcct tcgttctcag caagcagagg taccccagcc agccgcgagg agacactgtg 6241 gacctggcca agaagatctt cctcaaatat taccccggct gggtggccgg ctcttggtga 6301 tagattcgcc accactgggc cttgttttcc gctaattcca gggcagattc cagggcccag 6361 agctggacag acatcacagg ataacccagg cctgggagga ggccccacgg cctgctggtg 6421 gggtctgacc tggggggatt ggagggaaat gacctgccct ccaccaccac ccaaagtgtg 6481 ggattaaagt actgttttct ttccacttaa actgatgagt cccctgggtc tgtcaaaatg 6541 agaaggtcac tgctgccacg cttgggagga ctcagggcta tagcatggcc ctggggtggg 6601 acctgttctc ccatcccttg cctcacgtcc ctgtttttgt ttgtttgttt gtttgtgacg 6661 gagccttggt ctgttgccca ggcttgagta caatggcaca gtctcggctc actgcaacct 6721 ccgcctcctg ggttcaagca attcttgtgc ctcagcctcc ccggtagctg ggactatagg 6781 catgcaccac cacaccaggc taattttttt tttccaagat ggagtcttgc tctgtcgccc 6841 aggttggagt ttagtggcac catattggtt tactgcaacc tctgcctccc gggttcaagc 6901 aattctcctg cctcagtcta ccagggagtt aggactacgg gcctgtgcca tcacgcctgg 6961 ctaatttttg tatttttcat agagataagg tttcaccatg ttggccaggc tggtctttaa 7021 ctcctgaact caagtgatcc acctgcctcg gccttccaaa gtgctgggat tacaggagtg 7081 agccaccgtg cccggccatg tctctctttt taacactaat gttaccctga cctttgaacg 7141 tagaatgccc ttctgttgca ggaaaacctc ttttcaaacc atgtttgtcc tttgctggca 7201 tgccacagca acagtcacca acacagaaga cttctgtgac caaatatttg gaggattttc 7261 cccacacaca ccaagcagca gacatcagct gggtgtcctc caattcagtt ccaatgtaat 7321 caaccagaga cagcatcaga tcccacaggg ttagggtgca gatccatgag accaccccct 7381 ccttcccaac ggttacaagt cctgatccct ggaacttctg actaactggc ttcaagttgg 7441 agttcccatg acccccttcc cctctttgga gtcaactcat ttgcgacagt gacccacgaa 7501 acacagggaa acccttatta tgtttattgc tttattacag aggaaaaaaa tttttttctt 7561 tcttttttga gacagggtct cactctgtca tccagaatga ctgcagtggc aggatctggc 7621 tccgtcaccc aggctggagt gcagtggcat gatctcggct cactacagcc tccatccccc 7681 ccaaacccca cgcctcagcg ccccaccccg caagtggctg ggactctaag catacaccac 7741 cacacccagc taattttttt gtagtttttg caaagacggg gtctcattct gttgccctgg 7801 ctggtcttga actcctgagc tccagcaatc cccttgtctt ggcctcccaa agtgctggga 7861 ttacaggcat cagccaccgt gcccaacctc aaaggatatt ttaaaggata gaaataaaca 7921 gccatatgaa gagatacaga cagggcggtc tggaagggcc cagagcagga gcttctatct 7981 ccatagagtt ggggttacat caccctccag gcacatggat gagttcttca ccttctgtca 8041 gcctccacac gttcagctct cagaagcttc ccgaaccctg tcctttgggc cttttatgga 8101 gaactccatt ggctgtccgt gactgaagca tggacaactg tgataatgtg attgggcaaa 8161 aagggtctga tctaagccca gcaaggccag tccagattct tcgggccttt gtgcagcatt 8221 cctttctcca gggtatgggg caaggaccca ctctggaatg aggatcctac aacccacaat 8281 cagattagag tcctgccttg ggcagctgaa aagaggacag gagaaggtca aagagaggaa 8341 aggctgtttt ttgaggcctg aggcgcccca acatgacaac gaaagactgt aaccatggtc 8401 atgtgagtta tgagctagga accctggacg aaaccaacac