LOCUS HSMYCENH2 20521 bp DNA PRI 23-NOV-1994 DEFINITION H.sapiens DNA for enhancer elements. ACCESSION Z46773 KEYWORDS Alu repeat; dnase i hypersensitive site; enhancer. SOURCE human. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 20521) AUTHORS Mautner,J., Joos,S., Werner,T., Eick,D. and Bornkamm,G. TITLE Identification of two enhancer elements in the 3 region of the human c-myc gene JOURNAL Unpublished REFERENCE 2 (bases 1 to 20521) AUTHORS Mautner,J.J. TITLE Direct Submission JOURNAL Submitted (16-NOV-1994) to the EMBL/GenBank/DDBJ databases. Josef JM Mautner, GSF-Institut fuer Klinische Molekularbiologie, und Tumorg., Marchioninistr. 25, Muenchen, 81377, Germany COMMENT NCBI gi: 577565 FEATURES Location/Qualifiers source 1..20521 /organism="Homo sapiens" /isolate="Burkitt lymphoma BL72" repeat_region 386..786 /note="ALU repeat" repeat_region 2436..2836 /note="ALU repeat" enhancer 3493..4126 /evidence=experimental misc_feature 3585 /note="DNAseI hypersensitive site 6.5" /evidence=experimental repeat_region 4486..4836 /note="ALU repeat" repeat_region 4736..5136 /note="ALU repeat" repeat_region 5486..5886 /note="ALU repeat" misc_feature 6085 /note="DNAseI hypersensitive site 9" /evidence=experimental repeat_region 6386..6786 /note="ALU repeat" repeat_region 7686..8086 /note="ALU repeat" repeat_region 9286..9586 /note="ALU repeat" repeat_region 10236..10636 /note="ALU repeat" repeat_region 12536..12936 /note="ALU repeat" repeat_region 14286..14586 /note="ALU repeat" enhancer 14932..16267 /evidence=experimental misc_feature 15085 /note="DNAseI hypersensitive site 18" /evidence=experimental misc_feature 16185 /note="DNAseI hypersensitive site 19" /evidence=experimental repeat_region 16186..16486 /note="ALU repeat" repeat_region 16586..16986 /note="ALU repeat" repeat_region 17186..17586 /note="ALU repeat" repeat_region 18236..18636 /note="ALU repeat" misc_feature 19585 /note="DNAseI hypersensitive site 22" /evidence=experimental repeat_region 19786..20186 /note="ALU repeat" BASE COUNT 5435 a 4933 c 4547 g 5606 t ORIGIN 1 aagctttttc ggaagacaga gttgagggaa acaagtgttc atgggacgta gatcttctga 61 ggttgaaagg aatgctcttt gttttcaaag aatgcctggg acctcagcca cagtccccaa 121 cactttcttt ccattgtcat ccccgtcagc gctttaaggg ataaaatagt ccagtgcaat 181 ctgaggtcta tgggggtggg aaaggagaga gctcagagag agagaatgaa cctttattac 241 atacatacac tcttccagac tctccatctc accagacccg acaacagcca gctggaagaa 301 tgtgacagtt gttgaatgtg acaatactga ggtttaggca agttaaatgg ctgtccccaa 361 gtcacacaag ggccaacaac aaaacaacag taatatggct gagcgtggtg gctcacactt 421 gtaatcccag cattttggga ggccgaggcg ggtggatcac ttgagcccag gagttcgaga 481 ccagcctgac caacatggcg aaatcctgtc tctactaaac acacacacac acacacacac 541 aaattagctg gccgtggtga cagcctgtag tcccagctta ggctgagcac aaacacacac 601 acacaaatta gctggccgtg gtgacagcct gtagtcatag cttaggctga ggtaggagga 661 gaatcccttg aacctggcag gcggggattg cagtgagcca tgattgcacc actgcactcc 721 agcctgggca acagaatgag actctgtttc aaaaacaaac aaacaaaaac ctgtcatagt 781 agttaacatt tactgtgtgc taaacatttt tacatgtgtt acctgacttc atccccaaag 841 cagcagttag gaggtgaact ctatctccag tgcccatttc ccaaatgaga agactgaaac 901 tttgatggat taagtaaatt gcctgcattc acagagctgg caaaatggtg aaagcagaaa 961 ttatttattc attcaccaac atttgagcat gctgtttgcc cgcaccatgc tagaggtagg 1021 aagagatacc aagataaatg ggatggataa ggtcctggtg ctgaggggtt atggattaat 1081 ggagaacaaa gaaaacatgc attttttttt tctttgagat ggagtttctc tcttgttgcc 1141 caggctggag tgcaatggtg cagtctcgac tcactgcaac ctctgcctcc agggttcaag 1201 taagtctcct gcctcagcct cccagtaatc ctgtggaatc acaggcatgc accaccacac 1261 ccagctaatt ttgtattttt agtagagatg ggttttcacc atgtcggtca ggctggtctc 1321 caactcctga cctcaggtga tccacctgcc ttggcctccc aaagttctgg gattacaggc 1381 ataagccacc gcgccccacg gaaaacaggc aatttgattc tattttacaa acactttcga 1441 gcttactatg tagcaggagg aggttcaagc tccaggagct gctaaaggca ttccttctcc 1501 ccccagagaa aatagaatcc aggaaagagc ccaggaaatt ctggaagagg agccaaagga 1561 gaagacatca tcagagagat aaggagaagc ttggaggaaa gcatgtaacc aatgtcaggg 1621 aggaagccct ggtgtgtcaa aggcagcaag aagcacagca agatagcaga ggaaggtctg 1681 ttggatttaa tcacatgaac gcagcttcct ggctgcaccc ctcatgagtg ggatgacagc 1741 tccatccacc ggcatcctct ccttcattcc cttcattcaa tccatctcca gaaacggctg 1801 cttttctgtt ctcccagcac cctgccctac cttctccaag agttcccaaa gcatgattcc 1861 agacaagcag catccacatc atgtgtgtat ttgctgcaaa tgcgggtaca cagcctgaat 1921 tagaatctca ggagatgggg cccagaaaac tatttcaata agccctggat cgcttgatga 1981 agtttgagac cctctgcctt ctccatcatt cccagtgatc ctcttccaca atcccagtgc 2041 tacttatgaa tcacagataa aataatgccc gtctctgctt aaaaccatcc agaggggtcc 2101 tgctatcttc agaattaagt tcaaagccat tcttcccagt ggtccatgtt ctgtgagctt 2161 tttcagatgc cttgtcccct ctgttcaaag cactgttcac ccaccaccta cccatccact 2221 gacactgcta cccaccagcc tgccatgctc ttcttcatcc tttgtgactc accttccagt 2281 atcctctgac ctccagacaa gtttccacag gggaatggga gtgcctgaga taatactgct 2341 cacttctgtg aaaatcgctc ttcctgcctc ttaaatcaac tccttgagga atggacccac 2401 tatcagtctt gtttaacaat gaatcttcag tggcaacgta agtgcccagc atctaatagc 2461 aactcaataa tcctttgatg gggcttggca cagtggctca ctcctgtaat tccagtactt 2521 tgagaggccg atgggggtgg atcacaaggt caggaatcaa gaccagcctg gtcaaaatgg 2581 tgaaaccccg tctctactaa aaatacaaaa attagcagga tgctgtggca ggcacctgta 2641 atcccagcta ctttggaggc taaggcagga aaatcatgtg aacccaggag gcagagtttg 2701 cagtgagccg aggttgtgcc cctgcactcc agactgggtg acagagcaag actctgtctc 2761 aaataataat aataataata ataataataa taataataat aatagtcctt tgatgaatgg 2821 ctgaataaag acccattttg atggagtgaa ggatgttgga gcatgagtag ccgaggaagc 2881 aggagcaaag ttctcaacca cctttcaaga ctcaactggg aagagaagga aagagatgaa 2941 tacaccaagt gaagtcaaac atttttattt ggatttattt gattgactca atctttcttt 3001 ccttttatat ttatttattt atttatttat ttatttattt atttatttat tttgagacag 3061 agtcttgctc tgtctcccag gctggagtgc agtgtcatga tcttggctca ctgcaacctc 3121 cgcctcccag gttcaagtaa ttctctgcct cagactcccg agtagctggg attacaggct 3181 cctgccacca cacccagcta attttttgta tttttagtag aaacagggtt tcaccatctt 3241 ggccaggctg gtcttgaact cctgacctcg tgatccaccc acctcggcct cccaaagtgc 3301 tgggattgca ggcgtgagcc acagtgcccg gcccaaattg tattttatgt tatcaaagat 3361 agaagagata attagtttag atgctgatgg gaccgagctg agagagggag aactgaagat 3421 acaggagcaa aggggatgat gtagccagat gtaggcatct ccagggcagt ttccatcttt 3481 gttcagtgcc tggagctctc agctgtgtgt ggaactgagg tgaggaagaa tgcattcctg 3541 aacacagcct cacctccagg tggtgattct tccaggtagg aacttcaaag gccaggccag 3601 gtctccttct ctggactccc agagccctcc ccccttcctc tatcacagca caggttcatg 3661 tgctcatgtg tgtaaataac ctgtttaatt ctctttctct attgctagat tccttgtggg 3721 caaagactat gtctttctct ttcataacta tatcctgaag accaggcatg atgtccagtc 3781 tctaaaattg ttttgaataa atgaatgagc atataaacaa atgaatgaat gaataaatgg 3841 atgtatgtgc atatagttta agtttctact tcctgggact