atatacaatc atctcccacc 8461 tcccaacacc tttactttca cagcctctgc agcaaactgc ggtcactata atcgctcctg 8521 tggcacagag gcatacccag gggaatctgc ccagggggcc actctgtgcc cacatgggaa 8581 cccacatctg cttgtaaagc ctcccctccc tctgaccaga aacgaggaca gtttgttgtt 8641 ccaagcagtg ggctcatgtc tgttttggct cagaacaggg tggggagagc gggccaggga 8701 cccgaggagg gcttatcctt gagattgcgt gggagacaca acaaggggtg ggggcccgca 8761 ggcggggcgg ggcgaagcag gtgatatcca gcccagagcc ccagcctctc cccacagtct 8821 caccatggcc tgcaccgtgg tgctcatcac cggctgttcc tcaggtattg gcctgcactt 8881 ggcaatacat ctggctttgg acccatccca gagcttcaaa ggtatagata ggtagggaca 8941 gggagggaga gaagggaaaa gcccttggag gccagaagag aagtcagatc ttcctcctct 9001 cccaaaacct ccagtgtatg ccacgttgag ggacctgaaa acacagggcc ggctgtggga 9061 ggcggcccgg gccctggcat gccctcaggg atccctggag aggttgcagc tggatgtaag 9121 gaactcaagc tccctggccg ctgcccggga acgcgtgacc gagggccgtg tggatgtgct 9181 gggtgagcct cctggaagca tatgggctcc taggagcctt ctccgccctg cgttgaaacc 9241 aacatgtccc caggcccctg gagcatgagg ggacaggccg tgctgagggt gatgctgagg 9301 cgggctggtt gggcctctgt ccccgcagtg tgtaacacag gcctgggcct gctggggccg 9361 ctgggggagg acgccgtggc ctctgtactg gatgtgaatg tagtaggtac tgtgcgggtg 9421 ctgcaggact tcctgccaga catgaagcgg ccgggttcgg gacgcgtgtt ggtgactggg 9481 agcatgggag gattgatggg tgagtggcag ggaccgggcc ccggagctcc agattctttg 9541 tgtgcagagc tgagccttga aggcaggctc cttagggggt ggggtgcaat cagcttggag 9601 gggcactgcc tgccggggga tgaccccctg gccgctgcgc ctcaggaacc tcatcttccc 9661 acccaagggc tgcctttcaa tgacgtttat tgcgccagca agttcgcgct cgaaggctta 9721 tgcgagagtc tggcggttct gctgctgccc tttggggtcc agtgagtcaa cacccccgtc 9781 tcctcaaccc tcttaactct gacctagaga tgccgagcac cctgtcctgc ggaagccgct 9841 ctggtctctg cccggcttac atttgctgcg tgccaggcac ttaggctgga gcattggcac 9901 gcattgtgcc acttgctgac ctggctgctg aagtgttggt attgttatgg ggaagctcca 9961 gccaggagag gttaggtgac tggcccaagg tcatgcagcg gccggggatc ccgccaggtt 10021 cgaattctga caccagggct acctggcagc ctcagatggg tttgggaggg ctgtcgagca 10081 ataacccgct attcaaatgt tctggttatc cccagcgctc tttccacctt cgggacgcag 10141 cggtgctgtt ctgggtcgtg gccagggccg gggtcggggc cggtgctggg gcaggagatg 10201 ggacttggcg cctggtcgct ccgtccctgc ccacttgcgg ctctcgggcc agcagcgtga 10261 gcctgatcga gtgcggccct gtggacaccg ccttcatgca gaaggtgttg ggcggtcccg 10321 accaggtgat ggaccgcacg aacacccgga ccttccgcct cttgcactaa tacctccacc 10381 acagcaagga gatctaccgc gaggaggcgc agcaccctga ggaggtggtg aaggtgagcg 10441 gggggcggga ctccgggagc gggggcggtg cgtcgtcctg cgcgcagccg gggccagagc 10501 tcctctcccg ccgccgcagg tcttcctcac cgctatgcgc gccccgaagc cgaccctgcg 10561 ctacttcaca accaggcgct tcctgcacca gctgctgatg cgcctggacg acccctttgg 10621 cttcgactac gccgccgcca tgcaccggga cgtgttcgcc gacgatcccg cagaggccga 10681 