gtcagtcttt ttcaccccac 3901 tcagtcctat gctgcctcct cagctcatgc caaatctctt cccttttgtc tacctacttc 3961 attacagata gcaaaagact cagcaatagc ttctctgaat ctattagtca ggatctcctg 4021 gtgacaaatg acagaaactc agctcaaatg ggcaaaagca aaaaaaaaaa aaaaaaaaaa 4081 aagtgtatat tagtttatgt aactgaaaaa gcaggaatga ttcaatctag aggcttacac 4141 aatagcccat ctctgtagtt tcatctcagt caggatctat ctccacctgg ggcaaaggtg 4201 gctggcagcc tttggaggct tacacaagcc tctcaaagac agaacccctc tttccctcca 4261 aggcgaaagc cttagacagg attccagttg tctcccgcag tcatgtgccc actctgaggc 4321 cagtggatca actggatccc agcccccatc ctgtggtagc tttggggccc ttcggttggt 4381 agcaccatca ggaaggggaa agacaagttc taaaaggaaa ggatgggcac gcaaaaagga 4441 acagatgttc tctgcattga ctctttgggc aattgtgttg ctaagctcct gagagctaca 4501 tagaatgtag cgcagatgtt tttaaaaacc tggttttcag aattaccttt tgtgaaatag 4561 agatttcgaa agtccaccta agaactgcta aaccagaatg ttcagagagt gacgcctagg 4621 atttcatatt tttttaaagc tccataagta ggccaggtgt ggtggctaga tcttgtaatc 4681 ccagcacttt gagaggccaa ggtgggagaa ttgcttgagc ccaggagttc aagaccaact 4741 caggcaagat ggtgagaccc tgtctttaaa aaaattaaaa attagctggg tgatgcatgc 4801 ctgaagtccc agctatatga gaggacccct tgggtccagg aatttgaaga ggcagagagc 4861 tatgattgca cctctgcact ccagcctggg tgacaaagtg aaacgccagc tctaaaaaaa 4921 aaaaaagaca gttccacagg ggaagggaga aacaaataag ttgaggaatg aatgtcagag 4981 cagatggcaa gtggcttcta aagtcccata gacttgtttc aatctggctg tgcccccaga 5041 tagctgcctg acctagagga gaccttgctg ttctgagcct gactttcctg atttgtagca 5101 gggaaagaaa taaaggagtg gccagaagag tgtgggaacc atacctctct gccagagctt 5161 ttgagagaat taaatgagac aagatatgag aaatggtcta gcacaggttt agtaaatgag 5221 aatttctttc cctctttctc ctccgtcatc cttcctttcc tactttcctt ccttccttct 5281 ctctctcttt ctctttcttt ctctttcttt ctttctttat tctttctttc tttattcttt 5341 cttctttctt tcttctttct ttctctctct cccttccttc cttccttctc tctctctctc 5401 tttctctctt ccccttccct tccctcccct tccctttcct tcctccctcc cttctccctc 5461 tttttctctc ttctccttcc cttccctttc tttctttctt ccttcattcc ttttttcctt 5521 ccttcccttc ccttcccttc cttccttcct tccttccttc cttccttcca tccttccttc 5581 cttccttcct tccgatagtg tctcactctg ccacccaggc tggagtgcaa tgtcatgatc 5641 acagttcact gcagcctcaa cctcctaggc tcaaatgatc ctcccacctc agtctcccta 5701 gctaggacta cagatgccca gctaatttta aaatttttgt agagatgggt ttttgctatg 5761 ttgctcaggt tgatctcaaa tttctgggct caagcaatct gcttgcctca gcctcccaaa 5821 atgttgggat gacaggtgtg agccactgtg cctggcctca ccctcccttt ctaatgtatc 5881 acaaagtcct ttagattctg cctctgaaac actctaggct ctgtccacac atcccctggc 5941 ccattgctac tgctgtcttg ctgcctacca tcaccctgtg cctgggggtc tctgcagtat 6001 cttctccctg caggcttctc aaaggcacag gagtaggcta cctcaaaagc taacagagca 6061 gatcactctc caacatatag gaatttagta ctctccttgc tctgagtata aagtacaatt 6121 atcttcctac ctgttcaaga tctgccctca gattacctgt cctgcctcat ctgctgccat 6181 atcacctgct ccgatctagg cttcaaactt atggaggtaa tttctaatgt ctctgaaatg 6241 ctaggcacat tctccccttg gatctctacc cttgctcttt cctctgcctg agagatgttc 6301 attcagcaac ccccatcccg agtctccatg tctcattttg aatgtcactt cttcatggaa 6361 gccctacctg atctctactt tcctggttcc ccttatccat ggttatcttg atcacaatag 6421 ccagcaatcg ttaaccactg tggtaccctt ctcattcacc aggctattca tgtttcattt 6481 tctttcacaa caccccctta gaaaattaca cttcctcctt ttacacttca gggtactgag 6541 atttagagtc agcaggtaac gttctcaagg tcacatagca atgcattgca aagattcacc 6601 ctaggtcttt ctgattcctt gtcaccagcc ttctccactt tttgctactt cccatcaacc 6661 acaccatatt gaaattgcct atttcctcct cctgcttccc cattagaatt ggaactactt 6721 gcttatatgt catgatatcg cccatgctta gcacagactg ggtacctaga acagacccaa 6781 ttacacggtt gaataaatgc agtcggtgtg ctcaggtgct gagatccatg gccagaaaga 6841 gtctggtgat agatttatgc ccagaggagt ttgtacctgc ctggttgctt gagggttaaa 6901 atgggttaaa atataggatg atgactcaga gctggagaca accttagcat tcgctttcca 6961 gatgaagccc ctggagaaga cgcaatcttc ctgagatccc tctactggct tttggctgaa 7021 ttagcttatg acctcagggc cctggttgca tcctaactga ttatcaaagc aaagtaagac 7081 ctcaggtctt ctgagatgca ggatgcttac ttgccttact actaagatga agctttcaaa 7141 ctcaccccgt ttccaagtcc atgccaggtc ttatgcccac acccagactg gcccagtcaa 7201 caaatattta tcgggcacct ccgataaaca aaggaggcac ccgtgtggaa gaaacagatt 7261 caacagtcta gtagagaaga gtggcatgat acaagtattt acatacataa ttacctaaac 7321 agatgcaaag gcacaaagta gtggggtgag gaagtacaga gtatgtgggg gcatctgaca 7381 gcctaggagt tccaggaagt ttctcagcca agacatggag ggtgggtagg agttaggtaa 7441 gccaaatatc ctgagaccct gctatgggag agggggagac atgctcagga aatggagagc 7501 aaagcagaat ggaaggagca ggaaggacaa gagaatttcc acccctgggg gagacccatg 7561 ggtgggccca agtcagatca tccagggccc tggtgaaaca gtttggactg ttatctaaag 7621 acaaactcca cagtggggaa ggtcacattg atcccaccag ggctatctgg gtcctgtggt 7681 caaggtggca ccatcctcat ggtcaagggg aaagtaggtc aggcatggtg gctcacacct 7741 ataatcccag cacttcggga ggccaaggca gatcacttga tatcaggagt ttgagaccat 7801 cctggccaac atggtgagac ctcgtctcta ctaaaataca aaaattagcc gggcgtggtg 7861 gcgtgggcct ataatcccag ctactcaggg ggctgaggca ggagaatcgc ttgaacccag 7921 gaggcagatg ttgcagtgag ccaagactga gccactgtac tccttgctgg gtgacagagc 7981 gagagtccat ctaaaaaaaa aagggagtgg ggtgggggca aagtcatggt gctgaatgtt 8041 aggacaccgg attttctttt ttttttttgt tttgagacag agttggagtc tctctctgtc 8101 gcccatgcta gagtgcagtg gcacaatctt ggctcactgc agcctcctcc tcccgggttc 8161 aagtgattct cctgcctcgg ccccccaagt aactgggatt acagacacct gccaccacgc 8221 ccagctaatt tttgtatttt tagtaaagat ggggtttcgt catgttggtt gggctggtct 8281 caaactcctg acctcaggtg atccacccgc ctcagccccg caaagtgcta ggattacagg 8341 tatgactgga cactggattt tctacactgc cattatctcc ctccaggcct cagtatcctg 8401 cctgtagtat gggtcagtaa gtccagacca ggtaatgtta aggtctttcc agctgggaca 8461 aaacagtaat aataaggata gtaggctggg tgcaatggct cacacctgta atcccagcac 8521 tttgggaggc tgaggtgggc ggatcacaag ttcaggagtt cgagaccagc ctgatcaata 8581 tggtgaaaac ccgtctctac taaaaataca aaaattagac tggcacacac ctgtaatccc 8641 agctacttgg gaggctgagg cagaattgct tgaacccagg aagcggaaat tgcagtgagc 8701 cgagatcgtg ccattgcact cctgcctggg tgacagagtg agactccatt aaaaaaaaaa 8761 aaagtttcaa tgaagaatag taaggccaag tgcagtggct cacacctgta atcccagcac 8821 tttgggaggc tgaggcagga ttatcacttg atcctaggag tttgaagcca acctgggcaa 8881 cgtagcaaga ccctatccct acaaaaaata caaaaattag caatgcatgg tggtgtgcct 8941 gtagttccag ctactcaaga ggctgaggtg ggaggattac ttgagcccag gcagtcaagg 9001 ccgcaatgag ctatgatcat accactgcac tccagcctgg gtgatacagt aagaccgtga 9061 ctcaaaataa caagcaaaca aaaagaataa taacgctagc atttgtagtg tgttttctgt 9121 gtacctagta ctgtgcaaaa cacttctcat tgaatcttca tgacaaccac atgaagaggt 9181 aactatgatt atgcacattt gacagacaga tgagaaaaaa gactgaggaa ttaagtaaat 9241 agtgcaaggt cccccagcaa aaaagtgaaa gagctgggat tcaagcccga gtctgctctg 9301 acatccagcc tgactcatct gccatctctt actgctaaga tactttagga agtttcaaaa 9361 cctgaaaaat ccatgatggc ttgtgccagt ttaacatgtt ttaaggctgt ttcagctgct 9421 ttgaactttt gatgaggtgc cctgtgtgac tctggacggc tcccagatga agcactgagg 