ggctggggcc ggggctgggg ccgaggccgg gggcggggcc ggtgggatgg gagaccctga 10741 gctcagcgat cctctggccg ccccgcaaga aaggctccgt cagccactgt ctcccgcgcc 10801 ctcctttgtc tcctgggcct gtgcggtccc tggggatggg acggcggtga cggctgtgga 10861 tggctaatta agacagatca cgttagcccg ttatatctgc gcggctaggc gcgatggctg 10921 tcgcctataa tcccagagct ttggaaggcc gaggcaggag gatcgctcca ggccaggagt 10981 tccagaccag cctgagcaac atagtgagac accccatctc taaaataaaa aaattagcac 11041 agtggcacca ttccttgagc tcaggagttg gaggctgcag tgggcatgat cgagctactg 11101 ctctccagct tgggtgatag agtgagacac tgtcaattaa ttaatctaat caaccaacca 11161 acccaacaac ccagaaacca aggtccagaa agaagccagc ccaggatcat gcctcaagtc 11221 cacagtaaag cccagacaca gtcactggat acccaagggg catctgcagg acgagttagg 11281 tgggacttgg gttggggtag agtcaggttg tgacctgcac tccattagcc atgagacctc 11341 aggcaagttc cttgctttct ctgagtgctt tcctttcctt tcccttttct tttctttttt 11401 gtttttcttt tgttttgaga tggagtttca ctcttgttgc ccagcctgga gtgcaatagc 11461 gcggtctcag ttcaccacaa cctctgcctc ccgggttcaa gtgtagctag gattgcaggc 11521 atgtgccacc acgcccagct aattttgtgt ttttagtaga gacgaggttt ctccatgttg 11581 gtcagactgg tcttggactc ccgacctcag gtgatccgcc cgccctggcc tctcagagtg 11641 ctgggattac aggcatgacc caccccatcc ggccctctga gtctttctta tctgtaaaat 11701 gggtataata atacctatct aatcggtttt agtaatggtg gagataatgc ctgaaagtgc 11761 tagtatagag gtttaatagc cagcaaggac tgttattaga atgaatagta atatgactac 11821 tgtcacattt tgcaaatgtg taaagaagaa agagggctaa gtgaatcaaa gggagacagc 11881 cccactcacc ctgttctgcc ccagaggact gagcgatccc caccatctgg caagctgcct 11941 caccaggagg tccagctggg gctacaggac tggctacttt gctacaatgg cccgtctttc 12001 ctgagcccag tggagggtcc caggggggca gaagtcattg ataggggcca gtagggttgt 12061 agagccactg tctgaacttc tgtggaggtc tggtgcaggg gaggtgtgaa cagataggag 12121 gctaggtgag gatgcagcag aggaagggca ggagtccgca ggagggggcg gtaccgaggc 12181 agggattcag ctgggtctga gagggaggca aggctgaggg ggatggccct ttggagtggg 12241 cagggacatg accacagaaa gcctgggaag tggaaacaga caggagcctg ctggagctct 12301 tggagctttg tgtggggcac taggggaagg aggcaggcac tccaccctga cctgccccta 12361 cctctggatg agggtcttct ctgcctgttg gatgatgtgc tgcccctgct cttggaggaa 12421 gaggcctccc agccaccccc tcctgccagt cgccttgccc tgctgaccca gacagatctg 12481 ctatccctac agcatccagg aaggccacag ggagggggcc caggtggcat gggtttctga 12541 ggcctgggat ctgctctcag tcccgctctc gccaaccccc tttgcccctc tgtgacagtg 12601 tgtgtacata tgcgtgcatg tgtgtacctg tgtggtgtgg ctcacaaggt cacccctggg 12661 ggtgggataa taagaggtaa agtgtgaccc cctctcttcc gtacattcat tttttcaagc 12721 ttgtgaatat tcacattgtt aatataatct tctgcagtcc catgacttcg aatagcactt 12781 agatgccgat gaccccccca ccaaagaaac cccactgtct cccacagact ccaggtctgt 12841 atctccaact gcctactcaa tacaacacgt ccacctgatg caatgaactt aatgtgtcta 12901 