9481 aagcattccc cgaggtgctg gggcctcctc aagatctaat agcaatgtgg catgatgaac 9541 gcagagcgga cagaaaccac atctttgcgc cccagcctca tgaaccctca ccaggtctac 9601 tcaggccaga cagggatcct gaggttgttt ttccaggagc ctggcagggc cctctctctc 9661 tccctaacaa accaggctgt cattcccctc accttgtaaa taatctccct cccaggcacc 9721 gagactgctg ccttctgcag cataaatgtg aacactgttg tggaatgcct gccacactcc 9781 cgtgggcttt tgccagaggg cctcccgcca gtaatctgcc cttcagaaac tggccttgga 9841 tttctcagtc tccatttgtg accttggtgg cgagaggttt gggagtctaa atgcaaggaa 9901 atcaaagatc agagccgtga gagttaccag agtccagaga acaatctgga tggaaagact 9961 actaatgtca cgtgagtgga cagcctcatt ttacagggga aaaagctgag gtccagacag 10021 gagacagacg gtacgcagag gacacagaca tgcaggaata ggttgagaca gcaggtcaag 10081 ttcatttcca gggaagcttt atggcattgg gactgctcaa tgttctttcc tcctctttgg 10141 gtaaagcatc ccatctcttt ttggaatttt ctctctttta aaaaatttat ttttggccag 10201 gcatggtggc tcacacttgt aatcccagca ctttgggagg ccaagatggg tggatcatta 10261 gaggccagga gttcgagatc agccgggcca acatgccaaa accccatctc tactactaaa 10321 aatataaaaa ttagctgggt gtgttagtgc acacctgtaa tcccagctac tcgggaggct 10381 gaggcacaag aatcacttga acccaggagg cagaggttgc agtgggctga gattgtgcca 10441 ctgcactcta gtctgggtga cacagcgaga ccttgtctta aatatatata cgtgtgtgtg 10501 tgtatatatg tgtgtttgtg tgtgtgtgta tatatatact ttatttttaa attttaaaaa 10561 aagtttttca gtagagtcag ggtctcacca tgtggcccag gttggtcttg aactcctgga 10621 ctcaagtgat gctcctgcct tggcctccta aagtgctggg attacaagca aatgtcacca 10681 ggcccaacct ggaattttct cttacccatt gtgggtggtc tttgtaggcc caaggaagtg 10741 ccttccctct tctagccaca gagatgtcca gaagagatgg cacagactct ttctctcaga 10801 actttgaatc tttttttgtt tttttgtttt tttttggttt ttggttttgt tttgtttttt 10861 tttgttttgt gtttttttga gatggagtct cgccctgtct ccaggctgga gtgcagtggc 10921 atgatctcgg ctcattgcaa cctccacctc ccaggttcaa gtgattctca tgcctcagcc 10981 tcccaaatag ctgggactac aggtgcatgc cactatgccc agctaagttt tgcattttta 11041 gtagaaacgg ggtttcacca tgttggccag gatggtctcg atctcttgac tgtgtgatct 11101 gaccgccttg gcctcccaaa gtgctgggat tacaggcgtg aaccactgca cccggccaga 11161 ctttgaatct tacttaactg gaatgaccct aaacagagca catctcttct ggtgcctgtc 11221 cctggagtga ctgagtcatc cagctctcta aacacttggc gctgcctggg tcaaacctgt 11281 ctctaccctg gcttccctat ctccatcagt tctagagctc tccaacaccc ttctagaaaa 11341 ttcctctaaa ttagccagta ggagcttctg cttcttgcaa ctaaaaagcc atgaaggatg 11401 aagcatgctt taaattttcc ccacaatttc atgctgtctt gctctgaggc aacaaccttt 11461 aaaaaaaaaa tggcacagag acagaaacac tgcaagtcat aacagggtat acatacaacc 11521 aaaccctggg tagttgcatc ttttcagtca atggctgcat attttgttct ttcactatct 11581 aatttgggga tagtttgtac tggagatcag cccccactcg caacacagct gatagggtgg 11641 tctacacact atagtgtctc cactcttact gtctcgaagt atcaaaccca aataaactct 11701 gtgcagttta aacacaattc tcagattttt ttaaaaactg cctttttttt tttttttttt 11761 ttttttgaga cagagtctcg ctctatcacc aagttggaat gcagtggcgc gatctcggct 11821 caccgcaacc tccgcctccc gggttcatgc gattctcttg cctcagcctc ttaagtagct 11881 gggattacag gcgcccacca ccatgcccgg ctaatttttg tatttttact agagatgggg 11941 tttcatcatg ttggccaggc tggtctccaa ctcctgacct cagatgatcc acccgccttg 12001 gtctcccaaa gtgctggaat tacaggcgtg agccaccagg cccgaccaaa actgtcattt 12061 aagaaattac tattttatga aaggttttgt gctaaggatt ttatatacca tctaatcagc 12121 tgaacaattc tacagatggt gcattactat cagcttaatt gcattaatga gaaaactggc 12181 tgtccaaatt gggaaagggg cagttgtaaa tgaatgtcaa ggtcacatag ctcacagtgg 12241 tggtctttag gtataatccc agctcgatct gattccagag tccttgctgt aaaaccttag 12301 gctgaattgc ctggaaatga ctcagtggtg ccccagtcag gtggttctct attcagagaa 12361 tgccccacca taagatagtt gagtatcaga atctccagag aaattgccat ttgaaatgca 12421 tatttaatat gatgttataa ctttatattt ggaaagtgaa aagtaggctg ggagcagtgg 12481 ctcacacctg tagtcccaac acttttggag gccaaggcgg gctgatcact tgaggtcagg 12541 atttcaagac cagcctggcc aacatggcaa aaccctatct ctatcaaaag tacaaaaaaa 12601 ttagccaggt gtgatggcac atgcctgtag tcccagctat tcgggtggct gtggcacgag 12661 aatcacttga acccaggagg tggaggttcc agtgagccga tcatgccact gcactccagc 12721 ctgggtgaca gagcaagact ctgtctcaaa aagtaaataa ataaagtaaa acataaagac 12781 aatcccaatg tttttatttt tatttttatt ttttatttat ttttttaaga tggagtttcg 12841 ctctttcgcc caggctggag tgcagtggcg cgatctcagc tcactgcaac ctctgccttc 12901 cggtttcaag caattctcct gcctcagcct cccgagtagc tgggactaca ggtgcctgcc 12961 accatgcccg gctaattttt gtatttttag tagagacggg gtttcactat gttggccagg 13021 ctggtctcga actcctgacc tcatgatcca cccgcctcaa cctcccaaag tgccgggata 13081 acaggcgtga gccactgcgc caggcccccc agtgttttta atacaaacca ggccaccttt 13141 gagagtgcaa gtggctcctg cggttgatta ggtctaggtg ttcccaggca aactgggatg 13201 tatgatcacc tatccacaga agagaaaaca ggtgcaagta ggtgaagatg gcatagccag 13261 caagtggtag agtaggtatc agaatcctga aataaaataa cacccaacat tcccctgtga 13321 cttttctgac agcccgagtt cttccaacct tttaaaactc tgatcaaaac tagcttctgc 13381 caggaagccc ttcccaacta actccagctc cttctgcatc tttgtcttct gacagccacc 13441 ttgcactgta cttgatgaat tttctgttga attatagact gtggtttttc atgtgtgtgt 13501 gcacatgtgt aaacaggcag tccttgcttt gtatggttct ttttttcttt ttttctcaat 13561 gtgatagtat atctcatgtt aactgagacc tcaccttggt taccatggaa ccatgaaaaa 13621 tgaggacacg gttctgacac aaatgagttt ccatgaatac agtgccttac aaagtgagga 13681 gagcctgttt tctggttttc tttttcttat ttatttattt atttattttg agacagggtc 13741 tcactctgtc atccaggctg gagtacagtg gcataatcat gtctcactgt agcctggacc 13801 tcccaggctc aagcaatcct cccacctcag cctccagagt agctatcact acaggcgagt 13861 gctacttacc acacctggct actttctaaa ttttttgtag agatgggggt ctccctgtgt 13921 tgctcaggct ggcctcgaac tcctgggttc aagcaatctt cctgcattgg cccctcagac 13981 tgctggggtt acaggtgtga gccgccatac cttacttgtt ttttctctta tgatggtata 14041 ttagtttcct aggattgcca aaacagatta tgatgaattg tgtggcttat aacaataaaa 14101 ctttattgtc acggttctag agactagaaa tctaaaatta aggtgtcagc agggctgtgc 14161 tccctctgaa gattctagag gaaagtcatt ccctgccttt cccagcttct agtagatgct 14221 ggcattcctt ggctttcctt ggcatgtaga tgcatctcta caatctctgc ctctgacttc 14281 acatggcctc ctcccctgca tgtatgtatc tctgtaagtc cttgattttt ttttcttttt 14341 tgagacatag tctcactctg tcacctgggc tatagtgcag tggtgtgact tcagctcact 14401 gcaacctcca cctcccgggt tcaagcgaaa ttctcacgtg tcaggctccc aagtagctgg 14461 gaccagagat gcatgctacc atgcccagct aatttttgta ttttcagtac agacagggat 14521 tcactacgtt ggccaggctg gtctcgagct cctgacctca agcgatccac ctgcctcggt 14581 ctcccaaagt gctggaatta aaggcatgag ccaccttgcc cagcgtggat ttaaggattt 14641 aaatcagtca ttggatttaa ggtccaccct aattcagtat gatctcatct taactaacta 14701 attacatctg caaagactct atttccaaac aaggtcacat tctgaagttc ctggtggaca 14761 tgaacttgga ggatcactac tcagttcact acaggtggat aagaacctcc agggctggat 14821 ttatagcata aatcaactcc actcccagtg ctaaactagc aagtacacac agcaggcact 14881 caacaatcca ggaaagaccc attcacaggg ttggatctga atgagggcaa tgagctccgt 14941 tcactggaag ccagttttat tttctccttc cagccttctg tacagccaac cactcccaag 15001 