aaccccaatt ccacatttcc agtcctccta ccggctcctc ccccagtctt ctctacttta 12961 ctgtatgaca actccatttt tcccaatact ggttttaaaa accctggagt agtccttgac 13021 tccagtctct ctcacctttc aaccaattca gcagcaaata ctgacagctc tacctttgct 13081 catcaaagca tatccccaaa tcaccctatt ccagactgca cactgtcatc tctcccttca 13141 attacagcag tagcctccta actagttttc ttgattccac tcttgcccat cagcagtgaa 13201 attaccccag agcagttaaa atgatctttt aggatgggca cagtggctca cgcctgtaat 13261 accagcactt tgggaggtgg aggctggctg atccccttag gttgggagtt caagaccatc 13321 ctcaccaaca gggagaaacc ccatctctac taaaaataca aaaattagcc ggatgtggtg 13381 ggacgtgtct gtaatcccaa ctacttggga ggctgagaca ggagaactgc ttgaacccgg 13441 gaggtggagg ttgcagtgag ccagaatcgt gccacagcac tccagcctgg gcaagaagcg 13501 cgaaactccg tctcaaaata aaataatctt ctaaaaatga cagggccagg tggggtggca 13561 cttttttata atccgagcac tttgggaggc tgaggtgggc agatcgcttg acatcagggg 13621 tttgagacca gcctggccaa catggtgaaa cttcgtctct actaaaaata ctaaaaatta 13681 gctgggcgtg gtggcgggtg cctgtaatcc cagctactcg ggaggctgat gcaggagaat 13741 cgcctgaacc aggcagatgc aggatgcagt gagccaagat taagacactg cactccaacc 13801 taagcaatac tttgtctcaa aaataaaaaa aagcctggga aacaaagtga gaccccgtct 13861 ctacaaaaaa gtcaaaaaat tagctgggta tggtggcagt gatggcacac acctgtagtc 13921 ccggctactt gggaagcttt ttaatatttt ttgcagagac cgggtctcac tctgttacct 13981 ggcctggtct tgaactcctg ggctccaaca atcccctttc ctgggcctcc caaagtgctg 14041 ggattagagg catgagccac cgtgcccagc ctcaaagcat attttaaagg atagaaataa 14101 acagccatat gaagagatac agacagggcg gtctggaagg gtccagagca ggagcttcta 14161 tctccataga gttggggtta cgtcaccctc tgggcacatt ctgtcagcct ccacacgttc 14221 agctctcaga agctcccgaa ccctgtcctt tgggcctttt atggagaact ccattggctg 14281 tccatgactg aagcatggac aactgtgata atgtgattgg gcaaaaaggg tctgatctaa 14341 gcccagcaag gccagtccag attctttggg cctttgtgca gcattccttt ctccagggta 14401 tggggcaagg acccactctg gaatgaggat cctacaaccc acaatcagat tagagtcctg 14461 ccttgggcag ctgaaaagag gacaggagaa ggtcagagag acgaaaggct gttttttgag 14521 gcctgaggca ccccaacatg acaacgtaag actgtaacca tggtcatgtg agttatgagc 14581 taggaaccct ggacgaaacc aacacatata caatcatctc ccacctccca acgcctttac 14641 tttcacagcc tctgcagcaa actgcggtca ctataatcgc tcctgtggca cagaggcata 14701 cccaggggaa tctgcccagg gggccactct gtgcccacgt gggaacccac acctgcttgt 14761 aaagcctccc ctccctctga ccagcaacca ggacagtttg ttgttccaag cagtgggctc 14821 atgtctgttt tggctcagaa cagggtgggg agagcgggcc agggacccga ggaaggctta 14881 tccttgagat tgcgtgggag acacaacaag gggtgggggc ccgcaggcgg ggcggggcga 14941 agcaggtgat atcaagccca gagccccagc ctctccccac agtctcacca tggcccgcac 15001 cgtggtgctc atcaccggct gttcctcggg catcggcctg cacttggccg tacgtctggc 15061 ttcagatcca tcccagagct tcaaaggtat agataggcag ggacagggag ggagagaagg 15121 