cccatttcct tccctttttt gacatggctt tctcttcctg ctccccaccc acccttgctg 15061 cctcttttct ttcttcctcc cactttcccg ccttgaatga cagtttaagg gaagccgtat 15121 gtgtatgcat gtgagtgtgc atgggcatgc attctggaag caaggaagcc cctcctcact 15181 tcgagcacct tcacccatcc aagcatgtca ttattctctg cttttagggt gcaaggccat 15241 tagggttcct ctgaaagttg aactaaattc tcaaccctta gtcaaatgtc ctctcctagc 15301 cacataccct tccgattttt ttcttccaga agtcccaggc gaaaaggttc ctcattgtta 15361 gcactgcctg tgccttcctc tttttagttt ctggatgtca gttcactttt ttggtgaaaa 15421 attaacaata tgttgtcact ttatgaacac tgtgtgccaa gcagtgtgcc aagcccttca 15481 cacacattat cttgcccatt ctttatgtgt ttctcattgt accgaggaga atactgaggg 15541 cttaagcaac aaggtagttt gtcaaaagtc atgcagctga ttgaaggtgg agtcagaatt 15601 cgaacctacg ttcatcagat tccagagtgc attctctcca ccacagtata gggttgtgaa 15661 agcaaccttt gggaacatta ttcctttaga ctgcttccta gccaagcttc ctgaaaacac 15721 ataagaccat tgagtactaa ctgctgtttt ctttaaggag ttaaggttaa cagactcttt 15781 acacttccct tctcctctga aatcactgga gtgggagtag ggttgcagct aaaagggaac 15841 tcattgacaa cctgcagatt tttatacaaa atccccttgg aactggtttt tctcatagca 15901 gttgctttga gtttctgagt gcaataactt aaggtctaaa atgaaaacgc ctcaaaattt 15961 caaaatactc ctccttgttg gcagatttcc attaaacctg attcagcatt ttcagtcagg 16021 gaacaagtca caagatatcc ccaaatcaga ggcaactaac agacactcta atcatgttaa 16081 acttctcgca gttttatgaa caaaccattc tctcctgcct ctttgtacct tttccttctg 16141 cctgacacct ctctctgaac ccaactattt gccagtggca cagttttgag ggaggcattt 16201 agccatcctg gctctgccct ggaggagtcc ttatctgaac cctaaagcag cgcttgatgt 16261 ctcactccta gggaagcctg ggaaggagaa ggttgttaaa atctgggccc tgccccaaat 16321 ctactacgtc agaatctcta gggtggatcc tggggaagac gcatctcaac aagttctcca 16381 ggcgcttggg aagatgtcct ggaccaaggt tccaagcgtt gaatcgttac ttcatcttca 16441 caatttttat cttgtacttt aaaaaaatta acaaacactg atgtggagct tactgtgttc 16501 caggcactca tgcagtgatc atagcaaccc tagtgaggaa ggcaccgtca tcatccctgt 16561 gctgcagaca aggaaacagg ggcaccaaga ggttaaggaa ctggtcccgc cgggcgcggt 16621 ggctcacacc tgtaatccca gcactttggg aggccgaggc gggcagatca cgaggtcagg 16681 agatcgagac catcctggcc aacgtggtga aaccccgtct ctactaaaaa tacaaaaaat 16741 tagccaggcg tggtggcggg cgcctgtagt cccagctact cgggaggctg aggcaggaga 16801 acgacgtgaa cccgggaggc gtagctttca gtgagcggag atcgcgccac tgcgctccag 16861 cctgggcaac agagcgagac cctgtcttaa aaaaaaaaaa aaaaaagaaa ctggtccgaa 16921 gtcacccatc aagtaagcgg cagaactggc tcctgcctgc tgcactctcc tacttcttta 16981 tatctgtgga tttttttttt catttaaata attgatttga atttcatgtc aaatctatga 17041 gggcagagat tttcagctgt ttgttcactg ctggatacca atgggctaga acaatgccag 17101 gtggagtaac agtcaatata tatttgttaa gtgaataaat gcatagagaa aatctcaacc 17161 cggaattaag gtgttggtta tattttttcc ttatattcac taaaattaca cagatataat 17221 tattaccata aaaagtctat gtaggcaggg cgcagtggct cacgcctgta atcccagcac 17281 tttgggaggc tgaggctggc agatcatttg aggtcaggag tttgaaacca gcctggccaa 17341 catagtgaaa ccccgtctcc actaaaaatt caaaaattag ccggccatgg tggcgcgtgc 17401 ctgtaatacc agctacttga gaggttgagg catgagaatc gcttgatctc agaggtggag 17461 gttgcagtga gccaagatcg caccactgca ctccagcctg ggtgacagag taagactctg 17521 cctcaaaaaa aaaaaaaaaa ttctgtgtat caccttaagt cctgtcccat ttccatactg 17581 gtatctatac cctagtttgg gaagccctaa gctccagctt acttctatca ttatactgac 17641 aacagtaaac tgtaatttat gttccagact gtaagctccc aagaacaggg actcgattta 17701 cccatctttg tgtccctgtg gttgagggta aaggccaaca gtgccattct ccattcttgc 17761 tagaaagaac tggttataga tttgatggtt ccttcaaatc ctttgagata tgaaagaaaa 17821 tgataggatt caatggatgg caagaacaac aagaggaagg aggcctggac tggagcccat 17881 taaagggagg acttccaggt ttgagctgat gagcatcagg acacctgcac tctacttctg 17941 gctgattctt catgtcctgg agacagtcta ctactttgaa ctggtggcct ttctcaggct 18001 gcgaattcct tgagaaaaac atcatgtctt tcttgttgtt caccagttta tctgcagaac 18061 ctgcttagta accagcacac agaagatgct cagtaaaaaa atgtgggttg aatgaataca 18121 tgagggaaaa attgttaaat atgttctgat taggaaagta cagcatgctt tctccctcat 18181 tttcttctgt ttccacagtc tcctaaggct ctaatatttc cataaaatat gggtttgtgg 18241 aaggcaattt ggttggaagg gttgatttaa agttgtacgg gaggccaggc atggtcactc 18301 actcctgtaa tcccagcact ttgggaggcc aaggcaggtg gatcacgagg tcaagagatc 18361 gagaccatct tggccaacat ggtgaaacct cgtctctact aaaaatacaa aaattagctg 18421 ggcttggtgg tgcacgcctg tagtcccagc tacttgggag gctgaggcag gagaatcact 18481 tgaacccaga aggtggaagt tgcagtgagg caaggttgaa gcactgcact ccagcctggc 18541 gacagagcga gactctgtct caaaaaatat atataaaata aagttgtatg ggaaaagcat 18601 tatacacaag ctggaaaaat gacaataaga cacataaagg aaaagggact gtggaacttt 18661 ccctggggaa gagtatatgc ccagtcccac cccagatatc agcctccagc cccctggttg 18721 tcaaactctg ggactggtgc agtgacctca ccagaaggca tgagatccag cgaattattc 18781 agaatattgg ttctgcttcg gatgagatgc cagtgagaat atcaccagct aactgcaggc 18841 agggaggaag tcaatggtaa ttaaactttg tttccttgta cacagcagcc aaccgcaagg 18901 tacacaggaa atacacaggc agaagttgcc aagagcaact gcagatgaaa actagtaata 18961 aaatcaggta ccactccaaa aagagacact ggagaagaac gaaactagag ctatacggaa 19021 ttgtgcctga gatggcacac acgcttatga tgtatcaggt cactaccatc ctaacatatc 19081 aaactgaaaa tgtcaccccc atctggagag tgggacacgt tttattgaaa caatgttttc 19141 tcttgtttgt ttatatgctc tgcactagtg gctggttcag taataaatct gtaagggcct 19201 ttttttaaat aaataaataa taaattagga aaaaaaaaag actgtggctc ctatcttggg 19261 cacttcttgc tttctgcctc ccatcagtca tcccagggga cgccagctgc cactttgatg 19321 gctgcacttt ggagaggccc acagaggagg aaccaatgtc tccagccaac agtcagcaaa 19381 gacctgagaa gacctgaggc ctttccaaag ccgtgtgagt gacgctggga gggaatgctc 19441 ccagagtcca gccttgagaa gaccgcagct ttgacagaga gcttgagtgc aggctccaga 19501 gagaccagga gcagaaccac caactaggct gagccaggat tcctgtctct tagaaggtgt 19561 gagataatta gtgtttattg ttttcgcttg ctaacttttg gggtaatttg tcacacagca 19621 acagataatt agtatatcat tttaaaaaat tactctgggg ctgggcacag tagcttatac 19681 ctgtaatccc aatactttag gaggtcaagg tgagaggatt gcttgcgttc aagagttaga 19741 gaccagcctg ggcaacatag ccagatccca tctctacaaa aatttttaaa aattagctgg 19801 gccttcagcc agccgcagtg gctcatgcct gaaattccag cactttggga ggccgaggtg 19861 ggcagatcac ctgaggtcag gagtttgaga ctagcctgac cgacatggtg aaaccccgtc 19921 tccactaaaa aaaatacaaa aattatctgg gcatggtggc gcgcttctat aatcccagct 19981 actcaggagg ctggggcagg aaaatcgctt gaacccagga ggctgaggtt gcagtgagcc 20041 gagatcacac ctctgcgctc cagcctgggc gacagagtga gactctgtct caaaaaaaaa 20101 aattagctgg gcctggtggt gcatgcttgt ggtcccagtt tctcgagtgg ctgaggtggg 20161 agaatcatct gagctcggaa tgtcaaggct gtagtgaatc tttatcatgg atcactgtac 20221 tccagcctgg gcaaacagag tctctgggac cctgtctcaa aataaataaa taaataactc 20281 catagagata gtcattagct ttgttcacca aatatttcca gttctccctc ctcctgggaa 20341 catggtagaa ttaacttccc tgccccctct gttaggtgtg gccttcttat gtgccttggc 20401 cagtgaaatg tgagtggaag tgagatatga cactttcagg caaaagtttt tctgtgcaag 20461 tcactttgga tgtgtctctt tgttcctgta tggcaatctt ggaagcatag ggataaagct 20521 t //