gaggagccct tggaggctag aagggaagtc agatcttcct cctctcccaa aacctccagt 15181 gtatgccacg ttgagggacc tgaaaacaca gggccggctg tgggaggcgg cccgggccct 15241 ggcatgccct ccgggatccc tggagacgtt gcagctggac gtaagggact caaaatccgt 15301 ggccgctgcc cgggaacgcg tgactgaggg ccgcgtggac gtgctgggtg agcctcctgg 15361 aagcatatgg gctcctagga gccttctccg ccctgcgttg aaaccaacat gttcccaggc 15421 ccagggagca cgaggggaca ggccgtgctg agggtgatgc tgaggcgggc tggtcgggcc 15481 tcttgtctcc gcagtgtgta acgcaggcct gggcctgctg gggccgctgg aggcgctggg 15541 ggaggacgcc gtggcctctg tgctggacgt gaatgtagta gggactgtgc ggatgctgca 15601 ggccttcctg ccagacatga agaggcgcgg ttcgggacgc gtgttggtga ccgggagcgt 15661 gggaggattg atgggtgagt ggtagggagt ggcctcggca gctccagatt ctttgtgtgc 15721 ggagctgagc cttgaaggca ggttccgcgg ggagggtgga ggggggtgcc gtcagcttgg 15781 aggggcaccg tctgcccggg gatgaccccc tggccgctgc gcctcaggaa cctcgtctcc 15841 ccacctaagg gctgcctttc aatgacgttt attgcgccag caagttcgcg ctcgaaggct 15901 tatgcgagag tctggcggtt ctgctgctgc cctttggggt ccagtgagtc aacacccccg 15961 ttccccgaac cctcttaact ctgacctaga gatgccgagc accctgtcct gcgggagccg 16021 ctctggggcg atctccctgg ccctctctgc ccggctcaca ttagctgtgt gccaggcact 16081 tgggctgggc gcatggcacg cattgtgcca cctgctgacc tagctgctga agtgttggta 16141 ttgttatggg gaagctccag cccagagagg ttaggtgact ggcccaaggt cacacagcgg 16201 ccagggaccc cgctagattc gaatcctgac accagggctc ccttgtagcc tcagatggat 16261 ttgggagggc tgctccggca ggaacccgcg tttcaaatgt tctggttatc cccagcgccc 16321 tttccgcctc acttcccagc gcacggtgct gctcgcggtc gggggccggg acgtggttgg 16381 ggctgggact ggggttgggg ctgggactgg ggcctggctg gcgtccgccc cctcccactc 16441 gttgctctcc ggccagcagc ttgagcctga tcgagtgcgg cccagtgcac accgccttca 16501 tggagaaggt gttgggcagc ccagaggagg tgctggaccg cacggacatc cacaccttcc 16561 accgcttcta ccaatacctc gcccacagca agcaagtctt tcgcgaggcg gcgcagaacc 16621 ctgaggaggt ggcggaggtg agcgccgggc tggactccag gagtgggggc ggtgcgtcct 16681 ccggcgcgca gcggtggcca cagctctcct cccgccgccg caggtcttcc tcaccgcttt 16741 gcgcgccccg aagccgaccc tgcgctactt caccaccgag cgcttcctgc ccctgctgcg 16801 gatgcgcctg gacgacccca gcggctccaa ctacgtcacc gccatgcacc gggaagtgtt 16861 cggcgacgtt ccggcaaagg ccgaggctgg ggccgaggct gggggcgggg ccgggcctgg 16921 ggcagaggac gaggccgggc gcagtgcggt gggggaccct gagctcggcg atcctccggc 16981 cgccccgcag taaaggcttc ctcagccgct gtctcccgcg cccttctttg tcccctgggt 17041 ctgtgtggtc cctggggatg gggcggcggt agcagctgtg ggtggctaat taagatagat 17101 cgcgttagcc agttttacca gcgcagctag gcgcgatggc tgtcgcctgt aatgccagcg 17161 ctttgggagg cggaggcagg aggatcgctc aagccccgga gttggagacc agccagagca 17221 acacagtgag acccccatct ctacaaaaat aaagaaaatt taaaaatcag cacagtggca 17281 ccattccttg agcccaggag ttggagggtg cagtgagcat gatggggcca ctgcactcca 17341 gcctgggtga cagagtgaga ccctgtcaat taatcaaatg aaccaaccaa ccgaaaaact 17401 cagaaaccaa ggtccagaaa gaagccagcc caggatcaca cctcaagtcc atattaaagg 17461 ccagacacag tctctggata cccaaggggc atctgcagga ggagttaggt gggaattggc 17521 ttggggtaga gtcaggttgt gacttggacc ccattagcca tgagacctca ggcaagttcc 17581 ttgctttctc tcagtctttc ttttctttct ttcctttctt ttttttttat tttctgagac 17641 agagtttcgc tcttgttgcc taggctggag tgcaatgggg caatctcggc tcaccacaat 17701 ctccgcttcc cagattcaag tgattctcct gcctcagcct cccaagtagc tgggataccg 17761 gctaattttg tatgttcggt agagacgggg tttctccatg ttggtcaggc tggtctcaaa 17821 ctctcgacct taggtgatcc gcccgcctcg gcctctcaga ttgctgggca tacaggcatg 17881 agccaccgcg accggccctc tgagtctttc ttatctgtaa aatgggtata ataataccta 17941 tctaatcggt tttagtaatg gtggagataa tgcctgaaag tgctagtata gaggtttaat 18001 agccagcaag gactgttatt agaatgaata gtaatatgac tactgtcaca ttttgcaaat 18061 gtgtaaagaa gagggctaag tgaatcaaag ggagacagcc ccactcaccc tgttctgccc 18121 cagaggactg agcgatcccc accatctggc aagctgcctc accaggaggt ccagctgggg 18181 ctacaggact ggctactttg ctacaatggc ctgtctttcc tgagcccagt ggagggtccc 18241 aggggggcag aagtcattga taggggccag tagggttgta gagccactgt ctgaacttct 18301 gtggaggtct ggtgcagggg aggtgtgaac agataggagg ctaggtgagg atgcagcaga 18361 ggaaggggca ggagtgccca ggagggggcg gtaccgaggc agggattcag ctgggtctga 18421 gagggaggca aggctgaggg ggatggccct ttggagtggg cagggacatg accacagaaa 18481 gcctgggaag tggaaacaga caggagcctg ttggagctct tggagctttg tgtggggcac 18541 tgggggaagg aggcaggcac tccaccctga cctgccccta cctcggatga gggtcttctc 18601 tgcctgttgg atgatgtgct gcccctgctc ttggaggaag aggcctccca gccaccccct 18661 cctgccagtc gccctgacct gctgacccag acagatctgc tatccctaca gcatccagga 18721 aggccacagg gagggggccc aggtggcatg ggtttctgag gcctgggatc tgctctcagt 18781 ccccgtctcg ccaaccccct ttgcccctct gtgacagtgt gtgtacatat gcgtgcatgt 18841 gtgtacctgt gtggtgtggc tcacaaggtc acccctgggg gtgggataat aagaggtaaa 18901 gtgtgacccc ctctcttccg tacattcatt ttttcaagct tgtgaatatt cacattgtta 18961 atataatctt ctgcagtccc atgacttcga atagcactta gatgccgatg acccccccac 19021 caaagaaacc ccactgtctc ccacagactc caggtctgta tctccaactg cctactcaat 19081 acaacacgtc cacctgatgc aatgaactta atgtgtctaa accccaattc cacatttcca 19141 gtcctcctac cggctcctcc cccagtcttc tctactttac tgtatgacaa ctccattttt 19201 cccaatactg gttttaaaaa ccctggagta gtccttgact ccagtctctc tcacctttca 19261 accaattcag cagcaaatac tgacagctct acctttgctc atcaaagcat attccaaaat 19321 caccctattc gagactgcac actgtcatct ttcccttcaa ttacagcagt agcctcctaa 19381 ctagttttct tgattccact cttgcccatc agcagtaaaa ttagcacagt gcatttaaaa 19441 tgatctttta aaaatgacag ggccgggcgt gatggctcat gcctataatc acagcacttt 19501 gtgaggctga ggcggacgtt attgcttgag gtcaggagtt tgagaccaac ctggccaata 19561 tggtgaaacc ctgtgtctac taaaaatata aaaattagcc aggcatggtg gtgggcgcct 19621 gtaatcgcag ctgctccaga ggctgacaaa ggagaatctc ttgaaccagg gaggtggagg 19681 ctgcagtgag ccaagattgg gacactgcac tccagcctgg gcaacagaga ctttgtctca 19741 aaaaaataaa aattggccgg gcgtggtggc tcatgcctgt aatcccagca ctttgggagg 19801 ccgaggcggg tggatcacct gaggtcagga gttcaagacc agcctggcca acagggtgaa 19861 accttgtctc tactaaaaac ccaaaaaatt agccaggcgt ggtggcacgt gcctgtaatc 19921 ccagctactc aggcggctga ggcaggggaa ttgcttgaac cccggagcgg tacgctgcag 19981 tgagtggaga ttgcgccatt gtactctagc ctgggcaaca agagtgaaac tccatctcaa 20041 aataataata ataaaattaa aaaaaattta aaataaaaaa gggagcctgg gcaacaaagt 20101 gagaccccgt ctctacgaaa aaacaaaaaa aatagttggg tgtggttgca cacatctgta 20161 gtcccagctt cttgggaggc tgacatggga agactgtttg agcccaggag gttgaggcca 20221 cagtaagctg tgggcacacc actgcattcc agcctgggca agagagggag accctgtctc 20281 ataaaagaaa gaaagaggcc aggtgtggtg gctacgcctg taatcccaac actttgggag 20341 cccaaggccg gtgaatcact tgagatcagg agttcgagac cagcctggcc aacatggtaa 20401 aaccccgtct ctactaaaaa tacaaaaatt agctgggcgt ggtagtttgt gcctgtaatc 20461 ccagctactg gggaggctga ggcaggagaa tcgcttgaac ccgggagacg aaggttgcag 20521 tgagctgaga tttctccact gcactccagc ctgggtaaag agtgagactc ggccgggtgc 20581 ggtggctcat gtctttaatc ccagcacttt gggaggccga ggcgggtgga tcacctgagg 20641 tcaggagttc aagaccagcc tggccaacct ggtgaaagcc tgtctctact aaaaatagaa 20701 aaattagctg ggcgtggtgg tgggtgcctg taatcccagc tactcaggag gctgaagcag 20761 gagaatcact tgaacctggg aggcagaggt tgcagtgagc cgagatcatg cgttgcactc 20821 caacctgggt gacagtgaga ctctgtctta aaacaaaaca aaagaagcaa agtttatttt 20881 gctcagagct tcacagtttt aggggctgga aagtgcaaga acctcatgca gtatctggca 20941 aagggctgtc ccaggatgga agggcagaag gtggaagcaa atgagagaca cgaaattggg 21001 ccaaatgtcg tccatccatc aggagccact cccatgataa cagtatttat ctattcaaga 21061 gggcagagcc ctcatgatct aattatcttt tttttttttc tcctgcctcg gcctcttgag 21121 aagctgggat tttaggcgca tgccaccaca ccccgctaat ttttgtactt ttagtagaga 21181 cggggtttca ccacgttggt tgggctggtc gcaaactcct gatctcaggt gatccacctg 21241 agatccacca ctttggcttc ccaaagtgct gagattacag gagtgagcca cctcgcccag 21301 ctgacctaat tacctcttaa aggccccacc ctgcccagtg cagtggctca ggcctgtaat 21361 cccaacactt tgggaggctg aagtgggagg actgcttgag ttcaggagtt ggaaaccagc 21421 ccaggcaaca cagcaagatc ctgtctgtat gaaaaaaaaa attttttttt taattagcca 21481 ggtgtggtgg cacacatctg tagttccagc tgctcaggag gccaaggcag aggactgctt 21541 gagcccaggc agttgaggct gctgtgagcc atgatcaacc cactgcactc cagcctgggg 21601 gacaagagtg agaccctgtc tcaaagagaa aaaaagtccc atctcttaag acagtagcaa 21661 ttgaattttt tatttcaaca tgagttgtgg cagggacatt cgaaccatag caccaaggtt 21721 ctccccaaag ctctccaaga ccttctttga tctggttcct gccccctttc tgatccgttg 21781 acctgcag //